|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Fused-core particle technology in high-performance liquid chromatography: An overview显示文摘The advent of superfcially porous particles(SPPs)for packed HPLC columns has changed the way that many practitioners have approached the problem of developing needed separations.The very high effciency of such columns,combined with convenient operating conditions,modest back pressures and the ability to use conventional HPLC instruments has resulted in intense basic studies of SPP technology,and widespread applications in many sciences.This report contains an overview of the SPP technology frst developed in 2006 by Advanced Materials Technology,Inc.,for sub-3-mm particles,then expanded into a family of SPP products with different particle sizes,pore sizes and other physical parameters.This approach was designed so that each particle of the family could be optimized for separating a particular group of compounds,usually based on solute size. | Joseph J.Kirkland Stephanie A.Schuster William L.Johnson Barry E.Boyes | 2013 | Journal of Pharmaceutical Analysis2013，3，5： | 6 |
| 2 | Compact and robust supercontinuum generation and post-compression using multiple thin plates显示文摘We report on compact and robust supercontinuum generation and post-compression using transmission of light through multiple thin solid plates at the Swiss FEL X-ray free-electron laser facility.A single stage consisting of three thin plates followed by a chirped mirror compressor achieves compression of initially 30-fs pulses with 800-nm center wavelength to sub-10-fs duration.We also demonstrate a two-stage implementation to compress the pulses further to sub-5-fs duration.With the two-stage setup,the generated supercontinuum includes wavelengths ranging from 500 to 1100 nm.The multiplate setup is compact,robust,and stable,which makes it ideal for applications at free-electron laser facilities such as pump-probe experiments and laser-arrival timing tools. | Xinhua Xie Yunpei Deng Steven L.Johnson | 2021 | High Power Laser Science and Engineering2021，9，4： | 3 |
| 3 | Hippo signaling and epithelial cell plasticity in mammalian liver development, homeostasis, injury and disease显示文摘A traditional view of cellular differentiation is unidirectional: progenitor cells adopt specific fates in response to environmental cues resulting in deployment of cell-specific gene expression programs and acquisition of unique differentiated cellular properties such as production of structural and functional proteins that define individual cell types. In both development and in tissue repair stem and progenitor cells are thought to both self-renew to maintain the pool of precursors and to expand to give rise to transient amplifying and differentiated cell types. Recently, however, it has become appreciated that differentiated cell types can be reprogrammed to adopt progenitor and stem cell properties. In the case of epithelial cells in the mammalian liver, hepatocytes and biliary epithelial cells there is a significant degree of plasticity between these lineages that has been implicated in mechanisms of tissue repair and in liver pathologies such as cancer. Recent studies have highlighted the role of Hippo signaling, an emerging growth control and tumor suppressor pathway, in regulating epithelial cell plasticity in the mammalian liver and in this review, the role of cellular plasticity and Hippo signaling in regulating normal and abnormal tissue responses in the mammalian liver will be discussed. | Randy L.Johnson | 2019 | Science China(Life Sciences)2019，62，12： | 3 |
| 4 | Plant glycosylphosphatidylinositol anchored proteins at the plasma membrane-cell wall nexus显示文摘Approximately 1% of plant proteins are predicted to be post-translationally modified with a glycosylphosphatidylinositol(GPI) anchor that tethers the polypeptide to the outer leaflet of the plasma membrane. Whereas the synthesis and structure of GPI anchors is largely conserved across eukaryotes, the repertoire of functional domains present in the GPI-anchored proteome has diverged substantially. In plants, this includes a large fraction of the GPI-anchored proteome being further modified with plant-specific arabinogalactan(AG) O-glycans. The impor tance of the GPI-anchored proteome to plant development is underscored by the fact that GPI biosynthetic null mutants exhibit embryo lethality. Mutations in genes encoding specific GPI-anchored proteins(GAPs) further supports their contribution to diverse biological processes, occurring at the interface of the plasma membrane and cell wall including signaling, cell wall metabolism, cell wall polymer cross-linking, and plasmodesmatal transport. Here, we review the literature concerning plant GPI-anchored proteins, in the context of their potential to act as molecular hubs that mediate interactions between the plasma membrane and the cell wall, and their potential to transduce the signal into the protoplast and, thereby, activate signa transduction pathways. | Trevor H.Yeats Antony Bacic Kim L.Johnson | 2018 | Journal of Integrative Plant Biology2018，60，8： | 3 |
| 5 | 大学英语教师对课堂教学测试中道德问题的认知水平研究显示文摘本文采用定量研究方法,探究大学英语教师在课堂教学测试中对道德问题的认知水平,所用问卷包含大学英语教学测试中15个典型情景,共344名大学英语教师参加了调查。研究者用SPSS软件对调查数据进行了分析处理。研究发现,大学英语教师对6个测试情景中所涉及的道德问题认知水平较高;对另外6个情景中的道德问题认知水平一般;而对3个情景中的道德问题认知水平非常低。其中大学英语教师在测试保密性、成绩评定和测试实施三个维度的职业道德建设需要引起高度关注。研究结果启示大学英语教师应重视教学测试中的道德问题,保证教学测试的公正性与客观性。研究结果同时为高校教师职业发展提供有益借鉴。 | 刘秀梅 樊旭梅 Robert L.Johnson | 2018 | 外语教学2018，39，4： | 3 |
| 6 | The effects of psychological contract breach and organizational cynicism: not all social exchange violations are created equal显示文摘 | Jonathan L.Johnson Anne M.O’Leary‐Kelly | 2003 | J Organiz Behav2003，，5： | 2 |
| 7 | 甲状腺疾病患者的糖尿病控制显示文摘甲状腺疾病不利于患者的糖尿病控制且影响预后。在各型糖尿病患者中,尤其是2型糖尿病以及1型糖尿病患者,合并甲状腺疾病较为常见。本文阐述糖尿病患者中甲状腺疾病的患病率,讨论甲状腺疾病的正常生理和甲状腺疾病的筛查建议,通过病例对照研究说明对甲状腺疾病的评估、诊断、临床治疗,及对糖尿病的影响。 | Jennal L.Johnson 丁薇 金昕晔 邹大进 | 2008 | 糖尿病天地(临床)2008，，2： | 2 |
| 8 | 大学英语课堂教学测试中教师道德观念影响因素研究显示文摘本文用质性和量化相结合的研究方法研究大学英语课堂教学测试中影响教师道德观念的因素。来自全国143所高校的344名大学英语教师参加了问卷调查。问卷包括15个大学英语课堂教学测试中的典型情景,受访者对情景中教师做法是否符合职业道德规范做出判断,并就判断理由进行文字说明。研究采用专家对各情景的判断意见作为权威参照,根据受访者与专家意见的一致程度得出受访者对课堂教学测试中职业道德的整体认知水平。通过多元回归计算揭示教学测试中教师道德观念认知水平与教师性别、教龄、职称、对教学测试的态度以及是否对职业培训感兴趣之间的关系。同时,该研究还对受访者所给出的判断理由进行主题编码,用质性分析法剖析课堂教学测试中影响教师职业道德认知水平的主要因素。研究结论有助于提高教学测试的公正性,为高校教师职业发展提供借鉴,更好地发挥测试对课堂教学和学生发展的积极作用。 | 刘秀梅 樊旭梅 Robert L.Johnson | 2018 | 外语电化教学2018，，1： | 2 |
| 9 | Social-ecological correlates of fundamental movement skills in young children显示文摘Purpose: To identify the social-ecological correlates associated with fundamental movement skills at the child, family, and environment levels in young children.Methods: Preschool children from 4 Colorado Head Start/preschool centers were recruited from 2010 to 2012. Two hundred twenty-eight children(128 girls; age = 56.08 § 4.09 months; body mass index(BMI) z-score = 0.53 § 1.12(mean § SD); 42.1% Hispanic/Latino) and 159 families were included in the final analysis. Children's perceived competence and fundamental movement skills were assessed via the Pictorial Scale of Perceived Competence and Social Acceptance and the Bruininks-Oseretsky Test of Motor Proficiency, 2 nd edition. Data on the number of children in the family, parent age, BMI, education, employment status, family income, perception of child coordination, and home physical activity environment were collected via a questionnaire. Linear regressions adjusted for child BMI, age, sex, and school site were performed at each level.Results: Child perceived cognitive competence was positively associated with locomotor skills(p = 0.04; adjusted R2= 0.035) and object-control skills(p = 0.003; adjusted R2= 0.083) at the child level. Parent education, BMI, and perception of child coordination were positively associated with locomotor skills and explained 8.8% of variance, but only parent education was significant(p = 0.04) at the family level. In addition, physical environment was positively associated with locomotor skills(p = 0.02) and explained 5.5% of variance at the environment level.Conclusion: Social-ecological correlates associated with young children's fundamental movement skills are multidimensional and differ according to skill category at the child, family, and environment levels. | Nan Zeng Susan L.Johnson Richard E.Boles Laura L.Bellows | 2019 | Journal of Sport and Health Science2019，8，2： | 2 |
| 10 | Process Capability Indices-A Review,1992-2002显示文摘 | Samuel Kotz Norman L.Johnson | | 0，，01： | 1 |
| 11 | 全球地震台网:完成全球覆盖显示文摘1 GSN的起源 1983年7月,一个特设的地震学家小组在哈佛大学聚会,探讨全球地震学的未来。那时,已有的模拟和数字全球台网多年来一直没有什么发展,这些较老的台网要么是模拟的(在纸上记录)(诸如始于20世纪60年代USGS资助的世界标准地震台网(WWSSND),要么是早一代数字的(动态范围和带宽有限),像USGS和ARPA资助的地震研究观测台(SRO)和UCSD国际加速仪台网(IDA)。 | R.Butler L.Johnson 刘希玲 | 1997 | 世界地震译丛1997，，5： | 1 |
| 12 | AtDEK1 is essential for specification of embryonic epidermal cell fate显示文摘 | Kim L.Johnson Kathryn A.Degnan J.Ross Walker | 2005 | The Plant Journal2005，，1： | 1 |
| 13 | Characterization of a novel murine Sost ERT2 Cre model targeting osteocytes显示文摘Transgenic mice are widely used to delete or overexpress genes in a cell specific manner to advance knowledge of bone biology,function and disease.While numerous Cre models exist to target gene recombination in osteoblasts and osteoclasts,few target osteocytes specifically,particularly mature osteocytes.Our goal was to create a spatial and temporal conditional Cre model using tamoxifen to induce Cre activity in mature osteocytes using a Bac construct containing the 5’and 3’regions of the Sost gene(Sost ERT2 Cre).Four founder lines were crossed with the Ai9 Cre reporter mice.One founder line showed high and specific activity in mature osteocytes.Bones and organs were imaged and fluorescent signal quantitated.While no activity was observed in 2 day old pups,by 2 months of age some osteocytes were positive as osteocyte Cre activity became spontaneous or‘leaky’with age.The percentage of positive osteocytes increased following tamoxifen injection,especially in males,with 43%to 95%positive cells compared to 19%to 32%in females.No signal was observed in any bone surface cell,bone marrow,nor in muscle with or without tamoxifen injection.No spontaneous signal was observed in any other organ.However,with tamoxifen injection,a few positive cells were observed in kidney,eye,lung,heart and brain.All other organs,28 in total,were negative with tamoxifen injection.However,with age,a muscle phenotype was apparent in the Sost-ERT2 Cre mice.Therefore,although this mouse model may be useful for targeting gene deletion or expression to mature osteocytes,the muscle phenotype may restrict the use of this model to specific applications and should be considered when interpreting data. | Delphine B.Maurel Tsutomu Matsumoto Julian A.Vallejo Mark L.Johnson Sarah L.Dallas Yukiko Kitase Marco Brotto Michael J.Wacker Marie A.Harris Stephen E.Harris Lynda F.Bonewald | 2019 | Bone Research2019，7，1： | 1 |
| 14 | Customer retail-er loyalty in the context of multiple channel strategies显示文摘 | David W.Wal ace Joan L.Giese Jean L.Johnson | | 0，，： | 1 |
| 15 | Functional gamma‐secretase inhibitors reduce beta‐amyloid peptide levels in brain显示文摘 | H. F.Dovey V.John J. P.Anderson L. Z.Chen P.De Saint Andrieu L. Y.Fang S. B.Freedman B.Folmer E.Goldbach E. J.Holsztynska K. L.Hu K. L.Johnson‐Wood S. L.Kennedy D.Kholodenko J. E.Knops L. H.Latimer M.Lee Z.Liao I. M.Lieberburg R. N.Motter L. C.Mutter J.Ni | 2009 | Journal of Neurochemistry2009，，1： | 1 |
| 16 | 核酸在细菌分类中的应用显示文摘 | John L.Johnson 徐孝华 | 1986 | 微生物学通报1986，，06： | 1 |
| 17 | 肝肠循环因子FGF15/19调节胆汁酸代谢从而控制肝脏尺寸大小与肝癌发生显示文摘文章简介肝脏是人体的一个重要代谢器官,它的大小相对于整个个体大小始终维持在一个合适的比例。肝脏如何感知生长起始和停止是肝脏发育、再生以及癌症生物学中一个有待解决的基本科学问题。近年来研究发现,Hippo信号通路在从果蝇到哺乳动物个体的器官发育及大小调控中都起着至关重要的作用。然而具体何种外部因子在调控Hippo信号通路来维持肝脏大小稳态及抑制癌症发生,一直是领域内未解决的问题。 | 姬素渊 刘清许 张世浩 陈青花 王聪 Weiji Zhang Chen Xiao Yuxi Li Cheng Nian Jiaxin Li Junhong Li Jing Geng Lixin Hong Changchuan Xie Ying He Xing Chen Xun Li Zhen-Yu Yin Han You Kwang-Huei Lin Qiao Wu Chundong Yu Randy L.Johnson Li Wang Lanfen Chen Fen Wang 周大旺 | 2020 | 科学新闻2020，，2： | 1 |
| 18 | 随机扩增多态性DNA技术研究发现二氧化钛纳米颗粒对西葫芦具有基因毒性(英文)显示文摘研究目的:二氧化钛(TiO2)纳米颗粒已经广泛应用于化妆品、防晒霜、涂料和牙膏等。这些纳米颗粒性质非常稳定,能在废水和生物固体中转移和分散。现有研究表明,TiO2纳米颗粒对动物正常生理活动具有毒性等负面作用。但是,它们对植物是否具有毒性特别是是否会产生植物基因毒性至今尚不清楚。因此,本文使用随机扩增多态性DNA技术研究TiO2纳米颗粒是否对西葫芦具有基因毒性,为TiO2纳米颗粒排放进入环境后的潜在植物毒性风险评价提供依据。创新要点:首次发现了TiO2纳米颗粒对西葫芦具有基因毒性。重要结论:采用随机扩增多态性DNA技术,发现TiO2纳米颗粒污染处理的西葫芦样品与未处理样品的基因组DNA图谱相比,不仅在谱带强度有明显差异,而且存在谱带消失和新谱带产生现象,表明TiO2纳米颗粒对西葫芦具有基因毒性。 | Fabiola MORENO-OLIVAS Vincent U.GANT Jr. Kyle L.JOHNSON Jose R.PERALTA-VIDEA Jorge L.GARDEA-TORRESDEY | 2014 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2014，15，8： | 0 |
| 19 | 双金属注射成形的刚性/耐耐磨零件显示文摘用MIM工艺,利用双色注射成形与共同烧结可制造双金属零件,但是,为了使收缩失配最小化,同时形成所期望的性能,必须使组成与烧结周期最佳化。烧结温度影响研究的M2工具钢与含硼316L不锈钢的烧结件的密度、硬度及力学性能。根据烧结时零件的原位强度与热应力计算,预测了这些材料共同烧结的相容性。对于应用所需要的兼具刚性与耐磨性的316L-0.5B不锈钢/M2工具钢零件的成功生产,证明了这项预测。 | John L.Johnson Lye King Tan Ravi Bollina Pavan Suri Randall M.German 韩凤麟 | 2015 | 粉末冶金技术2015，33，5： | 0 |
| 20 | 人造卫星40年——回顾与展望显示文摘从人造地球卫星-1发射至今40年来,近地空间环境发生了巨大的变化,人们在地球周围留下了数以百万计的微小附属物。2亿公斤人造物体中约1/4仍在轨道上运行,人造地球卫星的数目仍在不断增长。但是,只有5%的大的轨道物体(直径大于10cm)是有用的。虽然国际上正在努力控制卫星数目的增长,但是目前还没有有效的补救措施。同时飞行器的设计者们正采取措施,保护飞行器免受日益增长的轨道碎片的威胁。 | Nicholas L.Johnson 殷书平 | 1999 | 控制工程(北京)1999，，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员