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| 1 | Role of autophagy in the pathophysiology of nonalcoholic fatty liver disease:A controversial issue显示文摘Autophagy is a mechanism involved in cellular homeostasis under basal and stressed conditions delivering cytoplasmic content to the lysosomes for degradation to macronutrients.The potential role of autophagy in disease is increasingly recognised and investigated in the last decade.Nowadays it is commonly accepted that autophagy plays a role in the hepatic lipid metabolism.Hence,dysfunction of autophagy may be an underlying cause of non-alcoholic fatty liver disease.However,controversy of the exact role of autophagy in the lipid metabolism exists:some publications report a lipolytic function of autophagy,whereas others claim a lipogenic function.This review aims to give an update of the present knowledge on autophagy in the hepatic lipid metabolism,hepatic insulin resistance,steatohepatitis and hepatic fibrogenesis. | Wilhelmus J Kwanten Wim Martinet Peter P Michielsen Sven M Francque | 2014 | World Journal of Gastroenterology2014，20，23： | 17 |
| 2 | A Randomized, Controlled Trial of the Pan-PPAR Agonist Lan ifi branor in NASH显示文摘Methods:In this phase 2b,double-blind,randomized,placebo-controlled trial,patients with noncirrhotic,highly active NASH were randomly assigned in a 1:1:1 ratio to receive 1200 mg or 800 mg of lanifibranor or placebo once daily for 24 weeks.The primary end point was a decrease of at least 2 points in the SAF-A score(the activity part of the Steatosis,Activity,Fibrosis[SAF]scoring system that incorporates scores for ballooning and inflammation)without worsening of fibrosis;SAF-A scores range from 0 to 4,with higher scores indicating more-severe disease activity.Secondary end points included resolution of NASH and regression of fibrosis. | Sven M Francque | 2021 | 四川生理科学杂志2021，43，8： | 3 |
| 3 | Cross talk of the immune system in the adipose tissue and the liver in non-alcoholic steatohepatitis: Pathology and beyond显示文摘Non-alcoholic steatohepatitis(NASH) is considered to be the hepatic manifestation of the metabolic syndrome, thus has a tight correlation with systemic metabolic impairment. The complex mechanisms underlying the pathogenesis of NASH involve different organs and systems that cross talk together contributing to the onset of NASH. A crucial role is played by inflammatory mediators, especially those deriving from the adipose tissue and the liver, which are involved in the cascade of inflammation, fibrosis and eventually tumorigenesis. In this setting cytokines and adipokines as well as immunity are emerging drivers of the key features of NASH. The immune system participates in this process with disturbances of the cells constituting both the innate and the adaptive immune systems that have been reported in different organs, such as in the liver and in the adipose tissue, in clinical and preclinical studies. The role of the immune system in NASH is increasingly studied, not only because of its contribution to the pathogenetic mechanisms of NASH but also because of the new potential therapeutic options it offers in this setting. Indeed, novel treatments acting on the immune system could offer new options in the management of NASH and the correlated clinical consequences. | Luisa Vonghia Sven Francque | 2015 | World Journal of Hepatology2015，7，15： | 2 |
| 4 | PPARa gene expression correlates with severity and histological treatment response in patients with non - alcoholic steatohepatitis显示文摘 | FRANCQUE S VERRIJKEN A CARON S | 2015 | J Hepatol2015，63，1： | 1 |
| 5 | Transcriptional Activation of Apolipoprotein CIII Expression by Glucose May Contribute to Diabetic Dyslipidemia显示文摘 | Sandrine Caron An Verrijken Ilse Mertens Carolina Huaman Samanez Gisèle Mautino Joel T. Haas Daniel Duran-Sandoval Janne Prawitt Sven Francque Emmanuelle Vallez Anne Muhr-Tailleux Isabelle Berard Folkert Kuipers Jan A. Kuivenhoven Sudha B. Biddinger Marja | 2011 | Arteriosclerosis Thrombosis and Vascular Biology2011，，3： | 1 |
| 6 | Viral hepatitis and hepatocellular carcinoma显示文摘 | Michielsen PP Francque SM Dongen JL | 2005 | Wor J Sur Oncol2005，3，27： | 1 |
| 7 | Evaluation of inflammatory and angiogenic factors in patients with non-alcoholic fatty liver disease显示文摘 | Stephanie Coulon Sven Francque Isabelle Colle An Verrijken Bram Blomme Femke Heindryckx Steffi De Munter Janne Prawitt Sandrine Caron Bart Staels Hans Van Vlierberghe Luc Van Gaal Anja Geerts | 2012 | Cytokine2012，，： | 1 |
| 8 | Viral hepatitis and hepatocellular carcinoma显示文摘 | MICHIELSEN P P FRANCQUE S M VAN DONGEN J L | 2005 | World J SurgOncol2005，3，： | 1 |
| 9 | Epidemiology and treatment ofautoimmune hepatitis显示文摘 | Francque S Vonghia L Ramon A | 2012 | Hepat Med2012，4，： | 1 |
| 10 | Mulitifactorial aetiology of hepatic infarction:a case report with literture review显示文摘 | Francque S Condat B Asselah T | 2004 | Eur J Gastroenterol Hepatol2004，16，： | 1 |
| 11 | Increased intrahepatic resistance in severe steatosis: endothelial dysfunction, vasoconstrictor overproduction and altered microvascular architecture 显示文摘 | Francque S Laleman W Verbeke L | 2012 | Lab Invest2012，92，10： | 1 |
| 12 | Biopsy of focal liver lesions: guidelines, comparison of techniques and costanalysis 显示文摘 | Francque SM De Pauw FF Vam den Steen GH | 2003 | Acta Gastroenterol Belg2003，66，2： | 1 |
| 13 | Viral hepatitis and hepatocellular carcinoma显示文摘 | Michielsen PP Francque SM Dongen JL | 2005 | Wor J Sur Onco2005，3，27： | 1 |
| 14 | Evaluation of inflammatory and angiogenic factors in patients with non-alcoholic fatty liver disease显示文摘 | Stephanie Coulon Sven Francque Isabelle Colle An Verrijken Bram Blomme Femke Heindryckx Steffi De Munter Janne Prawitt Sandrine Caron Bart Staels Hans Van Vlierberghe Luc Van Gaal Anja Geerts | 2012 | Cytokine2012，，2： | 1 |
| 15 | Diagnostic challenges in alcohol use disorder and alcoholic liver disease显示文摘Alcohol use disorders represent a heterogeneous spectrum of clinical manifestations that have been defined by the Diagnostic and Statistical Manual of Mental Disorders-5. Excessive alcohol intake can lead to damage of various organs, including the liver. Alcoholic liver disease includes different injuries ranging from steatosis to cirrhosis and implicates a diagnostic assessment of the liver disease and of its possible complications. There is growing interest in the possible different tools for assessing previous alcohol consumption and for establishing the severity of liver injury, especially by noninvasive methods. | Luisa Vonghia Peter Michielsen Geert Dom Sven Francque | 2014 | World Journal of Gastroenterology2014，20，25： | 1 |
| 16 | The metabolic syndrome and the liver显示文摘 | Verrijken A Francque S Van Gaudl L | 2008 | Acta Gastroenterol Belg2008，71，1： | 1 |
| 17 | Diarrhea and the rationale to use Sandostatin显示文摘 | Peeters M Vanden Brande J Francque S | 2010 | Acta Gastroenterol Belg2010，73，1： | 1 |
| 18 | Viral hepatitis and hepatocellular carcinoma显示文摘 | Michielsen PP Francque SM Dongen JL | 2005 | Wor J Sur Onco2005，3，27： | 1 |
| 19 | Diarrhea and the rationale to use Sandostatin显示文摘 | Peeters M Vanden Brande J Francque S | 2010 | Acta Gastroenterol Belg2010，73，1： | 1 |
| 20 | N -glycan based biomarker distinguishing non-alcoholic steatohepatitis from steatosis independently of fibrosis显示文摘 | Bram Blomme Sven Francque Eric Trépo Louis Libbrecht Dieter Vanderschaeghe An Verrijken Piet Pattyn Yves Van Nieuwenhove Dirk Van De Putte Anja Geerts Isabelle Colle Joris Delanghe Christophe Moreno Luc Van Gaal Nico Callewaert Hans Van Vlierberghe | 2011 | Digestive and Liver Disease2011，，4： | 1 |
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