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| 1 | Diabetic neuropathic pain:Physiopathology and treatment显示文摘Diabetic neuropathy is a common complication of both type 1 and type 2 diabetes,which affects over 90% of the diabetic patients.Although pain is one of the main symptoms of diabetic neuropathy,its pathophysiological mechanisms are not yet fully known.It is widely accepted that the toxic effects of hyperglycemia play an important role in the development of this complication,but several other hypotheses have been postulated.The management of diabetic neuropathic pain consists basically in excluding other causes of painful peripheral neuropathy,improving glycemic control as a prophylactic therapy and using medications to alleviate pain.First line drugs for pain relief include anticonvulsants,such as pregabalin and gabapentin and antidepressants,especial y those that act to inhibit the reuptake of serotonin and noradrenaline.In addition,there is experimental and clinical evidence that opioids can be helpful in pain control,mainly if associated with first line drugs.Other agents,including for topical application,such as capsaicin cream and lidocaine patches,have also been proposed to be useful as adjuvants in the control of diabetic neuropathic pain,but the clinical evidence is insufficient to support their use.In conclusion,a better understanding of the mechanisms underlying diabetic neuropathic pain will contribute to the search of new therapies,but also to the improvement of the guidelines to optimize pain control with the drugs currently available. | Anne K Schreiber Carina FM Nones Renata C Reis Juliana G Chichorro Joice M Cunha | 2015 | World Journal of Diabetes2015，6，3： | 34 |
| 2 | Sorafenib inhibits growth and metastasis of hepatocellular carcinoma by blocking STAT3显示文摘AIM: To investigate the inhibitory role and the underlying mechanisms of sorafenib on signal transducer and activator of transcription 3 (STAT3) activity in hepatocellular carcinoma (HCC).METHODS: Human and rat HCC cell lines were treated with sorafenib. Proliferation and STAT3 dephosphorylation were assessed. Potential molecular mechanisms of STAT3 pathway inhibition by sorafenib were evaluated. In vivo antitumor action and STAT3 inhibition were investigated in an immunocompetent orthotopic rat HCC model.RESULTS: Sorafenib decreased STAT3 phosphorylationat the tyrosine and serine residues (Y705 and S727), but did not affect Janus kinase 2 (JAK2) and phosphatase shatterproof 2 (SHP2), which is associated with growth inhibition in HCC cells. Dephosphorylation of S727 was associated with attenuated extracellular signal-regulated kinase (ERK) phosphorylation, similar to the effects of a mitogen-activated protein kinase (MEK) inhibitor U0126, suggesting that sorafenib induced S727 dephosphorylation by inhibiting MEK/ERK signaling. Meanwhile, sorafenib could also inhibit Akt phosphorylation, and both the phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002 and Akt knockdown resulted in Y705 dephosphorylation, indicating that Y705 dephosphorylation by sorafenib was mediated by inhibiting the PI3K/Akt pathway. Finally, in the rat HCC model, sorafenib signifi cantly inhibited STAT3 activity, reducing tumor growth and metastasis.CONCLUSION: Sorafenib inhibits growth and metastasis of HCC in part by blocking the MEK/ERK/STAT3 and PI3K/Akt/STAT3 signaling pathways, but independent of JAK2 and SHP2 activation. | Fang-Ming Gu, Quan-Lin Li, Qiang Gao, Jia-Hao Jiang, Xiao-Yong Huang, Jin-Feng Pan, Jia Fan, Jian ZhouFang-Ming Gu, Quan-Lin Li, Qiang Gao, Jia-Hao Jiang, Xiao-Yong Huang, Jin-Feng Pan, Jia Fan, Jian Zhou, Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Shanghai 200032, China Author contributions: Gu FM, Li QL and Gao Q contributed equally to this work Gu FM and Li QL performed the experi- ments and interpretation of the data and statistical analysis Zhou J and Gao Q contributed to the conception and design of the study Gu FM, Gao Q, Li QL and Zhou J wrote the manuscript Jiang JH, Huang XY, Pan JF and Fan J made substantial contri- bution to the design and conception of the study and interpreta- tion of data all authors read and approved the f inal manuscript. | 2011 | World Journal of Gastroenterology2011，17，34： | 18 |
| 3 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 4 | 血流介导的血管舒张,硝酸甘油诱导的血管舒张,基线肱动脉直径,充血剪切应力与心血管病危险因素之间的相关性显示文摘血流介导的血管舒张功能(flow-mediated vasodilation,FMD)已被用于评估内皮功能。充血性剪切应力(hyperemic shear stress,HSS,一种FMD的刺激因素)、硝酸甘油诱导的血管舒张(nitroglycerine-induced vasodilation,NID,非内皮依赖性血管舒张指数)以及基线肱动脉直径(brachial artery diameter,BAD)也参与血管舒张反应。 | 刘青 叶鹏 Maruhashi T Iwamoto Y Kajikawa M Oda N Kishimoto S Matsui S Hashimoto H Aibara Y Yusoff FM Hidaka T Kihara Y Chayama K Noma K Nakashima A Goto C Hida E Higashi Y | 2018 | 中华高血压杂志2018，26，1： | 5 |
| 5 | New fecal test for non-invasive Helicobacter pylori detection:A diagnostic accuracy study显示文摘AIM To assess the diagnostic accuracy of a new fecal test for detecting Helicobacter pylori(H. pylori), using ^(13)Curea breath test as the reference standard, and explore bacterial antibiotic resistance. METHODS We conducted a prospective two-center diagnostic test accuracy study. We enrolled consecutive people≥ 18 years without previous diagnosis of H. pylori infection, referred for dyspepsia between February and October 2017. At enrollment, all participants underwent 13 C-urea breath test. Participants aged over 50 years were scheduled to undergo upper endoscopy with histology. Participants collected stool samples 1-3 d after enrollment for a new fecal investigation(THD fecal test). The detection of bacterial 23 S rRNA subunit gene indicated H. pylori infection. We also used the index diagnostic test to examine mutations conferring resistance to clarithromycin and levofloxacin. Independent investigators analyzed index test and reference test standard results blinded to the other test findings. We estimated sensitivity, specificity, positive(PPV) and negative(NPV) predictive value, diagnostic accuracy, positive and negative likelihood ratio(LR), together with 95% confidence intervals(CI).RESULTS We enrolled 294 consecutive participants(age: Median 37.0 years, IQR: 29.0-46.0 years; men: 39.8%). Ninetyfive(32.3%) participants had a positive ^(13)C-urea breath test. Twenty-three(7.8%) participants underwent upper endoscopy with histology, with a full concordance between ^(13)C-urea breath test and histology in detecting H. pylori infection. Four(1.4%) out of the 294 participants withdrew from the study after the enrollment visit and did not undergo THD fecal testing. In the 290 participants who completed the study, the THD fecal test sensitivity was 90.2%(CI: 84.2%-96.3%), specificity 98.5%(CI:96.8%-100%), PPV 96.5%(CI: 92.6%-100%), NPV 95.6%(CI: 92.8%-98.4%), accuracy 95.9%(CI: 93.6%-98.2%), positive LR 59.5(CI: 19.3-183.4), negative LR 0.10(CI: 0.05-0.18). Out of 83 infected participants identified with the THD fecal test, 34(41.0%) had bacterial genotypic changes consistent with antibiotic-resistant H. pylori infection. Of these, 27(32.5%) had bacterial strains resistant to clarithromycin, 3(3.6%) to levofloxacin, and 4(4.8%) to both antibiotics. CONCLUSION The THD fecal test has high performance for the non-invasive diagnosis of H. pylori infection while additionally enabling the assessment of bacterial antibiotic resistances. | Andrea Iannone Floriana Giorgio Francesco Russo Giuseppe Riezzo Bruna Girardi Maria Pricci Suetonia C Palmer Michele Barone Mariabeatrice Principi Giovanni FM Strippoli Alfredo Di Leo Enzo Ierardi | 2018 | World Journal of Gastroenterology2018，24，27： | 5 |
| 6 | 寨卡病毒感染胎儿脑组织小神经胶质细胞并诱发炎症显示文摘卷土重来的寨卡病毒震惊了世界,巴西小头畸形的报道持续增加。寨卡病毒能够感染人类神经前体细胞,损害大脑生长。但目前尚缺乏寨卡病毒感染人类胎儿脑组织的直接证据。作者等对9份因寨卡病毒感染而终止妊娠的胎儿脑细胞标本进行了研究。 | Lum FM Low DK Fan Y 吴俊珍 刘笑芬 | 2017 | 中国感染与化疗杂志2017，17，5： | 5 |
| 7 | 下颌骨髁突骨折伴关节软组织损伤及其对口腔功能的影响显示文摘大多数关于下颌骨髁突骨折治疗优化的研究首先关注骨性方面,然而,下颌骨髁突骨折可能与颞下颌关节软组织损伤一起发生。本研究进行了关于该主题的文献检索,使用观察性队列和横断面研究的质量评估工具进行评估。回顾16篇文献显示,囊内骨折和脱位的髁突骨折导致更严重的损伤。 | Weinberg FM Speksnijder CM Forouzanfar T 赵泽亮 | 2019 | 中国口腔颌面外科杂志2019，17，2： | 5 |
| 8 | 一种离散点插值算法用于重建光谱反射率显示文摘提出了一种用离散点插值算法来重建光谱反射率的方法。首先建立数字相机响应值与典型反射样品表面光谱反射率之间的查找表,然后进行Delaullay分区、提取和插值,最后通过数字相机的输出数据来准确地重建物体表面的光谱反射率。实验结果表明,该方法能够重建典型反射样品的光谱反射率,能够实时获取被摄场景的多光谱图像,易于硬件的实现。 | 杨萍 廖宁放 FM Abed 李宝聚 | 2008 | 光学技术2008，34，6： | 4 |
| 9 | Single-nucleotide polymorphisms of matrix metalloproteinases and their inhibitors in gastrointestinal cancer显示文摘Matrix metalloproteinases(MMPs) are implicated in cancer development and progression and are associated with prognosis.Single-nucleotide polymorphisms(SNPs) of MMPs,most frequently located in the promoter region of the genes,have been shown to influence cancer susceptibility and/or progression.SNPs of MMP-1,-2,-3,-7,-8,-9,-12,-13 and-21 and of the tissue inhibitor of metalloproteinases(TIMPs) TIMP-1 and TIMP-2 have been studied in digestive tract tumors.The contribution of these polymorphisms to the cancer risk and prognosis of gastrointestinal tumors are reviewed in this paper. | Alexandra MJ Langers Hein W Verspaget Daniel W Hommes Cornelis FM Sier | 2011 | World Journal of Gastrointestinal Oncology2011，3，6： | 4 |
| 10 | 环境中的药物——LC-MS/MS分析地表水和地下水显示文摘 | Alida(Linda)AM Stolker Willem Niesing Frank Bakker Johanna(Ans)FM Versteegh Elbert A Hogendoorn Udo A Th Brinkman | 2007 | 环境化学2007，26，4： | 4 |
| 11 | Antioxidant enriched enteral nutrition and oxidative stress after major gastrointestinal tract surgery显示文摘AIM: To investigate the effects of an enteral supple-ment containing antioxidants on circulating levels of antioxidants and indicators of oxidative stress after major gastrointestinal surgery.METHODS: Twenty-one patients undergoing major upper gastrointestinal tract surgery were randomised in a single centre, open label study on the effect of postoperative enteral nutrition supplementedwith antioxidants. The effect on circulating levels of antioxidants and indicators of oxidative stress, such as F2-isoprostane, was studied. RESULTS: The antioxidant enteral supplement showed no adverse effects and was well tolerated. After surgery a decrease in the circulating levels of antioxidant parameters was observed. Only selenium and glutamine levels were restored to pre-operative values one week after surgery. F2-isoprostane increased in the first three postoperative days only in the antioxidant supplemented group. Lipopolysaccharide binding protein (LBP) levels decreased faster in the antioxidant group after surgery.CONCLUSION: Despite lower antioxidant levels there was no increase in the circulating markers of oxidative stress on the first day after major abdominal surgery. The rise in F2-isoprostane in patients receiving the antioxidant supplement may be related to the conversion of antioxidants to oxidants which raises questions on antioxidant supplementation. Module AOX restored the postoperative decrease in selenium levels. The rapid decrease in LBP levels in the antioxidant group suggests a possible protective effect on gut wall integrity. Further studies are needed on the role of oxidative stress on outcome and the use of antioxidants in patients undergoing major abdominal surgery. | Mireille FM van Stijn Gerdien C Ligthart-Melis Petra G Boelens Peter G Scheffer Tom Teerlink Jos WR Twisk Alexander PJ Houdijk Paul AM van Leeuwen | 2008 | World Journal of Gastroenterology2008，14，45： | 4 |
| 12 | 一九九五年度地下开采年评显示文摘一九九五年度地下开采年评FrankM.Russell如果认为60年代和70年代是开采大型贱金属露天矿的时期,80年代是开发小型露天矿时期,那么,90年代则可以被认为是露天矿转地下开采的年代。目前,计划转为地下开采的露天矿有:(1)美国亚利桑那州的Mi... | Russ.,FM | 1996 | 有色矿山1996，，2： | 4 |
| 13 | Initial assessment of chest X-ray in thoracic trauma patients: Awareness of specific injuries显示文摘AIM: To compare the reported injuries on initial assessment of the chest X-ray (CXR) in thoracic trauma patients to a second read performed by a dedicated trauma radiologist. METHODS: By retrospective analysis of a prospective database, 712 patients with an injury to the chest admitted to the University Medical Center Utrecht were studied. All patients with a CXR were included in the study. Every CXR was re-evaluated by a trauma radiologist, who was blinded for the initial results. The findings of the trauma radiologist regarding rib fractures, pneumothoraces, hemothoraces and lung contusions were compared with the initial reports from the trauma team, derived from the original patient files. RESULTS: A total of 516 patients with both thorax trauma and an initial CXR were included in the study. After re-evaluation of the initial CXR significantly more lung contusions (53.3% vs 34.1%, P < 0.001), hemothoraces (17.8% vs 11.0%, P < 0.001) and pneumothoraces (34.4% vs 26.4%, P < 0.001) were detected.During initial assessment significantly more rib fractures were reported (69.8% vs 62.3%, P < 0.001). CONCLUSION: During the initial assessment of a CXR from trauma patients in the emergency department, a significant number of treatment-dictating injuries are missed. More awareness for these specific injuries is needed. | Tjeerd S Aukema Ludo FM Beenen Falco Hietbrink Luke PH Leenen | 2012 | World Journal of Radiology2012，4，2： | 3 |
| 14 | Evaluation of the Effects of Cypermethrin on Female Reproductive Function by Using Rabbit Model and of the Protective Role of Chinese Propolis显示文摘对 cypermethrin 毒性的中国 propolis 的预防效果被执行卵巢和子宫组织病理学说,以及由描绘卵巢的功能,胚胎,和崽评估。Cypermethrin 在卵巢和子宫导致了 atypia,并且减少排卵地点和胚胎的数字。导致 Cypermethrin 的氧化应力在怀孕期间,减少后代的生产率以及数字和重量并且在后代增加了词法畸形性的发生。到对待 cypermethrin 的动物的 propolis 的管理减轻了导致 cypermethrin 的繁殖毒性。 | AE Khatab NM Hashem LM El-Kodary FM Lotfy GA Hassan | 2016 | Biomedical and Environmental Sciences2016，29，10： | 3 |
| 15 | 量表评估效度的项目反应理论(英文)显示文摘项目反应理论(Item response theory,IRT)是用来评估精神病学领域那些尚未被充分使用的测量量表效度一种重要方法。IRT描述了潜在心理特征(例如,该量表拟评估心理问题的架构)、量表中各项目的属性、以及被测试者对各项目应答之间的关系。本文介绍了IRT的基本前提,假设和方法。为了帮助解释这些概念,我们依据流行病学调查中心抑郁量表修订版中三个答案为是/否二分类选项的问题制定了一个假设的量表。流行病学调查中心抑郁量表已经用于19,399被测试者。我们首先用因子分析确认这三个项目的单维性,然后用Mplus软件建立2-Parameter Logic(2-PL)IRT模型,这是一种用来评估量表中各项目两两差异和项目难度的方法。本文将就这些分析结果的临床意义和在量表结构中的用途展开讨论。 | Yang FM Kao ST | 2014 | 上海精神医学2014，26，3： | 3 |
| 16 | 倾斜试验中血管迷走性晕厥患者血流动力学和神经激素的变化显示文摘目的 探讨血管迷走性晕厥患者倾斜试验中血流动力学和神经激素的变化及晕厥触发机制。方法 倾斜试验采用平卧 10min和倾斜80°直立 30 min。试验阳性标准为晕厥先兆伴收缩期血压<90 mmHg(1mmHg= 0.133 kPa)和/或心率<60次/min。超声心动图于基础平卧,直立 2min和每隔3min直至试验结束时连续记录左心室收缩末期内径(LVES),左心室舒张末期内径(LVEDD),短轴缩短分数(SF)和心排出量(CO)。同时测量儿茶酚胺血浆浓度。I组为正常自愿者且倾斜试验阴性者8例,Ⅱ组为原因不明晕厥伴倾斜试验阴性者8例,Ⅲ组为原因不明晕厥伴倾斜试验阳性者16例。结果3组间年龄、性别以及基础状态下心率、平均动脉压、左心室内径、SF、CO和儿茶酚胺血浆浓度差别不明显。I组和Ⅱ组完成了30min直立试验,Ⅲ组出现阳性反应时间为(10±4)min。直立时各组发生的改变为(1)I组和Ⅱ组虽心率明显增加,但血压稳定。Ⅲ组心率增快和血压逐渐下降,终止试验时心率由(110±22)次/min突然降至(82±16)次/min,平均动脉压由(78±14)mmHg降至(50±9)mm Hg,10例为血管抑制性晕厥,6例为混合? | 王珂 林治湖 Leonelli FM | 2001 | 中华心律失常学杂志2001，5，6： | 3 |
| 17 | Molecular genetic investigations of the mechanism of tumourgenesis in von Hippel-Lindau disease:analysis of allele loss in VHL tumors 显示文摘 | Foster K Crossey PA Richards FM | 1994 | Hum Mol Genet1994，3，： | 2 |
| 18 | Molecular genetic analysis of von Hippel-Lindau disease显示文摘 | Richards FM Webster AR McMahon R | 1998 | J Intern Med1998，243，： | 2 |
| 19 | 倾斜试验中真假阳性的血流动力学和神经激素的研究显示文摘目的 探讨血管迷走性晕厥患者和正常人倾斜试验阳性时不同的触发机制。方法 倾斜试验采用静息平卧 10min和 80°直立 30min。心脏监测仪连续监测心率和血压。试验阳性标准为晕厥先兆伴收缩压 <90mmHg (1mmHg =0 .133kPa)和 (或 )心率 <6 0次 /min。超声心动图于基础平卧 ,直立 2min和每隔 3min直至试验结束时连续记录左室内径及降低速率 ,左室短轴缩短分数 (SF)和每分心输出量 (CO)。同时测量平卧和直立时儿茶酚胺血浆浓度。试验分组为 :正常自愿者且倾斜试验阴性者 8例 (组 1) ,平均年龄 (34± 5 )岁 ;正常自愿者伴倾斜试验阳性者 8例 (组 2 ) ,平均年龄(31± 6 )岁 ;原因不明晕厥伴倾斜试验阳性者 16例 (组 3) ,平均年龄 (30± 9)岁。结果 三组间年龄、性别以及基础状态下心率 ,平均动脉压、左室内径、SF、CO和儿茶酚胺血浆浓度无明显差异。直立时各组发生改变为 :(1)组 3出现阳性反应时间明显短于组 2 [(10± 4)min比 (17± 8)min ,P <0 .0 5 ];(2 )组 3平均动脉压有即刻和持续性降低 ;(3)组 3左室舒张末期内径降低速率明显大于其他两组 ;(4)SF在组 3显著增强 ;(5 )肾上腺素浓度在组 3升高显著 ,试验终止时组 1为 (6 5± 35 )pg/ml,组 2为(78± 2 9)pg/ml,组 3为 (12 6± 80 )pg/ml (P均 <0 .0 | 王珂 逄健 FM Leonelli | 2001 | 中华心血管病杂志2001，29，8： | 2 |
| 20 | 云南红豆杉中紫杉烷类化合物的分离与鉴定显示文摘目的 为了进一步研究红豆杉中的紫杉烷二萜类化合物 ,对生长在我国的云南红豆杉 Taxus yunnanensis进行深入的化学研究。方法 云南红豆杉枝叶的乙醇提取物 ,经萃取、硅胶柱层析、PTLC、制备 HPLC等方法分离 ,从乙醇提取物的二氯甲烷萃取部分分离得到 5个化合物 ,采用波谱解析 (U V,IR,ESI-MS,1 HNMR,1 3 CNMR)等方法确定了它们的结构。结果 分别为 1-acetoxy-baccatin ( ) ,7-epi-taxol( ) ,taxchinin A( ) ,cephalemannine( )和 taxol( )。结论 化合物 为新化合物 ,化合物 、 | 梁敬钰 杨路 程奇蕾 Zheng FM 魏秀丽 张颖 | 2002 | 中草药2002，33，4： | 2 |
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