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| 1 | Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures显示文摘 | Bin-Kuan Chou Prashant Mali Xiaosong Huang Zhaohui Ye Sarah N Dowey Linda MS Resar Chunlin Zou Alex Zhang Jay Tong Linzhao Cheng | 2011 | Cell Research2011，21，3： | 38 |
| 2 | Serum IgA,IgM,and IgG responses in COVID-19显示文摘Currently,detecting SARS-CoV-2 RNAs is a standard approach for COVID-19 diagnosis.However,there is an urgent need for reliable and rapid serological diagnostic methods to screen SARS-CoV-2-infected people including those who do not have overt symptoms.Most emerging studies described serological tests based on detection of SARS-CoV-2-specific IgM and IgG.1–4 Although detection of SARS-CoV-2-specific IgA in serum has been reported in few papers,5,6 analyses of IgA levels in a larger number of COVID-19 patients are still lacking. | Huan Ma Weihong Zeng Hongliang He Dan Zhao Dehua Jiang Peigen Zhou Linzhao Cheng Yajuan Li Xiaoling Ma Tengchuan Jin | 2020 | Cellular & Molecular Immunology2020，17，7： | 12 |
| 3 | Serial imaging of human embryonic stem-cell engraftment and teratoma formation in live mouse models显示文摘表示为基于 radiopharmaceutical 的成像为生物体之发光成像或 HSV1 thymidine kinase (HSV1-TK ) 编码任何一个萤火虫酶(fLuc ) 的记者 transgene 的 lentiviral 向量的二种新类型被构造监视人的胚胎的干细胞(hESC ) 在在移植以后的活老鼠的嫁接和增长。任何一个 transgene 的组成的表示没在文化改变 hESCs 的性质。我们下次在 SCID 鼠标监视了 teratomas 的形成到测试(1 ) 是否修改基因的 hESCs 维持他们的发展 pluripotency,并且(2 ) 是否支撑了记者基因表示,允许 noninvasive,在一个活鼠标模型的 hESC 衍生物的整个身体的成像。我们在接种以后从修改基因的房间以及野类型的 hESCs 2-4 月的两种类型观察了 teratoma 形成。用一个光成像系统,从 fLuc-transduced hESCs 的生物体之发光容易在在摸得出的肿瘤能被检测以前,长忍受 teratomas 的老鼠被检测。开发一个 noninvasive 成像方法对诊所更容易地可译,我们也利用了 HSV1-TK 和它的特定的底层, 1-(2 鈥 ? deoxy-2 鈥 ?fluoro- 尾 - D-arabinofuranosyl )-5-[125I]iodouracil ([125I ] FIAU ) ,记者 / 探查对。在全身的管理以后,[125I ] FIAU 是仅仅由编码 transgene 的 HSV1-TK 酶的 phosphorylated 并且在 transduced 以内保留(并且移植) 房间,由单个光子的排放允许敏感、量的成像计算了断层摄影术。象这些那样的 Noninvasive 成像方法可以使我们能在实时接受者以内重复地监视移植人的干细胞的存在和分发在上一通过记者基因的表达式长期。 | Martin G Pomper Holly Hammond Xiaobing Yu Zhaohui Ye Catherine A Foss Doris D Lin James J Fox Linzhao Cheng | 2009 | Cell Research2009，19，3： | 9 |
| 4 | Promoting human embryonic stem cell renewal or differentiation by modulating Wnt signal and culture conditions显示文摘我们以前证明 Wnt3a 能刺激人的胚胎的茎(hES ) 细胞增殖并且影响房间命运决心。当 feeder cell-derivedfactors 不在时,在一个喂入器饲料分送器免费的条件下面有教养的 hES 房间糟糕幸存并且增殖。当 feeder 房间不在时的 Addingrecombinant Wnt3a 导出因素的刺激 hES 细胞增殖而且区别。在现在的学习,我们进一步扩大了我们的分析到象 Wnt1 和 Wnt5a 那样的另外的 Wntligands。当 Wnt1 作为 Wnt3a 在 hES 房间上显示了类似的效果时,在这个系统的 Wnt5ahad 小效果。当喂入器饲料分送器导出自强因素和 bFGF 也是现在时, Wnt3a 和 Wnt1 提高了无差别的 hES 房间的增长。探索可能性由激活 Wnt 发信号支持无差别的 hES 细胞的增长,在使不朽的人的成年成纤维细胞(HAFi ) 的 weoverexpressed Wnt3a 或 Wnt1 基因在比主要老鼠支持无差别的 hES 细胞的长期的生长是优异的细胞胚胎的成纤维细胞。HAFi 房间与或没有 Wnt transgene 能被宣传 Wnt3a 基因的 indefinitely.Over 表示显著地提高了 HAFi 喂入器饲料分送器房间的能力支持我们测试了的 3 根不同 hES 房间线的无差别的生长。在 Wnt3a-overpressing HAFi 房间的 threecommonly-used 药选择基因的合作表示进一步使我们能在稳定的 transfection 或转导以后选择稀罕 hES 克隆。这些使不朽的设计喂入器饲料分送器房间(W3R ) 那列合作快车象 Wnt3a 那样的支持生长的基因和三药选择基因应该授权我们高效地为基本、翻译的研究使修改 hES 房间线基因。 | Liuhong Cai Zhaohui Ye Betty Ying Zhou Prashant Mali Canquan Zhou Linzhao Cheng | 2007 | Cell Research2007，17，1： | 7 |
| 5 | Questions about NgAgo显示文摘 | Shawn Burgess Linzhao Cheng Feng Gu Zhiwei Huang Shuo Lin Jinsong Li Wei Li Wei Qin Yujie Sun Zhou Songyang Wensheng Wei Qiang Wu Haoyi Wang Xiaoqun Wang Jing-Wei Xiong Jianzhong Xi Hui Yang Bin Zhou Bo Zhang Junjiu Huang | 2016 | Protein & Cell2016，7，12： | 5 |
| 6 | Induced Pluripotent Stem Cell-derived Mesenchymal Stem Cell Seeding on Biofunctionalized Calcium Phosphate Cements显示文摘Induced pluripotent stem cells(iPSCs)have great potential due to their proliferation and differentiation capability.The objectives of this study were to generate iPSC-derived mesenchymal stem cells(iPSC-MSCs),and investigate iPSC-MSC proliferation and osteogenic differentiation on calcium phosphate cement(CPC)containing biofunctional agents for the first time.Human iPSCs were derived from marrow CD34+cells which were reprogrammed by a single episomal vector.iPSCs were cultured to form embryoid bodies(EBs),and MSCs migrated out of EBs.Five biofunctional agents were incorporated into CPC:RGD(Arg-Gly-Asp)peptides,fibronectin(Fn),fibronectin-like engineered polymer protein(FEPP),extracellular matrix Geltrex,and platelet concentrate.iPSC-MSCs were seeded on five biofunctionalized CPCs:CPC-RGD,CPC-Fn,CPC-FEPP,CPC-Geltrex,and CPC-Platelets.iPSC-MSCs on biofunctional CPCs had enhanced proliferation,actin fiber expression,osteogenic differentiation and mineralization,compared to control.Cell proliferation was greatly increased on biofunctional CPCs.iPSC-MSCs underwent osteogenic differentiation with increased alkaline phosphatase,Runx2 and collagen-I expressions.Mineral synthesis by iPSC-MSCs on CPC-Platelets was 3-fold that of CPC control.In conclusion,iPSCs showed high potential for bone engineering.iPSC-MSCs on biofunctionalized CPCs had cell proliferation and bone mineralization that were much better than traditional CPC.iPSC-MSC-CPC constructs are promising to promote bone regeneration in craniofacial/orthopedic repairs. | WahWah TheinHan Jun Liu Minghui Tang Wenchuan Chen Linzhao Cheng Hockin H.K.Xu | 2013 | Bone Research2013，1，4： | 3 |
| 7 | Production of Gene‐Corrected Adult Beta Globin Protein in Human Erythrocytes Differentiated from Patient i PSC s After Genome Editing of the Sickle Point Mutation显示文摘 | Xiaosong Huang Ying Wang Wei Yan Cory Smith Zhaohui Ye Jing Wang Yongxing Gao Laurel Mendelsohn Linzhao Cheng | 2015 | Stem Cells2015，，5： | 2 |
| 8 | Differential Sensitivity to JAK Inhibitory Drugs by Isogenic Human Erythroblasts and Hematopoietic Progenitors Generated from Patient‐Specific Induced Pluripotent Stem Cells显示文摘 | Zhaohui Ye Cyndi F. L iu Lucie Lanikova Sarah N. Dowey Chaoxia He Xiaosong Huang Robert A. Brodsky Jerry L. Spivak Josef T. Prchal Linzhao Cheng | 2014 | Stem Cells2014，，1： | 1 |
| 9 | Human adult marrow cells support prolonged expansion of human embryonic stem cell in culture显示文摘 | Linzhao Cheng Hammond H Zhaohui Ye | 2003 | Stem Cells2003，21，： | 1 |
| 10 | Functional antigen-presenting leucocytes derived from human embryonic stem cells in vitro显示文摘 | Xiangcan Zhan Gautam Dravid Zhaohui Ye Holly Hammond Michael Shamblott John Gearhart Linzhao Cheng | 2004 | The Lancet2004，，9429： | 1 |
| 11 | Role of leukemia inhibitory factor and its receptor in mouse primordial germ cell growth显示文摘 | Cheng Linzhao David P Gearing Lynn S White | 1994 | Development1994，120，： | 1 |
| 12 | Generation and application of human iPS cells显示文摘Human embryonic stem (ES) cells are capable of unlimited proliferation and maintenance of pluripo-tency in vitro;these properties may lead to potential applications in regenerative medicine. However,immune rejection hampers the allogenic application of human ES cells. Over-expression of several specific transcription factors has been used to reprogram human adult cells into induced pluripotent stem (iPS) cells,which are similar to hESCs in many aspects. The iPS technique makes it possible to produce patient-specific pluripotent stem cells for transplantation therapy without immune rejection. However,some challenges remain,including viral vector integration into the genome,the existence of exogenous oncogenic factors,and low induction efficiency. Here,we review recent advances in human iPS methodology,as well as remaining challenges and its potential applications. | CUI Chun RAO LingJun CHENG LinZhao XIAO Lei | 2009 | Chinese Science Bulletin2009，54，1： | 1 |
| 13 | Low Incidence of DNA Sequence Variation in Human Induced Pluripotent Stem Cells Generated by Nonintegrating Plasmid Expression显示文摘 | Linzhao Cheng Nancy F. Hansen Ling Zhao Yutao Du Chunlin Zou Frank X. Donovan Bin-Kuan Chou Guangyu Zhou Shijie Li Sarah N. Dowey Zhaohui Ye Settara C. Chandrasekharappa Huanming Yang James C. Mullikin P. Paul Liu | 2012 | Cell Stem Cell2012，，3： | 1 |
| 14 | Gene Targeting of a Disease-Related Gene in Human Induced Pluripotent Stem and Embryonic Stem Cells显示文摘 | Jizhong Zou Morgan L. Maeder Prashant Mali Shondra M. Pruett-Miller Stacey Thibodeau-Beganny Bin-Kuan Chou Guibin Chen Zhaohui Ye In-Hyun Park George Q. Daley Matthew H. Porteus J. Keith Joung Linzhao Cheng | 2009 | Cell Stem Cell2009，，1： | 1 |
| 15 | Erratum to: Questions about NgAgo显示文摘 | Shawn Burgess Linzhao Cheng Feng Gu Junjiu Huang Zhiwei Huang Shuo Lin Jinsong Li Wei Li Wei Qin Yujie Sun Zhou Songyang wensheng Wei Qiang Wu Haoyi Wang Xiaoqun Wang Jing-Wei Xiong Jianzhong Xi Hui Yang Bin Zhou Bo Zhang | 2017 | Protein & Cell2017，8，1： | 0 |
| 16 | Decline of SARS-CoV-2-specific IgG,IgM and IgA in convalescent COVID-19 patients within 100 days after hospital discharge显示文摘Dear editor,The 2019 novel coronavirus(later renamed as SARS-CoV-2 in February 2020)infected over 12 million people globally by early July 2020,causing mild to severe COVID-19 in millions.Monitoring the levels of antibodies such as immunoglobin(Ig)G,M and A that are specific to SARS-CoV-2 and present in the blood provides not only an alternative method for diagnosing SARS-CoV-2 infection(including asymptomatic carriers),but also a simple way to monitor immune responses in convalescent patients or after vaccination.A high and persistent level of antibodies specific to SARS-CoV-2,especially those that can bind to and neutralize the virus,would be a strong indication that an immunized host could resist to SRAS-CoV-2 infection.Currently,there are no effective drugs to specifically prevent or cure SARS-CoV-2 infection;therefore,host immune responses and antibody-based therapeutics will continue to play important roles in combating and later preventing COVID-19. | Huan Ma Dan Zhao Weihong Zeng Yunru Yang Xiaowen Hu Peigen Zhou Jianping Weng Linzhao Cheng Xueying Zheng Tengchuan Jin | 2021 | Science China(Life Sciences)2021，64，3： | 0 |
| 17 | More new lines of human parthenogenetic embryonic stem cells显示文摘二篇论文[l, 2 ] 在细胞研究的一个最近的问题出版了描述象细胞一样的人的胚胎的茎(hES ) 从 parthenogeneic 胚囊衬里的 pluripotent 的推导。这二篇论文补充并且证实一些月早出版的二篇另外的论文[3, 4 ] ,它看起来描述了 pathenogenetic hES 房间线的二个班。一起,这 4 篇论文在 hES 房间研究标记一个新时代的开始:单性生殖的 hES 房间线成年。 | Linzhao Cheng | 2008 | Cell Research2008，18，2： | 0 |
| 18 | Double knockouts in human embryonic stem cells显示文摘 | Jizhong Zou Rory Cochran Linzhao Cheng | 2010 | Cell Research2010，20，3： | 0 |
| 19 | In memory of Hal E.Broxmeyer,a pluripotent scientist,pioneer,and mentor显示文摘With great sadness,we residing in China heard the news that Professor Hal E.Broxmeyer passed away on December 8,2021,due to complications of thyroid cancer.He was 77.We regret that we could not say goodbye in person to Hal,as he was fondly called by his students and colleagues around the world.We wish to express publicly our heartfelt gratitude to Hal for his many seminal contributions to the scientific research and applications,and profound impact on the careers of younger scientists like us.We are sure that our feeling and gratitude are also shared by hundreds of youngsters who are fortunate to have interactions with Hal.He will continue to be a bright star in the sky,inspiring and guiding us for many years to come. | Linzhao Cheng Bin Guo Xinxin Huang Tao Cheng | 2022 | Blood Science2022，4，1： | 0 |
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