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| 1 | Combination of structural reliability and interval analysis显示文摘在设计应用,概率的可靠性理论看起来是一会儿然而,在许多情况中,精确概率的可靠性理论不能被认为实际事情的真实状态的模型同样足够、可信的最重要的方法。在这篇论文,当统计数据被发现不够时,我们开发了概率、非概率的可靠性理论的一个混血儿,它把结构的不明确的参数描述为间隔变量。由使用间隔分析,为计算结构的可靠性以及可靠性索引的间隔的一个新方法在这篇论文被介绍,并且传统的概率的理论与间隔分析被合并。而且,新方法保存传统的概率的可靠性理论的有用部分,但是在数据上移开它的严格的要求的限制获得。例子被举表明建议理论的可行性和有效性。 | Zhiping Qiu Di Yang Isaac Elishakoff | 2008 | Acta Mechanica Sinica2008，24，1： | 7 |
| 2 | Wind-induced instabilities and monitoring of wind turbine显示文摘This paper presents real-time monitoring data and analysis results of the non-stationary vibrations of an operational wind turbine. The advanced time-frequency spectrum analysis reveals varied non-stationary vibrations with timevarying frequencies, which are correlated with certain system natural modes characterized by finite element analysis. Under the effects of strong wind load, the wind turbine system exhibits certain resonances due to blade passing excitations. The system also exhibits certain instabilities due to the coupling of the tower bending modes and blade flapwise mode with blade passing excitations under the variation of wind speed. An analytical model is used to elaborate the non-stationary and instability phenomena observed in experimental results. The properties of the nonlinear instabilities are evaluated by using Lyapunov exponent estimation. | Isaac Wait Zhaohui (Joey) Yang Gang Chen Benjamin Still | 2019 | Earthquake Engineering and Engineering Vibration2019，18，2： | 1 |
| 3 | Preservation of facial nerve function after resection of vestibular schwannoma显示文摘 | Michael E. Sughrue Isaac Yang Martin J. Rutkowski Derick Aranda Andrew T. Parsa | 2010 | British Journal of Neurosurgery2010，，6： | 1 |
| 4 | Integrin-Associated CD151 Drives ErbB2-Evoked Mammary Tumor Onset and Metastasis显示文摘 | Xinyu Deng Qinglin Li John Hoff Marian Novak Helen Yang Hongyan Jin Sonia F. Erfani Chandan Sharma Pengcheng Zhou Isaac Rabinovitz Arnoud Sonnenberg Yajun Yi Peter Zhou Christopher S. Stipp David M. Kaetzel Martin E. Hemler Xiuwei H. Yang | 2012 | Neoplasia2012，，8： | 1 |
| 5 | Clinical characteristics and outcomes for a modern series of primary gliosarcoma patients 显示文摘 | Seunggu J Han Isaac Yang | 2010 | Cancer2010，，： | 1 |
| 6 | Roles of 17β-hydroxysteroid dehydrogenase type 10 in neurodegenerative disorders显示文摘 | Yang SY He XY Isaacs C | 2014 | J Ste- roid Biochem Mol Biol2014，143，： | 1 |
| 7 | Roles of 1713-hydroxysteroid dehydrogenase type 10 in neurodegenerative disorders显示文摘 | Yang SY He XY Isaacs C | 2014 | J Steroid Biochem Mol Biol2014，143，： | 1 |
| 8 | The role of cellular and molecular neuroimmune crosstalk in gut immunity显示文摘The gastrointestinal tract is densely innervated by the peripheral nervous system and populated by the immune system.These two systems critically coordinate the sensations of and adaptations to dietary,microbial,and damaging stimuli from the external and internal microenvironment during tissue homeostasis and inflammation.The brain receives and integrates ascending sensory signals from the gut and transduces descending signals back to the gut via autonomic neurons.Neurons regulate intestinal immune responses through the action of local axon reflexes or through neuronal circuits via the gut-brain axis.This neuroimmune crosstalk is critical for gut homeostatic maintenance and disease resolution.In this review,we discuss the roles of distinct types of gut-innervating neurons in the modulation of intestinal mucosal immunity.We will focus on the molecular mechanisms governing how different immune cells respond to neural signals in host defense and inflammation.We also discuss the therapeutic potential of strategies targeting neuroimmune crosstalk for intestinal diseases. | Daping Yang Nicole Almanzar Isaac M.Chiu | 2023 | Cellular & Molecular Immunology2023，20，11： | 1 |
| 9 | Simultaneous Detection of Major Drug Resistance Mutations in the Protease and Reverse Transcriptase Genes for HIV-1 Subtype C by Use of a Multiplex Allele-Specific Assay显示文摘 | Guoqing Zhang Fangping Cai Zhiyong Zhou Joshua DeVos Nick Wagar Karidia Diallo Isaac Zulu Nellie Wadonda-Kabondo Jeffrey S. A. Stringer Paul J. Weidle Clement B. Ndongmo Izukanji Sikazwe Abdoulaye Sarr Matthew Kagoli John Nkengasong Feng Gao Chunfu Yang | 2013 | Journal of Clinical Microbiology2013，，11： | 1 |
| 10 | SPONGE:A GPU-Accelerated Molecular Dynamics Package with Enhanced Sampling and AI-Driven Algorithms显示文摘SPONGE(Simulation Package tOward Next GEneration molecular modeling)is a software package for molecular dynamics(MD)simulation of solution and surface molecular systems.In this version of SPONGE,the all-atom potential energy functions used in AMBER MD packages are used by default and other all-atom/coarse-grained potential energy functions are also supported.SPONGE is designed to extend the timescale being approached in MD simulations by utilizing the latest CUDA-enabled graphical processing units(GPU)and adopting highly efficient enhanced sampling algorithms,such as integrated tempering,selective integrated tempering and enhanced sampling of reactive trajectories.It is highly modular and new algorithms and functions can be incorporated con veniently.Particularly,a specialized Python plugin can be easily used to perform the machine learning MD simulation with MindSpore,TensorFlow,PyTorch or other popular machine learning frameworks.Furthermore,a plugin of Finite-Element Method(FEM)is also available to handle metallic surface systems.All these advanced features increase the power of SPONGE for modeling and simulation of complex chemical and biological systems. | Yu-Peng Huang Yijie Xia Lijiang Yang Jiachen Wei Yi Isaac Yang Yi Qin Gao | 2022 | Chinese Journal of Chemistry2022，40，1： | 1 |
| 11 | The role of microglia in central nervous system immunity and glioma immunology显示文摘 | Isaac Yang Seunggu J. Han Gurvinder Kaur Courtney Crane Andrew T. Parsa | 2009 | Journal of Clinical Neuroscience2009，，1： | 1 |
| 12 | Primary gliosarcoma: key clinical and pathologic distinctions from glioblastoma with implications as a unique oncologic entity显示文摘 | Seunggu J. Han Isaac Yang Tarik Tihan Michael D. Prados Andrew T. Parsa | 2010 | Journal of Neuro-Oncology2010，，3： | 1 |
| 13 | Hearing preservation after LINAC radiosurgery and LINAC radiotherapy for vestibular schwannoma显示文摘 | Brendan M. Fong Patrick Pezeshkian Daniel T. Nagasawa Antonio De Salles Quinton Gopen Isaac Yang | 2012 | Journal of Clinical Neuroscience2012，，8： | 1 |
| 14 | Noppl40 functions as a molecular link between the nucleolus and the coiled bodies显示文摘 | Isaac C Yang Y Meier UT | 1998 | J Cell Biol1998，142，： | 1 |
| 15 | Conserved composition of mammalian box H/ACA and box C/Dsmall nucleolar ribonucleoprotein particles and their interaction with the common factor Noppl40显示文摘 | Yang Y Isaac C Wang C | 2000 | Mol Biol Cell2000，11，： | 1 |
| 16 | Impact of climate change on outdoor design conditions and implications to peak loads显示文摘This study exams the impact of climate change on outdoor design conditions and peak loads of five Chinese cities over the five major climate zones for the winter and summer conditions.The design dry-bulb temperature(DDBT)and the coincident wet-bulb temperature(CWBT)for two 30-year periods;1971–2000 and 1984–2013 were analysed.It was found that the DDBT of the period 1984–2013 was higher than that of the period 1971–2000,whereas the CWBT and the corresponding outdoor enthalpy of the period 1984–2013 was lower than that of 1971–2000 at the various cumulative frequencies.This trend implies that the increment in conductive heat gain through the building envelope due to the rising temperature can be lower than the reduction in fresh air load due to the lower outdoor air enthalpy.In this case,the peak cooling loads may reduce in all five cities under study,and this is different from the widely held view that global warming will lead to more stringent outdoor design conditions,higher peak cooling loads and larger heating,ventilation and air conditioning(HVAC)plants than the current or historical status.The implications to the“free-cooling”of HVAC systems with enthalpy control are discussed as well. | Xujie Huo Liu Yang Danny Hin Wa Li Isaac Lun Siwei Lou Yuan Shi | 2022 | Building Simulation2022，15，12： | 0 |
| 17 | Chronic inflammation drives glioma growth:cellular and molecular factors responsible for an immunosuppressive microenvironment显示文摘This review examines glioma disease initiation,promotion,and progression with a focus on the cell types present within the tumor mass and the molecules responsible for the immunosuppressive microenvironment that are present at each step of the disease.The cell types and molecules present also correlate with the grade of malignancy.An overall“type 2”chronic inflammatory microenvironment develops that facilitates glioma promotion and contributes to the neo-vascularization characteristic of gliomas.An immunosuppressive microenvironment shields the tumor mass from clearance by the patient’s own immune system.Here,we provide suggestions to deal with a chronically-inflamed tumor microenvironment and provide recommendations to help optimize adjuvant immune-and gene therapies currently offered to glioma patients. | Edward T.Ha Joseph P.Antonios Horacio Soto Robert M.Prins Isaac Yang Noriyuki Kasahara Linda M.Liau Carol A.Kruse | 2014 | Neuroimmunology and Neuroinflammation2014，1，1： | 0 |
| 18 | Global DNA methylation and transcriptional analyses of human ESC-derived cardiomyocytes显示文摘与定义文化协议,人的胚胎的干细胞(hESCs ) 能在 vitro 产生 cardiomyocytes,因此为人的心开发提供一个伟大的模型,并且保持为心脏病治疗的大潜力。在这研究,我们成功地产生了人的 cardiomyocytes (hCMs ) 的一张高度纯的人口(>95%cTnT+) 从 hESC,在基因表示和 DNA methylation 的线,使我们能识别并且描绘 hCM 特定的签名,铺平。这些充实 hCM 的基因的基因功能的协会网络和基因疾病网络分析提供新卓见进 hCM transcriptional 规定的机制,并且为调查心脏的基因函数和疾病机制作为一个增进知识、富有的资源站。而且,我们证明心脏结构的基因和心脏抄写的因素有不同 epigenetic 机制调整他们的基因表示,提供 epigenetic 机械怎么协调在不同房间调整基因表示的更好的理解打字。 | Ying Gut Guang-Hui Liu Nongluk Plongthongkum' Christopher Benner Fei Yi Jing Qu Keiichiro Suzuki Jiping Yang Weiqi Zhang Mo Li Nuria Montserrat Isaac Crespo Antonio del Sol Concepcion Rodriguez Esteban Kun Zhang Juan Carlos Izpisua Belmonte | 2014 | Protein & Cell2014，5，1： | 0 |
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