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| 1 | A unique sequence in the N-terminal regulatory region controls the nuclear localization of KLF8 by cooperating with the C-terminal zinc-fingers显示文摘Kr 眉 p 像像素的因素 8 (KLF8 ) 抄写因素在房间周期前进起一个关键作用, oncogenic 转变,对间充质的转变和侵略上皮。然而,它的原子本地化信号(NLS ) 没被识别。有另外的 KLF monopartite NLS (mNLS ) 和 C2H2 锌手指(ZF ) 的 KLF8 份额,哪个被显示了是为一些另外的 KLF 的 NLS。在这份报告,用指导 PCR 的 mutagenesis 和 immunofluorescent 显微镜学,我们显示出 mNLSs,任何单个 ZF 的删除,或变化的那混乱 Zn2+ 有约束力或联系 DNA 主题没影响 KLF8 的原子本地化。删除 > 然而,从 C 终点的 1.5 ZF 引起了 KLF8 的细胞质的累积。令人惊讶地,氨基酸(aa ) 的删除 151-200 区域几乎从原子核消除了 KLF8。有 PKC 禁止者的 S165A, K171E 或 K171R 变化,或处理导致了部分细胞质的累积。Co-immunoprecipitation 证明 KLF8 与 importin- 交往了,这个相互作用要求了 ZF 主题。aa 1-150 或 201-261 区域的删除独自没改变原子本地化。BrdU 加入和 cyclin D1 倡导者酶试金作为野类型的 KLF8 证明在原子本地化的 KLF8 异种有缺陷者不能支持 DNA 合成或 cyclin D1 倡导者激活。一起拿,这些结果建议 KLF8 有二 NLS,一包围 S165 和 K171 并且另外的是二双人脚踏车 ZF,它为 KLF8 原子本地化和它的细胞的功能的规定是批评的。 | Tina S Mehta Heng Lu Xianhui Wang Alison M Urvalek Kim-Hang H Nguyen Farah Monzur Jojo D Hammond Jameson Q Ma Jihe Zhao | 2009 | Cell Research2009，19，9： | 10 |
| 2 | Serial imaging of human embryonic stem-cell engraftment and teratoma formation in live mouse models显示文摘表示为基于 radiopharmaceutical 的成像为生物体之发光成像或 HSV1 thymidine kinase (HSV1-TK ) 编码任何一个萤火虫酶(fLuc ) 的记者 transgene 的 lentiviral 向量的二种新类型被构造监视人的胚胎的干细胞(hESC ) 在在移植以后的活老鼠的嫁接和增长。任何一个 transgene 的组成的表示没在文化改变 hESCs 的性质。我们下次在 SCID 鼠标监视了 teratomas 的形成到测试(1 ) 是否修改基因的 hESCs 维持他们的发展 pluripotency,并且(2 ) 是否支撑了记者基因表示,允许 noninvasive,在一个活鼠标模型的 hESC 衍生物的整个身体的成像。我们在接种以后从修改基因的房间以及野类型的 hESCs 2-4 月的两种类型观察了 teratoma 形成。用一个光成像系统,从 fLuc-transduced hESCs 的生物体之发光容易在在摸得出的肿瘤能被检测以前,长忍受 teratomas 的老鼠被检测。开发一个 noninvasive 成像方法对诊所更容易地可译,我们也利用了 HSV1-TK 和它的特定的底层, 1-(2 鈥 ? deoxy-2 鈥 ?fluoro- 尾 - D-arabinofuranosyl )-5-[125I]iodouracil ([125I ] FIAU ) ,记者 / 探查对。在全身的管理以后,[125I ] FIAU 是仅仅由编码 transgene 的 HSV1-TK 酶的 phosphorylated 并且在 transduced 以内保留(并且移植) 房间,由单个光子的排放允许敏感、量的成像计算了断层摄影术。象这些那样的 Noninvasive 成像方法可以使我们能在实时接受者以内重复地监视移植人的干细胞的存在和分发在上一通过记者基因的表达式长期。 | Martin G Pomper Holly Hammond Xiaobing Yu Zhaohui Ye Catherine A Foss Doris D Lin James J Fox Linzhao Cheng | 2009 | Cell Research2009，19，3： | 9 |
| 3 | Mainstreaming Early Warning Systems in Development and Planning Processes: Multilevel Implementation of Sendai Framework in Indus and Sahel显示文摘The third UN World Congress on Disaster Risk Reduction, held in Sendai, Japan in March 2015, agreed on a new framework to guide disaster risk reduction policy and practice for the next 15 years. The Sendai Framework for Disaster Risk Reduction 2015–2030(SFDRR) leaves important implementation issues unspecified and potentially creates both problems and opportunities for complex,multilevel governance systems in coping with hazards and disastrous events. Early warning systems(EWS), if built into the mainstream of planning for development and disaster relief and recovery, could present a significant opportunity to realize many SFDRR goals. We explore the complexities of using hydrometeorological EWS to prepare for drought and flood disasters in the densely populated communities of Pakistan’s Indus River Basin in contrast to the African Sahel’s less densely settled grasslands. Multilevel governance systems are often dominated by a topdown, technocentric, centralized management bias and have great difficulty responding to the needs of peripheral and vulnerable populations. People-centered, bottom-up approaches that incorporate disaggregated communities with local knowledge into a balanced, multilevel disaster risk management and governance structure have adramatically better chance of realizing the SFDRR goals for disaster risk reduction. | Asim Zia Courtney Hammond Wagner | 2015 | International Journal of Disaster Risk Science2015，6，2： | 9 |
| 4 | 转基因抗虫作物中苏云金芽孢杆菌Cry蛋白的食品安全问题显示文摘苏云金芽孢杆菌(Bt)微生物制剂是农业、林业和饮用水等领域用来控制靶标害虫幼虫的有效工具,至今已经有50余年的使用历史。同时其在美国、欧洲和其他一些国家被广泛用于经过认证的有机农业生产之中。目前已获审批的转基因Bt作物中最常使用的是Cry蛋白。Cry蛋白的作用机制、食品安全性以及致敏性已经经过啮齿类动物、农场动物和人体内试验和生物信息学研究的严格检验。Cry蛋白的杀虫作用只在靶标害虫的碱性消化道内,与中肠上皮细胞的特异蛋白受体结合才能起到杀虫作用,而其他非靶标生物体内(人类、猕猴、小鼠、大鼠和牛等)都被证明没有这种特异蛋白质受体。美国、欧洲和其他国家的管理机构都已经证实了转基因Bt作物和Cry蛋白在农作物和饮用水中残留的安全性。食物加工过程能够最大化地减少转基因作物中功能性Cry蛋白的摄入。转基因抗虫作物有利于降低农药杀虫剂的使用的同时,也能够有效防止玉米中伏马菌毒素的污染。 | 王春玲 Bruce Hammond | 2011 | 生物技术进展2011，1，4： | 8 |
| 5 | 2008年中国烟盒包装健康警示效果评估显示文摘目的评估中国居民对中国烟盒健康警示以及国外图形及文字方式健康警示有效性的感知。方法在北京、上海、昆明、银川4个城市共调查1169人,包括成年吸烟者、非吸烟者以及青少年,男女各半。以中华牌烟盒为背景,制作了10种不同的健康警示,包括我国大陆地区文字警示新版和旧版共2种,译成中文的国外图文警示共4种,以及以这4种图文警示为基础删除图形后的国外文字警示4种。调查对象对10种健康警示进行评分和排序。结果在促使吸烟者戒烟及阻止青少年吸烟方面,图文警示有效性评分最高,国外文字警示次之,中国文字警示旧版有效性评分最低。排序结果与评分结果基本一致,均表现为图文警示优于国外文字警示,优于中国文字警示。在不同研究对象组、城市、性别的分析中,结果一致。结论中国新烟盒健康警示与旧的警示相比,效果提高非常有限。中国应切实履行《烟草控制框架公约》第11条实施准则的要求,使用图形加文字方式的健康警示,向公众有效传播吸烟的健康危害知识。 | 姜垣 Geoffrey T.Fong 李强 David Hammond Anne C.K.Quah 杨焱 Pete Driezen Mi Yan | 2009 | 中国健康教育2009，25，6： | 6 |
| 6 | 中国部分疾病预防控制机构室内烟草烟雾浓度测定显示文摘目的检测室内工作场所烟草烟雾浓度,评价禁烟政策在降低烟草烟雾暴露中的作用。方法选取10个省市的14个卫生机构的办公楼,调查办公楼内的禁烟规定;用尼古丁作为烟草烟雾的标志物,评估禁烟规定对烟草烟雾暴露的作用。结果14个办公楼中,有4个实行了全面禁烟或部分禁烟规定。有禁烟规定办公楼的办公室的尼古丁浓度80百分位点低于2μg/m3,无禁烟规定办公楼的办公室尼古丁浓度80百分位点为20μg/m3。70%以上的吸烟办公室的尼古丁浓度超过1μg/m3;35%的非吸烟办公室和50%的走廊的尼古丁浓度超过1μg/m3。有1个办公楼在2006年1月1日颁布了禁烟规定,之后其尼古丁浓度大幅度下降:办公室的尼古丁平均值下降到原来的1/4以下,走廊下降到1/8以下。结论工作场所是烟草烟雾暴露的一个重要场所。禁烟或限制吸烟都可以有效降低室内烟草烟雾的暴露。 | 姜垣 李竹 邱五七 常爱玲 李明珠 赵白帆 杨焱 甘泉 Katharine Hammond 胡德伟 | 2007 | 中国慢性病预防与控制2007，15，2： | 5 |
| 7 | Composition Operators on a Banach Space of Analytic Functions | Cao Guangfu (Department of Mathematics,Sichuan University,Chengdu 610064,China)N.Elias (6611 Tauglewood Court 3B,Hammond,IN46323)P.Ghatage (Department of Mathematics,Cleveland State University,Cleveland,OH44115)Yu Dahai (Department of Mathematics,Sichuan University,Chengdu 610064,China) | 1998 | Acta Mathematica Sinica,English Series1998，14，2： | 4 |
| 8 | Agronomic value of unacidulated and partially acidulated phosphate rocks indigenous to the tropics显示文摘 | Hammond L L | 1986 | Adv Agron1986，40，： | 3 |
| 9 | American Gastroenterological Association Institute Guideline on the Prevention and Treatment of Hepatitis B Virus Reactivation During Immunosuppressive Drug Therapy显示文摘 | K. Rajender Reddy Kimberly L. Beavers Sarah P. Hammond Joseph K. Lim Yngve T. Falck-Ytter | 2015 | Gastroenterology2015，，1： | 3 |
| 10 | The next detectors for gravitational wave astronomy显示文摘This paper focuses on the next detectors for gravitational wave astronomy which will be required after the current ground based detectors have completed their initial observations, and probably achieved the first direct detection of gravitational waves. The next detectors will need to have greater sensitivity, while also enabling the world array of detectors to have improved angular resolution to allow localisation of signal sources. Sect. 1 of this paper begins by reviewing proposals for the next ground based detectors,and presents an analysis of the sensitivity of an 8 km armlength detector, which is proposed as a safe and cost-effective means to attain a 4-fold improvement in sensitivity. The scientific benefits of creating a pair of such detectors in China and Australia is emphasised. Sect. 2 of this paper discusses the high performance suspension systems for test masses that will be an essential component for future detectors, while sect. 3 discusses solutions to the problem of Newtonian noise which arise from fluctuations in gravity gradient forces acting on test masses. Such gravitational perturbations cannot be shielded, and set limits to low frequency sensitivity unless measured and suppressed. Sects. 4 and 5 address critical operational technologies that will be ongoing issues in future detectors. Sect. 4 addresses the design of thermal compensation systems needed in all high optical power interferometers operating at room temperature. Parametric instability control is addressed in sect. 5. Only recently proven to occur in Advanced LIGO, parametric instability phenomenon brings both risks and opportunities for future detectors. The path to future enhancements of detectors will come from quantum measurement technologies. Sect. 6 focuses on the use of optomechanical devices for obtaining enhanced sensitivity, while sect. 7 reviews a range of quantum measurement options. | BLAIR David JU Li ZHAO ChunNong WEN LinQing MIAO HaiXing CAI RongGen GAO JiangRui LIN XueChun LIU Dong WU Ling-An ZHU ZongHong HAMMOND Giles PAIK Ho Jung FAFONE Viviana ROCCHI Alessio BLAIR Carl MA YiQiu QIN JiaYi PAGE Michael | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，12： | 3 |
| 11 | The composition and diversity of natural regeneration of tree species in gaps under different intensities of forest disturbance显示文摘The positive ecological interaction between gap formation and natural regeneration has been examined but little research has been carried out on the effects of gaps on natural regeneration in forests under different intensities of disturbance.This study evaluates the composition,diversity,regeneration density and abundance of natural regeneration of tree species in gaps in undisturbed,intermittently disturbed,and disturbed forest sites.Bia Tano Forest Reserve in Ghana was the study area and three gaps each were selected in the three forest site categories.Ten circular subsampling areas of 1 m2 were delineated at 2 m spacing along north,south,east,and west transects within individual gaps.Data on natural regeneration<350 cm height were gathered.The results show that the intensity of disturbance was disproportional to gap size.Species diversity differed significantly between undisturbed and disturbed sites and,also between intermittently disturbed and disturbed sites for Simpson’s(1-D),Equitability(J),and Berger-Parker(B-P)indices.However,there was no significant difference among forest sites for Shannon diversity(H)and Margalef richness(MI)indices.Tree species composition on the sites differed.Regeneration density on the disturbed site was significantly higher than on the two other sites.Greater abundance and density of shade-dependent species on all sites identified them as opportunistic replacements of gap-dependent pioneers.Pioneer species giving way to shade tolerant species is a natural process,thus make them worst variant in gap regeneration. | Maame Esi Hammond Radek Pokorný Daniel Okae-Anti Augustine Gyedu Irene Otwuwa Obeng | 2021 | Journal of Forestry Research2021，32，5： | 3 |
| 12 | Closed-loop supply chain network equilibrium under legislation显示文摘 | David Hammond Patrick Beullens | 2006 | European Journal of Operational Research2006，，2： | 3 |
| 13 | Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/Ipr mouse model of systemic lupus erythematosus显示文摘热吃惊蛋白质 90 的提高的表示(HSP90 ) 在全身的豺狼座 erythematosus (SLE ) 的肾和浆液被发现了病人和 MRL/Mp-Fas lpr /Fas lpr (MRL/lpr ) 自体免疫的老鼠。如果 HSP90 的抑制将在 MRL/lpr 老鼠减少疾病,我们调查了。在在 vivo 的 vitro,有在 IL-6 的有免疫力刺激的显示出的减少的表示以前的 HSP90 禁止者 Geldanamycin 的 mesangial 房间的预告的处理, IL-12 和号码,我们发现当与 C57BL/6 相比鼠标和 MRL/lpr 鼠标与 HSP90 禁止者 17-DMAG 对待时, HSP90 表示在 MRL/lpr 肾被提高。与 17-DMAG 对待的 MRL/lpr 老鼠显示出减少的 proteinuria 并且减少了浆液 anti-dsDNA 抗体生产。Glomerulonephritis 和 glomerular IgG 和 C3 没被 17-DMAG 的管理显著地在 MRL/lpr 影响。17-DMAG 增加了 CD8 + T 房间,减少的双 negative T 房间,减少 CD4/CD8 比率和减少的小囊的 B 房间。这些研究建议 HSP90 可以在调整 T 房间区别和激活起一个作用并且 HSP90 抑制可以在豺狼座减少发炎。 | Samuel K Shimp III Cristen B Chafin Nicole L Regna Sarah E Hammond Molly A Read David L Caudell Marissa Nichole Rylander Christopher M Reilly | 2012 | Cellular & Molecular Immunology2012，9，3： | 3 |
| 14 | IL 28 B genotype is not useful for predicting treatment outcome in A sian chronic hepatitis B patients treated with pegylated interferon‐α显示文摘 | Jacinta A Holmes Tin Nguyen Dilip Ratnam Neel M Heerasing Jane V Tehan Sara Bonanzinga Anouk Dev Sally Bell Stephen Pianko Robert Chen Kumar Visvanathan Rachel Hammond David Iser Ferry Rusli William Sievert Paul V Desmond D Scott Bowden Alexander J Thomps | 2013 | J Gastroenterol Hepatol2013，，5： | 2 |
| 15 | Role for a bidentate ribonuclease in the initiation step of RNA interference显示文摘 | Bernstein E Caudy A A Hammond S M | 2001 | Nature2001，409，6818： | 2 |
| 16 | Hepatitis B Virus Reactivation following Allogeneic Hematopoietic Stem Cell Transplantation显示文摘 | Sarah P. Hammond Anne Marie Borchelt Chinweike Ukomadu Vincent T. Ho Lindsey R. Baden Francisco M. Marty | 2009 | Biology of Blood and Marrow Transplantation2009，，9： | 2 |
| 17 | DNA typing and genetic mapping with trimetric and tetrametric tandem repeats 显示文摘 | Edwards A Civitello A Hammond H A | 1991 | Am J Hum Genet1991，49，4： | 2 |
| 18 | Helicobacter pylori CagL Activates ADAM17 to Induce Repression of the Gastric H, K-ATPase α Subunit显示文摘 | Arindam Saha Steffen Backert Charles E. Hammond Monika Gooz Adam J. Smolka | 2010 | Gastroenterology2010，，1： | 2 |
| 19 | The PG500 series: novel heparan sulfate mimetics as potent angiogenesis and heparanase inhibitors for cancer therapy显示文摘 | K. Dredge E. Hammond K. Davis C. P. Li L. Liu K. Johnstone P. Handley N. Wimmer T. J. Gonda A. Gautam V. Ferro I. Bytheway | 2010 | Investigational New Drugs2010，，3： | 2 |
| 20 | The cryogenic nitrogen automotive engine 显示文摘 | Dooley J Hammond R P | 1984 | Mechanical Engineering1984，，： | 1 |
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