Epilepsy triggered by mefloquine in an adult traveler to Uganda

查看全文 作　　者：Federico [1]Gobbi;Andrea [1]Rossanese;Dora [1]Buonfrate;Andrea [1]Angheben;Chiara [2]Postiglione;Zeno [1]Bisoffi

机构地区：[1]Department of Tropical Diseases, Sacro Cuore-Don Calabria Hospital, 37024 Verona, Italy;[2]Prevention Department, ULSS 20 Verona, 37122 Verona, Italy

出　　处：《World Journal of Clinical Cases》索引2014年第2卷第1期,共4页

摘　　要：We report a case of a traveler who visited Uganda for 8 d, and took mefloquine one tablet/week for malaria prophylaxis. After the second dose, he suffered from two episodes of loss of consciousness with seizures, therefore mefloquine was discontinued. During the flight back after full recovery, seizures reoccurred while he was on board, he was disembarked in Addis Ababa and then transferred to Nairobi. After repatriation to Italy, he experienced four other similar episodes. The patient was still on full dose anticonvulsant therapy one year and a half after, as any attempt at reduced dose was unsuccessful. Currently, three agents(mefloquine, atovaquone/proguanil, and doxycycline) are recommended for malaria chemoprophylaxis, with similar efficacy but different adverse event profiles, regimens, and prices. Considering that mefloquine is associated with a higher risk of neurologic and psychiatric adverse events than the alternative regimens, we suggest considering mefloquine as a second line choice after atovaquone/progua-nil and doxycycline for short-term travelers. 关键词：MEFLOQUINE NEUROPSYCHIATRIC disorders EPILEPSY ANTIMALARIAL CHEMOPROPHYLAXIS Side effects

相关文献

参考文献（24）
引证文献（2）
耦合文献（0）

参考文献(24)

引证文献(2)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Epilepsy triggered by mefloquine in an adult traveler to Uganda

参考文献(24)

引证文献(2)

用户提示