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| 1 | Accurate diagnosis of prenatal cleft lip/palate by understanding the embryology显示文摘Cleft lip with or without cleft palate(CP) is one of the most common congenital malformations. Ultrasonographers involved in the routine 20-wk ultrasound screening could encounter these malformations. The face and palate develop in a very characteristic way. For ultrasonographers involved in screening these patients it is crucial to have a thorough understanding of the embryology of the face. This could help them to make a more accurate diagnosis and save time during the ultrasound. Subsequently, the current postnatal classification will be discussed to facilitate the communication with the CP teams. | Bram Smarius Charlotte Loozen Wendy Manten Mireille Bekker Lou Pistorius Corstiaan Breugem | 2017 | World Journal of Methodology2017，7，3： | 15 |
| 2 | Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages显示文摘How the innate and adaptive host immune system miscommunicate to worsen COVID-19 immunopathology has not been fully elucidated.Here,we perform single-cell deep-immune profiling of bronchoalveolar lavage(BAL)samples from 5 patients with mild and 26 with critical COVID-19 in comparison to BALs from non-COVID-19 pneumonia and normal lung.We use pseudotime inference to build T-cell and monocyte-to-macrophage trajectories and model gene expression changes along them.In mild COVID-19,CD8^(+)resident-memory(TRM)and CD4^(+)T-helper-17(T_(H17))cells undergo active(presumably antigen-driven)expansion towards the end of the trajectory,and are characterized by good effector functions,while in critical COVID-19 they remain more naïve.Vice versa,CD4^(+)T-cells with T-helper-1 characteristics(TH1-like)and CD8^(+)T-cells expressing exhaustion markers(T_(EX)-like)are enriched halfway their trajectories in mild COVID-19,where they also exhibit good effector functions,while in critical COVID-19 they show evidence of inflammation-associated stress at the end of their trajectories.Monocyte-to-macrophage trajectories show that chronic hyperinflammatory monocytes are enriched in critical COVID-19,while alveolar macrophages,otherwise characterized by anti-inflammatory and antigen-presenting characteristics,are depleted.In critical COVID-19,monocytes contribute to an ATP-purinergic signaling-inflammasome footprint that could enable COVID-19 associated fibrosis and worsen disease-severity.Finally,viral RNA-tracking reveals infected lung epithelial cells,and a significant proportion of neutrophils and macrophages that are involved in viral clearance. | Els Wauters Pierre Van Mol Abhishek Dinkarnath Garg Sander Jansen Yannick Van Herck Lore Vanderbeke Ayse Bassez Bram Boeckx Bert Malengier-Devlies Anna Timmerman Thomas Van Brussel Tina Van Buyten Rogier Schepers Elisabeth Heylen Dieter Dauwe Christophe Dooms Jan Gunst Greet Hermans Philippe Meersseman Dries Testelmans Jonas Yserbyt Sabine Tejpar Walter De Wever Patrick Matthys CONTAGIOUS collaborators Johan Neyts Joost Wauters Junbin Qian Diether Lambrechts | 2021 | Cell Research2021，31，3： | 11 |
| 3 | A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling显示文摘The stromal compartment of the tumor microenvironment consists of a heterogeneous set of tissue-resident and tumor-infiltrating cells,which are profoundly moulded by cancer cells.An outstanding question is to what extent this heterogeneity is similar between cancers affecting different organs.Here,we profile 233,591 single cells from patients with lung,colorectal,ovary and breast cancer(n=36)and construct a pan-cancer blueprint of stromal cell heterogeneity using different single-cell RNA and protein-based technologies.We identify 68 stromal cell populations,of which 46 are shared between cancer types and 22 are unique.We also characterise each population phenotypically by highlighting its marker genes,transcription factors,metabolic activities and tissue-specific expression differences.Resident cell types are characterised by substantial tissue specificity,while tumor-infiltrating cell types are largely shared across cancer types.Finally,by applying the blueprint to melanoma tumors treated with checkpoint immunotherapy and identifying a naive CD4+T-cell phenotype predictive of response to checkpoint immunotherapy,we illustrate how it can serve as a guide to interpret scRNA-seq data.In conclusion,by providing a comprehensive blueprint through an interactive web server,we generate the first panoramic view on the shared complexity of stromal cells in different cancers. | Junbin Qian Siel Olbrecht Bram Boeckx Hanne Vos Damya Laoui Emre Etlioglu Els Wauters Valentina Pomella Sara Verbandt Pieter Busschaert Ayse Bassez Amelie Franken Marlies Vanden Bempt Jieyi Xiong Birgit Weynand Yannick van Herck Asier Antoranz Francesca Maria Bosisio Bernard Thienpont Giuseppe Floris Ignace Vergote Ann Smeets Sabine Tejpar Diether Lambrechts | 2020 | Cell Research2020，30，9： | 11 |
| 4 | RNAi mechanisms in Huntington’s disease therapy:siRNA versus shRNA显示文摘Huntington’s Disease(HD)is a genetically dominant trinucleotide repeat disorder resulting from CAG repeats within the Huntingtin(HTT)gene exceeding a normal range(>36 CAGs).Symptoms of the disease manifest in middle age and include chorea,dystonia,and cognitive decline.Typical latency from diagnosis to death is 20 years.There are currently no disease-modifying therapies available to HD patients.RNAi is a potentially curative therapy for HD.A popular line of research employs siRNA or antisense oligonucleotides(ASO)to knock down mutant Huntingtin mRNA(mHTT).Unfortunately,this modality requires repeated dosing,commonly exhibit off target effects(OTEs),and exert renal and hepatic toxicity.In contrast,a single AAV-mediated short-hairpin RNA(shRNA)dose can last years with low toxicity.In addition,we highlight research indicating that shRNA elicits fewer OTEs than siRNA when tested head-tohead.Despite this promise,shRNA therapy has been held back by difficulties controlling expression(oversaturating cells with toxic levels of RNA construct).In this review,we compare RNAi modalities for HD and propose novel methods of optimizing shRNA expression and on-target fidelity. | Sebastian Aguiar Bram van der Gaag Francesco Albert Bosco Cortese | 2017 | Translational Neurodegeneration2017，6，1： | 3 |
| 5 | Atomic layer deposition enabling higher efficiency solar cells:A review显示文摘Atomic layer deposition(ALD)can synthesise materials with atomic-scale precision.The ability to tune the material composition,film thickness with excellent conformality,allow low-temperature processing,and in-situ real-time monitoring makes this technique very appealing for a wide range of applications.In this review,we focus on the application of ALD layers in a wide range of solar cells.We focus on industrial silicon,thin film,organic and quantum dot solar cells.It is shown that the merits of ALD have already been exploited in a wide range of solar cells at the lab scale and that ALD is already applied in high-volume manufacturing of silicon solar cells. | MdAnower Hossain Kean Thong Khoo Xin Cui Geedhika K Poduval Tian Zhang Xiang Li Wei Min Li Bram Hoex | 2020 | Nano Materials Science2020，2，3： | 3 |
| 6 | Upwind and High-Resolution Methods for Compressible Flow:From Donor Cell to Residual-Distribution Schemes显示文摘In this paper I review three key topics in CFD that have kept researchers busy for half a century.First,the concept of upwind differencing,evident for 1-D linear advection.Second,its implementation for nonlinear systems in the form of highresolution schemes,now regarded as classical.Third,its genuinely multidimensional implementation in the form of residual-distribution schemes,the most recent addition.This lecture focuses on historical developments;it is not intended as a technical review of methods,hence the lack of formulas and absence of figures. | Bram van Leer | 2006 | Communications in Computational Physics2006，1，2： | 2 |
| 7 | Advances in on-line drinking water quality monitoring and early warning systems显示文摘 | Michael V. Storey Bram van der Gaag Brendan P. Burns | 2010 | Water Research2010，，2： | 2 |
| 8 | UV-B light and its application potential to reduce disease and pest incidence in crops显示文摘Ultraviolet-B radiation(280–315 nm),perceived by the plant photoreceptor UVR8,is a key environmental signal that influences plant growth and development and can reduce disease and pest incidence.The positive effect of UV-B on disease resistance and incidence in various plant species supports the implementation of supplemental UV-B radiation in sustainable crop production.However,despite many studies focusing on UV-B light,there is no consensus on the best mode of application.This review aims to analyze,evaluate,and organize the different application strategies of UV-B radiation in crop production with a focus on disease resistance.We summarize the physiological effects of UV-B light on plants and discuss how plants perceive and transduce UV-B light by the UVR8 photoreceptor as well as how this perception alters plant specialized metabolite production.Next,we bring together conclusions of various studies with respect to different UV-B application methods to improve plant resistance.In general,supplemental UV-B light has a positive effect on disease resistance in many plant–pathogen combinations,mainly through the induction of the production of specialized metabolites.However,many variables(UV-B light source,plant species,dose and intensity,timing during the day,duration,background light,etc.)make it difficult to compare and draw general conclusions.We compiled the information of recent studies on UV-B light applications,including e.g.,details on the UV-B light source,experimental set-up,calculated UV-B light dose,intensity,and duration.This review provides practical insights and facilitates future research on UV-B radiation as a promising tool to reduce disease and pest incidence. | Prisca Meyer Bram Van de Poel Barbara De Coninck | 2021 | Horticulture Research2021，8，1： | 2 |
| 9 | Proton Pump Inhibitors Partially Restore Mucosal Integrity in Patients with PPI-responsive Esophageal Eosinophilia but not Eosinophilic Esophagitis显示文摘 | Bram D. van Rhijn Pim W. Weijenborg Joanne Verheij Marius A. van den Bergh Weerman Caroline Verseijden René M.J.G.J. van den Wijngaard Wouter J. de Jonge Andreas J.P.M. Smout Albert J. Bredenoord | 2014 | Clinical Gastroenterology and Hepatology2014，，： | 2 |
| 10 | Conventional Versus Invaginated Stripping of the Great Saphenous Vein: A Randomized, Double-Blind, Controlled Clinical Trial显示文摘 | Marc R. Scheltinga Edwin R. Wijburg Bram J. Keulers Karin E. Kroon | 2007 | World Journal of Surgery2007，，11： | 2 |
| 11 | Mechanical evaluation of various suburethral tapes used for the treatment of stress urinary incontinence 显示文摘 | Pariente J L Villars F Bram R | 2005 | Prog Urol2005，15，6： | 1 |
| 12 | The rdationship between social comparison processes and personality显示文摘 | Karen Vander Zee Bram Buunk & Robbert Sandemlan | 1996 | El- sevier Science Ltd1996，20，5： | 1 |
| 13 | Tick-borne livestock diseases and their vectors显示文摘 | Bram R A | 1975 | World Anim Rev1975，6，： | 1 |
| 14 | Nuclear association of a T-cell transcriptionfactor blocked by FK-506 and cycloprin A显示文摘 | Flanagan WM Corthesy B Bram RJ | 1991 | Nature1991，325，： | 1 |
| 15 | Chemotherapeutic drug in- duced ABCG2 promoter demethylatioo as a novel mechanism of ac- quired muhidrug resistance 显示文摘 | BRAM E E STARK M RAZ S | 2009 | Neoplasia2009，11，12： | 1 |
| 16 | Secondary interventions in patients with autologous arteriovenous fistulas strongly improve patency rates显示文摘 | Ninos Ayez Bram Fioole Ruud A. Aarts Marinus A. van den Dorpel George P. Akkersdijk Maarten K. Dinkelman André A. de Smet | 2011 | Journal of Vascular Surgery2011，，： | 1 |
| 17 | The global burden of asthma显示文摘 | Bram SS | 2006 | Chest2006，130，： | 1 |
| 18 | Principles of a novel multistage circulating fluidized bed reactor for biomass gasification显示文摘 | Sascha R A K Wolter Prins Bram van der Drift | 2003 | Chemical Engineering Science2003，58，36： | 1 |
| 19 | The application of computer-based imaging to the measurements of particle velocity and void age profiles in a fluidized bed显示文摘 | BRAM A KUROKI H | 2006 | Powder Technology2006，98，8： | 1 |
| 20 | Inviscid flux-splitting algorithms for real gases with non-equilibrium chemistry显示文摘 | SHUEN J S LIOU M S BRAM V L | 1990 | Journal of Computational Physics1990，90，： | 1 |
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