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| 1 | Effect of transjugular intrahepatic portosystemic shunt on pulmonary gas exchange in patients with portal hypertension and hepatopulmonary syndrome显示文摘AIM: To assess the impact of transjugular intrahepatic portosystemic shunt (TIPS) on pulmonary gas exchange and to evaluate the use of TIPS for the treatment of hepatopulmonary syndrome (HPS).METHODS: Seven patients, three of them with advanced HPS, in whom detailed pulmonary function tests were performed before and after TIPS placementat the University of Alabama Hospital and at the Hospital Clinic, Barcelona, were considered.RESULTS: TIPS patency was confirmed by hemodynamic evaluation. No changes in arterial blood gases were observed in the overall subset of patients. Transient arterial oxygenation improvement was observed in only one HPS patient, early after TIPS, but this was not sustained 4 mo later.CONCLUSION: TIPS neither improved nor worsened pulmonary gas exchange in patients with portal hypertension. This data does not support the use of TIPS as a specific treatment for HPS. However, it does reinforce the view that TIPS can be safely performed for the treatment of other complications of portal hypertension in patients with HPS. | Graciela Martínez-Pallí Britt B Drake Joan-Carles García-Pagán Joan-Albert Barberà Miguel R Arguedas Robert Rodriguez-Roisin Jaume Bosch Michael B Fallon | 2005 | World Journal of Gastroenterology2005，11，43： | 11 |
| 2 | Gender and racial differences in nonalcoholic fatty liver disease显示文摘Due to the worldwide epidemic of obesity, nonalcoholic fatty liver disease(NAFLD) has become the most com-mon cause of elevated liver enzymes. NAFLD represents a spectrum of liver injury ranging from simple steato-sis to nonalcoholic steatohepatitis(NASH) which may progress to advanced fibrosis and cirrhosis. Individuals with NAFLD, especially those with metabolic syndrome, have higher overall mortality, cardiovascular mortality, and liver-related mortality compared with the general population. According to the population-based studies, NAFLD and NASH are more prevalent in males and in Hispanics. Both the gender and racial ethnic differences in NAFLD and NASH are likely attributed to interaction between environmental, behavioral, and genetic fac-tors. Using genome-wide association studies, several genetic variants have been identified to be associated with NAFLD/NASH. However, these variants account for only a small amount of variation in hepatic steatosis among ethnic groups and may serve as modifiers of the natural history of NAFLD. Alternatively, these variants may not be the causative variants but simply markers representing a larger body of genetic variations. In this article, we provide a concise review of the gender and racial differences in the prevalence of NAFLD and NASHin adults. We also discuss the possible mechanisms for these disparities. | Jen-Jung Pan Michael B Fallon | 2014 | World Journal of Hepatology2014，6，5： | 10 |
| 3 | Hematological disorders and pulmonary hypertension显示文摘Pulmonary hypertension(PH),a serious disorder with a high morbidity and mortality rate,is known to occur in a number of unrelated systemic diseases.Several hematological disorders such as sickle cell disease,thalassemia and myeloproliferative diseases develop PH which worsens the prognosis.Associated oxidant injury and vascular inflammation cause endothelial damage and dysfunction.Pulmonary vascular endothelial damage/dysfunction is an early event in PH resulting in the loss of vascular reactivity,activation of proliferative and antiapoptotic pathways leading to vascular remodeling,elevated pulmonary artery pressure,right ventricular hypertrophy and premature death.Hemolysis observed in hematological disorders leads to free hemoglobin which rapidly scavenges nitric oxide(NO),limiting its bioavailability,and leading to endothelial dysfunction.In addition,hemolysis releases arginase into the circulation which converts L-arginine to ornithine,thus bypassing NO production.Furthermore,treatments for hematological disorders such as immunosuppressive therapy,splenectomy,bone marrow transplantation,and radiation have been shown to contribute to the development of PH.Recent studies have shown deregulated iron homeostasis in patients with cardiopulmonary diseases including pulmonary arterial hypertension(PAH).Several studies have reported low iron levels in patients with idiopathic PAH,and iron deficiency is an important risk factor.This article reviews PH associated with hematological disorders and its mechanism:and iron homeostasis and its relevance to PH. | Rajamma Mathew Jing Huang Joseph M Wu John T Fallon Michael H Gewitz | 2016 | World Journal of Cardiology2016，8，12： | 6 |
| 4 | Vanishing bile duct syndrome in human immunodeficiency virus: Nevirapine hepatotoxicity revisited显示文摘Vanishing bile duct syndrome (VBDS) refers to a group of disorders characterized by prolonged cholestasis as a result of destruction and disappearance ofintrahepatic bile ducts. Multiple etiologies have been indentifi ed including infections, neoplastic disorders, autoimmune conditions and drugs. The natural history of this condition is variable and may involve resolution of cholestasis or progression with irreversible damage. VBDS is extremely rare in human immunodeficiency virus (HIV)-infected patients and anti-retroviral therapy has never been implicated as a cause. We encountered a young pregnant female with HIV and VBDS secondary to anti-retroviral therapy. Here, we report her clinical course and outcome. | Rajan Kochar Moises I Nevah Frank J Lukens Michael B Fallon Victor I Machicao | 2010 | World Journal of Gastroenterology2010，16，26： | 6 |
| 5 | Impact of Hepatopulmonary Syndrome on Quality of Life and Survival in Liver Transplant Candidates显示文摘 | Michael B. Fallon Michael J. Krowka Robert S. Brown James F. Trotter Steven Zacks Kari E. Roberts Vijay H. Shah Neil Kaplowitz Lisa Forman Keith Wille Steven M. Kawut | 2008 | Gastroenterology2008，，4： | 4 |
| 6 | Screening for hepatocellular carcinoma in patients with hepatitis C cirrhosis: a cost-utility analysis显示文摘 | Miguel R Arguedas Victor K Chen Mohamad A Eloubeidi Michael B Fallon | 2003 | The American Journal of Gastroenterology2003，，3： | 3 |
| 7 | Utility of Pulse Oximetry Screening for Hepatopulmonary Syndrome显示文摘 | Miguel R. Arguedas Harpreet Singh Dorothy K. Faulk Michael B. Fallon | 2007 | Clinical Gastroenterology and Hepatology2007，，6： | 2 |
| 8 | Pulmonary Dysfunction in Chronic Liver Disease显示文摘 | Michael B Fallon Gary A Abrams | 2000 | Hepatology2000，，4： | 2 |
| 9 | Oxygen desaturation during sleep in hepatopulmonary syndrome显示文摘 | David T. Palma George M. Philips Miguel R. Arguedas Susan M. Harding Michael B. Fallon | 2008 | Hepatology2008，，4： | 2 |
| 10 | Pulmonary Angiogenesis in a Rat Model of Hepatopulmonary Syndrome显示文摘 | Junlan Zhang Bao Luo Liping Tang Yongming Wang Cecil R. Stockard Inga Kadish Thomas Van Groen William E. Grizzle Selvarangan Ponnazhagan Michael B. Fallon | 2009 | Gastroenterology2009，，3： | 2 |
| 11 | Cardiac papillary fibroelastoma:The need for a timely diagnosis显示文摘Cardiac papillary fibroelastomas(CPFs) are the second most common primary cardiac tumors and the most common cardiac valvular tumors. Although they are histologically benign and usually asymptomatic, CPFs can lead to serious and life-threatening complications like myocardial infarction, stroke, pulmonary embolus, cardiac arrest etc. CPFs represent a rare entity in clinical medicine and literature regarding their management is limited. We report two cases which illustrate such complications arising from undiagnosed CPFs on the aortic valve. We further stress on the importance of identifying CPFs early so that they can be managed appropriately based on recommendations from the available literature. | Srikanth Yandrapalli Bella Mehta Pratik Mondal Tanush Gupta Pallavi Khattar John Fallon Randy Goldberg Sachin Sule Wilbert S Aronow | 2017 | World Journal of Clinical Cases2017，5，1： | 2 |
| 12 | Hepatopulmonary syndrome and portopulmonary hypertension: A report of the multicenter liver transplant database显示文摘 | Michael J. Krowka M. Susan Mandell Michael A.E. Ramsay Steve M. Kawut Michael B. Fallon Cosme Manzarbeitia Manuel Pardo Paul Marotta Shinji Uemoto Markus P. Stoffel Joanne T. Benson | 2004 | Liver Transpl2004，，2： | 2 |
| 13 | Inflammation and Portal Hypertension – The Undiscovered Country显示文摘 | Gautam Mehta Thierry Gustot Rajeshwar P. Mookerjee Juan Carlos Garcia-Pagan Michael B. Fallon Vijay H. Shah Richard Moreau Rajiv Jalan | 2014 | Journal of Hepatology2014，，： | 2 |
| 14 | Ischemic Stroke Subtypes: A Population-Based Study of Functional Outcome, Survival, and Recurrence显示文摘 | George W. Petty Robert D. Brown Jack P. Whisnant JoRean D. Sicks W. Michael O’Fallon David O. Wiebers | 2000 | Stroke: Journal of the American Heart Association2000，，5： | 2 |
| 15 | MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells显示文摘 | Atsuo Ochi Andrew H. Nguyen Andrea S. Bedrosian Harry M. Mushlin Saman Zarbakhsh Rocky Barilla Constantinos P. Zambirinis Nina C. Fallon Adeel Rehman Yuliya Pylayeva-Gupta Sana Badar Cristina H. Hajdu Alan B. Frey Dafna Bar-Sagi George Miller | 2012 | Journal of Experimental Medicine2012，，9： | 2 |
| 16 | Helminth infection protects mice from anaphylaxis via IL-10-producing B cells显示文摘 | Mangan NE Fallon RE Smith P | 2004 | J Immunol2004，173，10： | 1 |
| 17 | Chemokine receptor-8(CCR8) mediates human vascular smooth muscle cell chemotaxis and metalloproteinase-2 secretion显示文摘 | Haque NS Fallon J T Pan JJ | 2004 | Blood2004，103，6： | 1 |
| 18 | Tlit athletes and gene for angiotensin I-converting enzyme gene显示文摘 | Taylor RR Mamotte CDS Fallon K | 1999 | J Appl physiol1999，87，： | 1 |
| 19 | Incidence of clinically diagnosed vertebral fractures: a population - based study in Rochester, Minnesota, 1985 - 1989显示文摘 | Cooper C A tkinson E J O' Fallon WM | 1992 | J Bone Miner Res1992，7，3： | 1 |
| 20 | Plasmal cell Labelling index and betd I-microglobulin predict surinual independent af thymidine Rinase and C-reactive protein in multiple myeloma显示文摘 | Creipp PR Lust IA O'Fallon Mu | 1993 | Blood1993，81，9： | 1 |
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