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185篇 您的检索式：作者名="Patchett"

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	题名	作者	年代	出处	被引量
1	Differences in proximal (cardia) versus distal (antral) gastric carcinogenesis via retinoblastoma pathway显示文摘AIM: Disruption of cell cycle regulation is a critical event in carcinogenesis, and alteration of the retinoblastoma (pRb)tumour suppressor pathway is frequent. The aim of this study was to compare alterations in this pathway in proximal and distal gastric carcinogenesis in an effort to explain the observed striking epidemiological differences. METHODS: Immunohistochemistry was performed to investigate expression of p16 and pRb in the following groups of both proximal (cardia) and distal (antral) tissue samples: (a) biopsies showing normal mucosa, (b) biopsies showing intestinal metaplasia and, (c) gastric cancer resection specimens including uninvolved mucosa and tumour. RESULTS: In the antrum there were highly significant trends for increased p16 expression with concomitant (and in the group of carcinomas inversely proportional) decreased pRb expression from normal mucosa to intestinal metaplasia to uninvolved mucosa (from cancer resections) to carcinoma. In the cardia, there were no differences in p16 expression between the various types of tissue samples whereas pRb expression was higher in normal mucosa compared with intestinal metaplasia and tissue from cancer resections. CONCLUSION: Alterations in the pRb pathway appear to play a more significant role in distal gastric carcinogenesis. It may be an early event in the former location since the trend towards p16 overexpression with concomitant pRb underexpression was seen as early as between normal mucosa and intestinal metaplasia. Importantly, the marked differences in expression of pRb and p16 between the cardia and antrum strongly support the hypothesis that tumours of the two locations are genetically different which may account for some of the observed epidemiological differences.	ChristianGulmann HelenHegarty AntoinetteGrace MaryLeader ElaineKay Stephen Patchett	2004	World Journal of Gastroenterology2004，10，1：	11
2	Hafnium variations in oceanic basalts 显示文摘	Patchett P J Tatsumoto M	1980	Geophys Res Lett1980，7，：	1
3	Synthe- sis and biological activities of spiroheteroeyelie growth hormone seeretagogues 显示文摘	Chen M H Pollard P P Patchett A A	1999	Bioorg Med Chem Lett1999，9，：	1
4	The influence of working fluid physical properties on weld qualification for in-service pipelines显示文摘	Belanger R J Patchett B L	2000	Welding Journal2000，79，8：	1
5	Importance of the Lu Hf isotope system in studies of planetary chronology and chemical evolution 显示文摘	Patchett P J	1983	Geochim Cosmochim Acta1983，47，：	1
6	Hafnium/rare earth element fractionation in sedimentary system and crustal recycling into the Earth s mantle 显示文摘	Patchett P J White W M Feldmann H	1984	Earth Planet Sci Lett1984，69，：	1
7	Cell wall degrading enzymes and the softening of senescent strawberry fruit显示文摘	Barnes M F Patchett B J	1976	Journal of Food Science1976，41，：	1
8	Cell wall degrading enzymes and the softening of senescent strawberry fruit 显示文摘	Arnes M F Patchett B J	1976	Food Sci1976，41，：	1
9	Behavior of hafnium and neodymium isotopes in the crust: Constraints from Precambrian crustally derived granites 显示文摘	Vervoort J D Patchett P J	1996	Geochim Cosmochim Acta1996，60，：	1
10	Using secretion to solve a solubility problem:high-yield expression in Escherichia coli and purification of the bacterial glycoamidase PNGase F显示文摘	Loo T Patchett M L Norris G E		0，，：	1
11	The 176Lu decay constant determined by Lu-Hf and U-Pb isotope systematics of Precambrian mafic intrusions显示文摘	Soderltmd U Patchett P J VervoortJ D	2004	Earth Planet Science Letters2004，219，：	1
12	Behavior of hafnium and neodymium isotopes in the crust: Constraints from Precambrian crustally derived granites显示文摘	VERVOORT J D JONATHAN Patchett P	1996	Geoehimet Cosmochim Acta1996，60，19：	1
13	Identifying stage B colorectal cancer patients at high risk of tumor recurrence and death显示文摘	MULCAHY H E TONER M PATCHETT S E	1997	Dis Colon Rectum1997，40，3：	1
14	The176Lu decay constant determined by Lu-Hf and U-Pb isotope sys- tematics of Precambrian mafic intrusions显示文摘	Soderlund U Patchett P J Vervoort J D	2004	Earth and Plan- etary Sciences Letters2004，219，：	1
15	Long-term prospective study ofHelicobacter pylori in nonulcer dyspepsia显示文摘	Conor McCarthy MRCPI Stephen Patchett MRCPI Rose Mary Collins MB Shona Beattie SRN Conor Keane MD Professor Colm O’Morain MD	1995	Digestive Diseases and Sciences1995，，1：	1
16	The 176Lu decay constant determined by Lu-Hf and U-Pb isotope systematics of Precambrian mafic intrusions显示文摘	Sederlund U Patchett P J Vervoort J D	2004	Earth and Planetary Science Letters2004，219，34：	1
17	The management of supernumerary teeth in childhood--a retrospective study of practice in Bristol Dental Hospital, England and Westmead Dental Hospital, Sydney, Australia显示文摘	Patchett CL Crawford PJ Cameron AC	2001	Int J Pacdiatr Dent2001，11，4：	1
18	Deformation microstructures intitanium sheet metal显示文摘	MULLINS S PATCHETT B M	1981	Metallurgical Transactions A1981，12，：	1
19	Evolution of continental crust and mantle heterogeneity: evidence from Hf isotopes显示文摘	Kouvo O Hedge C E	1981	Contrib Mineral Petrology1981，，78：	1
20	Use of a microbial fuel cell for the rapid enumeration of bacteria 显示文摘	Patchett R A Kelly A F Kroll R G	1988	Applied Microbiology and Biotechnology1988，28，：	1

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