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| 1 | Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels显示文摘Brachydactyly 打 A1 (BDA1 ) ,第一在人记录了孟德尔的正染色体的主导的混乱,被弄短或中间的指骨的缺席描绘。在印度刺猬(IHH ) 基因的异质接合的错误感觉变化作为 BDA1 的一个原因被识别了;然而,这些变化的生物化学的后果是不清楚的。在这份报纸,我们在印度刺猬(IhhN ) 的 N 终端碎片分析了三个 BDA1 变化(E95K, D100E,和 E131K ) 。结构的分析证明 E95K 变化在一条钙绑定沟把一个否定地控告的区域改变到一个断然控告的区域,并且 D100E 变化改变本地第三级的结构。而且,我们证明 E95K 和 D100E 变化导致了一温度敏感并且 IhhN 的钙依赖者不稳定性,它可能经由 lysosome 贡献变异的蛋白质的提高的细胞内部的降级。尤其是,所有三个变化影响了对受体 Patched1 (PTC1 ) 有约束力的 Hh,减少它的能力导致细胞的区别。我们建议这些是引起 BDA1 的变化的普通特征,影响 Hh 第三级的结构,细胞内部的命运,到受体 / 搭挡的绑定,和到细胞外的部件的绑定。这些特征的联合改变发信号的能力和范围,但是影响是可能的是变量和变化依赖者。在发信号的范围的潜在的变化被和 heparan 硫酸盐的一个提高的相互作用与 E95K 变化,然而并非 E131K 变化为 IHH 描绘。一起拿,我们的结果建议这些 IHH 变化影响在多重层次,引起的反常骨头发展和反常的位形成发信号的 Hh。 | Gang Ma Jiang Yu Yue Xiao Danny Chan Bo Gao Jianxin Hu Yongxing He Shengzhen Guo Jian Zhou Lingling Zhang Linghan Gao Wenjuan Zhang Yan Kang Kathryn SE Cheah Guoyin Feng Xizhi Guo Yujiong Wang Cong-zhao Zhou Lin He | 2011 | Cell Research2011，21，9： | 6 |
| 2 | Independent risk factors and predictive score for the development of hepatocellular carcinoma in chronic hepatitis B显示文摘 | Man-Fung Yuen Yasuhito Tanaka Daniel Yee-Tak Fong James Fung Danny Ka-Ho Wong John Chi-Hang Yuen David Yiu-Kuen But Annie On-On Chan Benjamin Chun-Yu Wong Masashi Mizokami Ching-Lung Lai | 2008 | Journal of Hepatology2008，，1： | 5 |
| 3 | Intervertebral disc development and disease-related genetic polymorphisms显示文摘The intervertebral disc(IVD)comprises a gelatinous inner core(nucleus pulposus;NP)and concentric rings(annulus fibrosus;AF).The NP,an important structure for shock absorption in the vertebrate spinal motion segment,can be traced back to the notochord in ontogenetic lineage.In vertebrates,the notochord undergoes mucinoid changes,and had been considered vestigial until recently.However,observed correlations between IVD degeneration and back pain in humans have renewed interest in the IVD in biomedical fields.Beyond its mechanical contribution to development,the notochord is also an essential signaling center,which coordinates formation of the neural tube and somites.The pertinent signaling molecules,particularly TGF-b and bone morphogenetic proteins(BMPs),continue to play roles in the adult tissues and have been utilized for tissue regeneration.Genetic factors are major determinants of who will develop IVD degeneration and related back pain,and seem to correlate better with disc degeneration and back pain than do external forces on the spine.In summary,the spinal column is a landmark development in evolution.Genes directing the development of the IVD may also contribute to its maintenance,degeneration,and regeneration.Likewise,structural genes as well as genes responsible for maintenance of the structure are related to IVD degeneration.Finally,genes responsible for inflammation may play a dual role in exacerbating degeneration or facilitating repair responses depending on the context. | Jason W.Ashley Motomi Enomoto-Iwamoto Lachlan J.Smith Robert L.Mauck Danny Chan Joseph Lee Martin F.Heyworth Howard An Yejia Zhang | 2016 | Genes & Diseases2016，3，3： | 3 |
| 4 | Clinicopathological survey of 23 patients with lacrimal fossa lesions in Hong Kong显示文摘AIM: To survey the clinicopathological correlations of lacrimal fossa lesions in the Hong Kong population.METHODS: A total of 23 patients with lacrimal fossa lesions were identified radiologically.The mean age at the time of diagnosis was 52 year-old.The medical records of patients diagnosed with lacrimal fossa lesions and subsequently underwent radiological investigations were collected and reviewed retrospectively throughout a six years period from 2000 to 2006 from three regional hospitals (Tung Wah Eastern Hospital,Pamela Youde Nethersole Eastern Hospital and Queen Mary Hospital) belonging to the Hong Kong Mega Cluster.Patient demographics,presenting signs and symptoms,imaging modalities,pathological reports and subsequent management were recorded.RESULTS: The most common initial presenting symptom was upper lid swelling (83%) followed by proptosis (13%).19 patients (83%) had benign lacrimal fossa lesion and 4 patients (17%) had malignancy.Three of the malignancies were lymphomas and one was adenoid cystic carcinoma.CONCLUSION: Age is an important factor in considering the differential diagnosis of lacrimal fossa lesion.Lymphoproliferative diseases have the highest incidence in patients over 60 years of age while inflammatory lesions are more common in younger patients in Hong Kong. | Danny Siu-Chun Ng Edwin Chan Kin Yau Clement Wai-Nang Chan | 2011 | International Journal of Ophthalmology(English edition)2011，4，3： | 3 |
| 5 | 遗传性骨软骨瘤软骨细胞的生物学特性显示文摘目的:观察遗传性骨软骨瘤软骨细胞的生物学特性。方法:采用透射电镜、细胞培养等方法观察肿瘤软骨细胞形态特征;同时观察肿瘤软骨细胞的增殖、贴附能力,与正常人关节软骨细胞做对照。结果:透射电镜(TEM)发现肿瘤软骨细胞膜附近含有大量的微丝结构,集结成束,与细胞突起有关;体外单层培养发现肿瘤软骨细胞突起增多,细胞呈现星形;骨软骨瘤软骨细胞的增殖与贴附能力随着传代的增加减慢和减低,传4代细胞增殖能力和贴附能力均与肿瘤原代细胞及正常关节软骨细胞具有明显差别(P<0.1)。结论:骨软骨瘤软骨细胞虽然与正常软骨细胞大体相似,但生物学特性存在明显区别:细胞形态改变,微丝增加,细胞增殖与贴附能力等均不同于正常软骨细胞。 | 杨柳 罗卓荆 颉强 靳小兵 Wing-Sum Hui Danny Chan Jian-Dong Huang Kenneth M.C.Cheung Kathryn S.E.Cheah | 2003 | 中国矫形外科杂志2003，11，22： | 3 |
| 6 | Mitochondrial neuronal uncoupling proteins:a target for potential disease-modification in Parkinson’s disease Philip显示文摘This review gives a brief insight into the role of mitochondrial dysfunction and oxidative stress in the converging pathogenic processes involved in Parkinson’s disease(PD).Mitochondria provide cellular energy in the form of ATP via oxidative phosphorylation,but as an integral part of this process,superoxides and other reactive oxygen species are also produced.Excessive free radical production contributes to oxidative stress.Cells have evolved to handle such stress via various endogenous anti-oxidant proteins.One such family of proteins is the mitochondrial uncoupling proteins(UCPs),which are anion carriers located in the mitochondrial inner membrane.There are five known homologues(UCP1 to 5),of which UCP4 and 5 are predominantly expressed in neural cells.In a series of previous publications,we have shown how these neuronal UCPs respond to 1-methyl-4-phenylpyridinium(MPP+;toxic metabolite of MPTP)and dopamine-induced toxicity to alleviate neuronal cell death by preserving ATP levels and mitochondrial membrane potential,and reducing oxidative stress.We also showed how their expression can be influenced by nuclear factor kappa-B(NF-B)signaling pathway specifically in UCP4.Furthermore,we previously reported an interesting link between PD and metabolic processes through the protective effects of leptin(hormone produced by adipocytes)acting via UCP2 against MPP+-induced toxicity.There is increasing evidence that these endogenous neuronal UCPs can play a vital role to protect neurons against various pathogenic stresses including those associated with PD.Their expression,which can be induced,may well be a potential therapeutic target for various drugs to alleviate the harmful effects of pathogenic processes in PD and hence modify the progression of this disease. | WL Ho Jessica WM Ho Hui-Fang Liu Danny HF So Zero HM Tse Koon-Ho Chan David B Ramsden Shu-Leong Ho | 2012 | Translational Neurodegeneration2012，1，1： | 3 |
| 7 | Characterization of interleukin-1β in Helicobacter pylori -induced gastric inflammation and DNA methylation in interleukin-1 receptor type 1 knockout (IL-1R1 ?/? ) mice显示文摘 | Fung-Yu Huang Annie On-On Chan Regina Cheuk-Lam Lo Asif Rashid Danny Ka-Ho Wong Chi-Hin Cho Ching-Lung Lai Man-Fung Yuen | 2013 | European Journal of Cancer2013，，12： | 3 |
| 8 | A single-cell transcriptome of mesenchymal stromal cells to fabricate bioactive hydroxyapatite materials for bone regeneration显示文摘The osteogenic microenvironment of bone-repairing materials plays a key role in accelerating bone regeneration but remains incompletely defined,which significantly limits the application of such bioactive materials.Here,the transcriptional landscapes of different osteogenic microenvironments,including three-dimensional(3D)hydroxyapatite(HA)scaffolds and osteogenic medium(OM),for mesenchymal stromal cells(MSCs)in vitro were mapped at single-cell resolution.Our findings suggested that an osteogenic process reminiscent of endochondral ossification occurred in HA scaffolds through sequential activation of osteogenic-related signaling pathways,along with inflammation and angiogenesis,but inhibition of adipogenesis and fibrosis.Moreover,we revealed the mechanism during OM-mediated osteogenesis involves the ZBTB16 and WNT signaling pathways.Heterogeneity of MSCs was also demonstrated.In vitro ossification of LRRC75A+MSCs was shown to have better utilization of WNT-related ossification process,and PCDH10+MSCs with superiority in hydroxyapatite-related osteogenic process.These findings provided further understanding of the cellular activity modulated by OM conditions and HA scaffolds,providing new insights for the improvement of osteogenic biomaterials.This atlas provides a blueprint for research on MSC heterogeneity and the osteogenic microenvironment of HA scaffolds and a database reference for the application of bioactive materials for bone regeneration. | Peng Guo Xizhe Liu Penghui Zhang Zhongyuan He Zhen Li Mauro Alini RGeoff Richards Sibylle Grad Martin J.Stoddart Guangqian Zhou Xuenong Zou Danny Chan Wei Tian Dafu Chen Manman Gao Zhiyu Zhou Shaoyu Liu | 2022 | Bioactive Materials2022，7，3： | 3 |
| 9 | High Incidence of Mortality and Recurrent Bleeding in Patients With Helicobacter pylori –Negative Idiopathic Bleeding Ulcers显示文摘 | Grace Lai–Hung Wong Vincent Wai–Sun Wong Yawen Chan Jessica Yuet–Ling Ching Kim Au Aric Josun Hui Larry Hin Lai Dorothy Kai–Lai Chow Danny Ka–Fai Siu Yan–Ni Lui Justin Che–Yuen Wu Ka–Fai To Lawrence Cheung–Tsui Hung Henry Lik–Yuen Chan Joseph Jao–Yiu Sung | 2009 | Gastroenterology2009，，2： | 2 |
| 10 | 深部脑刺激治疗帕金森病:下丘脑核团靶点定位的解剖与生理对比研究显示文摘目的 探讨脑深部STN刺激靶点时MRI直接定位法和MER术中导引定位法的解剖学偏差。方法 本组5例帕金森病患者,分别表现为运动迟缓、步态不稳及躯干症状,共安放6例次微电极。结果 采用MRI直接定位法和MER术中导引定位法,其定位靶点的平均偏差距离是1.25mm,尽管该偏差值较小,但是,基于影像学的立体定向法只能将刺激电极定位于距离靶点几毫米的范围内。结论 电生理学方法(MER)对于调整和确定靶点位置至关重要。MER术中导引定位法有助于手术的完全成功。 | Wai.S Poon Danny TM Chan XL Zhu Vincent CT Mok YL Chan | 2002 | 中华神经外科疾病研究杂志2002，1，2： | 2 |
| 11 | Multiresidue determination of triarylmethane and phenothiazine dyes in fish tissues by LC–MS/MS显示文摘 | Jonathan A. Tarbin Danny Chan George Stubbings Matthew Sharman | 2008 | Analytica Chimica Acta2008，，2： | 2 |
| 12 | Independent risk factors and predictive score for the development of hepatocellular carcinoma in chronic hepatitis B显示文摘 | Man-Fung Yuen Yasuhito Tanaka Daniel Yee-Tak Fong James Fung Danny Ka-Ho Wong John Chi-Hang Yuen David Yiu-Kuen But Annie On-On Chan Benjamin Chun-Yu Wong Masashi Mizokami Ching-Lung Lai | 2008 | Journal of Hepatology2008，，1： | 1 |
| 13 | Independent risk factors and predictive score for the development of hepatocellular carcinoma in chronic hepatitis B显示文摘 | Man-Fung Yuen Yasuhito Tanaka Daniel Yee-Tak Fong James Fung Danny Ka-Ho Wong John Chi-Hang Yuen David Yiu-Kuen But Annie On-On Chan Benjamin Chun-Yu Wong Masashi Mizokami Ching-Lung Lai | 2008 | Journal of Hepatology2008，，1： | 1 |
| 14 | Biliary decompression by nasobiliary catheter or biliary stent in acute suppurative cholangitis: A prospective randomized trial显示文摘 | Danny W.H. Lee Angus C.W. Chan Yuk-hoi Lam Enders K.W. Ng James Y.W. Lau Bonita K.B. Law Chi-wai Lai Joseph J.Y. Sung S.C.Sydney Chung | 2002 | Gastrointestinal Endoscopy2002，，3： | 1 |
| 15 | Helicobacter pylori induces promoter methylation of E‐cadherin via interleukin‐1β activation of nitric oxide production in gastric cancer cells显示文摘 | Fung‐Yu Huang Annie On‐On Chan Asif Rashid Danny Ka‐Ho Wong Chi‐Hin Cho Man‐Fung Yuen | 2012 | Cancer2012，，20： | 1 |
| 16 | Energy and cost analysis of semi-transparent photovoltaic in office building显示文摘 | Danny H W Li Tony N T Lam Wilcow W H Chan | 2009 | Applied Energy2009，86，5： | 1 |
| 17 | Design and Build Project Success Factors: Multivariate Analysis显示文摘 | Albert P. C. Chan Danny C. K. Ho C. M. Tam | 2001 | Journal of Construction Engineering and Management2001，，2： | 1 |
| 18 | Bevacizumab for neovascular age-related macular degeneration in Chinese patients in a clinical setting显示文摘AIM:To determine the outcome of non-investigational treatment with intravitreal bevacizumab(IVB) in neovascular age-related macular degeneration(AMD)patients.· METHODS:Retrospective chart review of 81 eyes with neovascular AMD followed-up for at least 12 mo and received 3-monthly loading IVB injections.Re-treat was based upon the individual clinician's judgment.Bestcorrected visual acuity(BCVA) and optical coherence tomography measurements of central foveal thickness outcomes were evaluated at 12,24 mo.· RESULTS:Eighty-one eyes(of 75 patients) completed12 mo of follow-up and 44 eyes(of 41 patients) completed24 mo of follow-up.The mean baseline logMAR BCVA significantly improved from 0.94±0.69 to 0.85±0.68 at12mo(P<0.001) and from 0.91±0.65 to 0.85±0.60(P=0.004)at 24 mo.The proportion of eyes that lost <15 logMAR letters at 12 mo was 90.1%and at 24 mo was 81.8%.IVB was effective in improving visual acuity in both treatment naive and previous photodynamic therapy(PDT)-treated subgroups.Treatment naive patients required significantly fewer injections than patients with prior PDT.Multiple regression analysis identified that poorer baseline visual acuity was associated with greater improvement in visual acuity(P=0.015).· CONCLUSION:Fewer injections in clinical practice may result in suboptimal visual outcomes compared with clinical trials of IVB in neovascular AMD patients.Poor baseline visual acuity and prior PDT treatment may also improve vision after IVB.The safety and durability of effect was maintained at 24 mo. | Danny Siu-Chun Ng Alvin Kwan-Ho Kwok Justin Man-Kit Tong Clement Wai-Nang Chan Walton Wai-Tat Li | 2016 | International Journal of Ophthalmology(English edition)2016，9，3： | 1 |
| 19 | Helicobacter pylori induces promoter methylation of E‐cadherin via interleukin‐1β activation of nitric oxide production in gastric cancer cells显示文摘 | Fung‐Yu Huang Annie On‐On Chan Asif Rashid Danny Ka‐Ho Wong Chi‐Hin Cho Man‐Fung Yuen | 2012 | Cancer2012，，20： | 1 |
| 20 | Design and Build Project Success Factors: Multivariate Analysis显示文摘 | Albert P. C. Chan Danny C. K. Ho C. M. Tam | 2001 | Journal of Construction Engineering and Management2001，，2： | 1 |
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