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| 1 | 糖尿病诊断:界定与替换显示文摘几乎所有人群血糖浓度都是单峰分布模式,因此没有明确的分界点来确定糖尿病的诊断。老的标准为空腹血糖浓度(fasting plasma glucose,FPG)≥140mg/dl或者口服葡萄糖耐量试验(oral glucose tolerance test,OGTT)2h血糖浓度≥200mg/dl,选择这样的标准是因为超过这些血糖值的部分病人3-8年后发生了视网膜病变。糖尿病诊断和分类专家委员会将FPG诊断标准降低到126mg/dl,使其和OGTT2h血糖浓度200mg/dl相当。过量的糖化蛋白产物在糖尿病微血管和神经并发症的病例机制中起重要作用。60%的新队列糖尿病病人,其FPG在126mg/dl-139mg/dl,且糖化血红蛋白(HbAIC)水平正常;35%的病人未用药物治疗之前就已经达到美国糖尿病学会(ADA)推荐的目标HbAl<7%。糖尿病病人维持HbAlC水平在7%以下的,6-10年之后几乎极少或者不发生视网膜病变和肾病变,或者巳有的病变不再进展。糖尿病的诊断对保险(生命和医疗),就业、社会和心理花费等均具有负面影响。此外,在糖尿病新的人群中,不论是诊断为糖尿病还是空腹血糖受损都可先予以非药物治疗,因此,以我的观点,FPG血糖标准仍应维持≥140mg/dl,除非有过量的糖化产物即HbAlC≥7%(假定上限值为6%)。依据HbAlC水平升高来诊断FPG<140mg/dl的糖尿病是和老的选择发生视网膜病变的葡萄糖浓度的诊断标准是一致的,因此建议选择性地使用初期FPG浓度加上以后糖化血红蛋白水平的流程来诊断糖尿病。学习目的:了解新推荐的糖尿病诊断中空腹血糖(FPG)标准的变化,以及这一变化导致的糖尿病“新队列”的重要意义。复习糖尿病并发症和FPG水平增高以及糖化血红蛋白(HbAlC)之间的关系。考虑临床实践中对FPG和HbAlC基本治疗可行性以及何种检测对“新队列”病人合适。 | Mayer B Davidson,MD 李玉秀 | 2001 | 世界医学杂志2001，5，10： | 3 |
| 2 | Ximelagatran与低分子肝素加华法令治疗深静脉血栓的比较 随机试验显示文摘背景:Ximelagatran是一种起效快、溶栓作用肯定的口服药,可直接抑制凝血酶。它用药简单,有望取代当前治疗急性静脉血栓栓塞的标准疗法。 | Jean-Noel Fiessinger,MD Menno V. Huisman, MD Bruce L. Davidson, MD 王莉华(译) 诸骏仁(校) | 2005 | 美国医学会杂志(中文版)2005，24，6： | 2 |
| 3 | Lymph Node Tumor Volumes in Patients Undergoing Sentinel Lymph Node Biopsy for Cutaneous Melanoma显示文摘 | Jeffrey D. Wagner MD Darrell Davidson MD PhD John J. Coleman MD Gary Hutchins PhD Donald Schauwecker MD PhD Hee-Myung Park MD Robert J. Havlik MD | 1999 | Annals of Surgical Oncology1999，，4： | 1 |
| 4 | Marine ecoregions of the world:a bioregionalization of coastal and shelf areas显示文摘 | Spalding MD Fox HE Allen GR Davidson N Ferdafia ZA Finlayson M Halpern BS Jorge MA Lombana AL Lourie SA Martin KD Manus EC Molnar J Recchia CA Robertson J | | 0，，： | 1 |
| 5 | An Overview of Metformin in the Treatment of Type 2 Diabetes Mellitus显示文摘 | Mayer B Davidson MD Anne L Peters MD | 1997 | The American Journal of Medicine1997，，1： | 1 |
| 6 | Soluble nickel interferes with cellular iron homeostasis显示文摘 | Davidson T Chen H Garrick MD | 2005 | Mol Cell Biochem2005，279，12： | 1 |
| 7 | Temperature and soil organic matter decomposition rates-synthesis of current knowledge and a way forward显示文摘 | Conant RT Ryan MG Agren GI Birge HE Davidson EA Eliasson PE Evans SE Frey SD Giardina CP Hopkins FM Hyvǒnen R Kirschbaum MUF Lavallee JM Leifeld J Parton WJ Megan Steinweg J Wallenstein MD Martin Wetterstedt JA Bradford MA | | 0，，： | 1 |
| 8 | Infrared thermographic SAR measurements of interstitial hyperthermia applicators:errors due to thermal conduction and convection显示文摘 | Sherar MD Gladman AS Davidson SR | 2004 | Int J Hyperthermia2004，20，5： | 1 |
| 9 | Posterior triangle metastases of squamous cell carcinoma of the upper aerodigestive tract显示文摘 | Davidson BJ Kulkarny V Delacure MD | 1993 | Am J Surg1993，166，4： | 1 |
| 10 | Sleep disturb- ance in cancer patients 显示文摘 | Davidson JR MacLean AW Brundage MD | 2002 | Soc Sci Med2002，54，9： | 1 |
| 11 | Lupus disease activity and the risk of subsequent organ damage and mortality in a large lupus cohort显示文摘 | Lopez R Davidson JE Beeby MD | 2012 | Rheumatology (Oxford)2012，51，： | 1 |
| 12 | Parkin is recruited into aggresomes in a stress-spxcific manner:over-expression of parkin reduces aggresome formation but can be dissociated from parkin's effect on neuronal survival显示文摘 | Davidson SM Smith MD | 2004 | Hum Mol Genet2004，13，： | 1 |
| 13 | Lung cancer treat- ment decisions : Patients' desires for participation and information 显示文摘 | Davidson JR Brundage MD Feldman - Stewart D | 1999 | Psychooncology1999，8，6： | 1 |
| 14 | Association between human immunodeficiency virus and osteonecrosis of the femoral head 显示文摘 | Ries MD Barcohana B Davidson A | 2002 | J Arthroplasty2002，17，： | 1 |
| 15 | Thrombotic thrombocytopenic purpura associated with ticlopidine in the setting of coronary artery stents and stroke prevention显示文摘 | Bennett CL Davidson CJ Raisch DW Weinberg PD Bennett RH Feldman MD | 1999 | Arch Iht Med1999，159，21： | 1 |
| 16 | U-500 regular insulin: clinical experience and pharmacokineties in obese, sev- erely insulin-resistant type 2 diabetic patients显示文摘 | Davidson MB Navar MD Eeheverry D | 2010 | Diabetes Care2010，33，2： | 1 |
| 17 | Effects of a novel DNA methyltransferase inhibitor zebularine on human breast cancer ceils 显示文摘 | Billam M Sobolewski MD Davidson NE | 2010 | Breast Cancer Res Treat2010，120，3： | 1 |
| 18 | Total substitution of hromedeoxyuridine for thymidine in the DNA of a hromodeoxyuridine-dependent cell line显示文摘 | Bick MD Davidson RL | 1974 | Proc Natl Aced Sci USA1974，71，5： | 1 |
| 19 | How do we diagnose diabetes and measure blood glueose control显示文摘 | Mayer B Davidson MD | 2001 | Diaberess Petrum2001，14，： | 1 |
| 20 | Interstitial microwave thermal therapy and its application to the treatment of recurrent prostate cancer 显示文摘 | Sherar MD Trachtenberg J Davidson SR | 2004 | Int J Hyperthermia2004，20，7： | 1 |
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