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| 1 | Contribution of oxidative stress to pulmonary arterial hypertension显示文摘Recent data implicate oxidative stress as a mediator of pulmonary hypertension (PH) and of the associated pathological changes to the pulmonary vasculature and right ventricle (RV). Increases in reactive oxygen species (ROS), altered redox state, and elevated oxidant stress have been demonstrated in the lungs and RV of several animal models of PH, including chronic hypoxia, monocrotaline toxicity, caveolin-1 knock-out mouse, and the transgenic Ren2 rat which overexpresses the mouse renin gene. Generation of ROS in these models is derived mostly from the activities of the nicotinamide adenine dinucleotide phosphate oxidases, xanthine oxidase, and uncoupled endothelial nitric oxide synthase. As disease progresses circulating monocytes and bone marrow-derived monocytic progenitor cells are attracted to and accumulate in the pulmonary vasculature. Once established, these inflammatory cells generate ROS and secrete mitogenic and fibrogenic cytokines that induce cell proliferation and fibrosis in the vascular wall resulting in progressive vascular remodeling. Deficiencies in antioxidant enzymes also contribute to pulmonary hypertensive states. Current therapies were developed to improve endothelial function, reduce pulmonary artery pressure, and slow the progression of vascular remodeling in the pulmonary vasculature by targeting deficiencies in either NO (PDE-type 5 inhibition) or PGI 2 (prostacyclin analogs), or excessive synthesis of ET-1 (ET receptor blockers) with the intent to improve patient clinical status and survival. New therapies may slow disease progression to some extent, but long term management has not been achieved and mortality is still high. Although little is known concerning the effects of current pulmonary arterial hypertension treatments on RV structure and function, interest in this area is increasing. Development of therapeutic strategies that simultaneously target pathology in the pulmonary vasculature and RV may be beneficial in reducing mortality associated with RV failure. | Vincent G DeMarco Adam T Whaley-Connell James R Sowers Javad Habibi Kevin C Dellsperger | 2010 | World Journal of Cardiology2010，2，10： | 21 |
| 2 | Nursing Students'Experiences With and Strategic Approaches to Case-based Instruction:a Replication and Comparison Study Between Two Disciplines显示文摘 | Demarco R Hayward L Lynch M | 2002 | The Journal of Nursing Education2002，41，4： | 1 |
| 3 | The significance of oil spill dispersants 显示文摘 | LESSARD R R DEMARCO G | 2000 | Spill Science & Technology Bulletin2000，6，1： | 1 |
| 4 | Percutaneous nephrolithotomy in children显示文摘 | DEMARCO R T | 2011 | Advances in Urology2011，2011，12： | 1 |
| 5 | Endoscopic revision of external dacryocystorhinostomy 显示文摘 | Demarco R Strose A Araujo M | 2007 | Otolaryngology-Head and Neck Surgery2007，137，3： | 1 |
| 6 | Use of degenerate primers and touchdown PCR for construction of cDNA libraries显示文摘 | Fietto JL DeMarco R VerjovskiAlmeida S | 2002 | Biotechniques2002，32，6： | 1 |
| 7 | Monocytes promote natural killer cell interferon gamma production in responseto the endogenous danger signal HMGB1显示文摘 | DeMarco R A Fink M P Lotze M T | 2005 | Mol Immunol2005，42，4： | 1 |
| 8 | An attenuated aro a salmonella typhimurium vaccine elicits humoral and cellular immunity to cloned γ-galactocidase in mice 显示文摘 | Brown A Hormaeche CE Demarco R | 1987 | J Infect Dis1987，155，： | 1 |
| 9 | Rapid detection of Escherichia coli O157:H7 in ground beef using a fiber optic biosensor显示文摘 | Demarco D R Saaski E W McCrae D A | 1999 | Journal of Food Protection1999，62，7： | 1 |
| 10 | Drug-selected human lung cancer stem cells:cytokine network,tumorigenic and metastatic properties显示文摘 | Levina V Marrangoni AM Demarco R | 2008 | PLoS One2008，3，8： | 1 |
| 11 | Structural Studies on Penicillin Derivates Ⅰ: The Configuration of Phenoxymethyl Penicillin Sulfoxide 显示文摘 | Cooper R D B Demarco P V Cheng J C | 1969 | J Am Chem Soc1969，91，： | 1 |
| 12 | The significance of oil spill dis- persants 显示文摘 | Lessard R R Demarco G | 2000 | Spill science & Technology Bulletin2000，6，1： | 1 |
| 13 | Drug - selected human lung cancer stem cells: cytokine network, tumorigenic and metastatic properties 显示文摘 | Levina V Marrangoni AM DeMarco R | 2008 | Plos 0ne2008，3，8： | 1 |
| 14 | Use of degenerate primers and touchdown PCR for construction of cDNA libraries显示文摘 | Fietto J L Demarco R Verjovsk-Almeida S | 2002 | Biotechniques2002，32，： | 1 |
| 15 | The significance of oil spill dispersants 显示文摘 | Lessard R R Demarco G | 2000 | Spill Science & Technology Bulletin2000，6，1： | 1 |
| 16 | Molecular characterization and immunolocalization of Schistosoma mansoni ATP-diphosphohydrolase显示文摘 | Demarco R Kowahowski AT Mortara RA | 2003 | Biochem Biophys Res Commun2003，307，4： | 1 |
| 17 | Drug-selected human lung cancer stem cells: eytokine network, tumorigenic and metastatic properties 显示文摘 | LEVINA V MARRANGONI A M DEMARCO R | 2008 | PLos ONE2008，3，8： | 1 |
| 18 | Advanced techniques in site characterization and mining hazard detection for the underground coal industry显示文摘 | David R Hanson Thamas L Vandergrift Mattehew J DeMarco | 2002 | International Journal of Coal Geology2002，，50： | 1 |
| 19 | Storing biological se- quence databases in relational form显示文摘 | Xie G DeMarco R Blevins R | 2000 | Bioinformatics2000，16，3： | 1 |
| 20 | Dealing with death:HMGB1 as a novel target for cancer therapy显示文摘 | Lotze M T DeMarco R A | 2003 | Curr Opin Investig Drugs2003，4，12： | 1 |
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