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| 1 | Radiofrequency ablation for early oesophageal squamous neoplasia:Outcomes form United Kingdom registry显示文摘AIM:To report outcomes on patients undergoing radiofrequency ablation(RFA)for early oesophageal squamous neoplasia from a National Registry.METHODS:A Prospective cohort study from 8 tertiary referral centres in the United Kingdom.Patients with squamous high grade dysplasia(HGD)and early squamous cell carcinoma(ESCC)confined to the mucosa were treated.Visible lesions were removed by endoscopic mucosal resection(EMR)before RFA.Following initial RFA treatment,patients were followed up 3monthly.Residual flat dysplasia was treated with RFA until complete reversal dysplasia(CR-D)was achieved or progression to invasive Squamous cell cancer defined as infiltration into the submucosa layer or beyond.The main outcome measures were CR-D at 12 mo from start of treatment,long term durability,progression to cancer and adverse events.RESULTS:Twenty patients with squamous HGD/ESCC completed treatment protocol.Five patients(25%)had EMR before starting RFA treatment.CR-D was 50%at12 mo with a median of 1 RFA treatment,mean 1.5(range 1-3).Two further patients achieved CR-D with repeat RFA after this time.Eighty per cent with CR-D remain dysplasia free at latest biopsy,with median follow up 24 mo(IQR 17-54).Six of 20 patients(30%)progressed to invasive cancer at 1 year.Four patients(20%)required endoscopic dilatations for symptomatic structuring after treatment.Two of these patients have required serial dilatations thereafter for symptomatic dysphagia with a median of 4 dilatations per patient.The other 2 patients required only a single dilatation to achieve an adequate symptomatic response.One patient developed cancer during follow up after end of treatment protocol.CONCLUSION:The role of RFA in these patients re-mains unclear.In our series 50%patients responded at12 mo.These figures are lower than limited published data. | Rehan J Haidry Mohammed A Butt Jason Dunn Matthew Banks Abhinav Gupta Howard Smart Pradeep Bhandari Lesley Ann Smith Robert Willert Grant Fullarton Morris John Massimo Di Pietro Ian Penman Marco Novelli Laurence B Lovat | 2013 | World Journal of Gastroenterology2013，19，36： | 7 |
| 2 | Intervertebral disc development and disease-related genetic polymorphisms显示文摘The intervertebral disc(IVD)comprises a gelatinous inner core(nucleus pulposus;NP)and concentric rings(annulus fibrosus;AF).The NP,an important structure for shock absorption in the vertebrate spinal motion segment,can be traced back to the notochord in ontogenetic lineage.In vertebrates,the notochord undergoes mucinoid changes,and had been considered vestigial until recently.However,observed correlations between IVD degeneration and back pain in humans have renewed interest in the IVD in biomedical fields.Beyond its mechanical contribution to development,the notochord is also an essential signaling center,which coordinates formation of the neural tube and somites.The pertinent signaling molecules,particularly TGF-b and bone morphogenetic proteins(BMPs),continue to play roles in the adult tissues and have been utilized for tissue regeneration.Genetic factors are major determinants of who will develop IVD degeneration and related back pain,and seem to correlate better with disc degeneration and back pain than do external forces on the spine.In summary,the spinal column is a landmark development in evolution.Genes directing the development of the IVD may also contribute to its maintenance,degeneration,and regeneration.Likewise,structural genes as well as genes responsible for maintenance of the structure are related to IVD degeneration.Finally,genes responsible for inflammation may play a dual role in exacerbating degeneration or facilitating repair responses depending on the context. | Jason W.Ashley Motomi Enomoto-Iwamoto Lachlan J.Smith Robert L.Mauck Danny Chan Joseph Lee Martin F.Heyworth Howard An Yejia Zhang | 2016 | Genes & Diseases2016，3，3： | 3 |
| 3 | Preoperative serum YKL-40 is a marker for detection and prognosis of endometrial cancer显示文摘 | Catherine S.M. Diefenbach Zharna Shah Alexia Iasonos Richard R. Barakat Douglas A. Levine Carol Aghajanian Paul Sabbatini Martee L. Hensley Jason Konner William Tew David Spriggs Martin Fleisher Howard Thaler Jakob Dupont | 2006 | Gynecologic Oncology2006，，： | 2 |
| 4 | Association Between Human Immunodeficiency Virus Infection and Stiffness of the Common Carotid Artery显示文摘 | Eric C. Seaberg Lorie Benning A. Richey Sharrett Jason M. Lazar Howard N. Hodis Wendy J. Mack Mark J. Siedner John P. Phair Lawrence A. Kingsley Robert C. Kaplan | 2010 | Stroke2010，，10： | 1 |
| 5 | ADVANCES IN SUSTAINABLE SECURITY SYSTEMS ENGINEERING WITH DRAMA THEORY (DT) Ⅱ显示文摘We put forth Drama Theory Ⅱ (DT Ⅱ) as a formal multiple participant decision making framework that can be used to systematically model complex security challenges,and advance the field of Sustainable Security Systems Engineering.DT Ⅱ is defined as a theory of 'large world' pre-game communication and equilibrium selection.While game theoretic tools have been widely applied to resolve environmental conflicts and promote global security,traditional game theory assumes that decision makers,options,and preferences are fixed.A mathematical treatment of key drama theoretic concepts (i.e.positions,intentions,doubts and dilemmas) is provided.The dynamics of the drama theoretic process are discussed and the expected equilibrium set is derived.The fundamental theorem of drama theory is proven and all theoretical results are applied to promote sustainable security solutions.It is emphasized that DT Ⅱ represents a flexible systems engineering technique to address time-sensitive,multi-faceted,and complex multiple participant negotiations. | Jason K. LEVY Nigel HOWARD | 2009 | Journal of Systems Science and Systems Engineering2009，18，4： | 1 |
| 6 | Essential role for Dicer during skeletal muscle development显示文摘 | Jason R. O’Rourke Sara A. Georges Howard R. Seay Stephen J. Tapscott Michael T. McManus David J. Goldhamer Maurice S. Swanson Brian D. Harfe | 2007 | Developmental Biology2007，，2： | 1 |
| 7 | Dynamic Contrast-Enhanced Magnetic Resonance Imaging as a Predictor of Outcome in Head-and-Neck Squamous Cell Carcinoma Patients With Nodal Metastases显示文摘 | Amita Shukla-Dave Nancy Y. Lee Jacobus F.A. Jansen Howard T. Thaler Hilda E. Stambuk Matthew G. Fury Snehal G. Patel Andre L. Moreira Eric Sherman Sasan Karimi Ya Wang Dennis Kraus Jatin P. Shah David G. Pfister Jason A. Koutcher | 2012 | International Journal of Radiation Oncology, Biology, Physics2012，，： | 1 |
| 8 | Effect of Statins Alone Versus Statins Plus Ezetimibe on Carotid Atherosclerosis in Type 2 Diabetes显示文摘 | Jerome L. Fleg Mihriye Mete Barbara V. Howard Jason G. Umans Mary J. Roman Robert E. Ratner Angela Silverman James M. Galloway Jeffrey A. Henderson Matthew R. Weir Charlton Wilson Mario Stylianou Wm. James Howard | 2008 | Journal of the American College of Cardiology2008，，25： | 1 |
| 9 | Between Physical and Electronic Spaces:the Implications for Organisations in the Networked Economy显示文摘 | FENG LI JASON W HOWARD W | 2001 | Environment and Planning A2001，33，4： | 1 |
| 10 | Radiofrequency Ablation and Endoscopic Mucosal Resection for Dysplastic Barrett’s Esophagus and Early Esophageal Adenocarcinoma: Outcomes of the UK National Halo RFA Registry显示文摘 | Rehan J. Haidry Jason M. Dunn Mohammed A. Butt Matthew G. Burnell Abhinav Gupta Sarah Green Haroon Miah Howard L. Smart Pradeep Bhandari Lesley Ann Smith Robert Willert Grant Fullarton John Morris Massimo Di Pietro Charles Gordon Ian Penman Hugh Barr Praf | 2013 | Gastroenterology2013，，1： | 1 |
| 11 | Effect of Statins Alone Versus Statins Plus Ezetimibe on Carotid Atherosclerosis in Type 2 Diabetes显示文摘 | Jerome L. Fleg Mihriye Mete Barbara V. Howard Jason G. Umans Mary J. Roman Robert E. Ratner Angela Silverman James M. Galloway Jeffrey A. Henderson Matthew R. Weir Charlton Wilson Mario Stylianou Wm. James Howard | 2008 | Journal of the American College of Cardiology2008，，25： | 1 |
| 12 | Characterization of microporous separators for lithium-ion batteries 显示文摘 | John Moore Jason Howard | 1999 | J Power Sources1999，77，： | 1 |
| 13 | Distribution of water molecules at Ag(111)/electrolyte interface as studied with surface X-ray scattering显示文摘 | Toney Michael F Howard Jason N Richer Jocelyn | 1995 | Surface Science1995，335，： | 1 |
| 14 | A Biomechanical Comparison of Modern Anterior and Posterior Plate Fixation of the Cervical Spine显示文摘 | Young Do Koh Tae-Hong Lim Jae Won You Jason Eck Howard S. An | 2001 | Spine2001，，1： | 1 |
| 15 | CT vs MRCP: Optimal Classification of IPMN Type and Extent显示文摘 | Joshua A. Waters C. Max Schmidt Jason W. Pinchot Patrick B. White Oscar W. Cummings Henry A. Pitt Kumar Sandrasegaran Fatih Akisik Thomas J. Howard Attila Nakeeb Nicholas J. Zyromski Keith D. Lillemoe | 2008 | Journal of Gastrointestinal Surgery2008，，1： | 1 |
| 16 | Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-Deficient Prostate Cancer显示文摘 | Brett S. Carver Caren Chapinski John Wongvipat Haley Hieronymus Yu Chen Sarat Chandarlapaty Vivek K. Arora Carl Le Jason Koutcher Howard Scher Peter T. Scardino Neal Rosen Charles L. Sawyers | 2011 | Cancer Cell2011，，5： | 1 |
| 17 | Novel CSF biomarkers for Alzheimer’s disease and mild cognitive impairment显示文摘 | William T. Hu Alice Chen-Plotkin Steven E. Arnold Murray Grossman Christopher M. Clark Leslie M. Shaw Eve Pickering Max Kuhn Yu Chen Leo McCluskey Lauren Elman Jason Karlawish Howard I. Hurtig Andrew Siderowf Virginia M.-Y. Lee Holly Soares John Q. Trojan | 2010 | Acta Neuropathologica2010，，： | 1 |
| 18 | Characterization of microporous separators for lithium-ion batteries 显示文摘 | Ganesh Venugopal John Moore Jason Howard | 1999 | Journal of Power Sources1999，77，： | 1 |
| 19 | Central Pressure More Strongly Relates to Vascular Disease and Outcome Than Does Brachial Pressure: The Strong Heart Study显示文摘 | Mary J. Roman Richard B. Devereux Jorge R. Kizer Elisa T. Lee James M. Galloway Tauqeer Ali Jason G. Umans Barbara V. Howard | 2007 | Hypertension2007，，1： | 1 |
| 20 | PI3K Regulation of RAC1 Is Required for Kras-Induced Pancreatic Tumorigenesis in Mice显示文摘 | Chia-Yen C. Wu Eileen S. Carpenter Kenneth K. Takeuchi Christopher J. Halbrook Louise V. Peverley Harold Bien Jason C. Hall Kathleen E. DelGiorno Debjani Pal Yan Song Chanjuan Shi Richard Z. Lin Howard C. Crawford | 2014 | Gastroenterology2014，，： | 1 |
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