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| 1 | Targeting the tumor stroma in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is one of the most common and deadly cancers worldwide. In ninety percent of the cases it develops as a result of chronic liver damage and it is thus a typical inflammationrelated cancer characterized by the close relation between the tumor microenvironment and tumor cells. The stromal environment consists out of several cell types, including hepatic stellate cells, macrophages and endothelial cells. They are not just active bystanders in the pathogenesis of HCC, but play an important and active role in tumor initiation, progression and metastasis. Furthermore, the tumor itself influences these cells to create a background that is beneficial for sustaining tumor growth. One of the key players is the hepatic stellate cell, which is activated during liver damage and differentiates towards a myofibroblast-like cell. Activated stellate cells are responsible for the deposition of extracellular matrix, increase the production of angiogenic factors and stimulate the recruitment of macrophages. The increase of angiogenic factors(which are secreted by macrophages, tumor cells and activated stellate cells) will induce the formation of new blood vessels, thereby supplying the tumor with more oxygen and nutrients, thus supporting tumor growth and offering a passageway in the circulatory system. In addition, the secretion of chemokines by the tumor cells leads to the recruitment of tumor associated macrophages. These tumor associated macrophages are key actors of cancer-related inflammation, being the main type of inflammatory cells infiltrating the tumor environment and exerting a tumor promoting effect by secreting growth factors, stimulating angiogenesis and influ-encing the activation of stellate cells. This complex interplay between the several cell types involved in liver cancer emphasizes the need for targeting the tumor stroma in HCC patients. | Femke Heindryckx Pär Gerwins | 2015 | World Journal of Hepatology2015，7，2： | 16 |
| 2 | Twin Anemia Polycythemia Sequence: Knowledge and Insights After 15 Years of Research显示文摘Twin anemia polycythemia sequence (TAPS) is a chronic form of unbalanced feto-fetal transfusion through minuscule placental anastomoses in monochorionic twin pregnancies, leading to anemia in the donor twin and polycythemia in the recipient twin. TAPS can occur spontaneously in up to 5% of monochorionic twins or can arise in 2%-16% of cases after incomplete laser surgery for twin-twin transfusion syndrome. TAPS can develop across the entire second and third trimester. Antenatal diagnosis for TAPS is reached via Doppler measurement of the fetal middle cerebral artery peak systolic velocity, showing an increased velocity in the donor, combined with a decreased velocity in the recipient. Treatment options for TAPS include expectant management, preterm delivery, intrauterine blood transfusion with or without a partial exchange transfusion, fetoscopic laser surgery and selective feticide. The best treatment option is unclear and is currently being investigated in an international multicenter randomized trial (the TAPS trial). Spontaneous fetal demise occurs in 5%-11% of TAPS twins, more often in donors (8%-18%) than in recipients (2%-5%). Severe long-term neurodevelopmental impairment is seen in 9% of TAPS twins, with donors having an increased risk for cognitive impairment and hearing problems (15%). | Lisanne S.A.Tollenaar Enrico Lopriore Dick Oepkes Monique C.Haak Frans J.C.M.Klumper Johanna M.Middeldorp Jeanine M.M.Van Klink Femke Slaghekke | 2021 | Maternal-Fetal Medicine2021，3，1： | 2 |
| 3 | Salpingotomy versus salpingectomy in women with tubal pregnancy (ESEP study): an open-label, multicentre, randomised controlled trial显示文摘 | Femke Mol Norah M van Mello Annika Strandell Karin Strandell Davor Jurkovic Jackie Ross Kurt T Barnhart Tamer M Yalcinkaya Harold R Verhoeve Giuseppe C M Graziosi Carolien A M Koks Ingmar Klinte Lars Hogstr?m Ineke C A H Janssen Harry Kragt Annemieke Hoek | 2014 | The Lancet2014，，： | 2 |
| 4 | Randomized trial on endoscopic resection-cap versus multiband mucosectomy for piecemeal endoscopic resection of early Barrett’s neoplasia显示文摘 | Roos E. Pouw Frederike G.I. van Vilsteren Femke P. Peters Lorenza Alvarez Herrero Fiebo J.W. ten Kate Mike Visser Boudewijn E. Schenk Erik J. Schoon Frans T.M. Peters Martin Houben Raf Bisschops Bas L.A.M. Weusten Jacques J.G.H.M. Bergman | 2011 | Gastrointestinal Endoscopy2011，，： | 1 |
| 5 | Randomized comparison of health-related quality of life in women with ectopic pregnancy or pregnancy of unknown location treated with systemic methotrexate or expectant management显示文摘 | Norah M van Mello Femke Mol | 2015 | European J Obstetrics&Gynecology and Reproductive Biology2015，192，2： | 1 |
| 6 | Evidence-based policy:Three Generations of Rrform in Mexico显示文摘 | Femk Julio | 2003 | Lancet2003，362，： | 1 |
| 7 | Superiority of collaborative learning with complex tasks: A research note on an alternative affective explanation显示文摘 | Femke Kirschner Fred Paas Paul A. Kirschner | 2010 | Computers in Human Behavior2010，，1： | 1 |
| 8 | A Cognitive Load Approach to Collaborative Learning: United Brains for Complex Tasks显示文摘 | Femke Kirschner Fred Paas Paul A. Kirschner | 2009 | Educational Psychology Review2009，，1： | 1 |
| 9 | High dietary menaquinone intake is associated with reduced coronary calcification显示文摘 | Joline W.J. Beulens Michiel L. Bots Femke Atsma Marie-Louise E.L. Bartelink Matthias Prokop Johanna M. Geleijnse Jacqueline C.M. Witteman Diederick E. Grobbee Yvonne T. van der Schouw | 2008 | Atherosclerosis2008，，2： | 1 |
| 10 | A case of mistaken identity: HSPs are no DAMPs but DAMPERs 显示文摘 | Willem VE Rachel S Femke B | 2012 | Cell Stress Chaperones2012，17，3： | 1 |
| 11 | Individual and group-based learning from complex cognitive tasks: Effects on retention and transfer efficiency显示文摘 | Femke Kirschner Fred Paas Paul A. Kirschner | 2008 | Computers in Human Behavior2008，，2： | 1 |
| 12 | The influence of psychological state and motivation on brain-computer interface performance in patients with amyotrophic lateral sclerosis - a longitudinal study显示文摘 | Femke Nijboer Niels | 2010 | Frontiers in Neu- roscienee2010，4，1： | 1 |
| 13 | Evaluation of inflammatory and angiogenic factors in patients with non-alcoholic fatty liver disease显示文摘 | Stephanie Coulon Sven Francque Isabelle Colle An Verrijken Bram Blomme Femke Heindryckx Steffi De Munter Janne Prawitt Sandrine Caron Bart Staels Hans Van Vlierberghe Luc Van Gaal Anja Geerts | 2012 | Cytokine2012，，： | 1 |
| 14 | Determination of volatile monophenols in beer using acetylation and headspace solid- phase microextraction in combination with gas chromatography and mass spectrometry显示文摘 | Femke L S Daan S Freddy R | 2010 | Delvaux Analytica Chimica Acta2010，676，2： | 1 |
| 15 | Intestinal T cells: Facing the mucosal immune dilemma with synergy and diversity显示文摘 | Femke van Wijk Hilde Cheroutre | 2009 | Seminars in Immunology2009，，3： | 1 |
| 16 | Mice lacking the Ub CKmit isoform of creatine kinase reveal slower spatial learning acquisition,diminished exploration and habituation,and reduced acoustic startle reflex responses显示文摘 | Femke S Carolina RJ Frank O | 2004 | Molecular and Cellular Biochemistry2004，256，： | 1 |
| 17 | The spectrum of neurobehavioural deficits in the Posterior Fossa Syndrome in children after cerebellar tumour surgery 显示文摘 | Catsman-Berrevoets Coriene EA Femke K | 2010 | Cortex2010，46，7： | 1 |
| 18 | Structural and behavioural consequences of double deficiency for creatine kinases BCK and Ub CKmit显示文摘 | Femke S Frank O Bart A | 2005 | Behavioural Brain Research2005，157，： | 1 |
| 19 | Tumor Cell Plasticity in Ewing Sarcoma, an Alternative Circulatory System Stimulated By Hypoxia 显示文摘 | DaisyWJ Van DS Femke H | 2005 | Cancer Res2005，65，11： | 1 |
| 20 | High Absolute Risks and Predictors of Venous and Arterial Thromboembolic Events in Patients With Nephrotic Syndrome: Results From a Large Retrospective Cohort Study显示文摘 | Bakhtawar K. Mahmoodi Min Ki ten Kate Femke Waanders Nic J.G.M. Veeger Jan-Leendert P. Brouwer Liffert Vogt Gerjan Navis Jan van der Meer | 2008 | Circulation2008，，2： | 1 |
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