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| 1 | Guidelines for evaluation and management of cerebral collateral circulation in ischaemic stroke 2017显示文摘Collateral circulation plays a vital role in sustaining blood flow to the ischaemic areas in acute,subacute or chronic phases after an ischaemic stroke or transient ischaemic attack.Good collateral circulation has shown protective effects towards a favourable functional outcome and a lower risk of recurrence in stroke attributed to different aetiologies or undergoing medical or endovascular treatment.Over the past decade,the importance of collateral circulation has attracted more attention and is becoming a hot spot for research.However,the diversity in imaging methods and criteria to evaluate collateral circulation has hindered comparisons of findings from different cohorts and further studies in exploring the clinical relevance of collateral circulation and possible methods to enhance collateral flow.The statement is aimed to update currently available evidence and provide evidence-based recommendations regarding grading methods for collateral circulation,its significance in patients with stroke and methods under investigation to improve collateral flow. | Liping Liu Jing Ding Xinyi Leng Yuehua Pu Li-An Huang Anding Xu Ka Sing Lawrence Wong Xin Wang Yongjun Wang 无 | 2018 | Stroke & Vascular Neurology2018，3，3： | 37 |
| 2 | 羊蹄甲属3种园艺树种分子鉴定及亲缘关系的ISSR分析显示文摘利用ISSRPCR方法对香港羊蹄甲属(Bauhinia)中最常见3种园艺树种:红花羊蹄甲(B.purpurea)、宫粉羊蹄甲(B.variegate)和洋紫荆(B.blakeana)的遗传变异进行了研究,从74个ISSR引物中筛选出9个多态性引物用于正式扩增,共扩增出80条DNA带,平均每个引物扩增的DNA带的数目为8.88条,多态性条带数目为55条,占总条带数的68.8%。其中,有8个引物扩增出差异条带和特异条带,并分别能准确地鉴定羊蹄甲属3个园艺树种。本研究的结果表明,ISSR-PCR的DNA电泳谱带在检测香港羊蹄甲(B.blakeana)品种的真实性方面非常有用。同时,通过对3个种扩增条带的叠加性进行分析,证实了洋紫荆杂交起源的父母本为红花羊蹄甲和宫粉羊蹄甲。 | 罗瑜萍 龚维 邱英雄 Yuk Sing Gibert Chan | 2006 | 园艺学报2006，33，2： | 30 |
| 3 | Review of endoscopic techniques in the diagnosis and management of cholangiocarcinoma显示文摘Cholangiocarcinoma is a rare malignancy of the biliary tract. Key factors in determining therapeutic options include knowledge of tumor extent, anatomy and obtaining tissue diagnosis. Endoscopically, there are three modalities available to make the diagnosis of cholangiocarcinoma. These include endoscopic retrograde cholangiopancreatography, endoscopic ultrasound with fine needle aspiration and cholangioscopy. Management of cholangiocarcinoma endoscopically is typically confined to stent placement for palliative purposes or as a bridge to surgery. In this article, we will review the endoscopic techniques available for the diagnosis and management of cholangiocarcinoma. | Katherine Nguyen James T Sing Jr | 2008 | World Journal of Gastroenterology2008，14，19： | 18 |
| 4 | Perfluorooctane sulfonate(PFOS) and related fluorochemicals in chicken egg in China显示文摘The ubiquitous occurrence of perfluorinated compounds(PFCs) in environmental samples has drawn much attention.Recent human exposure studies found relatively high perfluorooctane sulfonate(PFOS) concentrations in blood samples from several cities in China when compared with other countries.The objectives of the present study were:(1) to measure PFC concentrations and compositions in chicken egg samples from local markets in China;and(2) to conduct a preliminary human health risk assessment of egg consumption.Eight pooled egg samples from eight locations were analyzed for 11 PFCs.The results showed that close to 100% of the PFOS in the egg was distributed in egg yolk and PFOS was not detected in egg white(<0.08 ng/g wet weight,w/w).Of the perfluoroalkylsulfonates,only PFOS was detected in all egg samples,while of the perfluoroalkylcarboxylates,perfluoroundecanoic acid(PFUnDA) was detected in all samples,followed by perfluorooctanoate(PFOA)(75% occurrence) and perfluorodecanoic acid(PFDA)(50% occurrence).PFOS concentrations in egg ranged from 45.0 to 86.9 ng/g w/w.The results suggested that current concentrations of PFOS in domestic chicken eggs are unlikely to cause immediate harm to Chinese populations. | WANG Yuan YEUNG Leo Wai Yin YAMASHITA Nobuyoshi TANIYASU Sachi SO Man Ka Margaret B. MURPHY LAM Paul Kwan Sing | 2008 | Chinese Science Bulletin2008，53，4： | 13 |
| 5 | 金、银、铜等典型高反射率材料的激光增材制造显示文摘激光增材制造金银材料可用于艺术品、首饰、手表等的定制化制造.铜是传统工业的重要材料,具有良好的导电性和导热性;铜的激光增材制造材料被广泛用于电子设备、热管理系统、交通运输、工业制造等领域.金、银、铜的激光增材制造具有广阔的应用前景,但也面临着重要问题:金、银、铜材料对激光的吸收率很低.理论分析表明,光吸收率受材料的电导率和激光波长的直接影响.用合金化粉末或表面改性的粉末替代原始粉末打印,或用短波长蓝光或绿光激光打印,可以提高粉体对激光的吸收率,得到更好的打印态样品.本文总结了铜、金等高反射率材料的激光增材制造的激光成型现状和原料端现状,亦对铜、金等高反射率材料的激光增材制造的未来发展趋势做出了展望. | 顾瑞楠 WONG Kam Sing 严明 | 2020 | 中国科学:物理学、力学、天文学2020，50，3： | 12 |
| 6 | Effects of miR-219/miR-338 on microglia and astrocyte behaviors and astrocyte-oligodendrocyte precursor cell interactions显示文摘MiR-219 and miR-338(miR-219/miR-338)are oligodendrocyte-specific microRNAs.The overexpression of these miRs in oligodendrocyte precursor cells promotes their differentiation and maturation into oligodendrocytes,which may enhance axonal remyelination after nerve injuries in the central nervous system(CNS).As such,the delivery of miR-219/miR-338 to the CNS to promote oligodendrocyte precursor cell differentiation,maturation and myelination could be a promising approach for nerve repair.However,nerve injuries in the CNS also involve other cell types,such as microglia and astrocytes.Herein,we investigated the effects of miR-219/miR-338 treatment on microglia and astrocytes in vitro and in vivo.We found that miR-219/miR-338 diminished microglial expression of pro-inflammatory cytokines and suppressed astrocyte activation.In addition,we showed that miR-219/miR-338 enhanced oligodendrocyte precursor cell differentiation and maturation in a scratch assay paradigm that re-created a nerve injury condition in vitro.Collectively,our results suggest miR-219/miR-338 as a promising treatment for axonal remyelination in the CNS following nerve injuries.All experimental procedures were approved by the Institutional Animal Care and Use Committee(IACUC),Nanyang Technological University(approval No.A0309 and A0333)on April 27,2016 and October 8,2016. | Lan Huong Nguyen William Ong Kai Wang Mingfeng Wang Dean Nizetic Sing Yian Chew | 2020 | Neural Regeneration Research2020，15，4： | 11 |
| 7 | Clinical utility of Epstein-Barr virus DNA and other liquid biopsy markers in nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma(NPC)is a malignant epithelial tumor ubiquitously associated with the Epstein-Barr virus(EBV),which is highly prevalent in South China,Southeast Asia,and North Africa.Despite being a highly radio-sensitive and treatable cancer,a majority of NPC patients are diagnosed in their advanced stage,and locoregional and distant relapses following definitive treatment contribute largely to cancer-specific mortality among these patients.Given that EBV-driven NPC is the predominant variant seen in endemic regions,various EBV detection methods have been developed and are utilized in screening,prognostication,and post-treatment surveillance of NPC patients.While the Immunoglobulin A(IgA)serology assay is the most extensively studied EBV detection method,the detection of plasma EBV DNA released during replication or cellular apoptosis has shown superior outcomes in endemic population screening,prognostication,and detection of distant relapse.Furthermore,there is emerging evidence on the use of circulating tumor cells,microRNAs,DNA hypermethylation,and combination assays in various clinical scenarios.Herein,this paper provides a comprehensive overview of the relevant studies using various EBV detection techniques in the management of NPC.Specifically,the recent advances,clinical evidence,and challenges associated with the clinical application of EBV liquid biopsies in population screening,prognostication,and surveillance of NPC are presented. | Rong Tan Sean Kean Ann Phua Yoke Lim Soong Lynette Lin Ean Oon Kian Sing Chan Sasidharan Swarnalatha Lucky Jamie Mong Min Han Tan Chwee Ming Lim | 2020 | Cancer Communications2020，40，11： | 8 |
| 8 | 美国临床药学进展对中国未来临床药学发展的启示显示文摘1月8日上午,2010广东省药师周大会在广州东方宾馆隆重开幕,本次大会主题为'生命科学时代的药学探索'。来自全省200多家医疗单位、50多家医药企业的药学专业人员共300余人参加了此次会议,广东省药学会有关领导陆惠兴、朱家勇、黄民、涂瑶生、陶剑虹及各专业委员会主任委员出席了大会。全天的学术年会报告为我省的广大药学从业人员奉上了新年的第一次药学盛宴,选取其中两篇报告整理成文。 | Moses Sing Sum Chow | 2011 | 今日药学2011，21，1： | 8 |
| 9 | Lipids in liver transplant recipients显示文摘Hyperlipidemia is very common after liver transplantation and can be observed in up to 71% of patients. The etiology of lipid disorders in these patients is multifactorial, with different lipid profiles observed depending on the immunosuppressive agents administered and the presence of additional risk factors, such as obesity, diabetes mellitus and nutrition. Due to recent improvements in survival of liver transplant recipients, the prevention of cardiovascular events has become more important, especially as approximately 64% of liver transplant recipients present with an increased risk of cardiovascular events. Management of dyslipidemia and of other modifiable cardiovascular risk factors, such as hypertension, diabetes and smoking, has therefore become essential in these patients. Treatment of hyperlipidemia after liver transplantation consists of life style modification, modifying the dose or type of immunosuppressive agents and use of lipid lowering agents. At the start of administration of lipid lowering medications, it is important to monitor drugdrug interactions, especially between lipid lowering agents and immunosuppressive drugs. Furthermore, as combinations of various lipid lowering drugs can lead to severe side effects, such as myopathies and rhabdomyolysis, these combinations should therefore be avoided. To our knowledge, there are no current guidelines targeting the management of lipid metabolism disorders in liver transplant recipients. This paper therefore recommends an approach of managing lipid abnormalities occurring after liver transplantation. | anna hüsing iyad kabar hartmut h schmidt | 2016 | World Journal of Gastroenterology2016，22，12： | 6 |
| 10 | 中草药对良性前列腺增生的疗效及安个性:随机对照试验的系统回顾显示文摘中草药经常被用于治疗良性前列腺增生,但其疗效及安全性仍有待证实。为了比较单用中草药和中药与西药联合治疗良性前列腺增生的疗效及副作用,两位独立的评审员在主要的电子数据库中检索了单用中草药或中草药与西药联用与安慰剂或单用西药之间比较的随机对照试验,于动检索了相关期刊和灰色文献。评估的结果包括泌尿系统症状、尿动力学检测、小草药的效果优于西药。中草药的副作用发生需要有大型的质量更高的随机对照试验。 | Chun Ho Ma Wai Ling Lin Sing Leung Lui Xun-Yuan Cai Vivian Taam Wong Kun-Yuan Cai Eric Zie Zhang-Jin Zhang | 2013 | Asian Journal of Andrology2013，15，4： | 6 |
| 11 | The New Era of Organ Transplantation in China显示文摘 | Jie-Fu Huang Hai-Bo Wang Shu-Sen Zheng Yong-Feng Liu Bing-Yi Shi Zhong-Yang Shen Sheng-Shou Hu Qi-Fa Ye Wu-Jun Erie Xiao-Shun He Jing-Yu Chen Feng Huo Sing Du Jing Fan Yan-Hong Guo Zong-Jiu Zhang | 2016 | Chinese Medical Journal2016，，16： | 6 |
| 12 | Arterial vs venous blood gas differences during hemorrhagic shock显示文摘AIM: To characterize differences of arterial(ABG) and venous(VBG) blood gas analysis in a rabbit model of hemorrhagic shock. METHODS: Following baseline arterial and venous blood gas analysis, fifty anesthetized, ventilated New Zealand white rabbits were hemorrhaged to and maintained at a mean arterial pressure of 40 mm Hg until a state of shock was obtained, as defined by arterial p H ≤ 7.2 and base deficit ≤-15 mmol/L. Simultaneous ABG and VBG were obtained at 3 minute intervals. Comparisons of p H, base deficit, p CO2, and arteriovenous(a-v) differences were then made between ABG and VBG at baseline and shock states. Statistical analysis was applied where appropriate with a significance of P < 0.05. RESULTS: All 50 animals were hemorrhaged to shockstatus and euthanized; no unexpected loss occurred. Significant differences were noted between baseline and shock states in blood gases for the following parameters: p H was significantly decreased in both arterial(7.39 ± 0.12 to 7.14 ± 0.18) and venous blood gases(7.35 ± 0.15 to 6.98 ± 0.26, P < 0.05), base deficit was significantly increased for arterial(-0.9 ± 3.9 m Eq/L vs-17.8 ± 2.2 m Eq/L) and venous blood gasses(-0.8 ± 3.8 m Eq/L vs-15.3 ± 4.1 m Eq/L, P < 0.05). p CO2 trends(baseline to shock) demonstrated a decrease in arterial blood(40.0 ± 9.1 mm Hg vs 28.9 ± 7.1 mm Hg) but an increase in venous blood(46.0 ± 10.1 mm Hg vs 62.8 ± 15.3 mm Hg), although these trends were non-significant. For calculated arteriovenous differences between baseline and shock states, only the p CO2 difference was shown to be significant during shock.CONCLUSION: In this rabbit model, significant differences exist in blood gas measurements for arterial and venous blood after hemorrhagic shock. A widened p CO2 a-v difference during hemorrhage, reflective of poor tissue oxygenation, may be a better indicator of impending shock. | Kristopher Burton Williams Ashley Britton Christmas Brant Todd Heniford Ronald Fong Sing Joseph Messick | 2014 | World Journal of Critical Care Medicine2014，3，2： | 6 |
| 13 | Parity Relation Based Fault Estimation for Nonlinear Systems: An LMI Approach显示文摘这篇论文建议一种同等值关系为能被 Takagi-Sugeno (TS ) 建模的非线性的系统的一个班基于差错评价模糊模型。一种同等值关系的设计基于剩余生成器以线性矩阵不平等(LMI ) 的一个家庭被提出。一个数字例子被提供说明建议设计技术的有效性。关键词模糊系统 - 非线性的系统 - 差错鉴定 - 差错察觉 - 差错诊断这个工作被亚历山大·文·胡莫尔德特基础支持。唱 Kiong Nguang 毕业(与头等荣誉) 从部门电并且纽卡斯尔大学的计算机工程,在 1992 的澳大利亚,并且在 1995 从一样的大学收到了他的博士学位。他当前在部门正在保持伙伴教授之职电并且奥克兰的大学的计算机工程,新西兰。他出版了超过 90 份杂志报纸和超过 60 份会议报纸。他的研究兴趣包括非线性的控制,指责容忍的控制,模糊系统,和联网的控制系统。恩古昂博士当前为 IEEE 控制系统社会会议编辑董事会正在担任伙伴编辑,并且是 IEEE 的一个高级成员。砰张收到了她的 B.Sc。在从科技的 Huazhong 大学设计的控制的度,中国武汉,在 1997。从 1999 ~ 2001,她与在 Senftenberg 的应用科学 Lausitz 的大学,德国,在 DAAD-Sandwich-Program 的框架。她收到了 M.Sc。并且在从清华大学设计的控制的博士学位,中国北京,在 2002。从那以后,她在 Duisburg-Essen 的大学为自动控制和复杂系统(AKS ) 在研究所一直在工作,德国。她的研究兴趣包括模型基于的差错诊断,指责容忍的控制,为差错诊断的鉴定,周期、变化时间的系统和联网的控制系统。史蒂文· X 钟声收到了他的 Ph。D。在来自 Duisburg 的 Gerhard-Mercator 大学的电力工程的度,德国,在 1992。从 1992 ~ 1994,他是在 Rheinmetall GmbH 的一个 R&D 工程师。从 1995 ~ 2001,他是在 Senftenberg 在应用科学 Lausitz 的大学设计的控制的一个教授,德国,并且在 1998 鈥 ? 期间担任了这所大学的副校长 000。他当前在 Duisburg-Essen 的大学是自动控制的一个教授和为自动控制和复杂系统(AKS ) 的研究所的椅子,德国。他的研究兴趣包括模型基于的差错诊断,与汽车的系统的一个焦点在工业指责容忍的系统和他们的申请。 | Sing Kiong Nguang Ping Zhang Steven X. Ding | 2007 | International Journal of Automation and computing2007，4，2： | 6 |
| 14 | Factors That Predict Response of Patients With Hepatitis C Virus Infection to Boceprevir显示文摘 | Fred Poordad Jean–Pierre Bronowicki Stuart C. Gordon Stefan Zeuzem Ira M. Jacobson Mark S. Sulkowski Thierry Poynard Timothy R. Morgan Cliona Molony Lisa D. Pedicone Heather L. Sings Margaret H. Burroughs Vilma Sniukiene Navdeep Boparai Venkata S. Goteti | 2012 | Gastroenterology2012，，3： | 5 |
| 15 | 废米糠制备炭纳米颗粒及其对金属离子的光学传感性能(英文)显示文摘以废米糠为原料,浓硫酸为脱水剂,通过炭化法制备出炭纳米颗粒(CNPs),探讨CNPs荧光发射特征、金属离子的淬灭效应以及作为Sn(II)离子传感材料应用。CNPs产率最佳条件为:硫酸浓度12 mol/L、加热温度120℃及恒温时间30 min。样品在水中强蓝光的最大发射波为439 nm。通过加入金属离子,使金属离子与CNPs表面间形成复合物而淬灭荧光。Sn(II)离子对CNPs荧光具有显著的淬灭效应。Sn(II)离子浓度对淬灭效应符合Stern-Volmer线性关系,Sn(II)离子为6.13 mmol/L。Sn(II)离子的检测限为18.7μmol/L。 | Peggy Zhen Zhen Ngu Stephanie Pei Phing Chia Jessica Fung Yee Fong Sing Muk Ng | 2016 | 新型炭材料2016，31，2： | 4 |
| 16 | Paclitaxel-eluting balloon dilation of biliary anastomotic stricture after liver transplantation显示文摘AIM:To investigate the safety and effectiveness of endoscopic therapy with a paclitaxel-eluting balloon(PEB) for biliary anastomotic stricture(AS) after liver transplantation(LT).METHODS:This prospective pilot study enrolled 13 consecutive eligible patients treated for symptomatic AS after LT at the University Hospital of Münster between January 2011 and March 2014.The patients were treated by endoscopic therapy with a PEB and followed up every 8 wk by endoscopic retrograde cholangiopancreatography(ERCP).In cases of re-stenosis,further balloon dilation with a PEB was performed.Follow-up was continued until 24 mo after the last intervention.RESULTS:Initial technical feasibility,defined as successful balloon dilation with a PEB during the initial ERCP procedure,was achieved in 100% of cases.Long-term clinical success(LTCS),defined as no need for further endoscopic intervention for at least 24 mo,was achieved in 12 of the 13 patients(92.3%).The mean number of endoscopic interventions required to achieve LTCS was only 1.7 ± 1.1.Treatment failure,defined as the need for definitive alternative treatment,occurred in only one patient,who developed recurrent stenosis with increasing bile duct dilatation that required stent placement.CONCLUSION:Endoscopic therapy with a PEB is very effective for the treatment of AS after LT,and seems to significantly shorten the overall duration of endoscopic treatment by reducing the number of interventions needed to achieve LTCS. | Anna Hüsing Holger Reinecke Vito R Cicinnati Susanne Beckebaum Christian Wilms Hartmut H Schmidt Iyad Kabar | 2015 | World Journal of Gastroenterology2015，21，3： | 4 |
| 17 | Initial experience in children using conventional laparoscopic instruments in single-incision laparoscopic surgery显示文摘 | Yuk Him Tam Kim Hung Lee Jennifer Dart Yin Sihoe Kin Wai Chan Sing Tak Cheung Kristine Kit Yi Pang | 2010 | Journal of Pediatric Surgery2010，，12： | 4 |
| 18 | 先天性膈疝病人MR相对胎儿肺体积:存活率和体外膜人工氧合法的必需性显示文摘目的回顾性评估利用MRI测量绝对胎儿肺体积(fetallung volume,FLV)以及利用7个公式计算相对FLV以预测先天性膈疝(CDH)新生儿的存活率并判断患儿是否需要胎儿体外膜人工氧合(ECMO)治疗的准确性。方法此项回顾性研究得到伦理委员会的批准。并且得到本研究中所有母亲的知情同意书。对68例患CDH的23-29周胎儿进行了MRI检查以测量FLV。利用文献报道的7个公式的生物计量参数计算相对FLV,表示为肺预测体积的百分比。 | K.A. Büsing A.K. Kilian T. Schaible C. Endler R. Schaffelder K.W.Neff 叶锦棠(译) 唐光健(校) | 2008 | 国际医学放射学杂志2008，31，5： | 4 |
| 19 | Similar efficacy and safety of tenofovir in Asians and non-Asians with chronic hepatitis B显示文摘AIM:To compare the efficacy and safety of tenofovir disoproxil fumarate(TDF)in Asian and non-Asian chronic hepatitis B(CHB)patients.METHODS:The efficacy and safety of the initial 48wk of treatment with TDF was compared in a posthoc analysis of combined data from 217 Asians and299 non-Asians included in Studies 102 and 103and a post-approval,open-label trial(Study 123).Patient groups were compared according to baseline hepatitis B e antigen(HBe Ag)status and viral load.The main outcome measures included the proportion of patients who achieved a hepatitis B virus(HBV)DNA level<400 copies/m L at Week 48 of treatment.Secondary measures included:HBV DNA and alanine aminotransaminase(ALT)levels over time;proportion of patients with normal ALT levels;proportion of patients with HBe Ag loss/seroconversion and proportion of patients with hepatitis B surface antigen loss/seroconversion;changes in liver histology.Safety and tolerability were evaluated by the occurrence of adverse events(AEs),serious AEs,laboratory abnormalities,discontinuation of the study drug due to AEs,or death.The primary efficacy and safety analysis set included all patients who were randomly assigned to treatment and received at least one dose of study drug.RESULTS:At week 48,similar proportions of Asians and non-Asians reached HBV DNA<400 copies/m L(96%of Asian and 97%of non-Asian patients with HBe Ag-negative CHB and 83%of Asian and 79%of non-Asian patients with HBe Ag-positive CHB had HBV DNA)and normal ALT(78%of Asian and 81%of nonAsian patients with HBe Ag-negative CHB and 71%of Asian and 74%of non-Asian patients with HBe Agpositive CHB had normal ALT).On-treatment HBV DNA decline rates were similar between Asians and nonAsians regardless of baseline HBe Ag status and viralload.HBV DNA decline during the first four weeks was2.9 log10 copies/m L in HBe Ag-negative Asians and nonAsians,and in HBe Ag-positive non-Asians,and 3.1log10 copies/m L in HBe Ag-positive Asians.HBe Ag loss and seroconversion was achieved in 14%of Asians vs 26%and 24%,respectively,in non-Asians.Liver histology improved in 77.2%of Asians and 71.5%of non-Asians.No resistance to TDF developed.No renal safety signals were observed.CONCLUSION:TDF demonstrated similar viral suppression,normalization of ALT,improvements in liver fibrosis,and no detectable resistance in Asian and non-Asian patients regardless of baseline HBe Ag status. | Calvin Q Pan Sing Chan Huy Trinh Alan Yao Ho Bae Lillian Lou | 2015 | World Journal of Gastroenterology2015，21，18： | 4 |
| 20 | Peginterferon Alfa-2a Plus Ribavirin for the Treatment of Dual Chronic Infection With Hepatitis B and C Viruses显示文摘 | Chun–Jen Liu Wan–Long Chuang Chuan–Mo Lee Ming–Lung Yu Sheng–Nan Lu Shun–Sheng Wu Li–Ying Liao Chi–Ling Chen Hsing–Tao Kuo You–Chen Chao Shui–Yi Tung Sien–Sing Yang Jia–Horng Kao Chen–Hua Liu Wei–Wen Su Chih–Lin Lin Yung–Ming Jeng Pei–Jer Chen Ding–Shinn | 2009 | Gastroenterology2009，，2： | 3 |
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