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| 1 | Effect of Process Parameters of Microwave Assisted Extraction (MAE) on Polysaccharides Yield from Pumpkin显示文摘Process parameters of microwave assisted extraction (MAE) of the polysaccharides from pumpkin viz. extraction temperature, time and liquid-solid ratio were studied by using single factor and response surface methodology method. The results showed that the liquid-solid ratio was the most important factor in polysaccharides yield, followed by extraction time, and the extraction temperature was the least important factor. The optimum microwave assisted extraction conditions for the highest polysaccharides yield from pumpkin (16.76%±0.38%) were obtained by using the response surface methodology with extraction time of 29 min, an extraction temperature of 79℃ and a liquid-solid ratio of 22 mL · g-1. Validation experiment result well agreed with predicted value. | ZHENG Xianzhe YIN Fangping LIU Chenghai XU Xiangwen | 2011 | Journal of Northeast Agricultural University(English Edition)2011，18，2： | 13 |
| 2 | Selective enforcement of regulation显示文摘Regulatory agencies may,whether outside of set rules or within their discretion,depart from the original goals or principles set for enforcing the rules,which we term selective enforcement.Taking China,a country in transition,as an example,and using cases and large-sample tests,we present empirical evidence of selective enforcement.The results show that the China Securities Regulatory Commission(CSRC) takes into account whether companies violating the rules have a state-owned background and the strength of that background when investigating and punishing non-compliance.After controlling for the degree of violation,state-owned-enterprises(SOEs) are punished less severely than private companies;and the higher the hierarchy of the SOE in question,the less severe the punishment.It also takes longer for SOEs to be punished.We also find that companies that violate the rules less seriously have a greater tendency to apply for refinancing than those that violate the rules more seriously.This may be because the severity of the violation can affect listed companies' expectations of obtaining refinancing.The analysis and conclusions of this study prove useful in understanding the causes and consequences of selective enforcement in transition economies. | Donghua Chen Dequan Jiang Shangkun Liang Fangping Wang | 2011 | China Journal of Accounting Research2011，，Z1： | 10 |
| 3 | QTLs for Rice Leaf Chlorophyll Content Under Low N Stress显示文摘Quantitative trait loci (QTLs) for chlorophyll content of a rice leaf were mapped on to the molecular marker linkage nutrient solution and soil culture experiments to detect rice nitrogen nutrition status under low N stress. A chlorophyll meter was used to measure the soil plant analysis development (SPAD) value of the topmost fully expanded leaf as the index of chlorophyll content that expressed nitrogen status in rice plants. Totally 3 QTLs for SPAD values, two on chromosome 3 located at interval RG179-CDO337 and RG348-RZ329, respectively, and one on chromosome 10 at interval RZ500-RG134, were detected under stressed conditions of low N in the soil and/or nutrient solution culture experiments.One QTL located at interval RG179-CDO337 on chromosome 3 associated with a relative change in SPAD value from a high N level to a low N level in the soil culture experiment was also detected. Based on the different responses to low N stress between the two parents, it was supposed that the QTLs identified in this study associated with nitrogen efficiency in rice at low N levels might be useful in applying marker technology to rice breeding programs. | FANGPing YUXiao-Min ZHURi-Qing WUPing | 2004 | Pedosphere2004，14，2： | 9 |
| 4 | Diversity of root-associated fungi of Vaccinium mandarinorum along a human disturbance gradient in subtropical forests,China显示文摘Aims Ericaceous plant species can host diverse fungi in their roots,including ericoid mycorrhizal fungi(ERMF),endophytes,pathogens and some species with unknown functions.However,how this diversity of fungi responds to different human disturbances is not well understood.Methods In this study,we examined the effects of different human disturbance on fungal diversity in hair roots of Vaccinium mandarinorum,an ericaceous plant.Fungal DNA was extracted from hair roots of V.mandarinorum and high-throughput sequencing was applied to detect the diversity of root-associated fungi along a human disturbance gradient in subtropical forests in Gutianshan National Nature Reserve(GNNR)in East China.The four forest types with different disturbance regime were:old growth forest(OGF),secondary forest with once cut(SEC I),secondary forest with twice cut(SEC II)and Cunninghamia lanceolata plantation(PLF).Important Findings The results showed that:(i)diverse fungal operational units(OTUs)were detected in hair roots of V.mandarinorum in the four types of forests,covering fungal phyla of Ascomycota,Basidiomycota,Chytridiomycota,Glomeromycota and Zygomycota;(ii)Community composition of root-associated fungi of V.mandarinorum in PLF was distinct from those in the other three forest types,and two types of secondary forests had similar fungal community composition;(iii)Different fungal families respond differently to human disturbances:fungal families with significant preference to OGF were ectomycorrhizal or saprophytic fungi while fungal families with higher relative abundance in PLF were plant pathogenic or saprophytic fungi;(iv)The first principal component(PC1)of plant community had a significant effect on composition of root-associated fungal community,while edaphic parameters showed no significant effect on fungal community composition in roots of V.mandarinorum.Our results help to better understand the responses of both ericaceous plants and their fungal partners to human disturbances and forest managements. | Yanhua Zhang Jian Ni Fangping Tang Lifen Jiang Tianrong Guo Kequan Pei Lifu Sun Yu Liang | 2017 | Journal of Plant Ecology2017，10，1： | 6 |
| 5 | Dynamic Hand Gesture Recognition Based on Short-Term Sampling Neural Networks显示文摘Hand gestures are a natural way for human-robot interaction.Vision based dynamic hand gesture recognition has become a hot research topic due to its various applications.This paper presents a novel deep learning network for hand gesture recognition.The network integrates several well-proved modules together to learn both short-term and long-term features from video inputs and meanwhile avoid intensive computation.To learn short-term features,each video input is segmented into a fixed number of frame groups.A frame is randomly selected from each group and represented as an RGB image as well as an optical flow snapshot.These two entities are fused and fed into a convolutional neural network(Conv Net)for feature extraction.The Conv Nets for all groups share parameters.To learn longterm features,outputs from all Conv Nets are fed into a long short-term memory(LSTM)network,by which a final classification result is predicted.The new model has been tested with two popular hand gesture datasets,namely the Jester dataset and Nvidia dataset.Comparing with other models,our model produced very competitive results.The robustness of the new model has also been proved with an augmented dataset with enhanced diversity of hand gestures. | Wenjin Zhang Jiacun Wang Fangping Lan | 2021 | IEEE/CAA Journal of Automatica Sinica2021，8，1： | 5 |
| 6 | Realizing high low-electric-field energy storage performance in AgNbO_(3) ceramics by introducing relaxor behaviour显示文摘Both sustainable development in environment and safety of high-power systems require to develop a novel lead-free dielectric capacitor with high energy density(Wrec)at low applied electric field.In this work,a remarkably high Wrec of 2.9 J/cm^(3) accompanying with energy storage efficiency of 56% was achieved in Ag_(0.9)Sr_(0.05)NbO_(3) ceramic at a low applied electric field of 190 kV/cm,by improving antiferroelectricity and introducing relaxor behaviour.The improved anti-ferroelectric stability was attributed to the decreased tolerance factor and average electronegativity difference,while the relaxor behaviour was associated with the increased disordered local structure by Sr-doping.Moreover,the Ag_(0.9)Sr_(0.05)NbO_(3) ceramics also exhibited outstanding temperature stability in energy density with small variation less than 5% over 20-140℃.The results indicate that the Ag_(0.9)Sr_(0.05)NbO_(3) ceramic is a promising candidate for low-electric-field driving capacitors. | Kai Han Nengneng Luo Shuaifei Mao Fangping Zhuo Xiyong Chen Laijun Liu Changzheng Hu Huanfu Zhou Xinpeng Wang Yuezhou Wei | 2019 | Journal of Materiomics2019，5，4： | 5 |
| 7 | Regulation of CDllb transcription by decreasing PRC2 and increased acH4 level during ATRA-induced HL-60 differentiation显示文摘Polycomb 压抑的建筑群 2 (PRC2 ) ,它调停在 histone H3 (K27me3 ) 上的离氨酸 27 的 trimethylation,在干细胞区别的许多类型起一个重要作用。这里,我们试着揭示 PRC2,调停 PRC2 的压抑的 histone 标记 H3K27me3,和活跃 histone 标记 histone H4 acetylation (acH4 ) 怎么在导致的 all-trans retinoic 酸(ATRA ) 期间调整 CD11b 抄写 HL-60 白血病房间区别。由使用量的即时聚合酶链反应(qPCR ) 和西方的污点分析,我们发现 PRC2 的二个成员的 mRNA 和蛋白质表示层次分别地在导致 ATRA 的 HL-60 区别期间被减少。当为 72 h 与 ATRA 对待时, EZH2 和 SUZ12 mRNA 层次分别地被减少到 35% 控制组和 38% 。同时, granulocytic 成熟表面标记 CD11b 表示在 qPCR 检测的 mRNA 水平和流动 cytometry 检测的蛋白质水平显著地被增加。由使用染色质 immunoprecipitation 试金,我们在导致 ATRA 的 HL-60 区别期间在 CD11b 的倡导者在 SUZ12 有约束力、调停 PRC2 的 H3K27me3 比较了本地变化。两个都,在 CD11b 的倡导者的 SUZ12 有约束力、调停 PRC2 的 H3K27me3 的层次分别地为 4.1 和 3.8 褶层被减少。并且我们也在 ATRA 处理的 72 h 以后在 acH4 水平发现了增加直到 4 褶层。这些结果建议包括调停 PRC2 的压抑的 histone 标记 H3K27me3 和活跃 histone 标记 acH4 的 histone 修正可以在 HL-60 白血病房间 reprogramming 期间在 CD11b 包含抄写到终端区别。 | Huarong Tang Fangping Chen Qian Tan Sanqin Tan Linxin Liu Fan Zhang | 2009 | Acta Biochimica et Biophysica Sinica2009，41，7： | 5 |
| 8 | Chinese expert consensus on the management of chimeric antigen receptor T cell therapy-associated coagulopathy显示文摘Chimeric antigen receptor T-cell(CAR-T)therapy has greatly improved the disease remission rate and long-term survival rate of patients with relapsed/refractory hematological malignancies.[1-3]Currently,several commercial CAR-T products are available in the market and numerous CAR-T clinical trials have been conducted.Attention should be paid to the safety of CAR-T therapy.The main adverse effects of CAR-T therapy are cytokine release syndrome(CRS)and immune effector cell-associated neurotoxicity syndrome(ICANS).[4] | Heng Mei Fangping Chen Yue Han Ming Hou He Huang Xiaojun Huang Yuhua Li Aibin Liang Qifa Liu Ting Niu Jun Peng Wenbin Qian Yongping Song Jianxiang Wang Ying Wang Depei Wu Kailin Xu Linhua Yang Renchi Yang Lei Zhang Liansheng Zhang Xi Zhang Xiaohui Zhang Weili Zhao Weidong Han Yu Hu | 2022 | Chinese Medical Journal2022，，14： | 4 |
| 9 | Preparation of a Novel Acid Doped Polyaniline Adsorbent for Removal of Anionic Pollutant from Wastewater显示文摘Polyaniline(PANI) was one of the most extensively studied adsorbents due to its low cost and good environmental stability. The objective of the current study was to improve the selective capabilities of PANI for anionic dyes. We found that the acid doped PANI prepared with hydrochloric acid and p-toluenesulfonic acid(PTSA) could selectively adsorb anionic dyes. It exhibited very good selectivity for OG dye, the mechanism was proposed based on the chemical interaction of PANI with the sulfonate group of the dyes. The effects of solution p H, initial dye concentration, and different HCl/PTSA mole ratios on the adsorption capacity of OG have been investigated. Kinetic simulations indicated that the adsorption process could be well represented by pseudo-second-order kinetic plots. The isothermal adsorption curve fitting also showed that the adsorption process could be well described by the Langmuir isothermal equation. The results showed that acid doped PANI could be employed as a promising adsorbent for anion removal from dye wastewater. | 李佳佳 王其召 BAI Yan JIA Yongming SHANG Pan 黄皓浩 WANG Fangping | 2015 | Journal of Wuhan University of Technology(Materials Science)2015，30，5： | 3 |
| 10 | Carbonaceous matter in glacier at the headwaters of the Yangtze River:Concentration,sources and fractionation during the melting process显示文摘Carbonaceous matter has an important impact on glacial retreat in the Tibetan Plateau,further affecting the water resource supply.However,the related studies on carbonaceous matter are still scarce in Geladaindong(GLDD)region,the source of the Yangtze River.Therefore,the concentration,source and variations of carbonaceous matter at Ganglongjiama(GLJM)glacier in GLDD region were investigated during the melting period in 2017,which could deepen our understanding on carbonaceous matter contribution to glacier melting.The results showed that dissolved organic carbon(DOC)concentration of snowpit samples(283±200μg/L)was much lower than that of precipitation samples(624±361μg/L),indicating that large parts of DOC could be rapidly leached from the snowpit during the melting process.In contrast,refractory black carbon(rBC)concentration measured by Single Particle Soot Photometer of snowpit samples(4.27±3.15μg/L)was much higher than that of precipitation samples(0.97±0.49μg/L).Similarly,DOC with high mass absorption cross-section measured at 365 nm value was also likely to enrich in snowpit during the melting process.In addition,it was found that both r BC and DOC with high light-absorbing ability began to leach from the snowpit when melting process became stronger.Therefore,rBC and DOC with high light-absorbing ability exhibited similar behavior during the melting process.Based on relationship among DOC,rBC and K^+ in precipitation,the main source of carbonaceous matter in GLJM glacier was biomass burning during the study period. | Zhaofu Hu Shichang Kang Xiaobo He Fangping Yan Yulan Zhang Pengfei Chen Xiaofei Li Shaopeng Gao Chaoliu Li | 2020 | Journal of Environmental Sciences2020，32，1： | 3 |
| 11 | Allogeneic hematopoietic stem cell transplantation for patients with acute leukemia显示文摘Objective: The purposes of this study were to assess the efficacy of allogeneic hematopoietic stem cell transplantation (HSCT) for acute leukemia (AL) and analyze the factors affecting the prognosis of these patients. Methods: The clinical and follow-up data of 93 AL patients (median age, 30 years) undergoing allogeneic HSCT in Xiangya Hospital over the past 12 years were collected, and the potential factors affecting the efficacy and prognosis of allogeneic HSCT patients were determined. Results: Hematopoietic reconstitution was achieved in 90 patients. At the last follow-up, the incidences of severe acute graft versus host disease (aGvHD) and extensive chronic GvHD (cGvHD) were 14.0% and 20.0%, the 3-year cumulative incidence of transplantation related mortality (TRM) and relapse rate were 16.8%±6.1% and 21.3%±6.7%, and the estimated 3-year overall survival (OS) and disease-free survival (DFS) of the patients were 64.6%±5.4% and 56.5%±5.5%, respectively. Univariate analysis indicated that age older than 40 years, HLA mismatch, and severe lung infection within the first 100 days after transplantation were risk factors for severe aGvHD, age older than 40 years, HLA mismatch, severe lung infection within the first 100 days after transplantation, and severe aGvHD were risk factors for TRM, high-risk AL and lack of cGvHD were risk factors for relapse (all P<0.05). Survival estimation showed that HLA mismatch, severe lung infection occurring within the first 100 days post-transplantation, high-risk AL severe aGvHD and lack of cGvHD were risk factors associated with poor prognosis (all P<0.05). Further multivariate analyses revealed that severe lung infection within the first 100 days post-transplantation, severe aGvHD and lack of cGvHD were independent risk factors for unfavorable outcomes (all P<0.05). Conclusions: Allogeneic HSCT can improve the DFS of AL patients, and severe lung infection within the first 100 days post-transplantation, severe aGvHD and lack of cGvHD are independent risk factors affecting the prognosis. | Yan Chen Yajing Xu Gan Fu Yi Liu Jie Peng Bin Fu Xiaoyu Yuan Hongya Xin Yan Zhu Qun He Dengshu Wu Yigang Shu Xiaolin Li Xielan Zhao Fangping Chen | 2013 | Chinese Journal of Cancer Research2013，25，4： | 3 |
| 12 | Natural variations in grain length 10(GL10)regulate rice grain size显示文摘Grain size is an important determinant of grain weight and yield in rice.Although several genes related to grain size have been identified,natural variations in these genes that affect grain size are poorly characterized.Here,we describe the grain length QTL GL10,encoding MADS56,which positively regulates grain length and grain weight.A natural allelic variation of NIL-gl10,containing an~1.0-kb deletion in the first exon that abolishes its transcription,results in shorter grain length,lower grain weight and delayed flowering in gl10 plants.The knockout of GL10 in the HJX74 background leads to grain phenotypes similar to that of NIL-gl10,while overexpression of GL10 results in increased grain length and weight and earlier heading date.GL10 regulates grain length by promoting greater longitudinal cell growth in the grain glume.Additionally,GL10 participates in the regulation of gibberellic acid(GA)signaling pathway genes in young panicle tissues.Analysis of GL10 haplotypes shows obvious divergence between the japonica and indica lineages.Our findings reveal an allelic variation of GL10 that may explain differences in grain length among modern cultivars and could be used to breed rice varieties with optimized grain shape. | Penglin Zhan Shuaipeng Ma Zhili Xiao Fangping Li Xin Wei Shaojun Lin Xiaoling Wang Zhe Ji Yu Fu Jiahao Pan Mi Zhou Yue Liu Zengyuan Chang Lu Li Suhong Bu Zupei Liu Haitao Zhu Guifu Liu Guiquan Zhang Shaokui Wang | 2022 | Journal of Genetics and Genomics2022，49，5： | 3 |
| 13 | Methylesterification of cell-wall pectin controls the diurnal flower-opening times in rice显示文摘Flowers are the core reproductive organ of plants, and flowering is essential for cross-pollination. Diurnal flower-opening time is thus a key trait influencing reproductive isolation, hybrid breeding, and thermostability in plants. However, the molecular mechanisms controlling this trait remain unknown. Here, we report that rice Diurnal Flower Opening Time 1 (DFOT1) modulates pectin methylesterase (PME) activity to regulate pectin methylesterification levels of the lodicule cell walls, which affect lodicule swelling to control diurnal flower-opening time. DFOT1 is specifically expressed in the lodicules, and its expression gradually increases with the approach to flowering but decreases with flowering. Importantly, a knockout of DFOT1 showed earlier diurnal flower opening. We demonstrate that DFOT1 interacts directly with multiple PMEs to promote their activity. Knockout of PME40 also resulted in early diurnal flower opening, whereas overexpression of PME42 delayed diurnal flower opening. Lower PME activity was observed to be associated with higher levels of pectin methylesterification and the softening of cell walls in lodicules, which contribute to the absorption of water by lodicules and cause them to swell, thus promoting early diurnal flower opening. Higher PME activity had the opposite effect. Collectively, our work uncovers a molecular mechanism underlying the regulation of diurnal flower-opening time in rice, which would help reduce the costs of hybrid breeding and improve the heat tolerance of flowering plants by avoiding higher temperatures at anthesis. | Mumei Wang Xiaopei Zhu Guoqing Peng Minglong Liu Shuqing Zhang Minghao Chen Shitang Liao Xiaoying Wei Peng Xu Xiyu Tan Fangping Li Zhichuan Li Li Deng Ziliang Luo Liya Zhu Shuai Zhao Dagang Jiang Jing Li Zhenlan Liu Xianrong Xie Shaokui Wang Aimin Wu Chuxiong Zhuang Hai Zhou | 2022 | Molecular Plant2022，15，6： | 2 |
| 14 | GyrA and ParC Gene Mutation of Clinically Isolated Fluoroquinolones-resistant Strain of Salmonella显示文摘Nine strains resistant to five fluoroquinolones (Ciprofloxacin, Ofloxacin, Enrofloxacin, Danofloxacin, Sarafloxacin) were isolated from clinical samples and extracted the chromosomal DNA of these strains. Designed primers to amplify the Quinolone-resistance-determining region (QRDR) of gyrA and parC, then the PCR products were sequenced and analyzed. In comparision with NCTC5776, a single mutation was found at base 371 in gyrA of strain 38 which changed from C to T, and a single mutation was found at base 350 in gyrA of strain 60 which changed from A to C. No mutation was found in gyrA of the rest. The mutation of strain 38 led to an amino acid substitution of Arg99Cys and the mutation of 60 led to an amino acid substitution of Met 92 Leu. No mutation was found in parC QRDR of all the isolates. These results indicats that the DNA gyrase will be the primary target to salmonella of fluoroquinolone. | LIU Fangping TONG Hengmin | 2006 | Journal of Northeast Agricultural University(English Edition)2006，13，1： | 2 |
| 15 | Polymer-/Ceramic-based Dielectric Composites for Energy Storage and Conversion显示文摘Dielectric composites boost the family of energy storage and conversion materials as they can take full advantage of both the matrix and filler.This review aims at summarizing the recent progress in developing highperformance polymer-and ceramic-based dielectric composites,and emphases are placed on capacitive energy storage and harvesting,solid-state cooling,temperature stability,electromechanical energy interconversion,and high-power applications.Emerging fabrication techniques of dielectric composites such as 3D printing,electrospinning,and cold sintering are addressed,following by highlighted challenges and future research opportunities.The advantages and limitations of the typical theoretical calculation methods,such as finite-element,phase-field model,and machine learning methods,for designing high-performance dielectric composites are discussed.This review is concluded by providing a brief perspective on the future development of composite dielectrics toward energy and electronic devices. | Honghui Wu Fangping Zhuo Huimin Qiao Lalitha Kodumudi Venkataraman Mupeng Zheng Shuize Wang He Huang Bo Li Xinping Mao Qiaobao Zhang | 2022 | Energy & Environmental Materials2022，5，2： | 2 |
| 16 | 2021 Chinese consensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy显示文摘Immune thrombocytopenia(ITP)is an acquired disease characterized by isolated thrombocytopenia,which is one of the most common causes of thrombocytopenia during pregnancy.Women with ITP who have severe thrombocytopenia are at an increased risk for life-threatening obstetric complications.Therefore,we established this consensus statement on the diagnosis and management of ITP during pregnancy(detailed information is available in the Supplementary File,http://gffzz16e312a87a7141a5hpbow0pcnpnvx6qxx.ffgz.tsg.suse.edu.cn/A978). | Zhang Xiaohui Chen Fangping Chen Xiequn Cheng Yunfeng Fang Meiyun Feng Jianming Fu Haixia Gao Hong Han Yue He Aili Hou Ming Hu Yu Huang Ruibin Huang Wenrong Jing Zhicheng Kong Peiyan Liang Aibin Liang Meiying Liu Daihong Liu Junling Liu Lin Liu Xiaowei Ma Liangming Mei Heng Ni Heyu Niu Ting Peng Jun Qiao Jianlin Ren Jinhai Song Yongping Tang Liang V Tong Tong Wang Shaoyuan Wang Xin Wang Zhao Wei Hui Wu Depei Wu Guangsheng Xu Caigang Xu Xue Xu Yajing Yang Linhua Yang Renchi Yang Tonghua Yin Chenghong Yu Li Zhang Guangsen Zhang Lei Zhang Liansheng Zhang Xi Zhao Weili Zhao Yongqiang Zhou Daobin Zhou Hu Zhou Zeping Zhu Tienan Wang Jianliu Huang Xiaojun | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 17 | Resistin induces insulin resistance by both AMPK-dependent and AMPK-independent mechanisms in HepG2 cells显示文摘 | Zhaofan Luo Ying Zhang Fangping Li Juan He Helin Ding Li Yan Hua Cheng | 2009 | Endocrine2009，，1： | 2 |
| 18 | DNA barcoding of Antarctic marine zooplankton for species identification and recognition显示文摘Polar zooplankton are particularly sensitive to climate change, and have been used as rapid-responders to indicate climate-induced changes in the fragile Antarctic ecosystem. DNA barcoding provides an alternative approach for rapid zooplankton species identification. Ninety-four specimens belonging to 32 Antarctic zooplankton species were barcoded to construct a comprehensive reference library. An 830 to 1 050 base-pair region of the mitochondrial cytochrome c oxidase subunit I (mtCOI) gene was obtained as DNA barcodes. The intraspecific variation of the gene ranged from 0 to 2.6% (p-distance), with an average of 0.67% (SD=0.67%). The distance between species within the same genera ranged from 0.1% (Calanus) to 29.3%, with an average of 15.3% (SD=8.4%). The morphological and genetic similarities between Calanus propinquus and C. simillimus raise new questions about the taxonomic status of C. simillimus. With the exception of the two Calanus species, the intraspecific genetic divergence was much smaller than the interspecific divergence among congeneric species, confirming the existence of a barcode gap for Antarctic zooplankton. In addition, species other than Calanus sp. formed a monophyletic group. Therefore, we have confirmed DNA barcoding as an accurate and efficient approach for zooplankton identification in the Antarctic area (except for Hydromedusa, Tunicata, and other gelatinous zooplankton). Indicator vector analysis further confirmed this conclusion. The new primer sets issued here may facilitate the study of Antarctic marine zooplankton species composition by environmental metagenetic analysis. | CHENG Fangping WANG Minxiao SUN Song LI Chaolun ZHANG Yongshan | 2013 | Advances in Polar Science2013，24，2： | 2 |
| 19 | Preparation,Rheological Properties and Primary Cytocompatibility of TPU/PLA Blends as Biomedical Materials显示文摘A polymer blends containing thermoplastic polyurethane(TPU) and poly(lactic acid)(PLA) as a biomedical material were prepared by a process of modifying thermally induced phase separation(MTIPS) and melt blending.The influences of composition,shear frequency,and temperature on the rheological behaviors of the blends were investigated by small amplitude oscillatory shear rheology.The results revealed that the addition of TPU into PLA significantly decreased the non-Newtonian index of the blends,and increased the sensitivity of the blends on shear rate,suggesting that optimization of the shear rate and temperature could improve the flowability of the blend melts in the extrusion process.In addition,the results of SEM images revealed that TPU distributed well into PLA matrix and showed good compatibility between the TPU and PLA,which made the blends with good toughness.The primary cytocompatibility of the blends was evaluated using C2C12 cells.The results suggested that the TPU/PLA blends did not affect cell growth,showing no cytotoxicity.In short,the TPU/PLA blends with excellent toughness had potential application as biomedical devices. | 洪华 YANG Lili YUAN Yuan QU Xue CHEN Fangping 魏杰 刘昌胜 | 2016 | Journal of Wuhan University of Technology(Materials Science)2016，31，1： | 2 |
| 20 | Synergy effects of Asperosaponin Ⅵ and bioactive factor BMP-2 on osteogenesis and anti-osteoclastogenesis显示文摘Osteoporosis is a reduction in skeletal mass due to the decrease of osteogenic ability and the activation of the osteoclastic function.Inhibiting bone resorption and accelerating the new bone formation is a promising strategy to repair the bone defect of osteoporosis.In this study,we first systematically investigated the roles of Chinese medicine Asperosaponin Ⅵ(ASP Ⅵ)on osteogenic mineralization of BMSCs and osteoclastogenesis of BMMs,and then explored the synergistic effect of ASP Ⅵ and BS(BMP-2 immobilized in 2-N,6-O-sulfated chitosan)on bone formation.The result showed that ASP Ⅵ with the concentration lower than 10^(-4) M contributed to the expression of osteogenic gene and inhibited osteoclastic genes RANKL of BMSCs.Simultaneously,ASP Ⅵ significantly reduced the differentiation of mononuclear osteoclasts in the process of osteoclast formation induced by M-CSF and RANKL.Furthermore,by stimulating the SMADs,TGF-β1,VEGFA,and OPG/RANKL signaling pathways,ASBS(ASP Ⅵ and BS)substantially enhanced osteogenesis,greatly promoted angiogenesis,and suppressed osteoclastogenesis.The findings provide a new perspective on osteoporosis care and prevention. | Fangping Chen Qing Liang Lijie Mao Yanrong Yin b Lixin Zhang Cuidi Li Changsheng Liu | 2022 | Bioactive Materials2022，7，4： | 2 |
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