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| 1 | Is diabetic cardiomyopathy a specific entity?显示文摘Diabetes mellitus(DM) is characterised by hyperglycemia, insulin resistance and metabolic dysregulation leading to diastolic and systolic dysfunction in diabetes. In this review, the pathogenetic and pathomorphological changes leading to diastolic and systolic dysfunction in diabetes are discussed. Changes in metabolic signalling pathways, mediators and effectors contribute to the pathogenesis of cardiac dysfunction in DM called diabetic cardiomyopathy(DC). Echocardiographic studies report on the association between DM and the presence of cardiac hypertrophy and myocardial stiffness that lead to diastolic dysfunction. More recently reported echocardiographic studies with more sensitive techniques, such as strain analysis, also observed systolic dysfunction as an early marker of DC. Depression of systolic and diastolic function is continuum and the line of separation is artificial. To conclude, according to current knowledge, DC is expected to be a common single phenotype that is caused by different pathogenetic and pathomorphological changes leading to diastolic and systolic dysfunction in diabetes. | Mitja Letonja Danijel Petrovi | 2014 | World Journal of Cardiology2014，6，1： | 7 |
| 2 | 核仁素在糖尿病性心肌病中的表达显示文摘目的:探讨核仁素在糖尿病性心肌病中的表达情况。方法:实验分为对照组和II型糖尿病性心肌病模型组(模型组);模型组采用高脂高糖饲料持续喂养(第5,6周于小鼠腹腔注射60 mg/kg链脲佐菌素)构建,第8周末测定小鼠血糖,第20周末测定两组小鼠空腹血糖值并计算心脏质量与体质量的比值,观察心肌形态学病理改变,采用免疫组织化学法和Western印迹检测心肌核仁素的表达水平。结果:糖尿病模型组小鼠较对照组空腹血糖值明显升高(P<0.05);模型组小鼠心肌细胞肥大、排列紊乱,出现断裂及溶解;免疫组织化学染色及Western印迹显示模型组小鼠心肌核仁素蛋白水平较对照组明显升高(P<0.05)。结论:核仁素可能在糖尿病性心肌病的发生和发展中起着一定的作用。 | 孙丽 贺欣 王娟 蒋碧梅 童中艺 刘艳娟 李媛彬 肖献忠 | 2014 | 中南大学学报(医学版)2014，39，10： | 4 |
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