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| 1 | 材料基因组与相图计算显示文摘作为新型药品和医疗手段的发展基础,在过去10年间人类基因图谱的绘制获得了巨大的研究经费支持.2011年6月,美国总统奥巴马宣布了结合计算模拟和先进材料数据库的材料基因组计划(MGI).遗憾的是,在公告中对材料基因组仅仅给出了一个相当模糊的定义.材料基因组的定义与生物基因组类似,对于特定的材料,它的性能取决于其化学成分(储存在基因组中的固有特性)和使用环境(外部交互作用、加工处理、使用条件).基于此,材料基因组可以定义为一组通过仔细评估实验数据和量子力学的计算结果而获得的,以热力学语言描述的信息,从中可以得到材料的相关结论.相图计算(CALPHAD)数据库包含材料体系的热力学和动力学性质.这些数据库可以用于预测材料的组织结构以及加工和使用条件对结构的影响,是集成计算材料工程(ICME)的主要组成部分. | AGREN John | 2013 | 科学通报2013，58，35： | 7 |
| 2 | by a cascade optical field modulation strategy facilitating selective multispectral narrow-band near-infrared photodetection显示文摘Since selective detection of multiple narrow spectral bands in the near-infrared(NIR)region still poses a fundamental challenge,we have,in this work,developed NIR photodetectors(PDs)using photon upconversion nanocrystals(UCNCs)combined with perovskite films.To conquer the relatively high pumping threshold of UCNCs,we designed a novel cascade optical field modulation strategy to boost upconversion luminescence(UCL)by cascading the superlensing effect of dielectric microlens arrays and the plasmonic effect of gold nanorods,which readily leads to a UCL enhancement by more than four orders of magnitude under weak light irradiation.By accommodating multiple optically active lanthanide ions in a core-shell-shell hierarchical architecture,developed PDs on top of this structure can detect three well-separated narrow bands in the NIR region,i.e.,those centered at 808,980,and 1540 nm.Due to the large UCL enhancement,the obtained PDs demonstrate extremely high responsivities of 30.73,23.15,and 12.20 AW^(−1) and detectivities of 5.36,3.45,and 1.91×10^(11) Jones for 808,980,and 1540 nm light detection,respectively,together with short response times in the range of 80-120 ms.Moreover,we demonstrate for the first time that the response to the excitation modulation frequency of a PD can be employed to discriminate the incident light wavelength.We believe that our work provides novel insight for developing NIR PDs and that it can spur the development of other applications using upconversion nanotechnology. | Yanan Ji Wen Xu Nan Ding Haitao Yang Hongwei Song Qingyun Liu Hans Agren Jerker Widengren Haichun Liu | 2020 | Light(Science & Applications)2020，9，1： | 6 |
| 3 | Pharmacological interventions for improved colonic anastomotic healing:A meta-analysis显示文摘AIM:To identify pharmaceuticals for the prophylaxis of anastomotic leakage(AL),we systematically reviewed studies on anastomosis repair after colorectal surgery.METHODS:We searched PubMed and EMBASE for articles published between January 1975 and December 2012.We included studies in English with the primary purpose of promoting healing of anastomoses made in the colon or rectum under uncomplicated conditions.We excluded studies on adverse events from interventions,nutritional interventions or in situ physical supporting biomaterials.The primary outcome was biomechanical strength or AL.We performed meta-analyses on therapeutic agents investigated by three or more independent research groups using the same outcome.The DerSimonian-Laird method for random effects was applied with P < 0.05.RESULTS:Of the 56 different therapeutic agents assessed,7 met our inclusion criteria for the metaanalysis.The prostacyclin analog iloprost increased the weighted mean of the early bursting pressure of colonic anastomoses in male rats by 60 mmHg(95%CI:30-89) vs the controls,and the immunosuppressant tacrolimus increased this value by 29 mmHg(95%CI:4-53) vs the controls.Erythropoietin showed an enhancement of bursting pressure by 45 mmHg(95%CI:14-76).The anabolic compound growth hormone augmented the anastomotic strength by 21 mmHg(95%CI:7-35),possibly via the up-regulation of insulin-like growth factor-1,as this growth factor increased the bursting pressure by 61 mmHg(95%CI:43-79) via increased collagen deposition.Hyperbaric oxygen therapy increased the bursting pressure by 24 mmHg(95%CI:13-34).Broad-spectrum matrix metalloproteinase inhibitors increased the bursting pressure by 48 mmHg(95%CI:31-66) on postoperative days 3-4.In the only human study,the AL incidence was not significantly reduced in the 103 colorectal patients treated with aprotinin(11.7%) compared with the 113 placebo-treated patients(9.7%).CONCLUSION:This systematic review identified only one randomized clinical trial and seven therapeutic agents from pre-clinical models that could be explored further for the prophylaxis of AL after colorectal surgery. | Mari Nanna φines Peter-Martin Krarup Lars Nannestad Jorgensen Magnus Sven Agren | 2014 | World Journal of Gastroenterology2014，20，35： | 5 |
| 4 | Reactive oxygen species contribute to epidermal hyaluronan catabolism in human skin organ culture显示文摘 | Agren U M Tammi R H Tammi M I | 1997 | Free Radic Biol Med1997，23，7： | 2 |
| 5 | Phase-field simulation of sintering and related phenomena显示文摘 | Asp K Agren J | 2006 | Acta Mater2006，54，： | 1 |
| 6 | A model for interphase precipitation based on finite interface lute drag theory 显示文摘 | Okamoto P Agren J | 2010 | Acta Material&2010，58，： | 1 |
| 7 | Reduced brain norepinephrine and dopamine release in treatment-refractory depressive illness:evidengce in support of the catecholamine hypothesie of mood disorders显示文摘 | Johansson M Agren H | 2000 | Arch Gen Psychiatry2000，57，8： | 1 |
| 8 | A detailed investigation of HPGe detector response for improved Monte Carlo efficiency calculations显示文摘 | Jonas Boson G6ran Agren Lennart Johansson | 2008 | Nucl Instr Meth2008，587，： | 1 |
| 9 | Constitutive behaviour of WC-Co materials with different grain size sintered under load显示文摘 | PETERSSON A AGREN J | 2004 | Acta Materialia2004，52，： | 1 |
| 10 | Ultrasound attenuation of the calcaneus:a sensitive and specific discriminator of osteopenia in postnenopausal women显示文摘 | Agren M Karellas A Leahey D | 1991 | Calcif Tissue Int1991，48，4： | 1 |
| 11 | Collagenase in wound healing: effect of wound age and type显示文摘 | Agren MS Taplin CJ Woessner JF Jr | 1992 | J Lnvest Dermatol1992，99，6： | 1 |
| 12 | Effect of carbon activity and powder particle size on WC grain coarsening during sintering of cemented car- bides 显示文摘 | Borgh I Hedstr:m P Borgenstam A Agren J Odqvist J | 2014 | International Journal of Refractory Metals and Hard Materials2014，42，： | 1 |
| 13 | Carbon sequestration in ecosystems: the role of stoichiometry显示文摘 | HESSEN D O AGREN G I ANDERSON T R | 2004 | Ecology2004，85，5： | 1 |
| 14 | Phylogeny of the Fennoscandian cervid strainof Echinococcus granulosus显示文摘 | Lavikainen A Lehtinen M J Agren E | 2005 | Bulletin of the Scandinavian Baltic Society for Parasitology2005，14，： | 1 |
| 15 | Serum disposition of sertraline, N-desmethylsertraline and paroxetine : a pharmacokinetic evaluation of repeated drug concentration ts during 6 months of treatment for major depression 显示文摘 | REIS M ABERG-WISTEDT A AGREN H | 2004 | Hum Psychopharmacol2004，19，5： | 1 |
| 16 | Longitudinal changesin epitope recognition of autoantibodies against glutamate decar-boxylase 65 (GAD65Ab) in prediabetic adults developing dia-betes显示文摘 | HAMPE CS HALL TR AGREN A | 2007 | Clin Exp Immunol2007，148，： | 1 |
| 17 | Theories and methods on plant nutrition and growth显示文摘 | lngestad T Agren G I | 1992 | Physiologia Plantarum1992，84，： | 1 |
| 18 | $toichiometry and nutrition of plant growth in nature communities显示文摘 | Agren G I | 2008 | Annual Review Ecology Evolution and Systematics2008，2008，39： | 1 |
| 19 | The C:N:P stoichiometry of autotrophs-theory and observations显示文摘 | Agren G I | 2004 | Ecology Letters2004，，7： | 1 |
| 20 | Modelling carbon allocation : A review 显示文摘 | AGREN G I WIKSTROM J F | 1993 | New Zeal J For Sci1993，23，2： | 1 |
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