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| 1 | Short and long term prognosis in perinatal asphyxia: An update显示文摘Interruption of blood flow and gas exchange to the fetus in the perinatal period, known as perinatal asphyxia, can, if significant, trigger a cascade of neuronal injury, leading on to neonatal encephalopathy(NE) and resultant long-term damage. While the majority of infants who are exposed to perinatal hypoxia-ischaemia will recover quickly and go on to have a completely normal survival, a proportion will suffer from an evolving clinical encephalopathy termed hypoxic-ischaemic encephalopathy(HIE) or NE if the diagnosis is unclear. Resultant complications of HIE/NE are wide-ranging and may affect the motor, sensory, cognitive and behavioural outcome of the child. The advent of therapeutic hypothermia as a neuroprotective treatment for those with moderate and severe encephalopathy has improved prognosis. Outcome prediction in these infants has changed, but is more important than ever, as hypothermia is a time sensitive intervention, with a very narrow therapeutic window. To identify those who will benefit from current and emerging neuroprotective therapies we must be able to establish the severity of their injury soon after birth. Currently available indicators such as blood biochemistry, clinical examination and electrophysiology are limited. Emerging biological and physiological markers have the potential to improve our ability to select those infants who will benefit most from intervention. Biomarkers identified from work in proteomics, metabolomics and transcriptomics as well as physiological markers such as heart rate variability, EEG analysis and radiological imaging when combined with neuroprotective measures have the potential to improve outcome in HIE/NE. The aim of this review is to give an overview of the literature in regards to short and longterm outcome following perinatal asphyxia, and to discuss the prediction of this outcome in the early hours after birth when intervention is most crucial; looking at both currently available tools and introducing novel markers. | Caroline E Ahearne Geraldine B Boylan Deirdre M Murray | 2016 | World Journal of Clinical Pediatrics2016，5，1： | 16 |
| 2 | PM and light extinction model performance metrics, goals, and criteria for three-dimensional air quality models显示文摘 | James W. Boylan Armistead G. Russell | 2006 | Atmospheric Environment2006，，26： | 2 |
| 3 | The systemic inflammatory response to cardiac surgery: implications for the anesthesiologist显示文摘 | Laffey JG Boylan JF Cheng DC | 2002 | Anesthesiology2002，97，1： | 1 |
| 4 | Antepartum fetal heart rate monitoring value of Sowd stimution显示文摘 | Trudinger BJ Boylan P | 1980 | Obstet Gynecol1980，55，： | 1 |
| 5 | PM and light extinction model performance metrics, goals, and criteria for three-dimensional air quality models显示文摘 | Boylan J W Russell A G | 2006 | Atmospheric Environment2006，40，26： | 1 |
| 6 | PM and light extinction model performance metrics, goals and criteria for three-dimensional air quality models显示文摘 | BOYLAN J W RUSSELL A G | 2006 | Atmospheric Environment2006，40，26： | 1 |
| 7 | Activation-independent, antibody-mediated removal of GPVI from circulating human platelets: development of a novel NOD/SCID mouse model toevaluate the in vivo effectiveness of anti-humanplatelet agents显示文摘 | Boylan B Berndt MC Kahn ML | 2006 | Blood2006，108，3： | 1 |
| 8 | Transfection of mammalian cells with plasmid DNA by scrape loading and sonication loading显示文摘 | Fechheimer M Boylan JF Parker S | | 0，，： | 1 |
| 9 | EEG monitoring in the neonatal intensive care unit : a criti- cal juncture 显示文摘 | Boylan GB | 2011 | Clin Neurophysiol2011，122，10： | 1 |
| 10 | SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia显示文摘 | Bowers A J Scully S Boylan JF | 2003 | Oncogene2003，22，18： | 1 |
| 11 | Epidural bupivacaine-morphine analgesia versus patientcontrolled analgesia following ahdominal aortic surgery:analgesic,respiratory,and myocardial effects显示文摘 | Boylan JF Katz J Kavanagh BP | 1998 | Anesthesiology1998，89，3： | 1 |
| 12 | Construction of fused Lux AB gene by site directed mutagenesis显示文摘 | Boylan M O Pelletier J hepagnon S | 1989 | J Biolumin Chemilumin1989，4，： | 1 |
| 13 | Identification of a novel antigen on the apical surface of rat alveolar epithelial type Ⅱ and Clara cells 显示文摘 | Boylan G M Pryde J G Dobbs L G | 2001 | Am J Physiol Lung Cell Mol Physiol2001，280，6： | 1 |
| 14 | A Continuous striatal infusion of 6-OHDA prduces a terminal axolomy and delayed behavioval effects显示文摘 | Jones BE Boylan CB Fritsche M | 1996 | Brain Res1996，709，2： | 1 |
| 15 | Risk factors involved in pa- tients with bleeding peptic ulcers: a case-control study显示文摘 | Uppalapati SS Boylan JD Stoltzfus J | 2009 | Dig Dis Sci2009，54，3： | 1 |
| 16 | Association of nucleated red blood cells and severity of encephalopathy in nor- mothermic and hypothermic infants显示文摘 | WALSH BH BOYLAN GB DEMPSEY EM | 2013 | Acta Paediatr2013，102，2： | 1 |
| 17 | Transformationallearning in graduate nurse education through podcasting显示文摘 | Marrocco GF Kazer MW NealBoylan L | 2014 | Nurs Educ Perspect2014，35，1： | 1 |
| 18 | Disruptive technology roadmaps显示文摘 | Kostoff R N Boylan R Simons G R | 2004 | Technological Forecasing & Social Change2004，71，12： | 1 |
| 19 | Effects of initial graft tension on knee stability after anterior cruciate ligament reconstruction using hamstring tendons: A cadaver study 显示文摘 | Boylan D Greis P E West J R | 2003 | Arthroscopy2003，19，7： | 1 |
| 20 | Phytochromes: photosensory perception and signal transduction显示文摘 | Quail P H Boylan M T Parks B M | 1995 | Science1995，268，： | 1 |
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