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| 1 | 西藏恰功铁矿岩浆演化序列及斑岩出溶流体特征显示文摘冈底斯成矿带是碰撞造山过程形成的最重要的成矿带,恰功矽卡岩铁(铜)矿床即位于冈底斯成矿带中部。本文在详细的野外地质填图和室内研究基础上确定了恰功铁矿与成矿有关的斑岩体为二长花岗斑岩,锆石的U-Pb定年结果为68.8±2.2Ma,明显早于冈底斯东部与后碰撞伸展有关的斑岩型矿床和主碰撞期形成的矽卡岩型矿床,其应代表了冈底斯一次尚未被充分认识到的成矿事件。通过对成矿斑岩的岩石学、岩石化学、岩浆出溶流体的包裹体岩相学、显微测温分析及包裹体成分的LRM、LA-ICP-MS和PIXE分析,本文探讨了与该矽卡岩矿床有关的斑岩的岩浆起源、斑岩侵位机制及出溶流体特征。结果表明,成矿斑岩为矿区最早的侵入岩单元,具有壳幔源混源特征,其常量元素组成与冈底斯东部斑岩铜矿带的埃达克质岩相近,但稀土和微量元素组成与东部斑岩明显不同,为地幔物质上涌并诱发角闪岩相下地壳熔融的产物,岩体侵位深度大(>7km)、剥蚀程度高。早期岩浆出溶的流体为高温、高压、高盐度流体,其中富含Fe、Pb、Zn、Cu等成矿金属,与世界其他斑岩铜矿床相比,相对富铁、铅而贫铜。流体的沸腾作用发生于钾硅化阶段,形成了一套富气、高盐、高固相和气液包裹体组合,不同于早期出溶流体的包裹体组合。从岩浆起源和出溶流体性质可以看出,该斑岩具有形成与斑岩有关的铁铅多金属矿床的成矿潜力,但从该矿区地表出露的蚀变和包裹体测压结果可以看出,该斑岩体目前剥蚀深度较大,对斑岩型矿床保存不利,对该斑岩体及与成矿关系的认识对理解该区内的矿床成因和指导区域找矿具有重要的指示意义。 | 谢玉玲 李应栩 Zhaoshan CHANG David R. COOKE Chris G. RYAN Jamie LAIRD 白劲松 刘云飞 李光明 张丽 | 2009 | 地质学报2009，83，12： | 19 |
| 2 | Risk factors for post-ERCP pancreatitis: A prospective, multicenter study显示文摘 | Martin L. Freeman James A. DiSario Douglas B. Nelson M.Brian Fennerty John G. Lee David J. Bjorkman Carol S. Overby Johannes Aas Michael E. Ryan Gary S. Bochna Michael J. Shaw Harry W. Snady Robert V. Erickson Joseph P. Moore Joseph P. Roel | 2001 | Gastrointestinal Endoscopy2001，，4： | 5 |
| 3 | Motor competence and health-related fitness in children:A cross-cultural comparison between Portugal and the United States显示文摘Background: Motor competence and health-related fitness are important components for the development and maintenance of a healthy lifestyle in children. This study examined cross-cultural performances on motor competence and health-related fitness between Portuguese and U.S.children.Methods: Portuguese(n = 508; 10.14 § 2.13 years, mean § SD) and U.S.(n = 710; 9.48 § 1.62 years) children performed tests of cardiorespiratory fitness(Progressive Aerobic Cardiovascular Endurance Run), upper body strength(handgrip), locomotor skill performance(standing long jump), and object projection skill performance(throwing and kicking). Portuguese and U.S. children were divided into 2 age groups(6à9 and 10à13 years) for data analysis purposes. A twoàfactor oneàway analysis of covariance(ANOVA) was conducted with the Progressive Aerobic Cardiovascular Endurance Run, handgrip, standing long jump scores, kicking, and throwing speed(km/h) as dependent variables.Results: Results indicated that Portuguese children, irrespective of sex, presented better performances in locomotor and cardiorespiratory performance(standing long jump and Progressive Aerobic Cardiovascular Endurance Run) than U.S. children in both age bands. U.S. children outperformed Portuguese children during throwing and handgrip tests. Kicking tests presented gender differences: Portuguese boys and U.S. girls outperformed their internationally matched counterparts.Conclusion: Cultural differences in physical education curricula and sports participation may impact differences in motor competence and fitness development in these countries. | Carlos Luz Rita Cordovil Luis Paulo Rodrigues Zan Gao Jacqueline D.Goodway Ryan S.Sacko Danielle R.Nesbitt Rick C.Ferkel Larissa K.True David F.Stodden | 2019 | Journal of Sport and Health Science2019，8，2： | 5 |
| 4 | Microstructure and mechanical properties of Ti-6Al-4V-5% hydroxyapatite composite fabricated using electron beam powder bed fusion显示文摘A novel, Ti-6 Al-4 V(Ti64)/Hydroxyapatite(HA at 5% by weight concentration) metal/ceramic composite has been fabricated using electron beam powder bed fusion(EPBF) additive manufacturing(AM): specifically, the commercial electron beam melting(EBM?) process. In addition to solid Ti64 and Ti64/5% HA samples, four different unit cell(model) open-cellular mesh structures for the Ti64/5% HA composite were fabricated having densities ranging from 0.68 to 1.12 g/cm^3, and corresponding Young's moduli ranging from 2.9 to 8.0 GPa, and compressive strengths ranging from ~3 to 11 MPa. The solid Ti64/5%HA composite exhibited an optimal tensile strength of 123 MPa, and elongation of 5.5% in contrast to a maximum compressive strength of 875 MPa. Both the solid composite and mesh samples deformed primarily by brittle deformation, with the mesh samples exhibiting erratic, brittle crushing. Solid, EPBF-fabricated Ti64 samples had a Vickers microindentation hardness of 4.1 GPa while the Ti64/5%HA solid composite exhibited a Vickers microindentation hardness of 6.8 GPa. The lowest density Ti64/5%HA composite mesh strut sections had a Vickers microindentation hardness of 7.1 GPa. Optical metallography(OM) and scanning electron microscopy(SEM) analysis showed the HA dispersoids to be highly segregated along domain or grain boundaries, but homogeneously distributed along alpha(hcp) platelet boundaries within these domains in the Ti64 matrix for both the solid and mesh composites. The alpha platelet width varied from ~5 μm in the EPBF-fabricated Ti64 to ~1.1 m for the Ti64/5%HA mesh strut. The precursor HA powder diameter averaged 5 μm, in contrast to the dispersed HA particle diameters in the Ti64/5%HA composite which averaged 0.5 m. This work highlights the use of EPBF AM as a novel process for fabrication of a true composite structure, consisting of a Ti64 matrix and interspersed and exposed HA domains, which to the authors' knowledge has not been reported before. The results also illustrate the prospects not only for fabricating specialized, novel composite bone replacement scaffolds and implants, through the combination of Ti64 and HA, but also prospects for producing a variety of related metal/ceramic composites using EPBF AM. | César A.Terrazas Lawrence E.Murr Diego Bermudez Edel Arrieta David A.Roberson Ryan B.Wicker | 2019 | Journal of Materials Science & Technology2019，35，2： | 4 |
| 5 | Phase II Study of Everolimus in Patients with Metastatic Colorectal Adenocarcinoma Previously Treated with Bevacizumab-, Fluoropyrimidine-, Oxaliplatin-, and Irinotecan-Based Regimens显示文摘 | Kimmie Ng Josep Tabernero Jimmy Hwang Emilio Bajetta Sunil Sharma Salvatore A. Del Prete Edward R. Arrowsmith David P. Ryan Michaela Sedova Jin Jin Kamel Malek Charles S. Fuchs | 2013 | Clinical Cancer Research2013，，14： | 4 |
| 6 | Phylogenetically Distinct Cellulose Synthase Genes Support Secondary Wall Thickening in Arabidopsis Shoot Trichomes and Cotton Fiber显示文摘Through exploring potential analogies between cotton seed trichomes (or cotton fiber) and arabidopsis shoot trichomes we discovered that CesAs from either the primary or secondary wall phylogenetic clades can support secondary wall thickening. CesA genes that typically support primary wall synthesis, AtCesA1,2,3,5, and 6, underpin expansion and secondary wall thickening of arabidopsis shoot trichomes. In contrast, apparent orthologs of CesA genes that support secondary wall synthesis in arabidopsis xylem, AtCesA4,7, and 8, are up-regulated for cotton fiber secondary wall deposition. These conclusions arose from: (a) analyzing the expression of CesA genes in arabidopsis shoot trichomes; (b) observing birefringent secondary walls in arabidopsis shoot trichomes with mutations in AtCesA4, 7, or 8; (c) assaying up-regulated genes during different stages of cotton fiber development; and (d) comparing genes that were co-expressed with primary or secondary wall CesAs in arabidopsis with genes upregulated in arabidopsis trichomes, arabidopsis secondary xylem, or cotton fiber during primary or secondary wall deposition. Cumulatively, the data show that: (a) the xylem of arabidopsis provides the best model for secondary wall cellulose synthesis in cotton fiber; and (b) CesA genes within a 'cell wall toolbox' are used in diverse ways for the construction of particular specialized cell walls. | Lissete Betancur Bir Singh Ryan A.Rapp Jonathan F.Wendel M. David Marks Alison W.Roberts Candace H.Haigler | 2010 | Journal of Integrative Plant Biology2010，52，2： | 4 |
| 7 | Bioreduction of nitrate in groundwater using a pilot-scale hydrogen-based membrane biofilm reactor显示文摘A long-term pilot-scale H_(2)-based membrane biofilm reactor(MBfR)was tested for removal of nitrate from actual groundwater.A key feature of this secondgeneration pilot MBfR is that it employed lower cost polyester hollow fibers and still achieved high loading rate.The steady-state maximum nitrate surface loading at which the effluent nitrate and nitrite concentrations were below the Maximum Contaminant Level(MCL)was at least 5.9 g·N·(m^(2)·d)^(–1),which corresponds to a maximum volumetric loading of at least 7.7 kg·N·(m^(3)·d)^(–1).The steady-state maximum nitrate surface area loading was higher than the highest nitrate surface loading reported in the firstgeneration MBfRs using composite fibers(2.6 g·N·(m^(2)·d)^(–1)).This work also evaluated the H_(2)-utilization efficiency in MBfR.The measured H_(2)supply rate was only slightly higher than the stoichiometric H_(2)-utilization rate.Thus,H_(2)utilization was controlled by diffusion and was close to 100%efficiency,as long as biofilm accumulated on the polyester-fiber surface and the fibers had no leaks. | Youneng TANG Michal ZIV-EL Chen ZHOU Jung Hun SHIN Chang Hoon AHN Kerry MEYER Daniel CANDELARIA David FRIESE Ryan OVERSTREET Rick SCOTT Bruce ERITTMANN | 2010 | Frontiers of Environmental Science & Engineering2010，4，3： | 4 |
| 8 | 老年人处方遗漏筛查工具第2版(中文版)显示文摘近年来我国老年人口数量迅速增加,2013年老年人口突破2亿大关。老年人常伴有多种疾病且同时服用多种药物,容易出现药物相互作用和药物不良反应,所以老年人用药问题是医务人员关注的重点。老年人不适当用药问题主要包括两个方面:老年人需要避免使用的药物和老年人需要使用而未使用的药物。 | Denis O'Mahony David O'Sullivan Stephen Byrne Marie Noelle O'Connor Cristin Ryan Paul Gallagher 侯凯旋 邢晓璇 闫素英 | 2017 | 药物不良反应杂志2017，19，5： | 4 |
| 9 | Macrophages are the primary effector cells in IL-7-induced arthritis显示文摘Synovial macrophages are crucial in the development of joint inflammation and bone damage;however, the pathways that controlmacrophage remodeling in inflammatory M1 cells or bone-eroding osteoclasts are not fully understood. We determined thatelevated IL-7R/CD127 expression is the hallmark of rheumatoid arthritis (RA) M1 macrophages and that these cells are highlyresponsive to interleukin-7 (IL-7)-driven osteoclastogenesis. We established that lipopolysaccharide (LPS), interferon-γ (IFNγ), andtumor necrosis factor-α (TNFα), the classic M1 macrophage mediators, enhance IL-7R expression in RA and murine macrophages.The local expression of IL-7 provokes arthritis, predominantly through escalating the number of F480^(+)iNOS^(+) cells rather than CD3^(+)T cells. Ectopic LPS injection stabilizes IL-7-induced arthritis by increasing myeloid IL-7R expression, in part via IFNγ induction.Hence, in RAG−/− mice, IL-7-mediated arthritis is suppressed because of the reduction in myeloid IL-7R expression due to the lackof IFNγ. Moreover, the amelioration of IL-7-induced arthritis by anti-TNF therapy is due to a decrease in the number of cells in theunique F480^(+)iNOS^(+)IL-7R^(+)CCL5^(+) subset, with no impact on the F480^(+)Arginase^(+) cell or CD3^(+) T cell frequency. Consistent with thepreclinical findings, the findings of a phase 4 study performed with RA patients following 6 months of anti-TNF therapy revealedthat IL-7R expression was reduced without affecting the levels of IL-7. This study shifts the paradigm by discovering that IL-7-induced arthritis is dependent on F480^(+)iNOS^(+)IL-7R^(+)CCL5^(+) cell function, which activates TH-1 cells to amplify myeloid IL-7Rexpression and disease severity. | Seung-jae Kim Huan J.Chang Michael VVolin Sadiq Umar Katrien Van Raemdonck Aimee Chevalier Karol Palasiewicz John W.Christman Suncica Volkov Shiva Arami Mehrdad Maz Anjali Mehta Ryan K.Zomorrodi David A.Fox Nadera Sweiss Shiva Shahrara | 2020 | Cellular & Molecular Immunology2020，17，7： | 4 |
| 10 | The Cost-Effectiveness of Neoadjuvant Chemoradiation is Superior to a Surgery-First Approach in the Treatment of Pancreatic Head Adenocarcinoma显示文摘 | Daniel E. Abbott Ching-Wei David Tzeng Ryan P. Merkow Scott B. Cantor George J. Chang Matthew Harold Katz David J. Bentrem Karl Y. Bilimoria Christopher H. Crane Gauri R. Varadhachary James L. Abbruzzese Robert A. Wolff Jeffrey E. Lee Douglas B. Evans Jas | 2013 | Annals of Surgical Oncology2013，，3： | 3 |
| 11 | MicroRNA-155 Promotes Autoimmune Inflammation by Enhancing Inflammatory T Cell Development显示文摘 | Ryan M. O’Connell Daniel Kahn William S.J. Gibson June L. Round Rebecca L. Scholz Aadel A. Chaudhuri Melissa E. Kahn Dinesh S. Rao David Baltimore | 2010 | Immunity2010，，4： | 3 |
| 12 | 2.4GHz频段上的新一代点对点无线技术显示文摘替代电缆的解决方案
在设备之间实现无线通信是许多消费产品开发人员由来已久的梦想.然而,长期以来,无线电频谱资源一直是各国政府的管制对象,对其使用有着种种限制,目的是防止来自不同信号源的RF信号相互干扰.在大多数国家里,大部分无线电频谱是为广播、电视、军事、应急服务以及近期迅速普及的移动电话之用而保留的. | David Wright Ryan Winfield-Woodings | 2004 | 世界电子元器件2004，，1： | 3 |
| 13 | Pancreatic Ductal Adenocarcinoma: Is There a Survival Difference for R1 Resections Versus Locally Advanced Unresectable Tumors? What Is a “True” R0 Resection?显示文摘 | Ioannis T. Konstantinidis Andrew L. Warshaw Jill N. Allen Lawrence S. Blaszkowsky Carlos Fernandez-del Castillo Vikram Deshpande Theodore S. Hong Eunice L. Kwak Gregory Y. Lauwers David P. Ryan Jennifer A. Wargo Keith D. Lillemoe Cristina R. Ferrone | 2013 | Annals of Surgery2013，，4： | 3 |
| 14 | Jaundice: an important, poorly recognized risk factor for diminished survival in patients with adenocarcinoma of the head of the pancreas显示文摘 | Steven M. Strasberg Feng Gao Dominic Sanford David C. Linehan William G. Hawkins Ryan Fields Danielle H. Carpenter Elizabeth M. Brunt Carolyn Phillips | 2014 | HPB2014，，2： | 2 |
| 15 | Autonomic responses to blast overpressure can be elicited by exclusively exposing the ear in rats显示文摘Blast overpressure has become an increasing cause of brain injuries in both military and civilian populations. Though blast's direct effects on the cochlea and vestibular organs are active areas of study, little attention has been given to the ear's contribution to the overall spectrum of blast injury. Acute autonomic responses to blast exposure, including bradycardia and hypotension, can cause hypoxia and contribute to blast-induced neurotrauma. Existing literature suggests that these autonomic responses are elicited through blast impacting the thorax and lungs. We hypothesize that the unprotected ear also provides a vulnerable locus for blast to cause autonomic responses. We designed a blast generator that delivers controlled overpressure waves into the ear canal without impacting surrounding tissues in order to study the ear's specific contribution to blast injury. Anesthetized adult rats' left ears were exposed to a single blast wave ranging from 0 to 110 PSI(0-758 kPa). Blast exposed rats exhibited decreased heart rates and blood pressures with increased blast intensity, similar to results gathered using shock tubes and whole-body exposure in the literature. While rats exposed to blasts below 50 PSI(345 kPa) exhibited increased respiratory rate with increased blast intensity, some rats exposed to blasts higher than 50 PSI(345 kPa) stopped breathing immediately and ultimately died. These autonomic responses were significantly reduced in vagally denervated rats, again similar to whole-body exposure literature. These results support the hypothesis that the unprotected ear contributes to the autonomic responses to blast. | David S.Sandlin Yue Yu Jun Huang Chunming Zhang Alberto A.Arteaga John K.Lippincott Erin O.H.Peeden Ryan R.Guyton Lan Chen Laura L.S.Beneke Jerome C.Allison Hong Zhu Wu Zhou | 2018 | Journal of Otology2018，13，2： | 2 |
| 16 | Optimizing CT for the evaluation of vestibular aqueduct enlargement:Inter-rater reproducibility and predictive value of reformatted CT measurements显示文摘Enlarged vestibular aqueduct(EVA), the most frequent identifiable cause of congenital hearing loss, is evaluated with high-definition multidetector CT in the axial plane. Our purpose was to determine which reformatted CT measurements are most reproducible. Seven multiplanar reformatted images were created for each of the 64 temporal bones in patients with EVA. Intraclass correlation coefficients(ICC) were used to assess inter-observer variability, and both linear regression and ROC analyses were used to compare the measurements with severity of hearing loss, as assessed by pure tone audiometry. All seven measurements had excellent inter-observer variability, with average-measure ICC ranging from 0.92 to 0.98. There was no statistically significant correlation between the radiologic degree of aqueduct enlargement and severity of hearing loss using any of the seven measurements; ROC analyses revealed areas under the curves ranging from 0.57 to 0.73. Optimal accuracy was obtained with a threshold of 1.75 mm as measured at the aqueductal aperture in the P€oschl plane, with sensitivity of 0.75 and specificity of0.63. Although the radiologic measurement may not serve as a reliable tool for assessing severity of EVA, P€oschl plane reformatting has proven to be better than conventional axial acquisition plane for identifying patients with clinically significant hearing loss. | Misun Hwang Ryan Marovich Samuel S.Shin David Chi Barton F.Branstetter IV | 2015 | Journal of Otology2015，10，1： | 2 |
| 17 | Regional Lymphadenectomy Is Indicated in the Surgical Treatment of Pancreatic Neuroendocrine Tumors (PNETs)显示文摘 | Yassar M. Hashim Kathryn M. Trinkaus David C. Linehan Steven S. Strasberg Ryan C. Fields Dengfeng Cao William G. Hawkins | 2014 | Annals of Surgery2014，，2： | 2 |
| 18 | CD133 expression is not restricted to stem cells, and both CD133^sup +^ and CD133^sup -^ metastatic colon cancer cells initiate tumors显示文摘 | Shmelkov Sergey V Butler Jason M Hooper Andrea T Hormigo Adilia Kushner Jared Milde Till Clair Ryan St Baljevic Muhamed White Ian Jin David K Chadburn Amy Murphy Andrew J Valenzuela David M Gale Nicholas W Thurston Gavin Yancopoulos George | 2008 | Journal of Clinical Investigation2008，，： | 2 |
| 19 | Prevalence and factors of work-related musculoskeletal disorders among hand surgeons显示文摘BACKGROUND The nature of tasks required by hand surgeons require both forceful and repetitive maneuvers,thus subjecting these surgeons to the risk of musculoskeletal(MSK)injuries during their years in practice.AIM To assess the prevalence,characteristics and impact of MSK disorders among hand surgeons.METHODS A modified version of the physical discomfort survey was sent to surgeons who were members of the American Society for Surgery of the Hand via e-mail.The collected data were analyzed using descriptive statistics,one-way analysis of variance,and Fisher’s exact test.P values of<0.05 were considered statistically significant.RESULTS Of the 578 respondents,60.4%reported that they had sustained a work-related MSK injury,of which the most common diagnoses were lateral elbow epicondylitis(18.7%),low back pain(17.1%)and carpal tunnel syndrome(15.6%).Among those that reported an injury,73.1%required treatment and 29.2%needed time off work as a direct result of their injury.The number of work-related injuries incurred by a surgeon increased significantly with increasing age(P<0.003),increasing years in practice(P<0.001)and higher case load(P<0.05).CONCLUSION To our knowledge this study is the first of its kind to assess MSK injuries sustained by Hand surgeons with a high incidence.These results should increase awareness on this aspect and fuel future studies directed at preventing these types of work-related injuries,thus minimizing the financial and psychological burden on these surgeons and the healthcare system. | Saad M Alqahtani Mohammad M Alzahrani Ryan Bicknell David Pichora | 2022 | World Journal of Orthopedics2022，13，5： | 2 |
| 20 | Pancreatic Adenocarcinoma显示文摘 | David P. Ryan Theodore S. Hong Nabeel Bardeesy | 2014 | The New England Journal of Medicine2014，，： | 2 |
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