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| 1 | 破裂动脉瘤-栓塞或夹闭疗效相当(英文)显示文摘In the May 2009 issue of The Lancet Neurology,the 5-year follow-up results of the International Subarachnoid Aneurysm Trial(ISAT) were published.The authors concluded that,although the significant difference between coiling and neurosurgical clipping of ruptured intracranial aneurysms in terms of death and severe disability after 1 year has vanished(primary endpoint),coiling should still be favored over neurosurgical clipping because mortality rates significantly favored coiling.In this commentary,it is this particular conclusion that is challenged by combining data from previous ISAT publications with the current 5-year follow-up results.This modified intent-to-treat analysis clearly demonstrates that the significant advantage in terms of mortality in favor of the endovascularly treated patients is no longer present,with a hazard ratio of 0.80 in favor of endovascular treatment(95% confidence interval: 0.60-1.05;P =.10).Therefore,for everyday clinical practice and decision making,coiling and clipping are to be considered equivalent in the long term. | Bakker NA Metzemaekers JD Groen RJ Mooij JJ Van Dijk JM | 2010 | 中华神经外科疾病研究杂志2010，9，3： | 41 |
| 2 | Emerging roles of the intestine in control of cholesterol metabolism显示文摘The liver is considered the major “control center” for maintenance of whole body cholesterol homeostasis. This organ is the main site for de novo cholesterol synthesis, clears cholesterol-containing chylomicron remnants and low density lipoprotein particles from plasma and is the major contributor to high density lipoprotein (HDL; good cholesterol) formation. The liver has a central position in the classical definition of the reverse cholesterol transport pathway by taking up periphery-derived cholesterol from lipoprotein particles followed by conversion into bile acids or its direct secretion into bile for eventual removal via the feces. During the past couple of years, however, an additional important role of the intestine in maintenance of cholesterol homeostasis and regulation of plasma cholesterol levels has become apparent. Firstly, molecular mechanisms of cholesterol absorption have been elucidated and novel pharmacological compounds have been identified that interfere with the process and positively impact plasma cholesterol levels. Secondly, it is now evident that the intestine itself contributes to fecal neutral sterol loss as a cholesterol-secreting organ. Finally, very recent work has unequivocally demonstrated that the intestine contributes significantly to plasma HDL cholesterol levels. Thus, the intestine is a potential target for novel anti-atherosclerotic treatment strategies that, in addition to interference with cholesterol absorption, modulate direct cholesterol excretion and plasma HDL cholesterol levels. | Janine K Kruit Albert K Groen Theo J van Berkel Folkert Kuipers | 2006 | World Journal of Gastroenterology2006，12，40： | 4 |
| 3 | Collaborative multi-agent reinforcement learning based on experience propagation显示文摘For multi-agent reinforcement learning in Markov games, knowledge extraction and sharing are key research problems. State list extracting means to calculate the optimal shared state path from state trajectories with cycles. A state list extracting algorithm checks cyclic state lists of a current state in the state trajectory, condensing the optimal action set of the current state. By reinforcing the optimal action selected, the action policy of cyclic states is optimized gradually. The state list extracting is repeatedly learned and used as the experience knowledge which is shared by teams. Agents speed up the rate of convergence by experience sharing. Competition games of preys and predators are used for the experiments. The results of experiments prove that the proposed algorithms overcome the lack of experience in the initial stage, speed up learning and improve the performance. | Min Fang Frans C.A. Groen | 2013 | Journal of Systems Engineering and Electronics2013，24，4： | 4 |
| 4 | Multislice CT angiography in the selection of patients with ruptured intracranial aneurysms suitable for clipping or coiling显示文摘 | H. E. Westerlaan J. Gravendeel D. Fiore J. D. M. Metzemaekers R. J. M. Groen J. J. A. Mooij M. Oudkerk | 2007 | Neuroradiology2007，，12： | 2 |
| 5 | Pulmonary Angiogenesis in a Rat Model of Hepatopulmonary Syndrome显示文摘 | Junlan Zhang Bao Luo Liping Tang Yongming Wang Cecil R. Stockard Inga Kadish Thomas Van Groen William E. Grizzle Selvarangan Ponnazhagan Michael B. Fallon | 2009 | Gastroenterology2009，，3： | 2 |
| 6 | The global TRUST study of erlotinib in advanced non-small-cell lung cancer (NSCLC)显示文摘 | Groen H Arrieta O G Riska H | 2008 | J Clin Oncol2008，26，： | 1 |
| 7 | The prognostic value of histology in the assessment of patients with Budd-Chiari syndrome显示文摘 | Batts KP de Groen PC | 2001 | J Hepatol2001，35，3： | 1 |
| 8 | Clogging of biliary endoprosthesis: a new perspective显示文摘 | Coene P Groen A Cheng J | 1990 | Gut1990，31，： | 1 |
| 9 | Morphology of the human internal vertebral venous plexus:a cadaver study after intravenous Araldite CY 221 injection显示文摘 | Groen RJ Groenewegen HJ Van Alphen HA | 1997 | Anat Rec1997，249，2： | 1 |
| 10 | Antiremodeling effects on the left ventricle during beta-blockade with metoprolol in the treatment of chronic heart failure显示文摘 | Groenning BA Nilsson JG Sondergard L | 2000 | J Am Coll Cardiol2000，36，7： | 1 |
| 11 | Cholesterol nucleation-influencing activityin T-tube bile显示文摘 | Groen AK Drapers JAG Heok FJ | 1988 | Hepatology1988，8，2： | 1 |
| 12 | Surgical clipp- ing as the preferred treatment for aneurysms of the middle cerebral artery 显示文摘 | van Dijk JM Groen RJ Ter Laan M | 2011 | Acta Neurochir (Wien)2011，153，11： | 1 |
| 13 | Team coordination among robotic soccer players显示文摘 | Spaan M T J Groen F C A | 2009 | Journal of Control Science and Engineering2009，23，8： | 1 |
| 14 | Mechanism of hierarchical porosity development in MFI zeolites by desilication:The role of aluminium as a poredirecting agent显示文摘 | GROEN J C PEFFER L A A MOULIJN J A | 2005 | Chemisty-A European Journal2005，11，17： | 1 |
| 15 | A newly discov-ered human pneumovirus isolated from young children with respiratorytract disease显示文摘 | Van Den Hoogen BG De Jong JC Groen J | 2001 | Nat Med2001，7，6： | 1 |
| 16 | The relation between hip impact velocity and hip impact force differs between sideways fall techniques显示文摘 | Groen BE Weerdesteyn V Duysens J | 2008 | J Electromyogr Kineol2008，18，2： | 1 |
| 17 | A newly discovered human pneumovirus isolated from young children with respiratory tract disease显示文摘 | van den Hoogen BG de Jong JC Groen J | 2001 | Nat Med2001，7，6： | 1 |
| 18 | Discogenic low back pain显示文摘 | Kallewaard JW Terheggen MA Groen GJ | 2010 | Pain Pract2010，10，6： | 1 |
| 19 | Randomizedtrial of self-expanding metal stent versus polyethylene stents for distal malignant biliary obstruction显示文摘 | Davids PHP Groen AK Ronws EAJ | 1992 | Lancet1992，340，8834： | 1 |
| 20 | The spontaneous spinal epidural hematoma:a study of the etiology显示文摘 | Groen RJ Possen H | 1990 | J Neurol Sci1990，98，： | 1 |
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