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| 1 | Recipients po- tentially infected with parvovirus B19 by red blood cell products显示文摘 | Hourfar MK Mayr-Wohlfart U Themann A | 2011 | Transfusion2011，51，1： | 1 |
| 2 | Trends in worker hearing loss by industry sector, 1981–2010显示文摘 | Elizabeth A. Masterson James A. Deddens Christa L. Themann Stephen Bertke Geoffrey M. Calvert | 2015 | Am. J. Ind. Med2015，，4： | 1 |
| 3 | Comparison of two independent aromatic hydroxyl- ation assays in combination with intracerebral microdi- alysis to determine hydroxyl free radicals 显示文摘 | THEMANN C TEISMANN P KUSCHINSKY K | 2001 | Journal of Neuro-seienee Methods2001，108，1： | 1 |
| 4 | Blood donor screening for parvovirus B19 in Germany and Austria显示文摘 | Schmidt M Themann A Drexler C | 2007 | Transfusion2007，47，10： | 1 |
| 5 | Blood donor screening for parvovirus B19 in Germany and Austria 显示文摘 | Schmidt M1 Themann A Drexler C | 2007 | Transfusion2007，47，10： | 1 |
| 6 | Hepatic growth hormone and glucocortieoid receptor signaling in body growth, steato- sis and metabolic liver cancer development 显示文摘 | Mueller K M Themanns M Friedbichler K | 2012 | Mol Cell Endocri- nol2012，361，： | 1 |
| 7 | Comparison of two indepen dent aromat ic hydroxylation assays in combinatien with intracerebral microdialysis todetermine hydroxyl freeradicals 显示文摘 | C Themann P Teismann | 2001 | JNeurosciMethods2001，108，： | 1 |
| 8 | Ultrastructural alterations in the mouse liver following vincristine administration 显示文摘 | Rassat J Robenek H Themann H | 1981 | J Submicrosc Cytol1981，13，3： | 1 |
| 9 | Long-term results of subtalar fusions after operative versus nonoperative treatment of os ealcis fractures显示文摘 | Themann H Hufner T schratt E | 1999 | Foot Ankle Int1999，20，： | 1 |
| 10 | 6-hydroxydopamine increases the hydroxylation and nitration of phenylalanine in vivo: implication of peroxynitrite formation显示文摘 | Ferger B Themann C Rose S | 2001 | J Neurochem2001，78，3： | 1 |
| 11 | Blood donor screening for parvovirus B19 in Germany and Austria显示文摘 | Schmidt M Themann A Drexler C | 2007 | Transfusion2007，47，10： | 1 |
| 12 | Working in noise with a hearing loss:perceptions from workers,supervisors,and hearing conservation program managers显示文摘 | Themann CL Randolph RF | 2005 | Ear Hear2005，26，6： | 1 |
| 13 | Alcohol in pregnancy and fetal heart damage 显示文摘 | LOSER H PFEFFERKORN JR THEMANN H | 1992 | Klin Padiatr1992，204，5： | 1 |
| 14 | Monogenic deficiency in murine intestinal Cdc42 leads to mucosal inflammation that induces crypt dysplasia显示文摘CDC42 controls intestinal epithelial(IEC)stem cell(IESC)division.How aberrant CDC42 initiates intestinal inflammation or neoplasia is unclear.We utilized models of inflam-matory bowel diseases(IBD),colorectal cancer,aging,and IESC injury to determine the loss of intestinal Cdc42 upon inflammation and neoplasia.Intestinal specimens were collected to determine the levels of CDC42 in IBD or colorectal cancer.Cdc42 floxed mice were crossed with Villin-Cre,Villin-CreERT2 and/or Lgr5-eGFP-IRES-CreERT2,or Bmi1-CreERT2 mice to generate Cdc42 deficient mice.Irradiation,colitis,aging,and intestinal organoid were used to evaluate CDC42 upon mucosal inflammation,IESC/progenitor regenerative capacity,and IEC repair.Our studies revealed that increased CDC42 in colorectal cancer correlated with lower survival;in contrast,lower levels of CDC42 were found in the inflamed IBD colon.Colonic Cdc42 depletion significantly reduced Lgr5+IEsCs,increased progenitors'hyperplasia,and induced mucosal inflammation,which led to crypt dysplasia.Colonic Cdc42 depletion markedly enhanced irra-diation-or chemical-induced colitis.Depletion or inhibition of Cdc42 reduced colonic Lgr5+IESC regeneration.In conclusion,depletion of Cdc42 reduces the IESC regeneration and IEC repair,leading to prolonged mucosal inflammation.Constitutive monogenic loss of Cdc42 in-duces mucosal inflammation,which could result in intestinal neoplasia in the context of aging. | Dongsheng Zhang Wenjuan Tang Haitao Niu William Tse Hai-Bin Ruan Helmut Dolznig Thomas Knosel Friedrich Karl-Heinz Madeleine Themanns Jiang Wang Mingquan Song Lee Denson Lukas Kenner Richard Moriggl Yi Zheng Xiaonan Han | 2024 | Genes & Diseases2024，11，1： | 0 |
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