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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Effect of a retrograde-viewing device on adenoma detection rate during colonoscopy: the TERRACE study显示文摘 | Anke M. Leufkens Daniel C. DeMarco Amit Rastogi Paul A. Akerman Kassem Azzouzi Richard I. Rothstein Frank P. Vleggaar Alessandro Repici Giacomo Rando Patrick I. Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H. Deprez Brian P. Sau | 2011 | Gastrointestinal Endoscopy2011，，3： | 5 |
| 3 | Impact of experience with a retrograde-viewing device on adenoma detection rates and withdrawal times during colonoscopy: the Third Eye Retroscope study group显示文摘 | Daniel C. DeMarco Elizabeth Odstrcil Luis F. Lara David Bass Chase Herdman Timothy Kinney Kapil Gupta Leon Wolf Thomas Dewar Thomas M. Deas Manoj K. Mehta M. Badar Anwer Randall Pellish J. Kent Hamilton Daniel Polter K. Gautham Reddy Ira Hanan | 2010 | Gastrointestinal Endoscopy2010，，3： | 2 |
| 4 | An experimental model in calvaria to evaluate bone therapies显示文摘 | AYBAR ODSTRCIL A TERRITORIALE E MISSANA L | 2005 | Acta Odontol Latinoam2005，18，2： | 1 |
| 5 | Modeling 3-D solar wind structure显示文摘 | D. Odstrcil | 2003 | Advances in Space Research2003，，4： | 1 |
| 6 | The Solar Wind at 1 AU During the Declining Phase of Solar Cycle 23: Comparison of 3D Numerical Model Results with Observations显示文摘 | C. O. Lee J. G. Luhmann D. Odstrcil P. J. MacNeice I. Pater P. Riley C. N. Arge | 2009 | Solar Physics2009，，1： | 1 |
| 7 | Comparison of flux corrected transport and total variation diminishing numerical schemes for hydrodynmnic and magnetohydrodynamic problems显示文摘 | Toth G Odstrcil D | 1996 | J Comput Phys1996，128，： | 1 |
| 8 | Solving practical industrial problems in two-phase multicomponent mixture flow-critical velocity 显示文摘 | KOHOUTEK J ZACHOVAL J ODSTRCIL M | 2001 | Heat Transfer Eng2001，22，1： | 1 |
| 9 | The contribution of malabsorption to the reduction in net energy absorption after long-limb Roux-en-Y gastric bypass 显示文摘 | Odstrcil EA Martinez JG Santa Ana CA | 2010 | Am J Clin Nutr2010，92，4： | 1 |
| 10 | Protein-modified SEI formation and evolution in Li metal batteries显示文摘Despite numerous reported lithium metal batteries(LMBs) with excellent cycling performance achieved in labs, transferring the high performing LMBs from lab-scale to industrial-production remains challenging. Therefore, via imitating the stand-still process in battery production, a conventional but important procedure, to investigate the formation and evolution of a solid electrolyte interface(SEI) is particularly important for LMBs. Our previous studies indicate that zein(corn protein)-modified carbonate-ester electrolyte(the most commercialized) effectively improves the performance of LMBs through guiding Li-ions and repairing cracked SEI. Herein, we investigate the formation and evolution of the protein-modified SEIs on Li anodes by imitating the stand-still temperature and duration. A simulation study on the protein denaturation in the electrolyte under different temperatures demonstrates a highly unfolded configuration at elevated temperatures. The experiments show that this heat-treated-zein(H-zein) modified SEI forms quickly and becomes stable after a stand-still process of less than 100 min. Moreover, the Hzein SEI exhibits excellent wetting behavior with the electrolyte due to the highly unfolded protein structures with more functional groups exposed. The Li|Li cell with the H-zein SEI achieves prolonged cycling performance(>360 h vs. ~260 h of the cell with the untreated-zein(U-zein) modified SEI). The Li Fe PO_(4)|Li cell with the H-zein SEI shows much stable long-term cycling performance of capacity retention(70% vs.42% of the cell with U-zein SEI) after 200 cycles. This study confirms that the appropriately treated protein is able to effectively improve the performance of LMBs, and will inspire future studies for the production process of LMBs toward their commercialization. | Chenxu Wang Ryan Odstrcil Jin Liu Wei-Hong Zhong | 2022 | Journal of Energy Chemistry2022，31，10： | 0 |
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