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| 1 | Endothelial progenitor cells, potential biomarkers for diagnosis and prognosis of ischemic stroke: protocol for an observational case-control study显示文摘Ischemic stroke is a devastating,life altering event which can severely reduce patient quality of life.Despite years of research there have been minimal therapeutic advances.Endothelial progenitor cells(EPCs),stem cells involved in both vasculogenesis and angiogenesis,may be a potential therapeutic target.After a stroke,EPCs migrate to the site of ischemic injury to repair cerebrovascular damage,and their numbers and functional capacity may determine patients'outcome.This study aims to determine whether the number of circulating EPCs and their functional aspects may be used as biomarkers to identify the type(cortical or lacunar)and/or severity of ischemic stroke.The study will also investigate if there are any differences in these characteristics between healthy volunteers over and under 65 years of age.100 stroke patients(50 lacunar and 50 cortical strokes)will be recruited in this prospective,observational case-controlled study.Blood samples will be taken from stroke patients at baseline(within 48 hours of stroke)and days 7,30 and90.EPCs will be counted with flow cytometry.The plasma levels of pro-and anti-angiogenic factors and inflammatory cytokines will also be determined.Outgrowth endothelial cells will be cultured to be used in tube formation,migration and proliferation functional assays.Primary outcome is disability or dependence on day 90 after stroke,assessed by the modified Rankin Scale.Secondary outcomes are changes in circulating EPC numbers and/or functional capacity between patient and healthy volunteers,between patient subgroups and between elderly and young healthy volunteers.Recruitment started in February 2017,167 participants have been recruited.Recruitment will end in November 2019.West Midlands-Coventry&Warwickshire Research Ethics Committee approved this study(REC number:16/WM/0304)on September8,2016.Protocol version:2.0.The Bayraktutan Dunhill Medical Trust EPC Study was registered in ClinicalTrials.gov(NCT02980354)on November 15,2016.This study will determine whether the number of EPCs can be used as a prognostic or diagnostic marker for ischemic strokes and is a step towards discovering if transplantation of EPCs may aid patient recovery. | Kamini Rakkar Othman Othman Nikola Sprigg Philip Bath Ulvi Bayraktutan | 2020 | Neural Regeneration Research2020，15，7： | 7 |
| 2 | Blood pressure management in acute stroke显示文摘Blood pressure(BP)is elevated in 75%or more of patients with acute stroke and is associated with poor outcomes.Whether to modulate BP in acute stroke has long been debated.With the loss of normal cerebral autoregulation,theoretical concerns are twofold:high BP can lead to cerebral oedema,haematoma expansion or haemorrhagic transformation;and low BP can lead to increased cerebral infarction or perihaematomal ischaemia.Published evidence from multiple large,high-quality,randomised trials is increasing our understanding of this challenging area,such that BP lowering is recommended in acute intracerebral haemorrhage and is safe in ischaemic stroke.Here we review the evidence for BP modulation in acute stroke,discuss the issues raised and look to on-going and future research to identify patient subgroups who are most likely to benefit. | Jason P Appleton Nikola Sprigg Philip M Bath | 2016 | Stroke & Vascular Neurology2016，1，2： | 7 |
| 3 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 4 | Remote platelet function testing using P-selectin expression in patients with recent cerebral ischaemia on clopidogrel显示文摘Background Antiplatelet agents reduce recurrence after cerebral ischaemia but are not effective in all patients,in part because of treatment resistance.The primary aim was to assess the proportion of patients who are insensitive to clopidogrel.The secondary aim was to assess the association between insensitivity to clopidogrel and recurrent cerebrovascular events.Methods Following written informed consent,independent patients with a recent non-cardioembolic ischaemic stroke or transient ischaemic attack,and taking clopidogrel,were enrolled.Platelet function was assessed with remote measurement of surface expression of P-selectin(CD62P)using commercial kits sensitive to aspirin or clopidogrel.Participants’general practitioners provided details on recurrent vascular events at least 90 days later.Data are mean(SD)and median[IQR].Resistance was defined as:aspirin median fluorescence(MF)>500 units,clopidogrel MF>860 units.Non-parametric descriptors and tests were used.Results 63 patients were recruited:mean age 64(13.7)years,women 47%.At baseline,59(95%)patients were taking clopidogrel alone with 3(5%)on combined clopidogrel and aspirin.Assessment of platelet surface P-selectin revealed:aspirin test 528[317,834],>50054.8%;clopidogrel test 429[303,656],>86011.3%.No participants on aspirin and clopidogrel showed aspirin resistance.Thirteen(20.6%)patients had a recurrent cerebrovascular event;those with an ischaemic stroke had a non-significantly higher baseline P-selectin using the clopidogrel test as compared with those with no recurrence:626[380,801]versus 406[265,609],p=0.08.Conclusions Remote measurement of platelet function assessed using the platelet surface expression of P-selectin is feasible.11%of patients taking clopidogrel showed resistance.No significant associations were noted between clopidogrel resistance and recurrent ischaemic events. | Jason Philip Appleton Carla Richardson Natalia Dovlatova Jane May Nikola Sprigg Stan Heptinstall Philip M Bath | 2021 | Stroke & Vascular Neurology2021，6，1： | 2 |
| 5 | An extremely sensitive species-specific ARMS PCR test for the presence of tiger bone DNA显示文摘 | Wetton J H Tsang C S F Roney C A Spriggs A C | 2002 | Forensic Science international2002，126，： | 2 |
| 6 | 关于缺血性卒中后女性妊娠以及针对不育、避孕和绝经期进行激素治疗的共识文件显示文摘已有报道妊娠与缺血性卒中风险增高相关,妊娠期间发生卒中是导致孕产妇死亡的主要原因之一。Kuklina等对1994年至1995年与2006年至2007年的住院数据进行的比较显示,孕妇在产前发生任何类型卒中的风险增高47%(从0.15次/1000次分娩~0.22次/1000次分娩),在产后发生任何卒中的风险增高83%(从0.12次/1000次分娩~0.22次/1000次分娩)。 | Valeria Caso Alberto Falomi Cheryl D. Bushnell Monica Acciarresi Jose Ronohi Nikola Sprigg Sandro Gerli 李勍 景燕 李红燕 朱沂 | 2017 | 国际脑血管病杂志2017，25，8： | 2 |
| 7 | More than a biomarker: CA125 may contribute to ovarian cancer pathogenesis显示文摘 | Robert C. Bast David R. Spriggs | 2011 | Gynecologic Oncology2011，，： | 2 |
| 8 | Preoperative serum YKL-40 is a marker for detection and prognosis of endometrial cancer显示文摘 | Catherine S.M. Diefenbach Zharna Shah Alexia Iasonos Richard R. Barakat Douglas A. Levine Carol Aghajanian Paul Sabbatini Martee L. Hensley Jason Konner William Tew David Spriggs Martin Fleisher Howard Thaler Jakob Dupont | 2006 | Gynecologic Oncology2006，，： | 2 |
| 9 | 育龄期妊娠和非妊娠女性的初次脑卒中发生率比较:以英国人口为基础的队列研究显示文摘与相似年龄的非妊娠女性相比,妊娠女性的脑卒中风险可能增加,但这种风险的严重程度和影响时机尚不清楚。该研究调查了育龄女性初次发生脑卒中事件的风险,并比较了在妊娠期间与产后早期与平时的风险差异。 | 刘莉 叶鹏 Ban L Sprigg N Abdul Sultan A Nelson-Piercy C Bath PM Ludvigsson JF Stephansson O Tata LJ | 2017 | 中华高血压杂志2017，25，5： | 2 |
| 10 | Tumor necrosis factor and interleukin-6 mRAN expression in neonatal Lewvis rat Schwann cells显示文摘 | Zaheer T Zhong W | 1991 | Marcel Dekker Ink1991，72，1： | 1 |
| 11 | Removal of canal obstructions with the endoextractor 显示文摘 | Gettleman BH Spriggs KA E1Deeb ME | 1991 | J Endod1991，17，12： | 1 |
| 12 | The Gglycoprotein of human respiratory syncytial virus of subgroup A and B : extensive sequence divergence between antigenically related proteins 显示文摘 | Johnson P R Spriggs M K Olmsted R A | 1987 | Proc Natl Acad USA1987，84，16： | 1 |
| 13 | Advances in spontane- ous intracerebral haemorrhage显示文摘 | Thanvi BR Sprigg N Munshi SK | 2012 | Int J Clin Pratt2012，66，6： | 1 |
| 14 | Granulocyte-colony-stimulating factor mobilizes bone marrow stem cells in patients with subacute ischemic stroke显示文摘 | Sprigg N Bath PM Zhao L | | 0，，： | 1 |
| 15 | Beef producer attitudes to coordination and quality assurance in Canada and the UK 显示文摘 | John Spriggs Jill Hobbs Andrew Fearne | 2000 | International Food and Agribusiness Management Review2000，3，1： | 1 |
| 16 | IL-1 induced by TNF-α in macrophages in vivo显示文摘 | Michic HR Manogue KR Sprigg S | 1998 | N Eng J Med1998，318，1： | 1 |
| 17 | Relationship between outcome and baseline blood pressure and other haemodynamic measures in acute ischaemic stroke : data from the TAIST trial 显示文摘 | Sprigg N Gray LJ Bath PM | 2006 | J Hypertens2006，24，7： | 1 |
| 18 | Inhibition of Rho-kinase protects cerebral barrier from ischaemia-evoked injury through modulations of endothelial cell oxidative stress and tight junctions显示文摘 | Gibson CL Srivastava K Sprigg N | 2014 | Neurochem2014，129，5： | 1 |
| 19 | 4-Aminopyridine reverses saxitoxin (STX)- and tetrodotoxin (TTX)-induced cardiorespiratory depression in chronically instrumented guinea pigs显示文摘 | CHANG F T C SPRIGGS D L BENTON B J | 1997 | Fund Appl Toxico1997，38，1： | 1 |
| 20 | Relationship between outcome and baseline blood pressure and other haemodynamic measures in acute ischaemic stroke : data from the TAIST trial 显示文摘 | Sprigg N Gray LJ Bath PM | 2006 | J Hypertens2006，24，7： | 1 |
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