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| 1 | Intervertebral disc development and disease-related genetic polymorphisms显示文摘The intervertebral disc(IVD)comprises a gelatinous inner core(nucleus pulposus;NP)and concentric rings(annulus fibrosus;AF).The NP,an important structure for shock absorption in the vertebrate spinal motion segment,can be traced back to the notochord in ontogenetic lineage.In vertebrates,the notochord undergoes mucinoid changes,and had been considered vestigial until recently.However,observed correlations between IVD degeneration and back pain in humans have renewed interest in the IVD in biomedical fields.Beyond its mechanical contribution to development,the notochord is also an essential signaling center,which coordinates formation of the neural tube and somites.The pertinent signaling molecules,particularly TGF-b and bone morphogenetic proteins(BMPs),continue to play roles in the adult tissues and have been utilized for tissue regeneration.Genetic factors are major determinants of who will develop IVD degeneration and related back pain,and seem to correlate better with disc degeneration and back pain than do external forces on the spine.In summary,the spinal column is a landmark development in evolution.Genes directing the development of the IVD may also contribute to its maintenance,degeneration,and regeneration.Likewise,structural genes as well as genes responsible for maintenance of the structure are related to IVD degeneration.Finally,genes responsible for inflammation may play a dual role in exacerbating degeneration or facilitating repair responses depending on the context. | Jason W.Ashley Motomi Enomoto-Iwamoto Lachlan J.Smith Robert L.Mauck Danny Chan Joseph Lee Martin F.Heyworth Howard An Yejia Zhang | 2016 | Genes & Diseases2016，3，3： | 3 |
| 2 | Spine Update: Lumbar Foraminal Stenosis显示文摘 | Louis G. Jenis Howard S. An | 2000 | Spine2000，，3： | 2 |
| 3 | A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance显示文摘 | Christopher B. Newgard Jie An James R. Bain Michael J. Muehlbauer Robert D. Stevens Lillian F. Lien Andrea M. Haqq Svati H. Shah Michelle Arlotto Cris A. Slentz James Rochon Dianne Gallup Olga Ilkayeva Brett R. Wenner William S. Yancy Howard Eisenson Gera | 2009 | Cell Metabolism2009，，4： | 2 |
| 4 | En Bloc Spondylectomy for the Treatment of Spinal Tuberculosis With Fixed and Sharply Angulated Kyphotic Deformity显示文摘 | Youwen Deng Guohua Lv Howard S. An | 2009 | Spine2009，，20： | 1 |
| 5 | 2014 global geo- graphic analysis of mortality from ischaemic heart disease by country, age and income: statistics from World Health Or- ganisation and United Nations 显示文摘 | Nowbar AN Howard JP Finegold JA | 2014 | Int J Cardiol2014，174，2： | 1 |
| 6 | Market for Catastrophe and Non-Catastrophe Risks 显示文摘 | Erwann Michel-Kerjan Paul Raschky Howard Kunreuther Corporate Demand for Insurance : An Empirical Analysis of the U S | 2011 | The Na- tional Bureau of economic Research2011，，9： | 1 |
| 7 | 2014 Global geographic analysis of mortality from ischaemic heart disease by country,age and income:statistics from World Health Organisation and United Nations显示文摘 | Nowbar AN Howard JP Finegold JA | 2014 | Int J Cardiol2014，174，2： | 1 |
| 8 | A Novel Rabbit Model of Mild, Reproducible Disc Degeneration by an Anulus Needle Puncture: Correlation Between the Degree of Disc Injury and Radiological and Histological Appearances of Disc Degeneration显示文摘 | Koichi Masuda Yoichi Aota Carol Muehleman Yoshiyuki Imai Masahiko Okuma Eugene J. Thonar Gunnar B. Andersson Howard S. An | 2005 | Spine2005，，1： | 1 |
| 9 | Efficacy of system- ic administration of SDF-1 in a model of vascular insufficien- cy: support for an endothelium-dependent mechanism显示文摘 | Carr AN Howard BW Yang HT | 2006 | Cardiovasc Res2006，69，4： | 1 |
| 10 | Enhancement of Stability Following Anterior Cervical Corpectomy: A Biomechanical Study显示文摘 | Kern Singh Alexander R. Vaccaro Jesse Kim Eric P. Lorenz Tae-Hong Lim Howard S. An | 2004 | Spine2004，，8： | 1 |
| 11 | Does Multilevel Lumbar Stenosis Lead to Poorer Outcomes?: A Subanalysis of the Spine Patient Outcomes Research Trial (SPORT) Lumbar Stenosis Study显示文摘 | Daniel K. Park Howard S. An Jon D. Lurie Wenyan Zhao Anna Tosteson Tor D. Tosteson Harry Herkowitz Thomas Errico James N. Weinstein | 2010 | Spine2010，，4： | 1 |
| 12 | Efficacy of systemic administration of SDF-1 in a model of vascular insufficiency: Support for an endothelium-dependent mechanism显示文摘 | Carr AN Howard BW Yang HT | 2006 | Cardiovase Res2006，69，4： | 1 |
| 13 | Efficacy of systemic adminis-tration of SDF-1 in a model of vascular insufficiency:support for anendothelium-dependent mechanism显示文摘 | Carr AN Howard BW Yang HT | 2006 | Cardiovasc Res2006，69，： | 1 |
| 14 | Contact allergy to common ingredients in hair dyes显示文摘 | Heidi S?sted Thomas Rustemeyer Margarida Gon?alo Magnus Bruze An Goossens Ana M. Giménez‐Arnau Christophe J. Le Coz Ian R. White Thomas L. Diepgen Klaus E. Andersen Tove Agner Howard Maibach Torkil Menné Jeanne D. Johansen | 2013 | Contact Dermatitis2013，，1： | 1 |
| 15 | Efficacy of systemic administration of SDF-1 in a model of vascular insufficiency:Support for an endothelium-dependent mechanism显示文摘 | Carr AN Howard BW Yang HT | 2006 | Cardiovasc Res2006，9，： | 1 |
| 16 | Efficacy of systemic administration of SDF-1 in a model of vascular insufficiency: support for an endothelium-dependent mechanism 显示文摘 | Cart AN Howard BW Yang HT Eby-Wilkens E Loos P Varbanov A | 2005 | Cardiovasc Res2005，69，4： | 1 |
| 17 | Efficacy of systemic administration of SDF-1 in a model of vascular insufficiency: support for an endothelium-dependent mechanism 显示文摘 | Carr AN Howard BW Yang HT | 2006 | Cardiovasc Res2006，69，4： | 1 |
| 18 | Action of fibroblast growth factor-2 on the intervertebral disc显示文摘 | Xinli Howard S An Michael Ellman | 2008 | Arthritis Res Ther2008，10，2： | 1 |
| 19 | Vertebroplasty comparing injectable calcium phosphate cement compared with polymethylmethacrylate in a unique canine vertebral body large defect model显示文摘 | Thomas M. Turner Robert M. Urban Kern Singh Deborah J. Hall Susan M. Renner Tae-Hong Lim Michael J. Tomlinson Howard S. An | 2008 | The Spine Journal2008，，3： | 1 |
| 20 | IPNA临床实践建议:儿童激素敏感型肾病综合征的诊断和治疗显示文摘特发性肾病综合征是最常见的儿童肾小球疾病,其特征是大量蛋白尿、低蛋白血症和(或)伴有水肿,全球每年儿童患病率为(1.15~16.90)每10万例。约有85%~90%的患者在接受糖皮质激素治疗的4~6周内可达到蛋白尿完全缓解,表现为激素敏感型肾病综合征(SSNS)。约70%~80%的SSNS患者在随访期间至少复发1次,其中多达50%的患者出现频繁复发或依赖糖皮质激素以维持蛋白尿缓解。为延长复发间隔时间,激素治疗的用药剂量和用药时长始终是热点问题之一,且患者出现激素相关并发症的概率较高。临床已应用多种激素助减药物(免疫抑制药物),但在疾病治疗过程中这些药物的选择和用药时机存在明显差异。因此,需要国际循证临床实践建议(CPRs)来指导临床实践、减少实践差异。国际儿科肾脏病学会(IPNA)召集专家小组通过对12个临床相关PICO(研究对象、干预措施、对照、结果/结局)问题进行系统的文献回顾,制定了关于儿童SSNS诊断和治疗的建议和分级。对治疗转归提出了新的定义,有助于指导治疗改变,并为重要的研究问题提供了参考。 | Agnes Trautmann Olivia Boyer Elisabeth Hodson Arvind Bagga Debbie S.Gipson Susan Samuel Jack Wetzels Khalid Alhas an Sushmita Banerjee Rajendra Bhimma Melvin Bonilla-Felix Francisco Cano Martin Christian Deirdre Hahn Hee Gyung Kang Koichi Nakanishi Hesham Safouh Howard Trachtman Hong Xu Wendy Cook Marina Vivarelli Dieter Hafner on behalf of the International Pediatric Nephrology Association 韩思雨(翻译) 季丽娜(翻译) | 2023 | 中国合理用药探索2023，20，2： | 1 |
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