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| 1 | 全科医学科研的范畴、研究需求和适用方法——《欧洲全科医学/家庭医学和基本医疗保健科研纲要》中文摘译显示文摘本文对《欧洲全科医学/家庭医学和基本医疗保健科研纲要》的中文译稿进行了重点摘登。该文件由欧洲全科医学科研网络制订,包括7部分内容:序言、导言、方法、结果、独立章节,讨论和启示。作为在欧洲发展全科医学科研的核心指南,该文件对欧洲的全科医学学科和科研发展产生了深远的影响。欧洲的全科医学体系和以此为基础而构建的学科理论共识与我国全科医学当前的实际情况可能更为接近。因篇幅所限,本文刊登了其中最重要,对中国研究者也最实用的5部分内容,包括:(1)导言——全科医学的核心能力/特征以及全科医学科研的意义;(2)结果——全科医学的6个核心领域(基本保健管理、'以人为本'的照护、解决具体问题的技能、综合的方法、以社区为导向、整体的方法)的科研范畴,研究需求和适用方法;(3)独立章节——如何发展基本的科研能力和避免常见的科研失误;(4)讨论——未来的全科医学科研重点;(5)启示——科学协会、研究机构、患者参与、科研工作、期刊、科研政策在发展学科方面应注重的问题。因欧洲的全科医学体制和我国较为相似,且存在一定的科研发展代差,该文件在当前阶段也可为我国全科医学研究者所用,基于全科医学学科的视角,从概念、分类学、范围和科研方法等方面,为我国全科医学科研的发展提供参照。 | Eva Hummers-Pradier Martin Beyer Patrick Chevallier Sophia Eilat-Tsanani Christos Lionis Lieve Peremans Davorina Petek Imre Rurik Jean Karl Soler Henri E.J.H.Stoffers Pinar Topsever Mehmet Ungan Paul van Royen Hanny Prick 无 | 2022 | 中国全科医学2022，25，9： | 4 |
| 2 | Complementary research in mammals and fish indicates MMP-2 as a pleiotropic contributor to optic nerve regeneration显示文摘Matrix metalloproteinases(MMPs)are members of the metzincin superfamily named after the zinc ion and the conserved methionine residue at the active site.In addition to their role in extracellular matrix(ECM)remodeling,these proteinases(in)activate many signaling molecules such as growth factors,adhesion molecules and cytokines;and even exert some intra- | Kim Lemmens Inge Van Hove Lieve Moons | 2016 | Neural Regeneration Research2016，11，5： | 3 |
| 3 | Dendritic shrinkage after injury: a cellular killer or a necessity for axonal regeneration?显示文摘Dendrites form an essential component of the neuronal circuit have been largely overlooked in regenerative research. Nevertheless, subtle changes in the dendritic arbors of neurons are one of the first stages of various neurodegenerative diseases, leading to dysfunctional neuronal networks and ultimately cellular death. Maintaining dendrites is therefore considered an essential neuroprotective strategy. This mini-review aims to discuss an intriguing hypothesis, which postulates that dendritic shrinkage is an important stimulant to boost axonal regeneration, and thus that preserving dendrites might not be the ideal therapeutic method to regain a full functional network upon central nervous system damage. Indeed, our study in zebrafish, a versatile animal model with robust regenerative capacity recently unraveled that dendritic retraction is evoked prior to axonal regrowth after optic nerve injury. Strikingly, inhibiting dendritic pruning upon damage perturbed axonal regeneration. This constraining effect of dendrites on axonal regrowth has sporadically been proposed in literature, as summarized in this short narrative. In addition, the review discusses a plausible underlying mechanism for the observed antagonistic axon-dendrite interplay, which is based on energy restriction inside neurons. Axonal injury indeed leads to a high local energy demand in which efficient axonal energy supply is fundamental to ensure regrowth. At the same time, axonal lesion is known to induce m让ochondrial depolarization, causing energy depletion in the axonal compartment of damaged neurons. Mitochondria, however, become mostly stationary after development, which has been proposed as a potential underlying reason for the low regenerative capacity of adult mammals. Per contra, upon reduced neuronal activity, mitochondrial mobility enhances. In this view, dendritic shrinkage after axonal injury in zebrafish could result in less synaptic input and hence, a release of mitochondria within the soma-dendrite compartment that then translocate to the axonal growth cone to stimulate axonal regeneration. If this hypothesis proofs to be correct, i.e. dendritic remodeling serving as fuel for axonal regeneration, we envision a major shift in the research focus within the neuroregenerative field and in the potential uncovering of various novel therapeutic targets. | An Beckers Lieve Moons | 2019 | Neural Regeneration Research2019，14，8： | 2 |
| 4 | Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice显示文摘 | Roger Bouillon Geert Carmeliet Lieve Verlinden Evelyne van Etten Annemieke Verstuyf Hilary F. Luderer Liesbet Lieben Chantal Mathieu Marie Demay | 2008 | Endocrine Reviews2008，，6： | 2 |
| 5 | Diffusion of innovations: successful adoption needs more effective soft-DSS driven targeting显示文摘 | LIEVE G | 2005 | Jour- nal of Targeting Measurement and Analysis for Market- ing2005，13，2： | 1 |
| 6 | Frequencies of simultaneous transformation with different T-DNAs and their relevance to the Agrobacterium/plant cell interaction显示文摘 | Ann Depicker Lieve Herman Anni Jacobs Jozef Schell Marc Montagu | 1985 | MGG Molecular & General Genetics1985，，3： | 1 |
| 7 | Super-resolution optical DNA Mapping via DNA methyltransferase-directed click chemistry显示文摘 | Charlotte Vranken Jochem Deen Lieve Dirix Tim | 2014 | Nucleic acids research2014，42，7： | 1 |
| 8 | Effects of delays on human performance on a temporal discrimination procedure:evidence of a choose-short effect显示文摘 | Lieving L M Lane S D Cherek D R Tcheremissine O V | 2006 | Behavioural Processes2006，71，： | 1 |
| 9 | Application of laser ablation inductively coupled plasma (dynamic reaction cell) mass spectrometry for depth profiling analysis of high-tech industrial materi- als显示文摘 | BALCAEN LIEVE I L LENAERTS J MOENS L | 2005 | J Anal At Spectrom2005，20，： | 1 |
| 10 | Persistent left superior vena cava:case reports and clinical implications显示文摘 | Ratliff HL Yousufuddin M Lieving WR | 2006 | Int J Cardiol2006，113，： | 1 |
| 11 | Effect of milling on colorand nutritional properties of rice显示文摘 | Lieve L Els D B Greet E V | 2007 | Food Chemistry2007，100，4： | 1 |
| 12 | Effect of milling on colour and nutritional properties of rice 显示文摘 | Lieve Lamberts Els De Bie Greet E Vandeputte | 2007 | Food Chemistry2007，100，4： | 1 |
| 13 | Cognitive, affective and behavioural disturbances following vascular thalamic lesions: A review显示文摘 | Lieve De Witte Raf Brouns Dimokritos Kavadias | 2011 | Cortex2011，47，： | 1 |
| 14 | Inhibition tests for detection and presumptive identification of tetracyclines, beta-lactam antibiotics and quinolones in poultry meat显示文摘 | Lieve Okerman Siska Croubels Siegrid De Baere Jan Van Hoof Patrick De Backer Hubert De Brabander | 2001 | Food Additives & Contaminants: Part A2001，，5： | 1 |
| 15 | Effect of milling on colour and nutritional properties of rice显示文摘 | Lieve Lamberts Els De Bie Greet E. Vandeputte Wim S. Veraverbeke Veerle Derycke Walter De Man Jan A. Delcour | 2005 | Food Chemistry2005，，4： | 1 |
| 16 | Development of reverse tanscriptase PCR assays for detection of active human herpesvirus 6 infection显示文摘 | Giuseppe L Lieve G | 2001 | J Clin Microbiol2001，39，6： | 1 |
| 17 | Deficiency of urokinase-type plasminogen activator-Mediated plasmin generation Impairs vascular remodeling during hypoxia induced pulmonary hypertension in mice显示文摘 | Marcel L Lieve M Ann B | 2001 | Circulation2001，103，15： | 1 |
| 18 | Matrix metalloproteinase‐3 in the central nervous system: a look on the bright side显示文摘 | Inge Hove Kim Lemmens Sarah Velde Mieke Verslegers Lieve Moons | 2012 | Neurochem2012，，2： | 1 |
| 19 | Vitamin D and cancer 显示文摘 | Rofer B Guy E Lieve V | 2006 | The Journal of Steroid Biochemistry and Molecular Biology2006，102，15： | 1 |
| 20 | A direct PCR detection method for clostridium tyrobutyricum spores in up to 100 Milliliters of raw milk显示文摘 | LIEVE M F H JAN H G E De B GUIDO M A V J W | 1995 | Appl Environ Microbiol1995，12，61： | 1 |
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