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| 1 | Small gastrointestinal stromal tumor concomitant with early gastric cancer:A case report显示文摘术语胃肠的基质肿瘤(大意) 与锭子或上皮样细胞与免疫从胃肠道的墙产生特征地被定义为间充质的肿瘤的主要的组为 CD117 的组织化学的反应抗体。以前的研究表明在大意的细胞与酷氨酸激酶活动(称为的 c 工具包) 表示生长因素受体,它是 c 工具包 proto-oncogene 的产品。为大意的最特定、实际的诊断标准是:免疫组织化学地决定了 c 工具包(CD117 ) 表示;有丝分裂的分数;并且肿瘤尺寸。有早胃的癌症的小大意伴随物很少临床上被遇到。此处,我们报导了与早胃的癌症(环状体房间类型) 的一种 IIc 类型伴随物的 esophagogastroduodenoscopy 检测的 1.1 厘米的大意的一个案例。它在平淡的物理健康检查期间被检测。到我们的知识,这是有早胃的癌症的一种环状体房间类型的小大意伴随物的第一份报告。 | Ying-Lung Lin Jeh-En Tzeng Chih-Wen Lin | 2006 | World Journal of Gastroenterology2006，12，5： | 18 |
| 2 | Role of gut microbiota in identification of novel TCM-derived active metabolites显示文摘Traditional Chinese Medicine(TCM)has been extensively used to ameliorate diseases in Asia for over thousands of years.However,owing to a lack of formal scientific validation,the absence of information regarding the mechanisms underlying TCMs restricts their application.After oral administration,TCM herbal ingredients frequently are not directly absorbed by the host,but rather enter the intestine to be transformed by gut microbiota.The gut microbiota is a microbial community living in animal intestines,and functions to maintain host homeostasis and health.Increasing evidences indicate that TCM herbs closely affect gut microbiota composition,which is associated with the conversion of herbal components into active metabolites.These may significantly affect the therapeutic activity of TCMs.Microbiota analyses,in conjunction with modern multiomics platforms,can together identify novel functional metabolites and form the basis of future TCM research. | Tzu-Lung Lin Chia-Chen Lu Wei-Fan Lai Ting-Shu Wu Jang-Jih Lu Young-Mao Chen Chi-Meng Tzeng Hong-Tao Liu Hong Wei Hsin-Chih Lai | 2021 | Protein & Cell2021，12，5： | 16 |
| 3 | Tumor necrosis factor-alpha blockage therapy impairs hepatitis B viral clearance and enhances T-cell exhaustion in a mouse model显示文摘肝炎 B 病毒(HBV ) 复活和复发在经历免疫力的抑制治疗的病人是普通的。肿瘤坏死因素(TNF ) 阻塞治疗为许多自体免疫的煽动性的疾病的治疗是有效的。然而, TNF-α 的角色;在对 HBV 的天生、适应的有免疫力的回答的阻塞治疗仍然不是清楚的。A 在 TNF-α 下面详细说明了 HBV 感染的分析;阻塞治疗为 HBV 复活和复发为预防和治疗是必要的。在这研究, HBV 清理和 T 房间回答在 anti-TNF 阻塞治疗下面在一个 HBV-transfected 老鼠模型被分析。我们的结果在 TNF-α 下面表明了那;阻塞治疗, HBV 病毒的清理在一个剂量依赖者和时间依赖者的举止与坚持的提高的 HBV 病毒的负担被损害。在 anti-TNF-α 下面的 HBV 清理的缺陷;阻塞治疗在 HBV 感染以后发生在早时间点。另外, TNF-α封锁维持了更高的浆液 HBV 病毒的负担并且增加了 intrahepatic 的数字用尽的规划房间死亡(PD )-1highCD127low T 房间。而且, TNF-α封锁废除像使用费的受体 9 (TLR9 ) HBV 的导致 ligand 的容易病毒的清理。一起拿, TNF-α封锁损害 HBV 清理并且提高病毒的负担,和这些效果在 HBV 感染以后取决于早管理。我们这里的结果表明那早 TNF-α封锁减少病毒的清理并且固执地在一个老鼠模型维持提高的 HBV 病毒的负担,建议 HBV 可以在有 TNF-α 的治疗期间重新激活;堵住代理人。 | Hsu Chyuan Hwei-Fang Tsai Horng-Tay Tzeng Chi-Chang Sung Chien-Sheng Wu Pei-Jer Chen Ping-Ning Hsu | 2015 | Cellular & Molecular Immunology2015，12，3： | 9 |
| 4 | Role of peripheral eosinophilia in acute exacerbation of chronic obstructive pulmonary disease显示文摘BACKGROUND Eosinophil counts are a promising guide to systemic steroid administration for chronic obstructive pulmonary disease(COPD).AIM To study the role of peripheral eosinophilia in hospitalized patients with acute exacerbation of COPD(AECOPD).METHODS From January 2014 to May 2017,patients with AECOPD hospitalized in Taipei Tzu Chi Hospital were retrospectively stratified into two groups according to their peripheral eosinophil count:The EOS group(eosinophil count≥2%)and the non-EOS group(eosinophil count<2%).Demographics,comorbidities,laboratory data,steroid use,length of hospital stay,and COPD-related readmissions were compared between the groups.RESULTS A total of 625 patients were recruited,with 176 patients(28.2%)in the EOS group.The EOS group showed a lower prevalence of infection,lower cumulative doses of prednisolone equivalents,shorter length of hospital stay,and higher number of COPD-related readmissions than the non-EOS group.There were significantly linear correlations between eosinophil percentage and number of readmissions and between eosinophil percentage and length of hospital stay P<0.001,and a lower percent-predicted value of forced expiratory volume in one second(FEV1)were associated with shorter time to first COPD-related readmission[adjusted hazard ratio(adj.HR)=1.488,P<0.001;adj.HR=0.985,P<0.001,respectively].CONCLUSION The study findings suggest that the EOS group had the features of a shorter length of hospital stay,and lower doses of systemic steroids,but more frequent readmissions.The EOS group and lower percent-predicted FEV1 values were risk factors for shorter time to first COPD-related readmission. | Chih-Wei Wu Chou-Chin Lan Po-Chun Hsieh I-Shiang Tzeng Yao-Kuang Wu | 2020 | World Journal of Clinical Cases2020，8，13： | 7 |
| 5 | Randomized Controlled Trial of Entecavir Prophylaxis for Rituximab-Associated Hepatitis B Virus Reactivation in Patients With Lymphoma and Resolved Hepatitis B显示文摘 | Yi-Hsiang Huang Liang-Tsai Hsiao Ying-Chung Hong Tzeon-Jye Chiou Yuan-Bin Yu Jyh-Pyng Gau Chun-Yu Liu Muh-Hwa Yang Cheng-Hwai Tzeng Pui-Ching Lee Han-Chieh Lin Shou-Dong Lee | 2013 | Journal of Clinical Oncology2013，，22： | 6 |
| 6 | The Cost-Effectiveness of Neoadjuvant Chemoradiation is Superior to a Surgery-First Approach in the Treatment of Pancreatic Head Adenocarcinoma显示文摘 | Daniel E. Abbott Ching-Wei David Tzeng Ryan P. Merkow Scott B. Cantor George J. Chang Matthew Harold Katz David J. Bentrem Karl Y. Bilimoria Christopher H. Crane Gauri R. Varadhachary James L. Abbruzzese Robert A. Wolff Jeffrey E. Lee Douglas B. Evans Jas | 2013 | Annals of Surgical Oncology2013，，3： | 3 |
| 7 | A novel therapeutic anti-HBV antibody with increased binding to human FcRn improves in vivo PK in mice and monkeys显示文摘 | Ciming Kang Lin Xia Yuanzhi Chen Tianying Zhang Yiwen Wang Bing Zhou Min You Quan Yuan Chi-Meng Tzeng Zhiqiang An Wenxin Luo Ningshao Xia | 2018 | Protein & Cell2018，9，1： | 3 |
| 8 | Intestinal Absorption of Ergostane and Lanostane Triterpenoids from Antrodia cinnamomea Using Caco-2 Cell Monolayer Model显示文摘Antrodia cinnamomea is a precious medicinal mushroom.It exhibits promising therapeutic effects on cancer,intoxication,hypertension,hepatitis,and inflammation.Its major bioactive constituents are ergostane and lanostane triterpenoids.In this study,we used intestinal Caco-2 cell monolayer model to reveal the intestinal absorption property of 14 representative triterpenoids from A.cinnamomea.The bidirectional transport through the monolayer at different time points was monitored by a fully validated LC/MS/MS method.In the case of pure compounds,ergostanes 5(25R-antcin H),6(25Santcin H)and 10(25R-antcin B)could readily pass through the Caco-2 cell layer,whereas lanostanes 13(dehydroeburicoic acid)and 14(eburicoic acid)could hardly pass through.When the cells were treated with A.cinnamomea extract,antcins A,B,C,H and K(1–6 and 9–11)were absorbed via passive transcellular diffusion,and showed high PAB and PBA values(>2.5×10^(-5) cm/s).Meanwhile,the lanostanes dehydrosulphurenic acid(8),15a-acetyldehydrosulphurenic acid(12),13 and 14 exhibited poor permeability.Transport features of these compounds were consistent with their pharmacokinetic behaviors in rats.This study could also be helpful in predicting the intestinal absorption of A.cinnamomea in human. | Qi Wang Xue Qiao Yi Qian Zi-wei Li Yew-min Tzeng De-min Zhou De-an Guo Min Ye | 2015 | Natural Products and Bioprospecting2015，5，5： | 2 |
| 9 | Study on the Characteristics of the Ruthenium Oxide pH Electrode显示文摘Ruthenium oxide,which fabricated by radio frequency sputtering is used as the sensitive membrane,which shows that the pH sensitivity is very high and has a linear response in different buffer solutions.The pH electrode,which applies the structure of separative structure EGFET (Extended Gate Field Effect Transistor) insteads of the conventional gate ISFET (Ion Sensitive Field Effect Transistor) for reducing the cost of the fabrication and measurement.Unfortunately,the performance of the pH sensor was falsified by the drift and hysteresis.In addition,the total response is composed of the intrinsic response and drift,and the hysteresis effect combines the slow response with drift.Consequently,we would also investigate the drift in the buffer solutions and hysteresis effect in the different paths.In this way,the more accurate sensing properties are obtained by the RuO_x pH electrode. | Jung-Chuan Chou Diing-Jia Tzeng | 2006 | 稀有金属材料与工程2006，35，A03： | 2 |
| 10 | Three-Dimensional Imaging of Single Molecules Solvated in Pores of Poly (acrylamide)Gels 显示文摘 | Dickscn R M Norris D J Tzeng Y-L | 1996 | Science1996，274，： | 2 |
| 11 | An integrated MCDM technique combined with DEMATEL for a novel cluster-weighted with ANP method显示文摘 | Jiann Liang Yang Gwo-Hshiung Tzeng | 2010 | Expert Systems With Applications2010，，3： | 2 |
| 12 | Multi-objective optimal planning for designing relief delivery systems显示文摘 | Gwo-Hshiung Tzeng Hsin-Jung Cheng Tsung Dow Huang | 2007 | Transportation Research Part E2007，，6： | 2 |
| 13 | Evaluating intertwined effects in e-learning programs: A novel hybrid MCDM model based on factor analysis and DEMATEL显示文摘 | Gwo-Hshiung Tzeng Cheng-Hsin Chiang Chung-Wei Li | 2006 | Expert Systems With Applications2006，，4： | 2 |
| 14 | Influence of juxtapapillary diverticulum on hepatic clearance in patients after endoscopic sphincterotomy显示文摘 | Tzeng JJ Lai KH Peng NJ | 2005 | Gastroenterologia Y Hepatologia2005，，05： | 2 |
| 15 | Percutaneous transhepatic gall bladder drainage:a better initial therapeutic choice for patients with gall bladder perforation in the emergency department显示文摘 | C-C Huang H-C Lo Y-M Tzeng | 2007 | Emerg Med J2007，24，： | 1 |
| 16 | Combing the utrine depletion procedure and myomectomy may be useful for treating symptomatic fibroids 显示文摘 | Liu WM Tzeng CR Yi-Jen C | 2004 | Fertil Steril2004，82，1： | 1 |
| 17 | Evolution of microstructure and properties of phenolic resin based carbon/carbon composites during pyrolysis显示文摘 | TZENG S S CHT Y G | 2002 | Materials Chemistry and Physics2002，73，： | 1 |
| 18 | Regulation of the type I protein secretion system by the MisR/MisS two-component system in Neisseria meningitides 显示文摘 | Sannigrahi S Zhang X Tzeng YL | 2009 | Microbiology2009，155，5： | 1 |
| 19 | Evaluating intertwined effects in E-Learning programs:a novel hybrid MCDM model based onfactor analysis and DEMATEL显示文摘 | Tzeng G Chiang C Li C | 2007 | Expert System with Applications2007，32，4： | 1 |
| 20 | Nitric oxide synthase gene transfer to the vessel wall显示文摘 | Kibbe M Billiar T Tzeng E | 1999 | Curr Opin Neohrol Hypertens1999，8，： | 1 |
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