|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cold-chain food contamination as the possible origin of COVID-19 resurgence in Beijing显示文摘COVID-19,caused by SARS-CoV-2[1,2],has been contained in China through stringent non-pharmaceutical interventions.Border control and quarantine have effectively prevented the virus from being spread by infected travellers,but the risk of resurgence caused by other routes of introduction and transmission remains unclear,and current strategies to prevent resurgence could be flawed.Since July,SARS-CoV-2 RNA contaminations in frozen food imported from countries with ongoing epidemics have been reported in nine provinces in China[3,4].However,there is no robust evidence of COVID-19 outbreaks initiated by environmentto-human transmission.Here we add to evidence of such transmission by investigating the recent COVID-19 resurgence in Beijing. | Xinghuo Pang Lili Ren Shuangsheng Wu Wentai Ma Jian Yang Lin Di Jie Li Yan Xiao Lu Kang Shichang Du Jing Du Jing Wang Gang Li Shuguang Zhai Lijuan Chen Wenxiong Zhou Shengjie Lai Lei Gao Yang Pan Quanyi Wang Mingkun Li Jianbin Wang Yanyi Huang Jianwei Wang COVID-19 Field Response Group COVID-19 Laboratory Testing Group | 2020 | National Science Review2020，7，12： | 51 |
| 2 | A community-derived classification for extant lycophytes and ferns显示文摘发展史长通知了蕨类植物分类。当我们推断进化的树的能力改善了,针对认出生来的组的分类变得逐渐地预兆、稳定。这里,我们为 lycophytes 和蕨纲植物提供一个现代、全面分类,在下面,利用一条基于社区的途径类水平。我们 monophyly 用作主要标准让 taxa,而且目的识别保存两个广泛地被接受的存在 taxa 和界限并且与我们蕨类植物发展史的理解一致。总共,这个分类对待一在 337 个类, 51 个家庭, 14 目,和二个班估计了 11 916 种类。这个分类没在 lycophyte 和蕨纲植物上作为最后的词被打算分类,而是当前的假设的概括陈述,源于最好的可得到的数据并且在问题由熟悉植物的那些大多数塑造了。我们希望它将在蕨类植物上为最近的文学的那些想要的参考用作一个资源发展史和分类,为指导未来调查的一个框架,和推进讲话的刺激。 | Eric Schuettpelz Harald Schneider Alan R. Smith Peter Hovenkamp Jefferson Prado Germinal Rouhan Alexandre Salino Michael Sundue Thafs Elias Almeida Barbara Parris Emily B. Sessa Ashley R. Field Andre Luis de Gasper Carl J. Rothfels Michael D. Windham Marcus Lehnert Benjamin Dauphin Atsushi Ebihara Samuli Lehtonen Pedro Bond Schwartsburd Jordan Metzgar Li-Bing Zhang Li-Yaung Kuo Patrick J. Brownsey Masahiro Kato Marcelo Daniel Arana Francine C. Assis Michael S. Barker David S. Barrington Ho-Ming Chang Yi-Han Chang Yi-Shan Chao Cheng-Wei Chen De-Kui Chen Wen-Liang Chiou Vinicius Antonio de Oliveira Dittrich Yi-Fan Duan Jean-Yves Dubuisson Donald R. Farrar Susan Fawcett Jose Maria Gabriel y Galan Luiz Armando de Araujo Goes-Neto Jason R. Grant Amanda L. Grusz Christopher Haufler Warren Hauk Hai He Sabine Hennequin Regina Yoshie Hirai Layne Huiet Michael Kessler Petra Korall Paulo H. Labiak Anders Larsson Blanca Leen Chun-Xiang Li Fay-Wei Li Melanie Link-Perez Hong-Mei Liu Ngan Thi Lu Esteban I. Meza-Torres Xin-Yuan Miao Robbin Moran Claudine Massi Mynssens Nathalie Nagalingum Benjamin Ollgaard Alison M. Paul Jovani B. de S. Pereira Leon R. Perrie Monica Ponce Tom A. Ranker Christian Schulz Wataru Shinohara Alexander Shmakov Erin M. Sigel Filipe Soares de Souza Lana da Silva Sylvestre Weston Testo Luz Amparo Triana-Moreno Chie Tsutsumi Hanna Tuomisto IvAn A. Valdespino Alejandra Vasco Raquel Stauffer Viveros Alan Weakley Ran Wei Stina Weststrand Paul G. Wolf George Yatskievych Xiao-Gang Xu Yue-Hong Yan Liang Zhang Xian-Chun Zhang Xin-Mao Zhou | 2016 | Journal of Systematics and Evolution2016，54，6： | 44 |
| 3 | An Outbreak of NCIP (2019-nCoV) Infection in China --Wuhan, Hubei Province, 2019−2020显示文摘Emerging and re-emerging pathogens are great challenges to the public health(1).A cluster of cases of viral pneumonia of unknown etiology(VPUE),now known as novel coronavirus-infected pneumonia(NCIP),occurred in Wuhan,Hubei Province and was reported to health authorities on December 29,2019(2).A national,provincial,and municipal joint investigation team has been assembled to conduct field investigations and implement disease control and prevention measures.This report shows interim results of the investigation and makes recommendations for response measures. | The 2019-nCoV Outbreak Joint Field Epidemiology Investigation Team Qun Li | 2020 | China CDC weekly2020，2，5： | 31 |
| 4 | 不同基因型戊型肝炎病毒重组蛋白的抗原性分析显示文摘目的 :探讨不同基因型和亚型戊型肝炎病毒 (HEV)重组蛋白氨基酸序列的变化对HEV抗原性的影响 ,筛选出最佳的HEV抗原用于戊型肝炎的免疫诊断。方法 :用已知序列的HEV基因工程表达蛋白作为包被抗原 ,对已知血清标本进行酶联免疫吸附试验测定。结果 :6种不同抗原对 3 0份正常献血者血清无抗原性 ,对 17份急性戊型肝炎病人血清和 5份实验感染动物血清均呈阳性反应 ,但血清抗体滴度的高低与所用抗原的基因型有关 ,尤其是受到该抗原第 76位氨基酸变化的影响。结论 | 孟继鸿 戴星 窦晓光 YE KHUDYAKOV H A FIELDS | 2002 | 东南大学学报(医学版)2002，21，1： | 30 |
| 5 | 用微滤处理乳化含油废水显示文摘考察了PVDF膜和复合陶瓷膜的水通量、油截留率、以及膜堵塞等。研究结果表明:微滤的水通量和油截留率均很高,透过液中油含量<40~20mg/L。微滤是一种很有应用前景的废水处理方法。另外,还讨论了在膜堵塞状态下,微滤膜对溶于水小分子有机物的截留率。 | 宋航 Field,R | 1994 | 水处理技术1994，20，2： | 21 |
| 6 | Endoscopic retrograde cholangiopancreatography associated pancreatitis:A 15-year review显示文摘The aim of this article is to review the literature regarding post-endoscopic retrograde cholangiopancreatography(ERCP) pancreatitis.We searched for and evaluated all articles describing the diagnosis,epidemiology,pathophysiology,morbidity,mortality and prevention of post-ERCP pancreatitis(PEP) in adult patients using the PubMed database.Search terms included endoscopic retrograde cholangiopancreatography,pancreatitis,ampulla of vater,endoscopic sphincterotomy,balloon dilatation,cholangiography,adverse events,standards and utilization.We limited our review of articles to those published between January 1,1994 and August 15,2009 regarding human adults and written in the English language.Publicat ions from the reference sections were reviewed and included if they were salient and fell into the time period of interest.Between the dates queried,seventeen large(> 500 patients) prospective and four large retrospective trials were conducted.PEP occurred in 1-15 in the prospective trials and in 1-4 in the retrospective trials.PEP was also reduced with pancreatic duct stent placement and outcomes were improved with endoscopic sphincterotomy compared to balloon sphincter dilation in the setting of choledocholithiasis.Approximately 34 pharmacologic agents have been evaluated for the prevention of PEP over the last f ifteen years in 63 trials.Although 22 of 63 trials published during our period of review suggested a reduction in PEP,no pharmacologic therapy has been widely accepted in clinical use in decreasing the development of PEP.In conclusion,PEP is a well-recognized complication of ERCP.Medical treatment for prevention has been disappointing.Proper patient selection and pancreatic duct stenting have been shown to reduce the complication rate in randomized clinical trials. | Kevin E Woods Field F Willingham | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，5： | 20 |
| 7 | Mucosal mast cells are pivotal elements in inflammatory bowel disease that connect the dots:Stress,intestinal hyperpermeability and inflammation显示文摘Mast cells (MC) are pivotal elements in several physiological and immunological functions of the gastro- intestinal (GI) tract. MC translate the stress signals that has been transmitted through brain gut axis into release of proinflammatory mediators that can cause stimulation of nerve endings that could affect afferent nerve terminals and change their perception, affect intestinal motility, increase intestinal hyperpermeability and, in susceptible individuals, modulate the inflammation. Thus, it is not surprising that MC are an important element in the pathogenesis of inflammatory bowel disease and non inflammatory GI disorders such as IBS and mast cell enterocolitis. | Ashkan Farhadi Jeremy Z Fields Ali Keshavarzian | 2007 | World Journal of Gastroenterology2007，13，22： | 15 |
| 8 | Temperature and precipitation trends in Minqin Desert during the period of 1961-2007显示文摘This paper analyzed the data of temperature and precipitation in Minqin,typical desert area in north-west China,during the period of 1961 2007 by linear regression.The result indicated that the increasing rate of the mean annual temperature in Minqin was higher than that of the average of China;and the temperature in February increased by 3.01oC averagely in the past 47 years.The climate in Minqin displayed an evident warming trend.However,there was no evidently increasing trend of precipitation in the past 47 years,and drought occurred during the whole growing season. | ShuJuan ZHU1,2,3,ZhaoFeng CHANG1,2,3 1 Gansu Minqin National Field Observation & Research Station on Ecosystem of Desertified Rangeland,Minqin 733300,China 2 Key Laboratory of Desertification Combating of Gansu Province,Lanzhou 733070,China 3 Gansu Desert Control Research Institute,Lanzhou 733070,China | 2011 | Journal of Arid Land2011，3，3： | 14 |
| 9 | Field test of best management practice pollutant removal efficiencies in Shenzhen,China显示文摘This paper presents a study on the use of best management practices(BMPs)for controlling nonpoint pollution in the Xikeng Reservoir watershed located in Shenzhen,China.A BMP treatment train design,including a pond,a wetland,and a buffer strip placed in series was implemented at the reservoir location.A separate grass swale was also constructed at the site.Low impact development(LID)BMPs,namely a planter box and bioboxes,were used at the parking lot of the reservoir’s Administration Building.Samples were collected during storm events and were analyzed for total suspended solids(TSS),biochemical oxygen demand(BOD5),ammonia nitrogen(NH3-N),and total phosphorus(TP).The removal efficiencies of both BMP systems were evaluated using the Efficiency Ratio(ER)method based on the event mean concentration(EMC)data.In summary,the pond/wetland treatment train removed 70%–90%of TSS,20%–50%of BOD5,and 30%–70%of TP and NH3-N.The swale removed 50%–90%of TSS,30%–55%of BOD5,–10%–35%of NH3-N,and 25%–70%of TP.For the planter box and biobox,the ranges of removal rates were 70%–90%,20%–50%,and 30%–70%for TSS,BOD5,and ammonia and phosphorus,respectively. | Ru ZHANG Wenbin ZHOU Richard FIELD Anthony TAFURI Shaw LYU Keli JIN | 2009 | Frontiers of Environmental Science & Engineering2009，3，3： | 12 |
| 10 | Biochemical Models for S-RNase-Based Self-Incompatibility显示文摘S-RNase-based 自我障碍(SI ) 是许多 flowering 植物种类采用阻止使近交并且支持异型杂交后代的一个遗传上坚定的 self/non-self-recognition 过程。为 Plantaginaceae, Rosaceae 和 Solanaceae,分别地, S-RNase 和 S 地点 F 盒子(在 S 地点的二多重突变而产生之遗传的基因) 在 SI 相互作用期间决定女、男的特性,这现在被知道。然而,这二基因的突变而产生之遗传的产品怎么在花粉试管内交往导致自我花粉试管的特定的生长抑制,尚待被调查。这里,我们考察所有以前建议的生物化学的模型并且讨论他们的预言是否与所有 SI 现象一致,包括 SI 在带二不同花粉 S 等位基因的花粉垮掉的竞争相互作用。我们也在不兼容、兼容的花粉试管考虑到 S-RNases 的区分的最近的调查结果讨论这些模型。最后,我们从我们 PiSLF (暗紫色 inflata SLF ) 和 S-RNase 的最近的生物化学的研究总结结果,并且在 Solanaceae 为 SI 的生物化学的机制介绍一个新模型。这个模型的信条是 PiSLF 优先地在一个花粉试管的细胞质与它的非自我 S-RNases 交往导致象 E3 一样建筑群的集会,它然后调停通过 ubiquitin26S proteasome 小径的非自我 S-RNases 的 ubiquitination 和降级。这个模型能向所有 SI 解释现象并且同时,为进一步的学习提出了新问题。 | Zhi-Hua Hua Allison Fields Teh-hui Kao | 2008 | Molecular Plant2008，1，4： | 11 |
| 11 | The immune modifying effects of amino acids on gut-associated lymphoid tissue显示文摘The intestine and the gut-associated lymphoid tissue(GALT) are essential components of whole body immune defense,protecting the body from foreign antigens and pathogens,while allowing tolerance to commensal bacteria and dietary antigens.The requirement for protein to support the immune system is well established.Less is known regarding the immune modifying properties of individual amino acids,particularly on the GALT.Both oral and parenteral feeding studies have established convincing evidence that not only the total protein intake,but the availability of specific dietary amino acids(in particular glutamine,glutamate,and arginine,and perhaps methionine,cysteine and threonine) are essential to optimizing the immune functions of the intestine and the proximal resident immune cells.These amino acids each have unique properties that include,maintaining the integrity,growth and function of the intestine,as well as normalizing inflammatory cytokine secretion and improving T-lymphocyte numbers,specific T cell functions,and the secretion of IgA by lamina propria cells.Our understanding of this area has come from studies that have supplemented single amino acids to a mixed protein diet and measuring the effect on specific immune parameters.Future studies should be designed using amino acid mixtures that target a number of specific functions of GALT in order to optimize immune function in domestic animals and humans during critical periods of development and various disease states. | Megan R Ruth Catherine J Field | 2013 | Journal of Animal Science and Biotechnology2013，4，3： | 11 |
| 12 | A new cyamodontoid placodont from Triassic of Guizhou, China显示文摘A new cyamodontoid placodont is named (Pse-phochelys polyosteoderma gen. et. sp. nov.) and described based on a three-dimensionally preserved specimen. The material comes from the Wayao Member of the Falang Formation (Carnian, Late Triassic) in Guizhou Province, southwestern China. The skull of Psephochelys shows a unique combination of characteristics observed in Psepho-derma and Placochelys, and the carapace is diagnostic of a new taxon as well. The ventral dermal armor of Psephochelys differs from all other known cyamodontoids in that it comprises irregular marginal osteoderms in loose contact with each other, and gastralia between them. The cranial suture pattern is in part difficult to analyze due to apparent co-ossification of elements, or poor delimitation of sutures. This affects primarily the demarcation of the nasal from the prefrontal, and the relation between the anterior part of the parietal, posterior ends of the frontals, and postfrontals. However, the postfrontal appears to enter the | LI Chun & O. RieppelInstitute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing 100044, China The Field Museum, Chicago, II 60605-2496, USA | 2002 | Chinese Science Bulletin2002，47，5： | 10 |
| 13 | Intrahepatic natural killer T cell populations are increased in human hepatic steatosis显示文摘AIM: To determine if natural killer T cell (NKT) populations are affected in nonalcoholic fatty liver disease (NAFLD). METHODS: Patients undergoing bariatric surgery underwent liver biopsy and blood sampling during surgery. The biopsy was assessed for steatosis and immunocyte infiltration. Intrahepatic lymphocytes (IHLs) were isolated from the remainder of the liver biopsy, and peripheral blood mononuclear cells (PBMCs) were isolated from the blood. Expression of surface proteins on both IHLs and PBMCs were quantified using flow cytometry. RESULTS: Twenty-seven subjects participated in thisstudy. Subjects with moderate or severe steatosis had a higher percentage of intrahepatic CD3+/CD56+ NKT cells (38.6%) than did patients with mild steatosis (24.1%, P = 0.05) or those without steatosis (21.5%, P = 0.03). Patients with moderate to severe steatosis also had a higher percentage of NKT cells in the blood (12.3%) as compared to patients with mild steatosis (2.5% P = 0.02) and those without steatosis (5.1%, P = 0.05). CONCLUSION: NKT cells are significantly increased in the liver and blood of patients with moderate to severe steatosis and support the role of NKT cells in NAFLD. | Michael Adler Sarah Taylor Kamalu Okebugwu Herman Yee Christine Fielding George Fielding Michael Poles | 2011 | World Journal of Gastroenterology2011，17，13： | 10 |
| 14 | 加热环境对人工合成磁赤铁矿热磁行为的影响显示文摘热磁测量,包括高温磁化率和高温磁化强度测量,是根据热磁曲线转折点的温度(居里点、尼尔点或相变点)鉴定样品中磁性矿物种类的有效方法.本文选取两个人工合成磁赤铁矿样品,利用四种热磁测量仪器分析不同的条件下测得的热磁曲线.依据样品与空气接触程度,将测量环境设为开放、封闭、封闭(通入氩气或氮气)三类.结果表明:热磁测量环境的开放程度对居里点和曲线可逆程度产生极大的影响.封闭环境下测得的居里点较开放环境下的低,分别对应磁铁矿和磁赤铁矿;开放系统的热磁曲线不可逆程度高于封闭系统.造成这些差异的原因是氧化还原条件的不同.本文的磁赤铁矿样品在封闭的条件下,加热至250℃左右开始转化为磁铁矿,因此无法通过居里点被正确识别;在开放的氧化环境下,加热的最终产物为赤铁矿,能够测得正确的居里点.本实验结果启发人们:在不同的加热环境下,磁性矿物可能表现出不同的热磁行为,根据单一的热磁曲线,很容易对样品中磁性矿物的种类造成误判.全面对比不同条件下的测量结果,才能够得出更为准确的结果. | 刘秀铭 吕镔 李平原 Field Russell 毛学刚 郭晖 马明明 赵国永 | 2013 | 地球物理学报2013，56，5： | 10 |
| 15 | Impact of KRAS mutation and PTEN expression on cetuximab-treated colorectal cancer显示文摘AIM:To investigate the prognostic value of KRAS mutation,and phosphatase and tensin (PTEN) expression in Chinese metastatic colorectal cancer metastatic colorectal cancer (mCRC) patients treated with cetuximab.METHODS:Ninety Chinese mCRC patients treated with cetuximab were evaluated for KRAS mutation and PTEN protein expression by DNA sequencing of codons 12 and 13 and immunohistochemistry,respectively.We then selected 61 patients treated with cetuximab,either in combination with chemotherapy,or alone as a second-line or third-line regimen to assess whether KRAS mutation or PTEN protein expression is associated with the response and the survival time of mCRC patients treated with cetuximab.RESULTS:KRAS mutation was found in 30 (33.3%) tumor samples from the 90 patients,and positive PTEN expression was detected in 58 (64.4%) of the 90 patients.Among the 61 patients who were treated with cetuximab as a second-line or third-line regimen,the resistance to cetuximab was found in 22 patients with KRAS mutation and in 39 patients without KRAS mutation,with a response rate of 4.5% and 46.1% respectively (P=0.001),a shorter median progression-free survival (PFS) time of 14 ± 1.3 wk and 32 ± 2.5 wk respectively (P < 0.001),a median overall survival (OS) time of 11 ± 1.2 mo and 19 ± 1.8 mo respectively (P < 0.001),as well as in 24 patients with negative PTEN expression and in 37 patients with positive PTEN expression respectively (P < 0.001),with a responsive rate of 4.2% and 48.6% respectively,a shorter median PFS survival time of 17 ± 2.0 wk and 28 ± 1.9 wk respectively (P=0.07),and a median OS time of 11 ± 1.3 mo and 18 ± 1.9 mo respectively (P=0.004).Combined KRAS mutation and PTEN expression analysis showed that the PFS and OS time of patients with two favorable prognostic factors were longer than those of patients with one favorable prognostic factor or no favorable prognostic factor (P < 0.001).CONCLUSION:KRAS mutation and PTEN protein expression are significantly correlated with the response rate and survival time of Chinese mCRC patients treated with cetuximab. | Fang-Hua Li,Zhuang-Hua Li,Hui-Yan Luo,Miao-Zhen Qiu,Yu-Hong Li,Rui-Hua Xu,State Key Laboratory of Oncology in Southern China,Department of Medical Oncology,Sun YatSen University Cancer Center,Guangzhou 510060,Guangdong Province,China Fang-Hua Li,Department of Medical Oncology,Shengli Oil Field Central Hospital,Dongying 257034,Shandong Province,China Lin Shen,Department of GI Oncology,Peking University School of Oncology,Beijing Cancer Hospital and Institute,Beijing 100142,China Hui-Zhong Zhang,State Key Laboratory of Oncology in Southern China,Department of Pathology,Sun Yat-Sen University Cancer Center,Guangzhou 510060,Guangdong Province,China | 2010 | World Journal of Gastroenterology2010，16，46： | 9 |
| 16 | 28例转移性肝癌腹腔镜肝切除术显示文摘目的总结转移性肝癌的腹腔镜肝切除术经验。方法对1999—2006年度布里斯班医院所实施的转移性肝癌腹腔镜肝切除术病人进行回顾性研究。结果经病理证实的28例转移性肝癌病人进行了腹腔镜肝切除,13例进行左肝外侧叶切除,9例进行了右半肝切除。其余6例行肝段或不规则切除。追踪随访12例由直结肠转移的转移性肝癌病人2年存活率和无瘤生存率分别为75%和67%。结论在严格选择过的恶性肿瘤病人中行腹腔镜肝切除术是安全可行的。对病人要有适当的分期.术者需具丰富的开腹肝切除术经验和腹腔镜操作技能。 | 吴志明 Nick O'Rourke Lan Shaw Les Nathanson Lan Martin George Fielding | 2009 | 中华肝胆外科杂志2009，15，12： | 8 |
| 17 | Metastatic colorectal cancer-past,progress and future显示文摘The clinical management of metastatic (stage Ⅳ) colorectal cancer (CRC) is a common challenge faced by surgeons and physicians. The last decade has seen exciting developments in the management of CRC, with significant improvements in prognosis for patients diagnosed with stage Ⅳ disease. Treatment options have expanded from 5-fluorouracil alone to a range of pharmaceutical and interventional therapies, improving survival, and providing a cure in selected cases. Enhanced understanding of the biologic pathways most important in colorectal carcinogenesis has led to a new generation of drugs showing promise in advanced disease. It is hoped that in the near future the treatment paradigm of metastatic CRC will be analogous to that of a chronic illness, rather than a rapidly terminal condition. This overview discusses the epidemiology of advanced CRC and currently available therapeutic options including medical, surgical, ablative and novel modalities in the management of metastatic colorectal cancer. | Kathryn Field Lara Lipton | 2007 | World Journal of Gastroenterology2007，13，28： | 8 |
| 18 | Regulation of epithelium-specific Ets-like factors ESE-1 and ESE-3 in airway epithelial cells: potential roles in airway inflammation显示文摘航线发炎是许多呼吸障碍的特点,例如气喘和膀胱的纤维变性。在发炎触发的航线基因表示的变化在这些疾病的致病起一个关键作用。基因连接研究建议 ESE-2 和 ESE-3,编码上皮特定的 Ets-domain-containing 抄写因素,是候选人气喘危险性基因。我们这里报导 et 家庭抄写因素 ESE-1 的另一个成员的表示,以及 ESE-3,起来在支气管的上皮的房间线由煽动性的 cytokines interleukin-1beta (IL-1beta ) 和肿瘤坏死 factor-alpha (TNF-alpha ) 调整了。有 IL-1beta 和 TNF-alpha 的这些房间的处理为 ESE-1 和 ESE-3 导致了信使 rna 表示的戏剧的增加。我们证明导致的表示被抄写因素 NF-kappaB 的激活调停。我们描绘了 ESE-1 和 ESE-3 倡导者并且识别了为导致 cytokine 的表达式被要求的 NF-kappaB 有约束力的序列。另外,我们也表明那 ESE-1 在上面调整 ESE-3 表示, down 由 cytokines 调整它的自己的正式就职。最后,我们在 Elf3 显示出那(对人的 ESE-1 相应) 猛烈老鼠,煽动性的 cytokine interleukin-6 (IL-6 ) 的表示是调整的 down。我们的调查结果建议 ESE-1 和 ESE-3 在航线发炎起一个重要作用。 | Jing Wu Rongqi Duan Huibi Cao Deborah Field Catherine M Newnham David R Koehler Noe Zamel Melanie A Pritchard Paul Hertzog Martin Post A Keith Tanswell Jim Hu | 2008 | Cell Research2008，18，6： | 6 |
| 19 | Hijacking antibody-induced CTLA-4 lysosomal degradation for safer and more effective cancer immunotherapy显示文摘It remains unclear why the clinically used anti-CTLA-4 antibodies, popularly called checkpoint inhibitors, have severe immunotherapy-related adverse effects (irAEs) and yet suboptimal cancer immunotherapeutic effects (CITE). Here we report that while irAE-prone Ipilimumab and TremeIgG1 rapidly direct cell surface CTLA-4 for lysosomal degradation, the non-irAE-prone antibodies we generated, HL12 or HL32, dissociate from CTLA-4 after endocytosis and allow CTLA-4 recycling to cell surface by the LRBA-dependent mechanism. Disrupting CTLA-4 recycling results in robust CTLA-4 downregulation by all anti-CTLA-4 antibodies and confers toxicity to a non-irAE-prone anti-CTLA-4 mAb. Conversely, increasing the pH sensitivity of TremeIgG1 by introducing designed tyrosine-to-histidine mutations prevents antibody-triggered lysosomal CTLA-4 downregulation and dramatically attenuates irAE. Surprisingly, by avoiding CTLA-4 downregulation and due to their increased bioavailability, pH-sensitive anti-CTLA-4 antibodies are more effective in intratumor regulatory T-cell depletion and rejection of large established tumors. Our data establish a new paradigm for cancer research that allows for abrogating irAE while increasing CITE of anti-CTLA-4 antibodies. | Yan Zhang Xuexiang Du Mingyue Liu Fei Tang Peng Zhang Chunxia Ai James K. Fields Eric J. Sundberg Olga S. Latinovic Martin Devenport Pan Zheng Yang Liu | 2019 | Cell Research2019，29，8： | 6 |
| 20 | Mycophenolate mofetil for maintenance of remission in steroid-dependent autoimmune pancreatitis显示文摘Systemic corticosteroids represent the standard treatment for autoimmune pancreatitis with IgG4-associated cholangitis.For steroid-dependent disease,azathioprine has been used for maintenance of remission.Mycophenolate mofetil has been used for transplant immunosuppression and more recently for autoimmune hepatitis;however,there are no case reports to date on the use of mycophenolate mofetil in adult patients with autoimmune pancreatitis.A patient with IgG4-mediated autoimmune pancreatitis and IgG4-associated cholangitis refractory to steroids and intolerant of azathioprine was treated with mycophenolate mofetil,which inhibits de novo guanosine synthesis and blockade of both B and T lymphocyte production.Introduction of mycophenolate mofetil and uptitration to 1000 mg by mouth twice daily over a treatment period of 4 mo was associated with improvement in the patient's energy level and blood glucose control and was not associated with any adverse events.The patient was managed without a biliary stent.However,there was a return of symptoms,jaundice,increase in transaminases,and hyperbilirubinemia when the prednisone dose reached 11 mg per day.In the first report of mycophenolate mofetil use in an adult patient with IgG4-associated autoimmune pancreatitis and IgG4-associated cholangitis,the introduction of mycophenolate mofetil was safe and well-tolerated without adverse events,but it did not enable discontinuation of the steroids.Mycophenolate mofetil and other immunomodulatory therapies should continue to be studied for maintenance of remission in the large subset of patients with refractory or recurrent autoimmune pancreatitis. | Jamie B Sodikoff Steven A Keilin Sheila J Bharmal Melinda M Lewis Gottumukkala S Raju Field F Willingham | 2012 | World Journal of Gastroenterology2012，18，18： | 6 |
您所在的机构暂未开通此部分的功能，请联系管理员