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| 1 | p53 as a hub in cellular redox regulation and therapeutic target in cancer显示文摘The TP53 tumor suppressor gene encodes a DNA-binding transcription factor that regulates multiple cellular processes including cell growth and cell death. The ability of p53 to bind to DNA and activate transcription is tightly regulated by post-translational modifications and is dependent on a reducing cellular environment. Some p53 transcriptional target genes are involved in regulation of the cellular redox homeostasis, e.g. TIGAR and GLS2. A large fraction of human tumors carry TP53 mutations, most commonly missense mutations that lead to single amino acid substitutions in the core domain. Mutant p53 proteins can acquire so called gain-of-function activities and influence the cellular redox balance in various ways, for instance by binding of the Nrf2 transcription factor, a major regulator of cellular redox state. The DNA-binding core domain of p53 has 10 cysteine residues, three of which participate in holding a zinc atom that is critical for p53 structure and function. Several novel compounds that refold and reactivate missense mutant p53 bind to specific p53 cysteine residues. These compounds can also react with other thiols and target components of the cellular redox system, such as glutathione. Dual targeting of mutant p53 and redox homeostasis may allow more efficient treatment of cancer. | Sofi E.Eriksson Sophia Ceder Vladimir J.N.Bykov Klas G.Wiman | 2019 | Journal of Molecular Cell Biology2019，11，4： | 4 |
| 2 | Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study显示文摘 | Shamir R Mehta Salim Yusuf Ron JG Peters Michel E Bertrand Basil S Lewis Madhu K Natarajan Klas Malmberg Hans-Jürgen Rupprecht Feng Zhao Susan Chrolavicius Ingrid Copland Keith AA Fox | 2001 | The Lancet . 2001 (9281)2001，，9281： | 4 |
| 3 | 森林能“提供”水分:广泛流传的神话还是科学事实?显示文摘本文给出了砍伐森林与地下水补充/旱季径流关系的两种对立观点,找出并分析了造成这种分歧的7个原因,包括不同水文过程的相对重要性、研究方法、人们感觉的变化和定义的不清晰等。提出了用于描述流域对砍伐森林所产生响应的简易模式。文章认为通过大孔隙补充水分是热带干旱地区雨水转变为地下水的关键机制,并对森林和水分的管理问题进行了探讨。 | Klas Sandstrm 闵庆文 | 1998 | 人类环境杂志1998，27，2： | 3 |
| 4 | Stress hyperglycaemia and increased risk of death after myocardial infarction in patients with and without diabetes: a systematic overview显示文摘 | Sarah E Capes Dereck Hunt Klas Malmberg Hertzel C Gerstein | 2000 | The Lancet . 2000 (9206)2000，，9206： | 2 |
| 5 | Split-plot designs with general minimum lower-order confounding显示文摘Split-plot designs have been widely used in industrial experiments.Up to now,most methods for choosing this kind of designs are based on the minimum aberration (MA) criterion.Recently,by introducing a new pattern,called aliased effect-number pattern (AENP),Zhang et al.proposed a general minimum lowerorder confounding (denoted by GMC for short) criterion and established a general minimum confounding (also denoted by GMC for saving notations) theory.It is proved that,the GMC criterion selects optimal designs in a more elaborate manner than the existing ones,and when an experimenter has a prior about the importance ordering of factors in experiments the GMC designs are better than other optimal designs.In this paper we extend the GMC criterion to the split-plot design case and give a GMC-FFSP criterion for ranking split-plot designs.Some comparisons of the new criterion with the MA-MSA-FFSP criterion are given,and the optimal 32-run split-plot designs up to 14 factors under the two criteria are tabulated for comparison and application. | WEI JiaLin 1,4,YANG JianFeng 1,LI Peng 3 & ZHANG RunChu 1,2,1 School of Mathematical Sciences and LPMC,Nankai University,Tianjin 300071,China 2 KLAS and School of Mathematics and Statistics,Northeast Normal University,Changchun 130024,China 3 School of Mathematical Sciences,Capital Normal University,Beijing 100037,China 4 School of Sciences,Tianjin University of Commerce,Tianjin 300134,China | 2010 | Science China Mathematics2010，53，4： | 2 |
| 6 | Stress Hyperglycemia and Prognosis of Stroke in Nondiabetic and Diabetic Patients: A Systematic Overview显示文摘 | Sarah E. Capes Dereck Hunt Klas Malmberg Parbeen Pathak Hertzel C. Gerstein | 2001 | Stroke: Journal of the American Heart Association2001，，10： | 2 |
| 7 | Intimal Hyperplasia in Mouse Vein Grafts Is Regulated by Flow显示文摘 | Klas Osterberg Erney Mattsson | 2005 | J Vasc Res2005，，42： | 1 |
| 8 | E-learning Personalization Based on Hybrid Recommendation Strategy and Learning Style Identification显示文摘 | Kla?nja-Mili?evi? A Vesin B Ivanovic M | 2011 | Computers in Education2011，56，3： | 1 |
| 9 | Adsorption of copper ions from water by modified agricultural by-products显示文摘 | (S)ciban M Kla(s)nja M (S)krbiae B | | 0，，01： | 1 |
| 10 | Evaluation, verification and operational supervision of corona losses in Sweden显示文摘 | Frans Jonas Sollerkvist Andrew Maxwell Klas Rouden et al | 2007 | IEEE Trans on Power Delivery2007，22，2： | 1 |
| 11 | Process evaluation of an 865MWe lignite fired O2/CO2 power plant 显示文摘 | Klas A Filip J | 2006 | Energy Conversion and Management2006，47，1819： | 1 |
| 12 | Boundary regularity of proper holomorphic mappings显示文摘 | Klas Diederich John Eric Fornaess | 1982 | Inventiones Mathematicae1982，，3： | 1 |
| 13 | Effects of frame rate on threedimensional speckle-tracking-based measurements of myocardial deformation显示文摘 | Yodwut C Weinert L Klas B | 2012 | J Am Soc Echocardiogr2012，25，9： | 1 |
| 14 | Gut microbiota accelerate tumor growth via c-jun and STAT3 phosphorylation in APCMin/+ mice显示文摘 | Yinghui Li Parag Kundu Shih Wee Seow Cristina Teixeira de Matos Linda Aronsson Keh Chuang Chin Klas K?rre Sven Pettersson Gediminas Greicius | 2012 | Carcinogenesis2012，，6： | 1 |
| 15 | Positive corona discharge ion source with IMS/MS to detect impurities in high purity nitrogen 显示文摘 | Sabo M Klas M Wang H Huang C Chu Y Matejcik S | 2011 | European Physical Journal-applied Physics2011，55，： | 1 |
| 16 | Causal Role of Apoptosis-Inducing Factor for Neuronal Cell Death Following Traumatic Brain Injury显示文摘 | Jennifer E. Slemmer Changlian Zhu Stefan Landshamer Raimund Trabold Julia Grohm Ardavan Ardeshiri Ernst Wagner Marva I. Sweeney Klas Blomgren Carsten Culmsee John T. Weber Nikolaus Plesnila | 2008 | The American Journal of Pathology2008，，6： | 1 |
| 17 | On the fractional order model of viscoelasticity 显示文摘 | Klas A Mikael E | 2005 | Mechanics of Time-Dependent Materials2005，9，1： | 1 |
| 18 | Reduced neointima in vein grafts following a blockage of cell recruitment from the vein and the surrounding tissue显示文摘 | Per F Klas o Erney M | 2005 | Cardiovasc Res2005，67，： | 1 |
| 19 | Kinetic parameters andlactate dehydrogenase isozyme activities support possible lactate uti-lization by neurons显示文摘 | OBRIEN J KLA K M HOPKINS I B | 2007 | Neurochem Res2007，32，4： | 1 |
| 20 | Integrated Architecture for Industrial Robot Programming and control显示文摘 | Klas Nilsson | 1999 | Robotics and Autonomous Systems1999，29，： | 1 |
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