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| 1 | Effect of nutritional counselling on hepatic,muscle and adipose tissue fat content and distribution in non-alcoholic fatty liver disease显示文摘AIM: To assess the effectiveness of the current UK clinical practice in reducing hepatic fat (IHCL). METHODS: Whole body MRI and 1H MRS were obtained, before and after 6 mo nutritional counselling, from liver, soleus and tibialis muscles in 10 subjects with non-alcoholic fatty liver disease (NAFLD). RESULTS: A 500 Kcal-restricted diet resulted in an average weight loss of 4% (-3.4 kg,) accompanied by significant reductions in most adipose tissue (AT) depots, including subcutaneous (-9.9%), abdominal subcutaneous (-10.2%) and intra-abdominal-AT (-11.4%). Intramyocellular lipids (IMCL) were significantly reduced in the tibialis muscle (-28.2%). Decreases in both IHCL (-39.9%) and soleus IMCL (-12.2%) content were also observed, although these were not significant. Several individuals showed dramatic decreases in IHCL, while others paradoxically showed increases in IHCL content. Changes in body composition were accompanied by improvements in certain liver function tests: serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Significant correlations were found between decreases in IHCL and reductions in both intra-abdominal and abdominal subcutaneous AT. Improvements in liver function tests were associated with reductions in intra-abdominal AT, but not with changes in IHCL. CONCLUSION: This study shows that even a very modest reduction in body weight achieved through lifestyle modification can result in changes in body fat depots and improvements in LFTs. | E Louise Thomas Audrey E Brynes Gavin Hamilton Nayna Patel Adam Spong Robert D Goldin Gary Frost Jimmy D Bell Simon D Taylor-Robinson | 2006 | World Journal of Gastroenterology2006，12，36： | 13 |
| 2 | CTGF antagonism with mAb FG-3019 enhances chemotherapy response without increasing drug delivery in murine ductal pancreas cancer显示文摘 | Albrecht Neesse Kristopher K. Frese Tashinga E. Bapiro Tomoaki Nakagawa Mark D. Sternlicht Todd W. Seeley Christian Pilarsky Duncan I. Jodrell Suzanne M. Spong David A. Tuveson | 2013 | Proceedings of the National Academy of Sciences2013，，30： | 3 |
| 3 | Prediction and prevention of recurrent spontaneous preterm birth显示文摘 | Spong CR | 2007 | Obstet Gynecol2007，110，2： | 1 |
| 4 | Risks of uterine rupture with a trial of labor in women with multiple and single prior cesarean delivery显示文摘 | Landon MB Spong CY Thom E | 2006 | Am J Obstet Gynecol2006，108，： | 1 |
| 5 | Bilateral control of teleoperators with time delay显示文摘 | ANDERSON R J SPONG M W | 1989 | IEEE Trans on Automation Control1989，34，4： | 1 |
| 6 | Passivity-Based Control of Bipedal Locomotion 显示文摘 | Spong M W Holm J K Dongjun Lee | 2007 | IEEE Robotics & Automation Magazine (S1070-9932)2007，14，30： | 1 |
| 7 | Timing of elective repeat cesarean delivery at term and neonatal outcomes显示文摘 | Tita AT Landon MB Spong CY | 2009 | N Engl J Med2009，360，2： | 1 |
| 8 | A multicenter, ran- domized trial of treatment for mild gestational diabetes 显示文摘 | Landon MB Spong CY Thom E | 2009 | N Engl J Med2009，361，14： | 1 |
| 9 | Vaginal birth after cesarean:new insights manuscripts from an NIH consensus development conference,march 8-10,2010显示文摘 | Caroline S Catherine Y Spong CY | | 0，，05： | 1 |
| 10 | Severe meconium aspiration syndrome is not caused by aspiration of meconium 显示文摘 | Ghidini A Spong CY | 2001 | Am J Obstet Gynecol2001，185，4： | 1 |
| 11 | The 2008 National Institute of Child Health and Human Development Work shop Report on Electronic Fetal Monitoring-Update on Definitions,Interpretation,and Research Guidelines显示文摘 | Macones G A Hankins GD Spong CY | 2008 | Obstet Gynecol2008，112，3： | 1 |
| 12 | Hybrid control for global stabilization of the cart-pendulum system显示文摘 | Zhao J Spong M W | 2001 | Automatica2001，37，12： | 1 |
| 13 | Adaptive motion control of rigid robots: a tutorial 显示文摘 | ORLEGA R SPONG M W | 1989 | Automatica1989，25，6： | 1 |
| 14 | Prevention of' fetal demise and growth restriction in a mouse model of fetal alcohol syn- drome 显示文摘 | Spong CY Abebe DT Gozes I | 2001 | Pharmacol Exp Ther2001，297，2： | 1 |
| 15 | Bilateral control of te- leoperators with time delay 显示文摘 | ANDERSON R J SPONG M W | 1989 | IEEE Transactions on Automatic Control1989，34，5： | 1 |
| 16 | The 2008 National Institute of Child Health and Human Development workshop report on electronic fetal monitoring: update on definitions, interpretation, and research guidelines 显示文摘 | Macones GA Hankins GD Spong CY | 2008 | Obstet Gynecol2008，112，3： | 1 |
| 17 | Modeling and Control of Elastic Joint Robots显示文摘 | Spong M W | 1987 | Journal of Dynamics Systems Meas- urement and Control1987，109，： | 1 |
| 18 | Birth after previous cesar- ean delivery : short-term maternal outcomes 显示文摘 | Lydon-Rochelle MT Cahill AG Spong CY | 2010 | Semin Perinatol2010，34，4： | 1 |
| 19 | Timing of indicated late preterm and early term birth显示文摘 | Spong CY Mercer BM D'alton M | 2011 | Obstet Gynecol2011，118，21： | 1 |
| 20 | A multicenter,randomized trial of treatment for mild gestational diabetes 显示文摘 | Landon MB Spong CY Thom E | 2009 | N Engl J Med2009，361，14： | 1 |
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