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| 1 | Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts显示文摘The accumulation and aggregation of alpha-synuclein(α-syn)in several tissue including the brain is a major pathological hallmark in Parkinson’s disease(PD).In this study,we show that α-syn can be taken up by primary human cortical neurons,astrocytes and skin-derived fibroblasts in vitro.Our findings that brain and peripheral cells exposed to α-syn can lead to impaired mitochondrial function,leading to cellular degeneration and cell death,provides additional evidence for the involvement of mitochondrial dysfunction as a mechanism of toxicity of α-syn in human cells. | Nady Braidy Wei-Ping Gai Ying Hua Xu Perminder Sachdev Gilles J Guillemin Xing-Mai Jiang J William O Ballard Martin P Horan Zhi Ming Fang Beng H Chong Daniel Kam Yin Chan | 2013 | Translational Neurodegeneration2013，2，1： | 4 |
| 2 | Predictors of outcome following hip fracture. Admission time predicts length of stay and in-hospital mortality显示文摘 | John E Clague Elaine Craddock Glynn Andrew Michael A Horan Neil Pendleton | 2002 | Injury2002，，1： | 2 |
| 3 | Development and evaluation of the Osteoporosis Self-Efficacy Scale显示文摘 | Horan ML Kim KK Gendler P | | 0，，05： | 2 |
| 4 | 活性污泥过程MISO神经网络模型显示文摘用误差反向传递 ( BP)神经网络模拟了活性污泥过程 ,发现使用多输入多输出 ( MIMO)神经网络来模拟活性污泥过程变量间关系时 ,线性部分误差较小 ,非线性部分误差较大 ;但若用数个多输入单输出 ( MISO)神经网络的组合来模拟时 。 | 姚重华 Nigel Horan | 2002 | 华东理工大学学报(自然科学版)2002，28，1： | 2 |
| 5 | Regulation of matrix metallo-proteinase-9 and inhibition of tumor invasion by the membrane anchored glycoprotein RECK显示文摘 | TAKAHASHI C SHENG Z HORAN T P | 1998 | Proc Natl Acad Sci USA1998，95，13： | 1 |
| 6 | Bioadsorption of pentachlorophenol(PCP)from aqueous solution by activated sludge biomass显示文摘 | Wang J L Horan N Stentiford E | 2000 | Bioresouce Technology2000，75，： | 1 |
| 7 | CDC definitions of nosocomial surgical site infections,1992:A modification of CDC definitions of surgical wound infections显示文摘 | Horan TC Gaynes RP Martone WJ | 1992 | Infect Control Hosp Epidemiol1992，13，10： | 1 |
| 8 | Social cognition in psy- chosis: Multidimensional structure, clinical correlates and rela- tionship with functional outcome显示文摘 | Mancuso F Horan W P Kern R S | 2011 | Schizophr Res2011，125，23： | 1 |
| 9 | The psychosocial treatment of schizophrenia : an update显示文摘 | Bustillo J Lauriello J Horan W | 2001 | Am J Psychiatry2001，158，2： | 1 |
| 10 | Recommendations concerning use of echocardiography in hypertension and general population research显示文摘 | Devereux RB Liebson PR Horan MJ | 1987 | Hypertension1987，9，2： | 1 |
| 11 | The Economics of Nonpoint Pollution Control显示文摘 | JS Shortle RD Horan | 2001 | Journal of Economic Surveys2001，15，3： | 1 |
| 12 | Silk-based biomaterials显示文摘 | Gregory H Altman Frank Diaz Caroline Jakuba Tara Calabro Rebecca L Horan Jingsong Chen Helen Lu John Richmond David L Kaplan | 2002 | Biomaterials2002，，3： | 1 |
| 13 | Optimising the biogas production from leather fleshing waste by co-digestion with MSW 显示文摘 | Shanmugam P Horan N | 2009 | Bioresource Technology2009，100，18： | 1 |
| 14 | Repeatability of three-dimensional thorax and pelvis kinematics in the golf swingmeasured using a field-based motion capture system 显示文摘 | Evans K Horan S A Neal R J | 2012 | Sports Biomechanics2012，11，2： | 1 |
| 15 | CDC/NHSN surveil- lance definition of health care-associated infection and criteria for specific types of infections in the acute care setting 显示文摘 | Horan TC Andrus M Dudeck MA | 2008 | Am J Infect Control2008，36，5： | 1 |
| 16 | Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK 显示文摘 | Takahashi C Sheng Z Horan TP | 1998 | Proc Natl Acad Sci USA1998，95，13： | 1 |
| 17 | Silk matrix for tissue engineered anterior cruciate liga-ents显示文摘 | Altmana G H Horan R L Lu H H | 2002 | Biomaterials2002，，23： | 1 |
| 18 | Regulation of matrix metalloproteinase 9 and inhibition of tumor invasion by the membrane anchored glycoprotein RECK显示文摘 | TAKAHASHI C SHENG Z HORAN T P | 1998 | Proc Natl Acad Sci U S A1998，95，： | 1 |
| 19 | Guideline for prevention of surgical site Infection 显示文摘 | Mangram AJ Horan TC Pearson ML | 1999 | Infec Control Hosp Epidemiol1999，20，4： | 1 |
| 20 | Gu Prevention of ideline fo Surgical Sit Infection, 1999 显示文摘 | Mangram A J Horan T C PearsonM L | 1999 | American Journa of Infection ControlOutcome Management1999，27，2： | 1 |
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