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| 1 | Outcomes of curative esophageal cancer surgery in elderly:A metaanalysis显示文摘BACKGROUND An increasing number of older patients is undergoing curative,surgical treatment of esophageal cancer.Previous meta-analyses have shown that older patients suffered from more postoperative morbidity and mortality compared to younger patients,which may lead to patient selection based on age.However,only studies including patients that underwent open esophagectomy were included.Therefore,it remains unknown whether there is an association between age and outcome in patients undergoing minimally invasive esophagectomy.AIM To perform a systematic review on age and postoperative outcome in esophageal cancer patients undergoing esophagectomy.METHODS Studies comparing older with younger patients with primary esophageal cancer undergoing curative esophagectomy were included.Meta-analysis of studies using a 75-year age threshold are presented in the manuscript,studies using other age thresholds in the Supplementary material.MEDLINE,Embase and the Cochrane Library were searched for articles published between 1995 and 2020.Risk of bias was assessed with the Newcastle-Ottawa Scale.Primary outcomes were anastomotic leak,pulmonary and cardiac complications,delirium,30-and 90-d,and in-hospital mortality.Secondary outcomes included pneumonia and 5-year overall survival.RESULTS Seven studies(4847 patients)using an age threshold of 75 years were included for meta-analysis with 755 older and 4092 younger patients.Older patients(9.05%)had higher rates of 90-d mortality compared with younger patients(3.92%),(confidence interval=1.10-5.56).In addition,older patients(9.45%)had higher rates of in-hospital mortality compared with younger patients(3.68%),(confidence interval=1.01-5.91).In the subgroup of 2 studies with minimally invasive esophagectomy,older and younger patients had comparable 30-d,90-d and in-hospital mortality rates.CONCLUSION Older patients undergoing curative esophagectomy for esophageal cancer have a higher postoperative mortality risk.Minimally invasive esophagectomy may be important for minimizing mortality in older patients. | Nikolaj S Baranov Cettela Slootmans Frans van Workum Bastiaan R Klarenbeek Yvonne Schoon Camiel Rosman | 2021 | World Journal of Gastrointestinal Oncology2021，13，2： | 3 |
| 2 | Scholarly networks on resilience, vulnerability and adaptation within the human dimensions of global environmental change显示文摘 | Marco A. Janssen Michael L. Schoon Weimao Ke Katy B?rner | 2006 | Global Environmental Change2006，，3： | 2 |
| 3 | Remission of Barrett’s Esophagus With Early Neoplasia 5 Years After Radiofrequency Ablation With Endoscopic Resection: A Netherlands Cohort Study显示文摘 | K. Nadine Phoa Roos E. Pouw Frederike G.I. van Vilsteren Carine M.T. Sondermeijer Fiebo J.W. Ten Kate Mike Visser Sybren L. Meijer Mark I. van Berge Henegouwen Bas L.A. M. Weusten Erik J. Schoon Rosalie C. Mallant–Hent Jacques J.G. H.M. Bergman | 2013 | Gastroenterology2013，，： | 2 |
| 4 | S cholarly networks on resilience, vulnerability and adaptation within the human dimen- sions of global environmental change 显示文摘 | Janssen M A Schoon M L Ke W | 2006 | Global Environmental Change2006，16，3： | 1 |
| 5 | Variation in pathogenicity and multiplication of beet necrotic yellow vein virus(BNYVV)in relation to the resistance of sugar-beet cultivars显示文摘 | Heijbroek W Musters P M S Schoone A H L | 1999 | Eur J Plant Pathol1999，105，： | 1 |
| 6 | Reverse engineering based on multi-axis digitized data显示文摘 | Schoone C Hoffmann J | 1997 | International conference on manufacturing automation1997，，1： | 1 |
| 7 | Scholarly networks on resilience, vulnerability and adaptation within the human dimensions of global environmental change显示文摘 | Janssen M A Schoon M L Ke W | 2006 | Global Envi- ronmental Change2006，16，3： | 1 |
| 8 | Randomized trial on endoscopic resection-cap versus multiband mucosectomy for piecemeal endoscopic resection of early Barrett’s neoplasia显示文摘 | Roos E. Pouw Frederike G.I. van Vilsteren Femke P. Peters Lorenza Alvarez Herrero Fiebo J.W. ten Kate Mike Visser Boudewijn E. Schenk Erik J. Schoon Frans T.M. Peters Martin Houben Raf Bisschops Bas L.A.M. Weusten Jacques J.G.H.M. Bergman | 2011 | Gastrointestinal Endoscopy2011，，： | 1 |
| 9 | NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independ ent regulatory pathway显示文摘 | Billadeau DD Upshaw JL Schoon RA etal | 2003 | Nat Immunol2003，4，： | 1 |
| 10 | Scholarlynetworks on resilience,vulnerability and adaptationwithin the human dimensions of global environmentalchange显示文摘 | Janssen M A Schoon M L Ke W M | 2006 | Global Environmental Change2006，，16： | 1 |
| 11 | Scholarly Networks on Resilience,Vulnerability and Adaptation within the Human Dimensions of Global Envir- onmental Change显示文摘 | lanssen M A Schoon M L KeWM | 2006 | Global Environmental Change2006，16，3： | 1 |
| 12 | Developing a sus- tainable foot care clinic in a homeless shelter within an academic-community partnership显示文摘 | Schoon P M Champlin B E Hunt R J | 2012 | J Nurs Educ2012，51，12： | 1 |
| 13 | Fines extracted from recycled concrete as alternative raw material for portland cement clinker production显示文摘 | Schoon J Buysser K D Driessche I V | 2015 | Cement&Concrete Composites2015，58，： | 1 |
| 14 | MSG1, a surface-localised protein of Mycoplasma suis is involved in the adhesion to erythrocytes显示文摘 | Ludwig E. Hoelzle Katharina Hoelzle Marianne Helbling Heike Aupperle Heinz A. Schoon Mathias Ritzmann Karl Heinritzi Kathrin M. Felder Max M. Wittenbrink | 2007 | Microbes and Infection2007，，4： | 1 |
| 15 | Scholarly net works oil re- sihence,vulnerability and adaptation within the human dimensions of global environmental change 显示文摘 | Janssena M A Schoon M L Ke W | 2006 | Global Environmental Change2006，16，3： | 1 |
| 16 | High prevalence of morphometric vertebral deformities in pa- tients with inflammatory bowel disease 显示文摘 | Heijckmann AC Huijberts MS Schoon EJ | 2008 | Eur J Gastro- enterol Hepatol2008，20，： | 1 |
| 17 | Thrombophilia screening in pregnancy显示文摘 | Jordaan DJ Schoon MG Badenhorst PN | | 0，，： | 1 |
| 18 | Constitutive and regulated expression of telomerase reverse transcriptase(hTERT) in human lymphocyte 显示文摘 | Liu K Schoon MM Levine BL June CH Hode RJ Weng NP | 1999 | Proc Natl Acad Science1999，96，9： | 1 |
| 19 | Scholarly networks on resilience, vulnerability and adaptation within the Human Dimensions of Global Environmental Change 显示文摘 | Janssen M A Schoon M L Ke W M | 2006 | Global Environmental Change2006，16，3： | 1 |
| 20 | Scholarly networks on resilience, vulnerability and adaptation within the human dimensions of global environmental change显示文摘 | Janssen M A Schoon M L Ke W M | 2006 | Global Environmental Change2006，，16： | 1 |
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