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| 1 | 急性肾损伤诊断与分类专家共识显示文摘近几十来.临床和基础的研究工作者们针对急性肾功能衰竭(ARF)进行了广泛的研究,尽管我们在该疾病的生理和发病机制方面都取得了长足的进步,但如何将这些知识用于临床,改进ARF患者预后方面的工作却做得十分有限。ARF是由多种病因导致、可发生在各种临床情况之下(儿童或成人、门诊或住院、ICU或非ICU患者)的一种复杂的肾功能紊乱,其临床表现既可以是血肌酐水平的轻微升高,也可以是无尿性肾功能衰竭。 | RL Mehta JA Kellum S Shah B Molitoris C Ronco D Warnock A Levin 王欣 | 2006 | 中华肾脏病杂志2006，22，11： | 348 |
| 2 | Early palliative care for patients with metastatic non-small-cell lung cancer显示文摘Comments This landmark article demonstrates that integration of early palliative care with standard oncologic practice shortly after diagnosis may improve quality of life,mood,and overall survival for adults with advanced non-small-cell lung cancer(NSCLC).If validated,these findings could support a paradigm shift in the care of adults with metastatic NSCLC and possibly patients with other tumor types characterized by short survival and high symptom burden. | Temel JS Greer JA Muzikansky A Gallagher ER Admane S Jackson VA Dahlin CM Blinderman CD Jacobsen J Pirl WF Billings JA Lynch TJ | 2010 | 中国肺癌杂志2010，13，9： | 165 |
| 3 | 2022年WHO甲状腺肿瘤分类概述显示文摘2022年WHO第5版甲状腺肿瘤分类按细胞起源、病理特征、分子分型及生物学行为,分为良性、低危组和恶性。新分类变化不少,作者做了综述。将发育异常甲状舌管纳入;为避免结节性甲状腺肿定义为增生性、肿瘤性或矛盾的“腺瘤样增生”,编委会达成共识,命名为甲状腺滤泡结节性病变(FND)。基于分子谱和侵袭性,多种形态亚型的甲状腺乳头状癌(PTC)代表了BRAF样癌(浸润性生长、核非典型明显);而包裹型浸润性乳头状癌滤泡变异型/[IEFVPC,分子检测证实与滤泡性甲状腺癌(FTC)关系密切,不再归于PTC]与FTC代表RAS样癌(膨胀性生长、核非典型轻度)。 | Baloch ZW Asa SL Barletta JA 方三高(译) 魏建国(校) | 2022 | 诊断病理学杂志2022，29，12： | 63 |
| 4 | 生物可吸收依维莫司洗脱冠状动脉支架系统2年随访及多种成像法结果显示文摘生物可吸收支架较金属药物洗脱支架(DES)有可能减少晚期支架内血栓(ST)的发生,因不存在外源性的金属材料和血液相接触,所以不必顾虑血管内皮化延迟或不完全。此外,永久置入的金属支架会影响外科血运重建,堵塞边支血管,妨碍血管的扩张性重塑和血管舒缩反应,还将影响非介入性检查如冠脉多层CT和MRI的成像。 | Serruys PW Ormiston JA Onuma Y 张瑞生 | 2009 | 中国心血管杂志2009，14，2： | 49 |
| 5 | 数字图像的质量评价显示文摘图像质量评价的研究已成为图像信息工程的基础技术之一。本文对目前一些典型的数字图像质量评价方法进行了简要综述 ,并着重介绍了一种基于视觉兴趣的图像质量评价方法 ,最后指出了图像质量评价研究可能发展的方向。 | 汪孔桥 Kang.,JA | 2000 | 测控技术2000，19，5： | 43 |
| 6 | The promise and challenge of therapeutic genome editing显示文摘Genome editing,which involves the precise manipulation of cellular DNA sequences to alter cell fates and organism traits,has the potential to both improve our understanding of human genetics and cure genetic disease.Here I discuss the scientific,technical and ethical aspects of using CRISPR(clustered regularly interspaced short palindromic repeats)technology for therapeutic applications in humans,focusing on specific examples that highlight both opportunities and challenges.Genome editing is-or will soon be-in the clinic for several diseases,with more applications under development.The rapid pace of the field demands active efforts to ensure that this breakthrough technology is used responsibly to treat,cure and prevent genetic disease. | Doudna JA | 2020 | 四川生理科学杂志2020，42，1： | 30 |
| 7 | 手术夹闭与血管内弹簧栓塞对动脉瘤蛛网膜下腔出血后症状性血管痉挛的发生率与预后的影响显示文摘 | Rabinstein AA Pichelmann MA Friedman JA 李林 | 2003 | 中国微侵袭神经外科杂志2003，8，4： | 29 |
| 8 | Establishment and characterization of four human hepatocellular carcinoma cell lines containing hepatitis B virus DNA显示文摘INTRODUCTIONHepatocelularcarcinoma(HCC)isoneofthemostprevalentmalignantdiseasesencounteredintheworld,kilingupto1milionpeoplea... | Jae Ho Lee 1, Ja Lok Ku 1, Young Jin Park 1,2 , Kuhn Uk Lee 2, Woo Ho Kim 3 and Jae Gahb Park 1,2 | 1999 | World Journal of Gastroenterology1999，5，4： | 28 |
| 9 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 10 | 妊娠期细菌性阴道病显示文摘 | McGr.,JA 张羽 等 | 2001 | 世界医学杂志2001，5，1： | 19 |
| 11 | Acute liver failure is frequent during heat stroke显示文摘Acute liver failure (ALF) is relatively frequent during heat stroke (HS). This risk must be emphasized, because its incidence is higher than is usually thought. In a recent study by Weigand et al , two cases were reported in which liver failure was the leading symptom. We have confirmed their conclusion in a study of 25 cases of HS with ALF, compared with 25 other cases without ALF. Moreover, we observed that hypophosphatemia on admission could predict occurrence of ALF during HS. As for clinical and other biological parameters, phosphatemia should be monitored for at least 3 d in all cases of HS, even when it is thought to be mild. | JM Garcin JA Bronstein S Cremades P Courbin F Cointet | 2008 | World Journal of Gastroenterology2008，14，1： | 18 |
| 12 | 住院老年病人的非药物睡眠方法显示文摘 | Mcdo.,JA Mion.,LC | 1999 | 世界医学杂志1999，3，5： | 17 |
| 13 | 108例创伤性动静脉瘘的介入诊疗分析显示文摘目的分析创伤性动静脉瘘(AVF)的临床特点、造影表现、造影技术及治疗方式的选择。方法回顾性分析纽约Kings County医疗中心25年间全部确诊的108例创伤性AVF的介入相关诊疗资料。分析内容包括患者外伤种类、临床表现、损伤部位、血管造影异常特征、AVF血流动力学特征(分5个类型)、治疗方式的选择等。结果 108例患者中共发现117处AVF,大多数患者临床特征不明确。创伤种类包括枪伤(导致72处AVF)、刺伤(24处)、钝性伤(8处)、高处坠落伤(3处)、医源性损伤(2处)。损伤部位常见于肢体(46例)、颈部(19例)、肝脏(13例)和锁骨下血管(11例)。所有病变均可见静脉早显,显示动脉横断52处,撕裂37处,49.6%的AVF与假性动脉瘤有关。最常见的血流特点是Ⅰ型,即瘘口所在的动脉近段和远段、静脉的近段和远段都显示,伴远侧段静脉瓣功能不全,共40处瘘(34.2%),其次是Ⅲ型22个(18.8%),Ⅴ型最不常见(4.3%)。34例接受手术治疗,61例栓塞治疗,7例临床观察。分别采用弹簧圈(47例)、明胶海绵(9例)、无水乙醇(3例)、可脱球囊(2例),其中弹簧圈效果理想、并发症少。6例采用覆膜支架效果好。结论血管造影是诊断创伤性AVF的金标准,造影时准确观察动脉损伤的性质,瘘口的解剖和血流特点及所有进入瘘口的动脉分支,对于选择治疗方式及保证介入治疗的成功完成至关重要。 | 王晓东 Salvatore JA Sclafani | 2010 | 介入放射学杂志2010，19，7： | 16 |
| 14 | NDCI法Ⅱ类水体叶绿素a浓度高光谱遥感数据估算显示文摘以太湖、巢湖为研究区,以Hyperion和HJ-1A卫星HSI高光谱数据以及实测水质浓度数据为实验数据,引入归一化叶绿素指数(NDCI),对Ⅱ类水体的高光谱叶绿素a浓度估算进行分析研究.首先对高光谱数据的光谱通道设置以及水体光谱特征进行分析,研究确定模型的最优波段.然后,将确定最优波段后的NDCI反射率因子作为变量与实测样本点数据进行回归分析,得到NDCI与叶绿素a浓度之间的回归关系,进行叶绿素a浓度的估算.与常用的比值法、一阶微分法和三波段法相比,NDCI的性能优于这3种方法,表明NDCI是一种计算简单、估算精度高、实用性强的Ⅱ类水体叶绿素a浓度估算方法. | 安如 刘影影 曲春梅 Quaye-Ballard JA 梁欣 徐晓峰 王喆 姜丹萍 | 2013 | 湖泊科学2013，25，3： | 16 |
| 15 | 多发性硬化基于病程的分型(2013版)简介显示文摘1996年,美国全国多发性硬化协会(US National Multiple Sclerosis Society, NMSS)的临床试验建议委员会(Advisory Committee on Clinical Trials in Multiple Sclerosis)根据对多发性硬化(multiple sclerosis,MS)专家的调查问卷确立了MS基于病程的临床分型,旨在明确自然史和人口学研究的亚组定义、促进临床试验受试者的均质化纳入以及在医生和MS患者之间的明确交流,确定了复发缓解型(RRMS)、继发进展型(SPMS)、原发进展型(PPMS)和进展复发型(PRMS)四种类型,并给出了良性和恶性MS的定义。 | Lublin FD Reingold SC Cohen JA 李海峰 | 2014 | 中国神经免疫学和神经病学杂志2014，21，4： | 16 |
| 16 | 不同湖泊入湖河流沉积物可转化态氮的空间分布及其影响因素显示文摘研究河流沉积物氮形态的分布可以了解流域的水环境现状.本研究通过分级浸取方法得到沉积物的离子交换态氮(IEF-N)、弱酸浸取态氮(WAEF-N)、强碱浸取态氮(SAEF-N)以及强氧化剂浸取态氮(SOEF-N),对比研究了太湖西部入湖河流(东苕溪、西苕溪)和洪泽湖西部入湖河流(安河、濉河)沉积物中氮形态的空间分布特征,分析了可转换态氮的主要影响因素.结果表明,不同流域之间沉积物的基本理化性质存在明显的差异,导致沉积物总氮以及可转化态氮的含量及空间分布也不相同.总体而言,太湖西部河流沉积物中总氮和总可转化态氮的含量略高于洪泽湖西部河流,但前者的空间变化小于后者.太湖西部河流沉积物与洪泽湖西部河流沉积物的可转化态氮含量大小排列顺序也有所不同,前者为SOEF-N>SAEF-N>WAEF-N>IEF-N,后者为SOEF-N>SAEF-N>IEF-N>WAEF-N,且后者各形态氮的含量变化更为明显,这主要与沉积物的组成和氮来源有关.研究区沉积物中可转化态氮的分布受其理化性质的影响明显,尤以有机质和粒度的影响最明显. | 周睿 袁旭音 Marip Ja Bawk 于辉辉 章琪 唐豆豆 | 2018 | 环境科学2018，39，3： | 16 |
| 17 | Prognostic significance of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with stage Ⅲ and Ⅳcolorectal cancer显示文摘AIM To evaluate the prognostic value of the neutrophil-tolymphocyte ratio(NLR) and platelet-to-lymphocyte ratio(PLR) in patients with colorectal cancer(CRC).METHODS Between April 1996 and December 2010, medical records from a total of 1868 patients with CRC were retrospectively reviewed. The values of simple inflammatory markers including NLR and PLR in predicting the long-term outcomes of these patients were evaluated using Kaplan-Meier curves and Cox regression models.RESULTS The median follow-up duration was 46 mo(interquartile range, 22-73). The estimation of NLR and PLR was based on the time of diagnosis. In multivariate Cox regression analysis, high NLR (≥ 3.0) and high PLR(≥ 160) were independent risk factors predicting poor long-term outcomes in patients with stage Ⅲ and Ⅳ CRC. However, high NLR and high PLR were not prognostic factors in patients with stage Ⅰ and Ⅱ CRC.CONCLUSION In this study, we identified that high NLR (≥ 3.0) and high PLR (≥ 160) are useful prognostic factors to predict long-term outcomes in patients with stage Ⅲ and Ⅳ CRC. | Jae Hyun Kim Jun Yeop Lee Hae Koo Kim Jin Wook Lee Sung Gyu Jung Kyoungwon Jung Sung Eun Kim Won Moon Moo In Park Seun Ja Park | 2017 | World Journal of Gastroenterology2017，23，3： | 16 |
| 18 | Gastric cancer patients at high-risk of having synchronous cancer显示文摘瞄准:识别病人与一在胃的癌症病人之中有同步癌症高风险。方法:我们回顾地在国家癌症中心分析了未来的胃的癌症数据库,从 2000 年 12 月的朝鲜到 2004 年 12 月。有没有同步癌症的病人的同步癌症和那些的病人的 clinicopathological 特征被比较。Multivariate 分析被执行在胃的癌症病人为同步癌症的存在识别风险因素。结果:在数据库登记的 3291 个胃的癌症病人(3.4%) 中的 111 个有同步癌症。在这 111 个病人之中, 109 有单个同步癌症, 2 个病人有二同步癌症。同步癌症的最普通的形式是颜色表面的癌症(42 个病人, 37.2%) 由肺癌症列在后面(21 个病人, 18.6%) 。Multivariate 分析表明有区分的早胃的癌症的老病人有同步癌症的更高的可能性。结论:在胃的癌症病人的同步癌症不是很少发生的。医生应该试着在胃的癌症病人发现同步癌症,在特别与区分的早胃的癌症老。 | Jun Ho Lee Ja Seong Bae Keun Won Ryu Jong Seok Lee Sook Ryun Park Chan Gyoo Kim Myoung Cheorl Kook Il Ju Choi Young Woo Kim Jae-Gahb Park Jae-Moon Bae | 2006 | World Journal of Gastroenterology2006，12，16： | 15 |
| 19 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 20 | Modulatory effect of pineapple peel extract on lipid peroxidation,catalase activity and hepatic biomarker levels in blood plasma of alcoholinduced oxidative stressed rats显示文摘Objective:To investigate the ability of the methanolic extract of pineapple peel to modulate alcohol-induced lipid peroxidation,changes in catalase activities and hepatic biochemical marker levels in blood plasma.Methods:Oxidative stress was induced by oral administration of ethanol(20%w/v) at a dosage of 5 niL/kg bw in rats.After 28 days of treatment,the rats were fasted overnight and sacrificed by cervical dislocation.Blood was collected with a 2 mL syringe by cardiac puncture and was centrifuged at 3000 rpm for 10 min.The plasma was analyzed to evaluate malondialdehyde(MDA),catalase activity,aspartate aminotransferase(AST),alkaline phosphatase(ALP) and alanine aminotransferase(ALT) concentrations.Results:Administration of alcohol caused a drastic increase(87.74%) in MDA level compared with the control.Pineapple peel extract significantly reduced the MDA level by 60.16%at 2.S mL/kg bw.Rats fed alcohol only had the highest catalase activity,treatment with pineapple peel extract at 2.5 mL/kg bw however, reduced the activity.Increased AST,ALP and ALT activities were observed in rats fed alcohol only respectively,treatment with pineapple peel extract drastically reduced their activities. Conclusions:The positive modulation of lipid peroxidation,catalase activities as well as hepatic biomarker levels of blood plasma by the methanolic extract of pineapple peels under alcoholinduced oxidative stress is an indication of its protective ability in the management of alcoholinduced toxicity. | Okafor OY Erukainure OL Ajiboye JA Adejobi RO Owolabi FO Kosoko SB | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，1： | 13 |
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