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您的检索式：作者名="Christopher Benner"
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| 1 | Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis显示文摘 | Tatiana Kisseleva Min Cong YongHan Paik David Scholten Chunyan Jiang Chris Benner Keiko Iwaisako Thomas Moore-Morris Brian Scott Hidekazu Tsukamoto Sylvia M. Evans Wolfgang Dillmann Christopher K. Glass David A. Brenner | 2012 | Proceedings of the National Academy of Sciences2012，，24： | 1 |
| 2 | Clonal Heterogeneity As Detected by Metaphase Karyotyping Is an Indicator of Poor Prognosis in Acute Myeloid Leukemia显示文摘 | Tilmann Bochtler Friedrich St?lzel Christoph E. Heilig Christina Kunz Brigitte Mohr Anna Jauch Johannes W.G. Janssen Michael Kramer Axel Benner Martin Bornh?user Anthony D. Ho Gerhard Ehninger Markus Schaich Alwin Kr?mer | 2013 | Journal of Clinical Oncology2013，，31： | 1 |
| 3 | Mutations in foregut SOX2^+ cells induce efficient proliferation via CXCR2 pathway显示文摘Identification of the precise molecular pathways involved in oncogene-induced transformation may help us gain a better understanding of tumor initiation and promotion. Here, we demonstrate that SOX2^+ foregut epithelial cells are prone to oncogenic transformation upon mutagenic insults, such as Kras^G12D and p53 deletion. GFP-based lineage-tracing experiments indicate that SOX2^+ cells are the cells-of-origin of esophagus and stomach hyperplasia. Our observations indicate distinct roles for oncogenic KRAS mutation and P53 deletion. p53 homozygous deletion is required for the acquisition of an invasive potential, and Kras^G12D expression, but not p53 deletion, suffices for tumor formation. Global gene expression analysis reveals secreting factors upregulated in the hyperplasia induced by oncogenic KRAS and highlights a crucial role for the CXCR2 pathway in driving hyperplasia. Collectively, the array of genetic models presented here demonstrate that stratified epithelial cells are susceptible to oncogenic insults, which may lead to a better understanding of tumor initiation and aid in the design of new cancer therapeutics. | Tomoaki Hishida Eric Vazquez-Ferrer Yuriko Hishida-Nozaki Ignacio Sancho-Martinez Yuta Takahashi Fumiyuki Hatanaka Jun Wu Alejandro Ocampo Pradeep Reddy Min-Zu Wu Laurie Gerken Reuben J. Shaw Concepcion Rodriguez Esteban Christopher Benner Hiroshi Nakagawa Pedro Guillen Garcia Estrella Nunez Delicado Antoni Castells Josep M. Campistol Guang-Hui Liu Juan Carlos Izpisua Belmonte | 2019 | Protein & Cell2019，10，7： | 1 |
| 4 | Global DNA methylation and transcriptional analyses of human ESC-derived cardiomyocytes显示文摘与定义文化协议,人的胚胎的干细胞(hESCs ) 能在 vitro 产生 cardiomyocytes,因此为人的心开发提供一个伟大的模型,并且保持为心脏病治疗的大潜力。在这研究,我们成功地产生了人的 cardiomyocytes (hCMs ) 的一张高度纯的人口(>95%cTnT+) 从 hESC,在基因表示和 DNA methylation 的线,使我们能识别并且描绘 hCM 特定的签名,铺平。这些充实 hCM 的基因的基因功能的协会网络和基因疾病网络分析提供新卓见进 hCM transcriptional 规定的机制,并且为调查心脏的基因函数和疾病机制作为一个增进知识、富有的资源站。而且,我们证明心脏结构的基因和心脏抄写的因素有不同 epigenetic 机制调整他们的基因表示,提供 epigenetic 机械怎么协调在不同房间调整基因表示的更好的理解打字。 | Ying Gut Guang-Hui Liu Nongluk Plongthongkum' Christopher Benner Fei Yi Jing Qu Keiichiro Suzuki Jiping Yang Weiqi Zhang Mo Li Nuria Montserrat Isaac Crespo Antonio del Sol Concepcion Rodriguez Esteban Kun Zhang Juan Carlos Izpisua Belmonte | 2014 | Protein & Cell2014，5，1： | 0 |
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