|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Gastroenterologist perceptions of faecal microbiota transplantation显示文摘AIM: To explore gastroenterologist perceptions towards and experience with faecal microbiota transplantation(FMT).METHODS: A questionnaire survey consisting of 17 questions was created to assess gastroenterologists' attitude towards and experience with FMT. This was anonymously distributed in hard copy format amongst attendees at gastroenterology meetings in Australia between October 2013 and April 2014. Basic descriptive statistical analyses were performed.RESULTS: Fifty-two clinicians participated. Twenty one percent had previously referred patients for FMT,8% more than once. Ninety percent would refer patients with Clostridium difficile infection(CDI) for FMT if easily available,37% for ulcerative colitis,13% for Crohn's disease and 6% for irritable bowel syndrome. Six percent would not refer any indication,including recurrent CDI. Eighty-six percent would enroll patients in FMT clinical trials. Thirty-seven percent considered the optimal mode of FMT administration transcolonoscopic,17% nasoduodenal,13% enema and 8% oral capsule. The greatest concerns regarding FMT were: 42% lack of evidence,12% infection risk,10% non infectious adverse effects/lack of safety data,10% aesthetic,10% lack of efficacy,4% disease exacerbation,and 2% inappropriate use; 6% had no concerns. Seventy seven percent believed there is a lack of accessibility while 52% had an interest in learning how to provide FMT. Only 6% offered FMT at their institution.CONCLUSION: Despite general enthusiasm,most gastroenterologists have limited experience with,or access to,FMT. The greatest concerns were lack of supportive evidence and safety issues. However a significant proportion would refer indications other than CDI for FMT despite insufficient evidence. These data provide guidance on where education and training are required. | Sudarshan Paramsothy Alissa J Walsh Thomas Borody Douglas Samuel Johan van den Bogaerde Rupert WL Leong Susan Connor Watson Ng Hazel M Mitchell Nadeem O Kaakoush Michael A Kamm | 2015 | World Journal of Gastroenterology2015，21，38： | 5 |
| 2 | Chronic pancreatitis:A diagnostic dilemma显示文摘Typical clinical symptoms of chronic pancreatitis are vague and non-specific and therefore diagnostic tests are required, none of which provide absolute diagnostic certainly, especially in the early stages of disease. Recently-published guidelines bring much needed structure to the diagnostic work-up of patients with suspected chronic pancreatitis. In addition, novel diagnostic modalities bring promise for the future. The assessment and diagnosis of pancreatic exocrine insufficiency remains challenging and this review contests the accepted perspective that steatorrhea only occurs with > 90% destruction of the gland. | Sinead N Duggan Hazel M NíChonchubhair Oladapo Lawal Donal B O’Connor Kevin C Conlon | 2016 | World Journal of Gastroenterology2016，22，7： | 4 |
| 3 | BRAF inhibitor treatment of melanoma causing colonic polyps:An alternative hypothesis显示文摘Colonic polyps may arise from BRAF inhibitor treatment of melanoma, possibly due paradoxical activation of the mitogen-activated protein(MAP)-kinase pathway. In an alternative evidence based scenario, tubular colonic adenomas with APC gene mutations have also been identified in the context of BRAF inhibitor treatment, in the absence of mutations of MAPK genes. A minority of colorectal cancers develop by an alternative 'serrated polyp pathway'. This article postulates a novel hypothesis, that the established phenotypic and molecular characteristics of serrated colonic polyps/CRC offer an intriguing insight into the pathobiology of BRAF inhibitor induced colonic polyps. Serrated polyps are characterized by a Cp G island methylation phenotype, MLH1 silencing and cellular senescence. They also have BRAF mutations. The contention is that BRAF inhibitor induced polyps mimic the afore-described histology and molecular features of serrated polyps with the exception that instead of the presence of BRAF mutations they induce C-RAF homodimers and B-RAF: C-RAF heterodimers. | Fergal C Kelleher Grainne Callaghan Catriona Gallagher Hazel O'Sullivan | 2017 | World Journal of Gastroenterology2017，23，17： | 2 |
| 4 | Coral bleaching in philippine reefs: coincident evidences with mesoscale thermal anomalies显示文摘 | Hazel O Arceo Miledel C Quibilan Porfirio M Alno | 2001 | Bullenin of marine science2001，69，2： | 1 |
| 5 | Coral bleaching in Philippine reefs: Coinci-dent evidences with mesoseale thermal anomalies显示文摘 | Hazel O A Miledel C Q Porfirio M A | 2001 | Bullenin of Marine Seienee2001，69，2： | 1 |
| 6 | Tricyclic drugs for depression in children and adolescents 显示文摘 | Hazell P O'Connell D Heathcote D | 2002 | Cochrane Database Syst Rev2002，，00： | 1 |
| 7 | Regional Inequalities in the Peruvian Tourist Industry 显示文摘 | Greg O Hazel B | 1999 | The Geographi- cal Journal1999，，1： | 1 |
| 8 | Coral bleaching in Philippine reefs:Coincident evidences with mesoscale thermal anomalies显示文摘 | HAZEL O ARCEO MILEDEL C QUIBILAN PORFIRIO M ALNO | 2001 | Bullenin of Marine Science2001，69，2： | 1 |
| 9 | Formaldehydeasa pretreatment for dermal collagen heterografts显示文摘 | Roy O Roy G | 1980 | Biochemicalet Biophysica Acta1980，632，： | 1 |
| 10 | pH-dependent processing of yeast procarboxypeptidase Y by proteinase A in vivo and in vitro显示文摘 | Susanne O van den Hazel H B Kielland-Brandt M C | 1994 | Eur J Biochem1994，220，1： | 1 |
| 11 | Fibroblast growth factor receptors, developmental corruption and malignant disease显示文摘 | Fergal C. Kelleher Hazel O’Sullivan Elizabeth Smyth Ray McDermott Antonella Viterbo | 2013 | Carcinogenesis2013，，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员