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| 1 | 鼻腔鼻窦结局测试-20(SNOT-20)量表中文版的研制显示文摘目的研制鼻腔鼻窦结局测试-20(sino-nasal outcome test-20,SNOT-20)量表中文版。方法通过前期SNOT-20量表的引进、翻译、预试、调适及性能初测试,形成中文量表试用版,进而收集国内10家医院的临床应用反馈意见,对量表作进一步修订,最终在60例慢性鼻-鼻窦炎患者中进行更加严格的性能再测试,并与英文源表作性能比较。结果中文量表修订版各项性能表现如下:①可行性:量表的接收率、回收率和有效率分别为98.4%、98.4%和98.3%,平均完成时间(6.0±3.0)min,患者无答卷负担的比例为96.7%;②信度:分半信度=0.95,克郎巴赫系数α=0.88,重测信度项内相关系数=0.98;③效度:条目内容通过专家认可及维度相关性检测,量表评分与标准量表“医学结局研究短表-36”的相关系数为-0.67;量表结构经证实性因子分析,拟合优度指数=0.93,提取“鼻部症状、相关症状、睡眠障碍、情感结局”4个因子,与源表设计结构吻合;④尺度:评分等级词条“无、轻、中、重”分别与数字“0、1、2、3”对应;⑤灵敏度:4个维度均能区分患者与健康人群的生存质量差异(P值均〈0.01);⑥反应度:术后3个月全部条目总分和5大条目总分的标准化反应均数分别为0.48、0.57。中文量表修订版上述性能均达到或接近检验水准,与英文源表性能相当。结论SNOT-20中文版通过严格的性能测试,可在我国慢性鼻-鼻窦炎患者中推广应用。 | 左可军 方积乾 Piccirillo JF 王慧 许庚 | 2008 | 中华耳鼻咽喉头颈外科杂志2008，43，10： | 160 |
| 2 | Helicobacter pylori infection in bleeding peptic ulcer patients after non-steroidal antiinflammatory drug consumption显示文摘AIM:To establish the prevalence of Helicobacter pylori (H. pylori ) infection in patients with a bleeding peptic ulcer after consumption of non-steroidal antiinflamma- tory drugs (NSAIDs). METHODS:A very early upper endoscopy was performed to find the source of upper gastrointestinal bleeding and to take biopsy specimens for analysis of H. pylori infection by the rapid urease (CLO) test, histological examination, and bacterial culture. IgG anti-CagA were also sought. The gold standard for identifying H. pylori infection was positive culture of biopsy specimens or contemporary positivity of the CLO test and the presence of H. pylori on tissue sections. RESULTS:Eighty patients, 61 males (76.3%), mean age 61.2 ± 15.9 years, were consecutively enrolled. Forty-seven (58.8%) patients occasionally consumed NSAIDs, while 33 (41.3%) were on chronic treatment with low-dose aspirin (LD ASA). Forty-four (55.0%) patients were considered infected by H. pylori . The infection rate was not different between patients who occasionally or chronically consumed NSAIDs. The culture of biopsy specimens had a sensitivity of 86.4% and a specificity of 100%; corresponding figures for histological analysis were 65.9% and 77.8%, for the CLO test were 68.2% and 75%, for the combined use of histology and the CLO test were 56.8% and 100%, and for IgG anti-CagA were 90% and 98%. The highest accuracy (92.5%) was obtained with the culture of biopsy specimens.CONCLUSION:Patients with a bleeding peptic ulcer after NSAID/LD ASA consumption frequently have H. pylori infection. Biopsy specimen culture after an early upper gastrointestinal tract endoscopy seems the most efficient test to detect this infection. | Francesco Manguso Elisabetta Riccio Germana de Nucci Maria Luisa Aiezza Gerardino Amato Linda Degl'Innocenti Maria Maddalena Piccirillo Gianfranco De Dominicis Tara Santoro Elena Trimarco Antonio Balzano | 2011 | World Journal of Gastroenterology2011，17，40： | 4 |
| 3 | Early radiological assessment of locally advanced pancreatic cancer treated with electrochemotherapy显示文摘AIM To report early imaging assessment of ablated area post electrochemotherapy(ECT) in patients with locally advanced pancreatic cancer(LAPC). METHODS ECT was performed in 19 LAPC patients enrolled in an approved ongoing clinical phase Ⅰ/Ⅱ study. Before and after ECT, 18 patients underwent computed tomography(CT) scan, 11 patients underwent morphological and functional magnetic resonance(MR) scan(dynamic contrast enhanced-MRI) calculating wash-in slope(WIS) and wash-out slope(WOS); diffusion weighted imaging calculating pseudo-diffusivity(Dp), perfusion fraction(fp) and tissue diffusivity(Dt); 10 patients underwentpositron emission tomography(PET). Response evaluation criteria in solid tumour(RECIST) on MR and CT were used to assess tumour therapy response. Choi on CT, PET response criteria in solid tumors(PERCIST) on PET and functional parameters on MR were used to evaluate treatment response.RESULTS For each patient no significant reduction was measurable by CT and MR using RECIST. According Choi criteria a partial response was obtained in 18/18(100.0%) patients. According PERCIST criteria 6/10(60.0%) patients showed a partial response, 3/10(30.0%) stable disease and 1/10(10.0%) progression disease. Moreover, using functional MR parameters, a significant reduction of viable tumour after ECT can be observed. According ΔWIS and ΔWOS 9/11(81.8%) patients exhibited a partial response and 2/11(18.2%) stable disease; 8/11(72.7%) patients were considered in partial response by ΔDp evaluation and 3/11(27.3%) in stable disease; according ΔDt 7/11(63.6%) patients showed a partial response, 1/11(9.1%) showed progression of disease and 3/11(27.3%) were stable. Perfusion fraction fp showed a significant reduction after ECT only in four patients. No significant difference was observed after ECT in signal intensity of T1-weighted images and T2-weighted images, and in equilibrium-phase of contrast study, according to χ2 test was observed. A good correlation was reported between ΔHounsfield unit and Δmaximum standardized uptake value and between Δfp and ΔWOS, with a significant statistically difference(P < 0.05) using Spearman correlation coefficient.CONCLUSION Perfusion and diffusion MR derived parameters, Choi, PERCIST criteria are more performant than morphological MR and CT criteria to assess ECT treatment response. | Vincenza Granata Roberta Fusco Sergio Venanzio Setola Mauro Piccirillo Maddalena Leongito Raffaele Palaia Francesco Granata Secondo Lastoria Francesco Izzo Antonella Petrillo | 2017 | World Journal of Gastroenterology2017，23，26： | 3 |
| 4 | Is human hepatocellular carcinoma a hormone-responsive tumor?显示文摘Before the positive results recently obtained with multitarget tyrosine kinase inhibitor sorafenib,there was no standard systemic treatment for patients with advanced hepatocellular carcinoma(HCC).Sex hormones receptors are expressed in a significant proportion of HCC samples.Following preclinical and epidemiological studies supporting a relationship between sex hormones and HCC tumorigenesis,several randomized controlled trials (RCTs)tested the efficacy of the anti-estrogen tamoxifen as systemic treatment.Largest among these trials showed no survival advantage from the administration of tamoxifen,and the recent Cochrane systematic review produced a completely negative result.This questions the relevance of estrogen receptor-mediated pathways in HCC.However,a possible explanation for these disappointing results is the lack of proper patients selection according to sex hormones receptors expression,but unfortunately the interaction between this expression and efficacy of tamoxifen has not been studied adequately.It has been also proposed that negative results might be explained if tamoxifen acts in HCC via an estrogen receptor-independent pathway,that requires higher doses than those usually administered, but an Asian RCT conducted to assess dose-response effect was completely negative.Interesting,preliminaryresults have been obtained when hormonal treatment (tamoxifen or megestrol)has been selected according to the presence of wild-type or variant estrogen receptors respectively,but no large RCTs are available to support this strategy.Negative results have been obtained also with anti-androgen therapy.In conclusion,there is no robust evidence to consider HCC a hormone-responsive tumor.Hormonal treatments should not be part of the current management of HCC. | Massimo Di Maio Bruno Daniele Sandro Pignata Ciro Gallo Ermelinda De Maio Alessandro Morabito Maria Carmela Piccirillo Francesco Perrone | 2008 | World Journal of Gastroenterology2008，14，11： | 2 |
| 5 | 吊顶灯照明行巩膜扣带术治疗孔源性视网膜脱离(英文)显示文摘目的:评估治疗孔源性视网膜脱离(RRD)的巩膜扣带术中使用吊顶灯照明系统的优势。方法:在这一对照、回顾性研究中,72例72眼于密涅瓦医院接受巩膜扣带术治疗的RRD患者分为两组。A组在吊顶灯照明下行巩膜扣带术,B组进行常规巩膜扣带术。两组均于术前、术后1、3、7、14、30、90和180d进行随访。指标包括其它手术操作、最佳框架眼镜矫正视力(BSVA)、手术时间、视网膜裂孔再次出现进行了分析和比较。结果:术后6mo,两组BSVA均较术前显著改善(P<0.01)。两组再次出现视网膜裂孔的比例未见明显差异,但A组手术时间较B组明显缩短。结论:通过我们观察得出结果,使用巩膜扣带术治疗RRD时,吊顶灯照明系统是一个有价值的工具。 | Valerio Piccirillo Michele Lanza Carlo Irregolare Antonello Iovine Agostino Diplomatico Sandro Sbordone Alfonso Savastano | 2018 | 国际眼科杂志2018，18，10： | 2 |
| 6 | Clinical assessment of patients with advanced non-small-cell lung cancer eligible for second-line chemotherapy: A prognostic score from individual data of nine randomised trials显示文摘 | Massimo Di Maio Nicola Lama Alessandro Morabito Egbert F. Smit Vassilis Georgoulias Koji Takeda Elisabeth Quoix Dora Hatzidaki Floris M. Wachters Vittorio Gebbia Chun-Ming Tsai Carlos Camps Wolfgang Schuette Paolo Chiodini Maria Carmela Piccirillo Frances | 2009 | European Journal of Cancer2009，，4： | 2 |
| 7 | Cutting edge:control of CD8^+ T cell activation by CD4^+ CD25^+ immunoregulatory cells 显示文摘 | Piccirillo C A Shevach E M | 2001 | J Immunol2001，167，： | 1 |
| 8 | CD4 + Foxp3 + regulatory T cells in the control of autoimmunity : in vivo veritas 显示文摘 | Piccirillo CA d'Hennezel E Sgouroudis E | 2008 | Curr Opin Immunol2008，20，6： | 1 |
| 9 | Control of T cell activation by CD4+CD25 + suppressor T cells显示文摘 | SHEVACH E M MUHUGH R S PICCIRILLO C A | 2001 | Immunol Rev2001，182，： | 1 |
| 10 | CD4^+ CD25^+ immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticod-induced TNF receptor显示文摘 | McHugh RS Whitters MJ Piccirillo CA | 2002 | Immunity2002，16，2： | 1 |
| 11 | Autonomic nervous system activity measured directly and Q T interval variability in normal and pacing-induced tachycardia heart failure dogs显示文摘 | Piccirillo G Magri D Ogawa M | 2009 | J Am Coll Cardiol2009，54，9： | 1 |
| 12 | CD4^+CD25^+ immunoregulatory T cells:gene expression analysis reveals a functional role for the glucocorticod 2 induced TNF receptor显示文摘 | McHugh RS Whitters MJ Piccirillo CA | 2002 | Immunity2002，16，2： | 1 |
| 13 | CD4+ Foxp3 + regulatory T cells in the control of autoimmunity: in vivo veritas 显示文摘 | Piccirillo C A d'Hennezel E Sgouroudis E | 2008 | Curr Opin lmmunol2008，20，6： | 1 |
| 14 | CD8 + T cell immunity a- gainst a tumor/self-antigen is augmented by CD4 + T helper cells and hindered by naturally occurring T regulatory cells 显示文摘 | Antony P A Piccirillo C A Akpinarli A | 2005 | J Immunol2005，174，： | 1 |
| 15 | Autonomic modulator and QT in-terval dispersion in hypertensive subjects withanxiety显示文摘 | Piccirillo G Viola E Nocco M | 1999 | Hypertension1999，34，： | 1 |
| 16 | Control of T cell activation by CD4^+CD25^+ suppressor T cells显示文摘 | Shevach E M McHugh R S Piccirillo C A | 2001 | Immunol Rev2001，182，： | 1 |
| 17 | Anterior and posterior facial nerve rerouting:a comparative study显示文摘 | Rosso A Piccirillo E De Donato G | 2003 | Skull Base2003，13，3： | 1 |
| 18 | Cutting edge:IL-2 is critically required for the in vitro activation of CD4^+CD25^+ T cell suppressor function显示文摘 | Thornton AM Donovan EE Piccirillo CA | 2004 | J Immunol2004，172，11： | 1 |
| 19 | Heart rate variability in hypertensive subjects 显示文摘 | Piccirillo G Munizzi MR Fimognari FL | 1996 | Int J Cardiol1996，53，3： | 1 |
| 20 | Control of T cell activa- tion by CD4+,CD25+ suppressor T cells 显示文摘 | Shevach EM McHugh RS Piccirillo CA | 2001 | J Immunol Rev2001，182，： | 1 |
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