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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Drug eluting biliary stents to decrease stent failure rates:Areview of the literature显示文摘Biliary stenting is clinically effective in relieving both malignant and non-malignant obstructions. However, there are high failure rates associated with tumor ingrowth and epithelial overgrowth as well as internally from biofilm development and subsequent clogging. Within the last decade, the use of prophylactic drug eluting stents as a means to reduce stent failure has been investigated. In this review we provide an overview of the current research on drug eluting biliary stents. While there is limited human trial data regarding the clinical benefit of drug eluting biliary stents in preventing stent obstruction, recent research suggests promise regarding their safety and potential efficacy. | Joseph Shatzel Jisoo Kim Kartik Sampath Sharjeel Syed Jennifer Saad Zilla H Hussain Kabir Mody J Marc Pipas Stuart Gordon Timothy Gardner Richard I Rothstein | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，2： | 6 |
| 3 | Effect of a retrograde-viewing device on adenoma detection rate during colonoscopy: the TERRACE study显示文摘 | Anke M. Leufkens Daniel C. DeMarco Amit Rastogi Paul A. Akerman Kassem Azzouzi Richard I. Rothstein Frank P. Vleggaar Alessandro Repici Giacomo Rando Patrick I. Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H. Deprez Brian P. Sau | 2011 | Gastrointestinal Endoscopy2011，，3： | 5 |
| 4 | Inducible resistance to Fas-mediated apoptosis in B cells显示文摘Apoptosis produced in B cells through Fas (APO-1, CD95) triggering is regulated by signals derived from other surface receptors: CD40 engagement produces upregulation of Fas expres. sion and marked susceptibility to Fas-induced cell death, whereas antigen receptor engagement, or IL-4R engagement, inhibits Fas killing and in so doing induces a state of Fas-resistance, even in otherwise sensitive, CD40-stimulated targets. Surfaceim. munoglobulin and IL-4R utilize at least partially distinct pathways to produce Fas-resistance that differentially depend on PKC and STAT6, respectively. Further, surface immunoglob- 'lin signaling for inducible Fas-resistance bypasses Bib, requires NF-GB, and entails new macromolecular synthesis. Terminal effectors of B cell Fas-resistance include the known anti-apoptotic gene products, Bcl-xL and FLIP, and a novel anti-apoptotic gene that encodes FAIM (Fas Apoptosis Inhibitory Molecule). faim was identified by differential display and exists in two alternatively spliced forms; maim-S is broadly expressed, but faim-L expression is tissue-specific. The FAIM sequence is highly evolu tionarily conserved, suggesting an important role for this molecule throughout phylogeny. Inducible resistance to Fas killing is hypothesized to protect foreign antigen-specific B cells during potentially hazardous interactions with FasL-bearing T cells, whereas autoreactive B cells fail to become Fas-resistant and are deleted via Fas-dependent cytotoxicity. Inadvertent or aberrant acquisition of Fas-resistance may permit autoreactive B cells to escape Fas deletion, and malignant lymphocytes to impede anti-tumor immunity. | ROTHSTEIN THOMAS L Departments of Medicine and Microbiology, and the Evans Memorial Department of Clinical Research, Boston University Medical Center, Boston, MA, USA | 2000 | Cell Research2000，10，4： | 4 |
| 5 | Pathologic features of Hashimoto’s-associated papillary thyroid carcinomas显示文摘 | Marcello Di Pasquale Jay L Rothstein Juan P Palazzo | 2001 | Human Pathology2001，，1： | 2 |
| 6 | Incomplete Polyp Resection During Colonoscopy—Results of the Complete Adenoma Resection (CARE) Study显示文摘 | Heiko Pohl Amitabh Srivastava Steve P. Bensen Peter Anderson Richard I. Rothstein Stuart R. Gordon L. Campbell Levy Arifa Toor Todd A. Mackenzie Thomas Rosch Douglas J. Robertson | 2013 | Gastroenterology2013，，： | 2 |
| 7 | Predicting high explosive detonation velocities from their composition and structure显示文摘 | Rothstein L R | 1981 | Prop and Explo1981，6，： | 1 |
| 8 | Dental and facial skeletal characteristics and growth of males and females with class Ⅱ, division 1 malocclusion between the ages of 10 and 14 (revisited)-part 1: characteristics of size, form, and position 显示文摘 | Rothstein T Yoon-Tarlie C | 2000 | Am J Orthod Dentofacial Orthop2000，117，3： | 1 |
| 9 | More is not always better:the genetic constraints of polyploidy显示文摘 | Thorpe PH González-Barrera S Rothstein R | 2007 | Trends Genet2007，23，6： | 1 |
| 10 | Perinatal hypoxia-ischemia induces apoptotic and excitotoxic death of periventricular white matter oligodendrocyte progenitors显示文摘 | Ness J K Romanko M J Rothstein R P | 2001 | Dev Neurosci2001，23，3： | 1 |
| 11 | Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules显示文摘 | Rock KL Gramm C Rothstein L | 1994 | Cell1994，78，5： | 1 |
| 12 | Glutanate transporter protein subtypes are expressed differentially during rat CNS development显示文摘 | Furuta A Rothstein J D Martin L J | 1997 | J Neurosci1997，17，： | 1 |
| 13 | Interannual and decadal variability of the subsurface thermal structure in the Pacific Ocean: 1961-1990 显示文摘 | ZHANG R H ROTHSTEIN L M BASALACCHI A J | 1999 | Climate Dynamic1999，15，： | 1 |
| 14 | Dying of Corruption显示文摘 | Holmberg S Rothstein B | | 0，，04： | 1 |
| 15 | Genetic regulation by NLA and microRNA827for maintaining nitratedependent phosphate homeostasis in Arabidopsis显示文摘 | Kant S Peng M Rothstein S J | 2011 | Plos Genetics2011，7，3： | 1 |
| 16 | Drag reduction in turbulent flows over superhydrophobic surfaces显示文摘 | Daniello R J Waterhouse N E Rothstein J P | 2009 | Physics of Fluids2009，21，8： | 1 |
| 17 | Treatment and prognosis of symptomatic gallbladder disease in patients with cystic fibrosis显示文摘 | Stern RC Rothstein FC Doershuk CF | 1986 | Journal of Pediatric Gastroenterology and Nutrition1986，5，1： | 1 |
| 18 | Mechanisms of avian egg recognition: possi- ble learned and innate factors显示文摘 | Rothstein S I | 1974 | The Auk1974，91，： | 1 |
| 19 | Laminar drag reduction in microchannels using ultrahydrophobic surfaces 显示文摘 | Ou J Perot B Rothstein J P | 2004 | Physics of Fluids (S1070-6631)2004，16，12： | 1 |
| 20 | The role of evoked potentials in anoxic-ischemic coma and severe brain trauma 显示文摘 | Rothstein TL | 2000 | J Clin Neurophysiol2000，17，5： | 1 |
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