|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Distribution and effects of polymorphic RANTES gene alleles in HIV/HCV coinfection - A prospective cross-sectional study显示文摘AIM: Chemokines and their receptors are crucial for immune responses in HCV and HIV infection. RANTES gene polymorphisms lead to altered gene expression and influence the natural course of HIV infection. Therefore,these mutations may also affect the course of HIV/HCV coinfection.METHODS: We determined allele frequencies of RANTES-403 (G→A), RANTES-28 (C→G) and RANTESIN1.1 (T→C) polymorphisms using real-time PCR and hybridization probes in patients with HIV (n = 85), HCV (n= 112), HIV/HCV coinfection (n = 121), and 109 healthy controls. Furthermore, HIV and HCV loads as well as CD4+ and CD8+ cell counts were compared between different RANTES genotypes.RESULTS: Frequencies of RANTES-403 A, RANTES-28 G and RANTES-IN1.1 C alleles were higher in HIV infected patients than in healthy controls (-403: 28.2% vs 15.1%,P = 0.002; -28: 5.4% vs 2.8%, not significant; IN1.1:19.0% vs 11.0%, P = 0.038). In HIV/HCV coinfected patients, these RANTES alleles were less frequent than in patients with HIV infection alone (15.4% P = 0.002;1.7%; P = 0.048; 12.0%; not significant). Frequencies of these alleles were not significantly different between HIV/HCV positive patients, HCV positive patients and healthy controls.CONCLUSION: All three RANTES polymorphisms showed increased frequencies of the variant allele exclusively in patients with HIV monoinfection. The finding that the frequencies of these alleles remained unaltered in HIV/HCV coinfected patients suggests that HCV coinfection interferes with selection processes associated with these alleles in HIV infection. | Golo Ahlenstiel Agathe Iwan Jacob Nattermann Karin Bueren Jürgen K Rockstroh Hans H Brackmann Bernd Kupfer Olfert Landt Amnon Peled Tilman Sauerbruch Ulrich Spengler Rainer P Woitas | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 2 | Impaired CD4 + T cell stimulation of NK cell anti-fibrotic activity may contribute to accelerated liver fibrosis progression in HIV/HCV patients<!-- Doctopic: VH -->显示文摘 | Andreas Gl?ssner Marianne Eisenhardt Pavlos Kokordelis Benjamin Kr?mer Franziska Wolter Hans Dieter Nischalke Christoph Boesecke Tilman Sauerbruch Jürgen K. Rockstroh Ulrich Spengler Jacob Nattermann | 2013 | Journal of Hepatology2013，，： | 1 |
| 3 | The CXCL1 rs4074 A allele is associated with enhanced CXCL1 responses to TLR2 ligands and predisposes to cirrhosis in HCV genotype 1-infected Caucasian patients显示文摘 | Hans Dieter Nischalke Cordula Berger Carolin Luda Tobias Müller Thomas Berg Martin Coenen Benjamin Kr?mer Christian K?rner Jonel Trebicka Frank Grünhage Frank Lammert Jacob Nattermann Tilman Sauerbruch Ulrich Spengler | 2011 | Journal of Hepatology2011，，4： | 1 |
| 4 | The HLA-A2 Restricted T Cell Epitope HCV Core 35–44 Stabilizes HLA-E Expression and Inhibits Cytolysis Mediated by Natural Killer Cells显示文摘 | Jacob Nattermann Hans Dieter Nischalke Valeska Hofmeister Golo Ahlenstiel Henning Zimmermann Ludger Leifeld Elisabeth H. Weiss Tilman Sauerbruch Ulrich Spengler | 2005 | The American Journal of Pathology2005，，2： | 1 |
| 5 | Interferon-lambda serum levels in hepatitis C显示文摘 | Bettina Langhans Bernd Kupfer Ingrid Braunschweiger Simone Arndt Wibke Schulte Hans Dieter Nischalke Jacob Nattermann Johannes Oldenburg Tilman Sauerbruch Ulrich Spengler | 2010 | Journal of Hepatology2010，，5： | 1 |
| 6 | Interferon-lambda serum levels in hepatitis C显示文摘 | Bettina Langhans Bernd Kupfer Ingrid Braunschweiger Simone Arndt Wibke Schulte Hans Dieter Nischalke Jacob Nattermann Johannes Oldenburg Tilman Sauerbruch Ulrich Spengler | 2010 | Journal of Hepatology2010，，5： | 1 |
| 7 | The cytotoxic lymphocyte antigen 4 polymorphisms affect response to hepatitis C virus-specific therapy in HIV(+) patients with acute and chronic hepatitis C virus co-infection显示文摘 | Hans Dieter Nischalke Martin Vogel Stefan Mauss Axel Baumgarten Thomas Lutz Marc Danta Uwe Naumann Martin Coenen Tilman Sauerbruch Jürgen K Rockstroh Ulrich Spengler Jacob Nattermann | 2010 | AIDS2010，，13： | 1 |
| 8 | Impaired CD4 + T cell stimulation of NK cell anti-fibrotic activity may contribute to accelerated liver fibrosis progression in HIV/HCV patients显示文摘 | Andreas Gl?ssner Marianne Eisenhardt Pavlos Kokordelis Benjamin Kr?mer Franziska Wolter Hans Dieter Nischalke Christoph Boesecke Tilman Sauerbruch Jürgen K. Rockstroh Ulrich Spengler Jacob Nattermann | 2013 | Journal of Hepatology2013，，： | 1 |
| 9 | The HLA-A2 Restricted T Cell Epitope HCV Core 35–44 Stabilizes HLA-E Expression and Inhibits Cytolysis Mediated by Natural Killer Cells显示文摘 | Jacob Nattermann Hans Dieter Nischalke Valeska Hofmeister Golo Ahlenstiel Henning Zimmermann Ludger Leifeld Elisabeth H. Weiss Tilman Sauerbruch Ulrich Spengler | 2005 | The American Journal of Pathology2005，，2： | 1 |
| 10 | Interferon-lambda serum levels in hepatitis C显示文摘 | Bettina Langhans Bernd Kupfer Ingrid Braunschweiger Simone Arndt Wibke Schulte Hans Dieter Nischalke Jacob Nattermann Johannes Oldenburg Tilman Sauerbruch Ulrich Spengler | 2010 | Journal of Hepatology2010，，5： | 1 |
| 11 | The ratio of calprotectin to total protein as a diagnostic and prognostic marker for spontaneous bacterial peritonitis in patients with liver cirrhosis and ascites显示文摘 | Philipp Lutz Kenneth Pfarr Hans Dieter Nischalke Benjamin Kr?mer Felix Goeser Andreas Gl?ssner Franziska Wolter Pavlos Kokordelis Jacob Nattermann Tilman Sauerbruch Achim Hoerauf Christian P. Strassburg Ulrich Spengler | 2015 | Clinical Chemistry and Laboratory Medicine (CCLM)2015，，12： | 1 |
| 12 | Angiotensin‐II type 1 receptor‐mediated Janus kinase 2 activation induces liver fibrosis显示文摘 | Michaela Granzow Robert Schierwagen Sabine Klein Benita Kowallick Sebastian Huss Markus Linhart Irela G. Reza Mazar Jan G?rtzen Annabelle Vogt Frank A. Schildberg Maria A. Gonzalez‐Carmona Alexandra Wojtalla Benjamin Kr?mer Jacob Nattermann S?ren V. Siegm | 2014 | Hepatology2014，，1： | 1 |
| 13 | Between Scylla and Charybdis:The role of the human immune system in the pathogenesis of hepatitis C显示文摘Hepatitis C virus(HCV)frequently elicits only mild immune responses so that it can often establish chronic infection.In this case HCV antigens persist and continue to stimulate the immune system.Antigen persistence then leads to profound changes in the infected host’s immune responsiveness,and eventually contributes to the pathology of chronic hepatitis.This topic highlight summarizes changes associated with chronic hepatitis C concerning innate immunity(interferons,natural killer cells),adaptive immune responses(immunoglobulins,T cells,and mechanisms of immune regulation(regulatory T cells).Our overview clarifies that a strong anti-HCV immune response is frequently associated with acute severe tissue damage.In chronic hepatitis C,however,the effector arms of the immune system either become refractory to activation or take over regulatory functions.Taken together these changes in immunity may lead to persistent liver damage and cirrhosis.Consequently,effector arms of the immune system will not only be considered with respect to antiviral defence but also as pivotal mechanisms of inflammation,necrosis and progression to cirrhosis.Thus,avoiding Scylla-a strong,sustained antiviral immune response with inital tissue damage-takes the infected host to virus-triggered immunopathology,which ultimately leads to cirrhosis and liver cancerthe realm of Charybdis. | Ulrich Spengler Hans Dieter Nischalke Jacob Nattermann Christian P Strassburg | 2013 | World Journal of Gastroenterology2013，19，44： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员