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10639篇 您的检索式:作者名="Smith P"
    题名 作者 年代 出处 被引量
1Report of an international workshop to standardize baseline evaluation and response criteria for primary CNS lymphoma.显示文摘Abrey LE Batchelor TT Ferreri A J Gospodarowicz M Pulczynski EJ Zucca E Smith JR Korfel A Soussain C DeAngelis LM Neuwelt EA O′Neill BP Thiel E Shenkier T Graus F van den Bent M Seymour JF Poortmans P Armitage JO Cavalli F 2005中国神经肿瘤杂志2005,3,3:53
2局灶节段透明变性及硬化在判断IgA肾病预后中的意义显示文摘目的 探讨IgA肾病 (IgAN)进展为慢性肾功能不全 (CRI)的病理学危险因素。方法 对 6 40例经肾活检确诊的IgAN病人进行平均 5 3个月的追踪观察。用病例对照法研究所有病人的病理学资料 ,同时还对其中 2 0 4例活检当时肾功能正常 ,5年后发展为CRI或终末期肾功能衰竭(ESRF) (n =18)以及 5年后肾功能仍保持正常 (n =186 )的病例进行了比较。结果 弥漫性系膜增生型 (DMP)为最常见的病理型 ,占 5 0 %。 / 间质纤维化 ,>40 %硬化肾小球 , / 血管病变 ,局灶节段透明变性及硬化 (FSHS)的均为预测肾功能恶化的危险因素 ,其中FSHS的意义更大 (P <0 0 0 0 1)。结论 FSHS的存在是IgAN病人正常肾功能进展恶化的显著指标。严海东 Packham D Kincaid Smith P Becker G 周希静 1999中华肾脏病杂志1999,15,5:20
3在血压控制不良的高血压患者中使用数字化干预的家庭和在线血压管理:随机对照试验显示文摘HOME BP试验(The home and online management and evaluation of blood pressure)的目的是评估在初级预防中结合自我监测和自我管理的数字化干预在高血压管理中的作用。研究者纳入英国76个治疗中心经过治疗但血压控制不好(>140/90 mm Hg, 1 mm Hg=0.133 kPa)并能上网的患者622例,进行自动确定主要终点的公开随机对照试验。McMa-nus RJ Little P Stuart B Morton K Raftery J Kelly J Bradbury K Zhang J Zhu S Murray E May CR Mair FS Michie S Smith P Band R Ogburn E AllenJ Rice C Nut-tall J Williams B Yardley L 陈嘉睿(译) 叶鹏(审校) 2021中华高血压杂志2021,29,5:15
4Cerebral radiation necrosis: incidence, outcomes, and risk factors with emphasis on radiation parameters and chemotherapy显示文摘Ruben JD Dally M Bailey M Smith R McLean CA Fedele P 2006中国神经肿瘤杂志2006,4,3:15
5Encapsulating peritoneal sclerosis显示文摘Encapsulating peritoneal sclerosis(EPS) is a debilitating condition characterized by a fibrocollagenous membrane encasing the small intestine, resulting in recurrent small bowel obstructions. EPS is most commonly associated with long-term peritoneal dialysis, though medications, peritoneal infection, and systemic inflammatory disorders have been implicated. Many cases remain idiopathic. Diagnosis is often delayed given the rarity of the disorder combined with non-specific symptoms and laboratory findings. Although cross-sectional imaging with computed tomography of the abdomen can be suggestive of the disorder, many patients undergo exploratory laparotomy for diagnosis. Mortality approaches 50% one year after diagnosis. Treatment for EPS involves treating the underlying condition or eliminating possible inciting agents(i.e. peritoneal dialysis, medications, infections) and nutritional support, frequently with total parenteral nutrition. EPSspecific treatment depends on the disease stage. In the inflammatory stage, corticosteroids are the treatment of choice, while in the fibrotic stage, tamoxifen may be beneficial. In practice, distinguishing between stages may be difficult and both may be used. Surgical intervention, consisting of peritonectomy and enterolysis, is timeconsuming and high-risk and is reserved for situations in which conservative medical therapy fails in institutions with surgical expertise in this area. Herein we review the available literature of the etiology, pathogenesis, diagnosis, and treatment of this rare, but potentially devastating disease.Christopher J Danford Steven C Lin Martin P Smith Jacqueline L Wolf 2018World Journal of Gastroenterology2018,24,28:13
6miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus显示文摘AIM: To investigate miR-200 family expression in Barrett's epithelium, gastric and duodenal epithelia, and esophageal adenocarcinoma. METHODS: Real-time reverse transcriptase-polymerase chain reaction was used to measure miR-200, ZEB1 and ZEB2 expression. Ingenuity Pathway Analysis of miR-200 targets was used to predict biological outcomes. RESULTS: Barrett's epithelium expressed lower levels of miR-141 and miR-200c than did gastric and duodenal epithelia (P < 0.001). In silico analysis indicated roles for the miR-200 family in molecular pathways that distinguish Barrett's epithelium from gastric and duodenalepithelia, and which control apoptosis and proliferation. All miR-200 members were downregulated in adenocarcinoma (P < 0.02), and miR-200c expression was also downregulated in non-invasive epithelium adjacent to adenocarcinoma (P < 0.02). The expression of all miR-200 members was lower in Barrett's epithelium derived high-grade dysplastic cell lines than in a cell line derived from benign Barrett's epithelium. We observed signif icant inverse correlations between miR-200 family expression and ZEB1 and ZEB2 expression in Barrett's epithelium and esophageal adenocarcinoma (P < 0.05). CONCLUSION: miR-200 expression might contribute to the anti-apoptotic and proliferative phenotype of Barrett's epithelium and regulate key neoplastic processes in this epithelium.Cameron M Smith David I Watson Mary P Leong George C Mayne Michael Z Michael Bas PL Wijnhoven Damian J Hussey 2011World Journal of Gastroenterology2011,17,8:13
7高龄对男性生育力的影响显示文摘在过去的几十年里,现代社会的压力和期望使得育龄夫妇生育年龄总体推迟。已知女性在临近40岁时卵母细胞的产生将会明显减少,而高龄对男性精子生成能力的影响还知之甚少。男性生育年龄无明确限制,因而高龄对男性生育能力的影响还不完全清楚。本文将就目前已知的高龄对男性精子质量、生育能力和子代健康的影响进行综述,希望能在医生就男性推迟生育及高龄相关的风险咨询时起到一定的指导作用。Jason R Kovac Josephine Addai Ryan P Smith Robert M Coward Dolores J Lamb Larry I Lipshultz 2013Asian Journal of Andrology2013,15,6:12
8Redox therapeutics in hepatic ischemia reperfusion injury显示文摘Ischemia-reperfusion plays a major role in the injury experienced by the liver during transplantation. Much work has been done recently investigating the role of redox species in hepatic ischemia-reperfusion. As animal models are better characterized and developed, and more insights are gained into the pathophysiology of hepatic ischemia reperfusion injury in humans the questions into exactly how oxidants participate in this injury are becoming more refined. These questions include effects of cellular location, timing of injury, and ability of therapeutics to access this site are increasing our appreciation of the complexity of ischemia reperfusion and improving attempts to ameliorate its effects. In this review, we aim to discuss the various methods to alter redox chemistry during ischemia reperfusion injury and future prospects for preventing organ injury during hepatic ischemia reperfusion.Rakesh P Patel John D Lang Alvin B Smith Jack H Crawford 2014World Journal of Hepatology2014,6,1:9
9如何设计高质量针刺临床研究:基于证据的专家共识显示文摘本针刺随机对照试验(Randomised controlled trials, RCT)专家共识是基于目前针刺试验面临的最普遍、最关键问题,由临床医生、研究人员、从事针灸和外科的临床试验专家、统计专家、临床流行病学和方法学专家以及患者组成的国际临床研究小组联合制订。该共识将有助于临床试验资助者、注册者以及期刊编辑等评估针刺RCT方案及研究结果的相关性、重要性和质量。张誉清 焦睿珉 Claudia M Witt 劳力行 刘建平 Lehana Thabane Karen J Sherman Mike Cummings Dawn P Richards Eun-Kyung Anna Kim Tae-Hun Kim Myeong Soo Lee Michael E Wechsler Benno Brinkhaus Jun J Mao Caroline A Smith 岗卫娟 刘保延 刘志顺 刘岩 郑晖 吴佳霓 AloBSO Carrasco-Labra Mohit Bhandari Philip J Devereaux 景向红 Gordon Guyatt 2022英国医学杂志中文版2022,25,6:7
10Men with a complete absence of normal sperm morphology exhibit high rates of success without assisted reproduction显示文摘在里面结合不孕, 0% 正常形式(NF ) 的反常严格的形态学是一个标准很快继续到在 vitro 授精(IVF ) 。自从没有数据,当前存在,我们与 0% NF 为人调查了结果没有帮助繁殖技术(艺术) 的使用,决定繁殖成功。有 0% NF 的 24 个人的一个队被识别(2010-2013 ) 随机与 ≥ 与 27 选择了人;是的 4% NF 控制。耐心的图表与联系并且管理同意的一块机构的评论板(IRB ) 的人一起被考察查明结果的电话问询表。在 2.5 年的一中部的后续时间以后,有 0% NF 的 29.2% 人没为他们的第一怀孕要求艺术(控制 =55.6% , P ≤0.05 ) 。当所有怀孕一起被分析时,有 0% NF 的人完成了 75% 没要求 IVF 的二十怀孕(控制 = 三十怀孕;76.7% 没要求 IVF ) 。人和女搭挡的平均年龄在有 0% NF 和 ≥ 的人之间是类似的; 4% NF。所有人有正常刺激滤泡的荷尔蒙(FSH ) ,睾丸激素,催乳激素,性别荷尔蒙绑定血球素(SHBG ) ,和 estradiol。尽管,当第一怀孕是一个自然概念(NC ) 时,全球精液参数在有 0% NF 的人是更坏的,有 0% NF (n = 7/7 ) 的人的 100% 并且 37.5% 控制(n = 3/8 ) 继续了经由 NC 有随后的怀孕。没有 IVF,有 0% NF 的人与 55.6% 控制相比在 29.2% 盒子中怀孕了。严格的形态学不应该被用来预言授精,怀孕,或实时出生潜力。在有 0% NF 的人,其他的形式应该被认为 IVF 以前立即。Jason R Kovac Ryan P Smith Miguel Cajipe Dolores J Lamb Larry I Lipshultz 2017Asian Journal of Andrology2017,19,1:7
11Endoscopic retrograde cholangiography for pediatric choledocholithiasis: Assessing the need for endoscopic intervention显示文摘AIM:To assess pediatric patients for choledocholithiasis.We applied current adult guidelines to identify predictivefactors in children.METHODS:A single-center retrospective analysis was performed at a tertiary children's hospital.We evaluated 44 consecutive pediatric patients who underwent endoscopic retrograde cholangiography(ERCP) for suspected choledocholithiasis.Patients were stratified into those with common bile duct stones(CBDS) at ERCP vs those that did not using the American Society of Gastrointestinal Endoscopy(ASGE) guidelines(Very Strong and Strong criteria) for suspected CBDS.RESULTS:CBDS were identified in 84% at the time of ERCP.Abdominal ultrasound identified CBDS in 36% of patients.Conjugated bilirubin ≥ 0.5 mg/d L was an independent risk factor for CBDS(P = 0.003).The Very Strong(59.5%) and Strong(48.6%) ASGE criteria identified the majority of patients(P = 0.0001).A modified score using conjugated bilirubin had a higher sensitivity(81.2% vs 59.5%) and more likely to identify a stone than the standard criteria,odds ratio of 25.7 compared to 8.8.Alanine aminotransferase and gamma-glutamyl transferase values identified significant differences in a subset of patients with odds ratio of 4.1 and 3.25,respectively.CONCLUSION:Current adult guidelines identified the majority of pediatric patients with CBDS,but specific pediatric guidelines may improve detection,thus decreasing risks and unnecessary procedures.Douglas S Fishman Bruno P Chumpitazi Isaac Raijman Cynthia Man-Wai Tsai E O’Brian Smith Mark V Mazziotti Mark A Gilger 2016World Journal of Gastrointestinal Endoscopy2016,8,11:6
12麻风无痛性神经炎——康复试点报告显示文摘对八个康复试点的3571例病人定期进行神经功能检查,发现无痛性神经炎151例(4.2%),共累及330条神经,包括面神经15条,尺神经98条,正中神经36条,胫后神经148条及腓总神经33条。经强的松标准方案治疗,神经功能好转235条(71.2%),其中恢复优、良者196条(59.4%),表明强的松治疗麻风无痛性神经炎既简单又行之有效,可作为常规,以减少神经不可逆性损害。讨论了无痛性神经炎与MDT的关系及其感觉与运动功能的恢复。蒋娟 张国成 韦晓宇 严良斌 李文忠 郑逖生 Jakeman P Watson J Smith C Goh Siam Kiang 1996中国麻风杂志1996,12,3:5
13A post-classical theory of enamel biomineralization… and why we need one显示文摘Enamel crystals are unique in shape,orientation and organization.They are hundreds of thousands times longer than they are wide,run parallel to each other,are oriented with respect to the ameloblast membrane at the mineralization front and are organized into rod or interrod enamel.The classical theory of amelogenesis postulates that extracellular matrix proteins shape crystallites by specifically inhibiting ion deposition on the crystal sides,orient them by binding multiple crystallites and establish higher levels of crystal organization.Elements of the classical theory are supported in principle by in vitro studies;however,the classical theory does not explain how enamel forms in vivo.In this review,we describe how amelogenesis is highly integrated with ameloblast cell activities and how the shape,orientation and organization of enamel mineral ribbons are established by a mineralization front apparatus along the secretory surface of the ameloblast cell membrane.James P Simmer Amelia S Richardson Yuan-Yuan Hu Charles E Smith Jan Ching-Chun Hu 2012International Journal of Oral Science2012,4,3:4
14Vasectomy reversal: a clinical update显示文摘输精管切除术是一只保险箱,避孕的有效方法由 42-60 使用世界范围的百万个人。近似人的 3%-6% 由于一个孩子或离婚和再婚的死亡为输精管切除术颠倒抉择,处于金融状况变化,在一样的婚姻以内为更多的孩子需要,或伤害症候群减轻畏惧的 postvasectomy。不同于输精管切除术,输精管切除术颠倒是仅仅由少数泌尿科医师被执行并且自从它没被保险通常盖住,把更大的金融紧张放在病人上的一个更技术上挑战性的过程。自从操作显微镜在 1970 年代变得可得到,对这个过程的兴趣增加了,它因而导致了跟随过程的改进明显和怀孕率。在这临床的更改,我们讨论耐心的评估,可以影响颠倒成功率的变量,在选择执行 vasovasostomy 对 vasoepididymostomy 考虑的因素,和减轻 postvasectomy 疼痛症候群的输精管切除术颠倒的实用性。我们也为出现在最近的年里帮助这个手术的成功的输精管切除术颠倒和另外的新奇技术和乐器学考察机器人学的使用。Abhishek P Patel Ryan P Smith 2016Asian Journal of Andrology2016,18,3:3
15呼吸音分析技术用于心源性和非心源性呼吸困难的鉴别诊断显示文摘目的 临床上心力衰竭,慢性阻塞性怖病和哮喘急性加重时均可以通过听诊器发现异常呼吸音,目前为止尚不能对以上呼吸音进行定量分析。对于就诊于急诊科的呼吸困难患者,鉴别诊断其发生原因对于临床治疗措施和预后关系密切。本研究的目的就是应用计算机辅助的呼吸音分析技术对心源性和非心源行呼吸困难时的呼吸音进行定量分析,同时评价其临床应用价值。方法本实验为前瞻性临床研究,应用呼吸音分析记录装置记录患者呼吸过程中所产生的呼吸音,通过计算机辅助技术将呼吸音转化成图像。收集因急性呼吸困难来北京大学第三医院急诊就诊的患者59人,根据患者最终出院诊断分为3组:急性心力衰竭患者22人,慢性阻塞性肺病急性加重期患者19人,哮喘急性发作患者18人。选择同期健康志愿者20人作为对照组。对三组患者的呼吸音图像进行定量分析,分析指标为吸气相最大呼吸音能量图面积和最大吸气相/最大呼气相能量比值。组间比较采用t检验。结果健康对照组、心力衰竭组、慢性阻塞性肺病急性加重期患者和哮喘急性发作患者的吸气相最大呼吸音能量图面积分别为:(76.2±4.5),(67.6±6.7),(72.2±7.6)和(52±11.7)千像素(P〈0.01)。健康对照组、心力衰竭组、慢性阻塞性肺病急性加重期患者和哮喘急性发作患者的吸气相最大呼吸音能量图左右侧面积之比分别为1:1、1:1、1:1和1:0.4。健康对照组、心力衰竭组、慢性阻塞性肺病急性加晕期患者和哮喘急性发作患者的最大吸气相/呼气相能量峰值比值分别为:(6.3±5.2),(5.6±4.0),(2.0±2.2)和(0.3±0.3),P〈0.01:结论与健康对照相比较,心力衰竭患者组的吸气相最大呼吸音能量图面积明显缩小,吸气相最大呼吸音能量图左右面积之比及最大吸气相/最大呼气相能量比值尢差别;与健康对照相比较,慢性阻塞性肺病患者的吸气相最大呼吸音能量图面积无差别,吸气相最大呼吸音能量图左右面积之比无差别,最大吸气相/最大呼气相能量比值明显缩小;与健康对照相比较,哮喘患者的吸气相最大呼吸音能量图面积明显缩小,吸气相最大呼吸音能量图左右面积不对称,最大吸气相/最大呼气相能量比值明显缩小。以上图像特点对鉴别心力衰竭、阻塞性肺病和哮喘所引起的呼吸困难有帮助。王真 Smith Jean Richard P Dellinger 2009中华急诊医学杂志2009,18,12:3
16Gamma irradiation of HIV-1显示文摘Richard A Smith Jesse Ingels John J Lochemes Joseph P Dutkowsky Linda L Pifer 2001Journal of Orthopaedic Research2001,,5:2
17European powdered rubber technology 显示文摘Smith L P 1978Elastomerics1978,4,11:2
18Carbyne forms of carbon: do they exist?显示文摘Smith P P K Buseck P R 1982Science1982,216,:2
19Pentraxin binding to isolated rat liver nuclei显示文摘Shephard E G Smith P J Coetzee S 1991Biochem J1991,279,1:2
20Adrenomedullin,a multifunctional regulatory peptide 显示文摘HINSON J P KAPAS S SMITH D M 2000Endocrine Reviews2000,21,2:2
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