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| 1 | Two stages of immiscible liquid separation in the formation of Panzhihua-type Fe-Ti-V oxide deposits,SW China显示文摘在 260 妈 Emeishan 大火的省(ELIP ) 的 Magmatic 氧化物沉积物, SW 中国和北越南,是 Fe, Ti 和 V 的重要来源。一些巨大的 magmatic Fe-Ti-V 氧化物沉积物例如 Panzhihua, Hongge,和 Baima 沉积物,很好在文学被描述并且在 Panxi 区域在分层的 mafic-ultramafic 侵入被招待,中央 ELIP。ELIP 相关的沉积物的一样的类型也远发生到南方并且在红河差错地区包括 Anyi 沉积物, Panzhihua 的大约 130 km 南方,和 Mianhuadi 沉积物。Anyi 沉积物是相对小的,但是同样在分层的 mafic 侵入被招待。Mianhuadi 沉积物有 260 妈的锆石 U-Pb 年龄并且与 ELIP 因此是同时期的。这存款易变地在指责的 Indosinian 造山运动和红河期间被变形。组合地, Mianhuadi 存款的磁铁矿比另外的存款的包含 Ti 和 V 的更小的数量,对以后的变态可能可归因。氧化物矿石存款的分发不与 ELIP 的 domal 结构有关。在 ELIP 的所有氧化物存款的一个主要特征是忍受氧化物的 gabbroic 侵入,黑花岗石 plutons 和 high-Ti 洪水暗岩的空间协会。因此,我们建议从一根披风羽毛的岩浆是进他们被发展进液体 immiscibility 的域形成二硅酸盐液体的一个浅岩浆房间的 emplaced,与一极其 Fe-Ti-rich gabbroic 作文和另外的黑花岗石。不能混合的 Fe-Ti-(P) 氧化物融化然后可以与 mafic 岩浆分开形成氧化物存款。这些存款从形成了的父母岩浆是在作文的可能的 Fe-Ti-rich picritic 并且比生产了 ELIP 的忍受硫化物的侵入的岩浆在更大的深度从充实的 asthenospheric 披风被导出。 | Mei-Fu Zhou Wei Terry Chen Christina Yan Wang Stephen A.Prevec Patricia Pingping Liu Geoffrey H.Howarth | 2013 | Geoscience Frontiers2013，4，5： | 35 |
| 2 | Assimilation of carbonate country rock by the parent magma of the Panzhihua Fe-Ti-V deposit(SW China):Evidence from stable isotopes显示文摘在西南中国的 Panzhihua 侵入是 Emeishan 大火的省的部分和大 Fe-Ti-V 矿石存款的主人。在主要侵入的炮兵阵地期间, mafic 女同性恋的多重代入侵了碳酸盐墙岩石,生产一个大接触光环。我们测量了国家岩石的侵入,他们的成分矿物质,和样品的氧同位素作文。从 Panzhihua 侵入的磁铁矿和斜长石有与 magmatic 平衡一致,并且比在导出披风的岩浆期望与高是 12 的 18O 价值从岩浆形成的 18O 价值。unmetamorphosed 国家岩石有高 18O 价值,从 13.2 (沙岩) 到 24.628.6 (白云石) 。从光环的 skarns 和云石比他们与在有邻近的 mafic 岩浆和侵入的特别众多的 mafic 女同性恋的交换平衡的液体建议相互作用的 protolith 有更低的 18O 和 13C 价值光环。这将比为导出披风的岩浆期望解释有显著地更高的价值的女同性恋的 18O 的改变。取决于为岩浆和沾染物假定的准确 18O 价值,要求生产 Panzhihua 侵入的提高的 18O 价值的吸收的数量在 8 和 13.7 wt.% 之间,假定简单混合。污染的准确机制是不清楚的,但是可以包含体积国家岩石的吸收的联合,混合与一有 CO2 富有的液体的国家岩石和交换的 melt 源于泥土和白云石的 decarbonation。这些机制,特别地后者,可能涉及 Fe-Ti-V 矿石的形成。 | Clement Ganino Chris Harris Nicholas T.Arndt Stephen A.Prevec Geoffrey H.Howarth | 2013 | Geoscience Frontiers2013，4，5： | 20 |
| 3 | B7-H7 (HHLA2) inhibits T-cell activation and proliferation in the presence of TCR and CD28 signaling显示文摘Modulation of T-cell responses has played a key role in treating cancers and autoimmune diseases.Therefore,understanding how different receptors on T cells impact functional outcomes is crucial.The influence of B7-H7(HHLA2)and CD28H(TMIGD2)on T-cell activation remains controversial.Here we examined global transcriptomic changes in human T cells induced by B7-H7.Stimulation through TCR with OKT3 and B7-H7 resulted in modest fold changes in the expression of select genes;however,these fold changes were significantly lower than those induced by OKT3 and B7-1 stimulation.The transcriptional changes induced by OKT3 and B7-H7 were insufficient to provide functional stimulation as measured by evaluating T-cell proliferation and cytokine production.Interestingly,B7-H7 was coinhibitory when simultaneously combined with TCR and CD28 stimulation.This inhibitory activity was comparable to that observed with PD-L1.Finally,in physiological assays using T cells and APCs,blockade of B7-H7 enhanced T-cell activation and proliferation,demonstrating that this ligand acts as a break signal.Our work defines that the transcriptomic changes induced by B7-H7 are insufficient to support full costimulation with TCR signaling and,instead,B7-H7 inhibits T-cell activation and proliferation in the presence of TCR and CD28 signaling. | Sadiye Amcaoglu Rieder Jingya Wang Natalie White Ariful Qadri Catherine Menard Geoffrey Stephens Jodi LKarnell Christopher ERudd Roland Kolbeck | 2021 | Cellular & Molecular Immunology2021，18，6： | 9 |
| 4 | Effect of organic-matter type and thermal maturity on methane adsorption in shale-gas systems显示文摘 | Tongwei Zhang Geoffrey S. Ellis Stephen C. Ruppel Kitty Milliken Rongsheng Yang | 2012 | Organic Geochemistry2012，，： | 6 |
| 5 | Hydration vs.oxidation:Modelling implications for Fe-Ti oxide crystallisation in mafic intrusions,with specific reference to the Panzhihua intrusion,SW China显示文摘Recent work on the Panzhihua intrusion has produced two separate models for the crystallisation of the intrusion:(1) low-Ti,high CaO and low H2O(0.5 wt.%) parent magma(equivalent to Emeishan low-Ti basalt) at FMQ;and(2) high-Ti,low CaO and higher H2O(>1.5 wt.%) parent magma(equivalent to Emeishan high-Ti basalt) at FMQ + 1.5.Modelling of these parent magma compositions produces significantly different results. We present here detailed f(O2) and H2O modelling for average compositions of both Emeishan high-Ti and low-Ti ferrobasalts in order to constrain the effects on crystallisation sequences for Emeishan ultra-mafic -mafic layered intrusions.Modelling is consistent with numerous experimental studies on ferro-basaltic magmas from other localities(e.g.Skaergaard intrusion).Modelling is compared with the geology of the Panzhihua intrusion in order to constrain the crystallisation of the gabbroic rocks and the Fe-Ti oxides ore layers.We suggest that the gabbroic rocks at the Panzhihua intrusion can be best explained by crystallisation from a parent magma similar to that of the high-Ti Emeishan basalt at moderate H2O contents(0.5-1 wt.%) but at the lower end of TiO2 content for typical high-Ti basalts(2.5 wt.%TiO2). Distinct silicate disequilibrium textures in the Fe-Ti oxide ore layers suggest that an influx of H2O may be responsible for changing the crystallisation path.An increase in H2O during crystallisation of gabbroic rocks will result in the depression of silicate liquidus temperatures and resultant disequilibrium with the liquid.Continued cooling of the magma with high H2O then results in precipitation of Mt-Uv alone. The H2O content of parent magmas for mafic layered intrusions associated with the ELIP is an important variable.H2O alters the crystallisation sequence of the basaltic magmas so that at high H2O and f(O2) Mt -Uv crystallises earlier than plagioclase and clinopyroxene.Furthermore,the addition of H2O to an anhydrous magma can explain silicate disequilibrium texture observed in the Fe-Ti oxide ore layers. | Geoffrey H.Howarth Stephen A.Prevec | 2013 | Geoscience Frontiers2013，4，5： | 4 |
| 6 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 7 | Stroke显示文摘 | Geoffrey A Donnan Marc Fisher Malcolm Macleod Stephen M Davis | 2008 | The Lancet . 2008 (9624)2008，，9624： | 2 |
| 8 | Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db / db Mice显示文摘 | Hong Chen Olga Charlat Louis A Tartaglia Elizabeth A Woolf Xun Weng Stephen J Ellis Nathan D Lakey Janice Culpepper Karen J More Roger E Breitbart Geoffrey M Duyk Robert I Tepper Jay P Morgenstern | 1996 | Cell1996，，3： | 2 |
| 9 | Stroke显示文摘 | Geoffrey A Donnan Marc Fisher Malcolm Macleod Stephen M Davis | 2008 | The Lancet2008，，9624： | 2 |
| 10 | Impaired Uptake of Serotonin by Platelets From Patients With Irritable Bowel Syndrome Correlates With Duodenal Immune Activation显示文摘 | Stephen Foley Klara Garsed Gulzar Singh Nathalie P. Duroudier Caroline Swan Ian P. Hall Abed Zaitoun Andrew Bennett Charles Marsden Geoffrey Holmes Andrew Walls Robin C. Spiller | 2011 | Gastroenterology2011，，5： | 2 |
| 11 | Effect of organic-matter type and thermal maturity on methane adsorption in shale-gas systems显示文摘 | Zhang T Geoffrey S E Stephen C R etal | 2012 | Organic Geo- chemistry2012，47，： | 1 |
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| 13 | Activity and safety of crizotinib in patients with ALK -positive non-small-cell lung cancer: updated results from a phase 1 study显示文摘 | D Ross Camidge Yung-Jue Bang Eunice L Kwak A John Iafrate Marileila Varella-Garcia Stephen B Fox Gregory J Riely Benjamin Solomon Sai-Hong I Ou Dong-Wan Kim Ravi Salgia Panagiotis Fidias Jeffrey A Engelman Leena Gandhi Pasi A J?nne Daniel B Costa Geoffrey | 2012 | Lancet Oncology2012，，10： | 1 |
| 14 | Trends in worker hearing loss by industry sector, 1981–2010显示文摘 | Elizabeth A. Masterson James A. Deddens Christa L. Themann Stephen Bertke Geoffrey M. Calvert | 2015 | Am. J. Ind. Med2015，，4： | 1 |
| 15 | Ethnic Tourism Development:Chinese Government Perspectives显示文摘 | LI Yang Geoffrey Wall Stephen Smith | 2006 | Annals of Tourism Re- search2006，35，3： | 1 |
| 16 | What lessons have been learned in reforming the renewable obligation? An analysis of internal and external failures in UK renewable energy policies 显示文摘 | Geoffrey Wood Stephen Dow | 2011 | Energy Policy2011，，39： | 1 |
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| 19 | Ethnic tourism development: Chinese Government Perspectives 显示文摘 | Li Yang Geoffrey Wall Stephen L J Smith | 2008 | Annals of Tourism Research2008，35，3： | 1 |
| 20 | Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial显示文摘 | Stephen M Davis Geoffrey A Donnan Mark W Parsons Christopher Levi Kenneth S Butcher Andre Peeters P Alan Barber Christopher Bladin Deidre A De Silva Graham Byrnes Jonathan B Chalk John N Fink Thomas E Kimber David Schultz Peter J Hand Judith Frayne Graeme | 2008 | Lancet Neurology2008，，4： | 1 |
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