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| 1 | Response to endoscopic therapy for biliary anastomotic strictures in deceased versus living donor liver transplantation显示文摘BACKGROUND:Endoscopic therapy has been successful in the management of biliary complications after both deceased donor liver transplantation(DDLT) and living donor liver transplantation(LDLT).LDLT is thought to be associated with higher rates of biliary complications,but there are few studies comparing the success of endoscopic management of anastomotic strictures between the two groups.This study aims to compare our experience in the endoscopic management of anastomotic strictures in DDLT versus LDLT.METHODS:This is a retrospective database review of all liver transplant patients undergoing endoscopic retrograde cholangiopancreatography(ERCP) after liver transplantation.The frequency of anastomotic stricture and the time to develop and to resolve anastomotic stricture were compared between DDLT and LDLT.The response of anastomotic stricture to endoscopic therapy was also analyzed.RESULTS:A total of 362 patients underwent liver transplantation between 2003 and 2011,with 125 requiring ERCP to manage biliary complications.Thirty-three(9.9%) cases of DDLT and 8(27.6%) of LDLT(P=0.01) were found to have anastomotic stricture.When comparing DDLT and LDLT,there was no difference in the mean time to the development of anastomotic strictures(98±17 vs 172±65 days,P=0.11),likelihood of response to ERCP [22(66.7%) vs 6(75.0%),P=0.69],mean time to the resolution of anastomotic strictures(268±77 vs 125±37 days,P=0.34),and the number of ERCPs required to achieve resolution(3.9±0.4 vs 4.7±0.9,P=0.38).CONCLUSIONS:Endoscopic therapy is effective in the majority of biliary complications relating to liver transplantation.Anastomotic strictures occur more frequently in LDLT compared with DDLT,with equivalent endoscopic treatment response and outcomes for both groups. | Calvin HY Chan Fergal Donnellan Michael F Byrne Alan Coss Mazhar Haque Holly Wiesenger Charles H Scudamore Urs P Steinbrecher Alan A Weiss Eric M Yoshida | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，5： | 7 |
| 2 | BRAF inhibitor treatment of melanoma causing colonic polyps:An alternative hypothesis显示文摘Colonic polyps may arise from BRAF inhibitor treatment of melanoma, possibly due paradoxical activation of the mitogen-activated protein(MAP)-kinase pathway. In an alternative evidence based scenario, tubular colonic adenomas with APC gene mutations have also been identified in the context of BRAF inhibitor treatment, in the absence of mutations of MAPK genes. A minority of colorectal cancers develop by an alternative 'serrated polyp pathway'. This article postulates a novel hypothesis, that the established phenotypic and molecular characteristics of serrated colonic polyps/CRC offer an intriguing insight into the pathobiology of BRAF inhibitor induced colonic polyps. Serrated polyps are characterized by a Cp G island methylation phenotype, MLH1 silencing and cellular senescence. They also have BRAF mutations. The contention is that BRAF inhibitor induced polyps mimic the afore-described histology and molecular features of serrated polyps with the exception that instead of the presence of BRAF mutations they induce C-RAF homodimers and B-RAF: C-RAF heterodimers. | Fergal C Kelleher Grainne Callaghan Catriona Gallagher Hazel O'Sullivan | 2017 | World Journal of Gastroenterology2017，23，17： | 2 |
| 3 | Biomaterials & scaffolds for tissue engineering显示文摘 | Fergal J. O’Brien | 2011 | Materials Today2011，，3： | 2 |
| 4 | Wide Variation in Definition, Detection, and Description of Lacunar Lesions on Imaging显示文摘 | Gillian M. Potter Fergal J. Marlborough Joanna M. Wardlaw | 2011 | Stroke2011，，： | 2 |
| 5 | Predicting neointimal hyperplasia in stented arteries using time-dependant computational fluid dynamics: A review 显示文摘 | Jonathan Murphy Fergal Boyle | 2010 | Computers in Biology and Medicine2010，40，： | 1 |
| 6 | First -trimester or second-trimester screening, or both, for Down syndrome显示文摘 | Fergal D Malone Canick Jacob A Robert H | 2005 | N Engl Med2005，353，19： | 1 |
| 7 | Fibrodysplasia ossificans progressiva显示文摘 | Andrew Hughes Fergal Monsell | 2008 | Current Orthopaedics2008，22，1： | 1 |
| 8 | Forestry and the environment - a sustainable prospect 显示文摘 | Fergal M | 1997 | Irish For1997，，2： | 1 |
| 9 | First-trimester or secondtrimester screening, or both, for down's syndrome 显示文摘 | Fergal DM Jacob AC Robert HB | 2005 | The New England journal of medicine2005，353，19： | 1 |
| 10 | Tidal energy update 2009 显示文摘 | Rourke Fergal O Boyle Fergal Reynolds Anthony | 2010 | Applied Energy2010，87，2： | 1 |
| 11 | Fetal growth disorders in twin gestations显示文摘 | Fionnuala M Breathnach MD Fergal D | 2012 | Seminars in Perinatology2012，36，： | 1 |
| 12 | Renewable energy resources and technologies applicable to Ireland显示文摘 | Fergal O Rourke Fergal Boyle Anthony Reynolds | | 0，，01： | 1 |
| 13 | Application of selected lactic acid bacteria and coagulants for improving the quality of low-salt Cheddar cheese: Chemical, microbiological and rheological evaluation显示文摘 | Kirsten Kastberg M?ller Fergal P. Rattray Ylva Ard? | 2013 | International Dairy Journal2013，，： | 1 |
| 14 | Metabolites of Pseudornonas involved in the biocomrol of plant disease显示文摘 | David N D Fergal O | 1994 | Trends in Biotechnology1994，2，： | 1 |
| 15 | Young women,cervical intraepithelial neoclassical and Human papinoma virus:risk factors for persistence and recurrence显示文摘 | Fergal A Stent Ella P Deloris A | 2013 | Cancer Letters2013，196，2： | 1 |
| 16 | The behavior of structural steels at elevated temperatures and the design of fire resistant steels 显示文摘 | Wei Sha Brian R Kirby Fergal S Kelly | 2001 | Materials Transactions2001，42，9： | 1 |
| 17 | Second-stage labor duration in nulliparous women: relationship to maternal and perinatal outcomes显示文摘 | Dwight J. Rouse Steven J. Weiner Steven L. Bloom Michael W. Varner Catherine Y. Spong Susan M. Ramin Steve N. Caritis Alan M. Peaceman Yoram Sorokin Anthony Sciscione Marshall W. Carpenter Brian M. Mercer John M. Thorp Fergal D. Malone Margaret Harper Jay | 2009 | American Journal of Obstetrics and Gynecology2009，，4： | 1 |
| 18 | Efficacy and safety of colonic stenting for malignant disease in the elderly显示文摘 | Fergal Donnellan Garret Cullen Daniel Cagney Phil O’Halloran Gavin C. Harewood Frank E. Murray Stephen E. Patchett | 2010 | International Journal of Colorectal Disease2010，，6： | 1 |
| 19 | Novel Microhydroxyapatite Particles in a Collagen Scaffold: A Bioactive Bone Void Filler?显示文摘 | Frank G. Lyons John P. Gleeson Sonia Partap Karen Coghlan Fergal J. O’Brien | 2014 | Clinical Orthopaedics and Related Research?2014，，4： | 1 |
| 20 | Comparison of biomaterial delivery vehicles for improving acute retention of stem cells in the infarcted heart显示文摘 | Ellen T. Roche Conn L. Hastings Sarah A. Lewin Dmitry E. Shvartsman Yevgeny Brudno Nikolay V. Vasilyev Fergal J. O’Brien Conor J. Walsh Garry P. Duffy David J. Mooney | 2014 | Biomaterials2014，，25： | 1 |
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