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	题名	作者	年代	出处	被引量
1	Involvement of eicosanoids in the pathogenesis of pancreatic cancer: the roles of cyclooxygenase-2 and 5-lipoxygenase显示文摘The interplay between inflammation and cancer progression is a growing area of research. A combination of clinical, epidemiological, and basic science investigations indicate that there is a relationship between inflammatory changes in the pancreas and neoplastic progression. Diets high in ω-6 polyunsaturated fatty acids provide increased substrate for arachidonic acid metabolism by cyclooxygenase-2(COX-2) and 5-lipoxygenase(5-LOX) to form eicosanoids. These eicosanoids directly contribute to pancreatic cancer cell proliferation. Both COX-2 and 5-LOX are upregulated in multiple cancer types, including pancreatic cancer. In vitro studies using pancreatic cancer cell lines have demonstrated upregulation of COX-2 and 5-LOX at both the mRNA and protein levels. When COX-2 and 5-LOX are blocked via a variety of mechanisms, cancer cell proliferation is abrogated both in vitro and in vivo.The mechanism of COX-2 has been shown to include effects on apoptosis as well as angiogenesis. 5-LOX has been implicated in apoptosis. The use of COX-2 and 5-LOX inhibitors in clinical studies in patients with pancreatic cancer has been limited. Patient enrollment has been restricted to those with advanced disease which makes evaluation of these drugs as chemopreventive agents difficult. COX-2 and 5-LOX expression have been shown to be present during the early neoplastic changes of pancreatic cancer, well before progression to invasive disease. This indicates that the ideal role for these interventions is early in the disease process as preventive agents, perhaps in patients with chronic pancreatitis or hereditary pancreatitis.	Lawrence M Knab Paul J Grippo David J Bentrem	2014	World Journal of Gastroenterology2014，20，31：	9
2	The Cost-Effectiveness of Neoadjuvant Chemoradiation is Superior to a Surgery-First Approach in the Treatment of Pancreatic Head Adenocarcinoma显示文摘	Daniel E. Abbott Ching-Wei David Tzeng Ryan P. Merkow Scott B. Cantor George J. Chang Matthew Harold Katz David J. Bentrem Karl Y. Bilimoria Christopher H. Crane Gauri R. Varadhachary James L. Abbruzzese Robert A. Wolff Jeffrey E. Lee Douglas B. Evans Jas	2013	Annals of Surgical Oncology2013，，3：	3
3	Extent of Surgery Affects Survival for Papillary Thyroid Cancer显示文摘	Karl Y. Bilimoria David J. Bentrem Clifford Y. Ko Andrew K. Stewart David P. Winchester Mark S. Talamonti Cord Sturgeon	2007	Annals of Surgery2007，，3：	3
4	A Multicenter Analysis of Distal Pancreatectomy for Adenocarcinoma: Is Laparoscopic Resection Appropriate?显示文摘	David A. Kooby William G. Hawkins C. Max Schmidt Sharon M. Weber David J. Bentrem Theresa W. Gillespie Johnita Byrd Sellers Nipun B. Merchant Charles R. Scoggins Robert C.G. Martin Hong Jin Kim Syed Ahmad Clifford S. Cho Alexander A. Parikh Carrie K. Chu	2010	Journal of the American College of Surgeons2010，，5：	2
5	The Value of Peritoneal Cytology as a Preoperative Predictor in Patients With Gastric Carcinoma Undergoing a Curative Resection显示文摘	David Bentrem Andrew Wilton Madhu Mazumdar Murray Brennan Daniel Coit	2005	Annals of Surgical Oncology2005，，：	2
6	Left-sided Pancreatectomy: A Multicenter Comparison of Laparoscopic and Open Approaches显示文摘	David A. Kooby Theresa Gillespie David Bentrem Attila Nakeeb Max c. Schmidt Nipun B. Merchant Alex A. Parikh Robert C. G. Martin Charles R. Scoggins Syed Ahmad Hong Jin Kim Jaemin Park Fabian Johnston Matthew J. Strouch Alex Menze Jennifer Rymer Rebecca M	2008	Annals of Surgery2008，，3：	2
7	Utilization of Parenteral Nutrition Following Pancreaticoduodenectomy: Is Routine Jejunostomy Tube Placement Warranted?显示文摘	Irina Yermilov Sushma Jain Evan Sekeris David J. Bentrem Oscar J. Hines Howard A. Reber Clifford Y. Ko James S. Tomlinson	2009	Digestive Diseases and Sciences2009，，7：	2
8	Extent of surgery affects survival for papillary thyroid cancer显示文摘	Bilimoria KY Bentrem D J Ko CY	2007	Ann Surg2007，246，3：	1
9	Surgical therapy formetastatic disease to the liver显示文摘	Bentrem D J de Matteo R P Blumgart L H	2005	Ann Rev Med2005，56，：	1
10	Laparoscopic versus open resection of gastric gastrointestinal stromal tu- mors显示文摘	Melstrom LG Phillips JD Bentrem D J	2012	Am J Clin Oncol2012，35，5：	1
11	Overex-pression of 5-lipoxygenase in colon polyps and cancer and theeffect of 5-LOX inhibitors in vitro and in a murine model显示文摘	Melstrom L G Bentrem D J Salabat M R	2008	Clin Cancer Res2008，14，20：	1
12	T1 adenocarci- noma of the rectum: transanal excision or radical surgery?显示文摘	Bentrem DJ Okabe S Wong WD	2005	Ann Surg2005，242，4：	1
13	Extent of surgery affects survival for papillary thyroid cancer显示文摘	Bilimoria KY Bentrem DJ Ko CY		0，，03：	1
14	Extent of surgery affects survival for papillary thyroid cancer 显示文摘	Bilimoria KY Bentrem DJ Ko CY	2007	Ann Surg2007，246，3：	1
15	Tamoxifen, raloxifene and the prevention of breast cancer显示文摘	Craig Jordan V	2002	Minerva Endocrinol2002，27，2：	1
16	Small bowel cancer in the United States: changes in epidemiology, treatment, and survival over the last 20 yeas 显示文摘	BILIMORIA K Y BENTREM D J WAYNE J D	2009	Ann Surg2009，249，1：	1
17	Clinical correlation of endoscop-ic ultrasonography with pathologic stage and outcome in patients un-dergoing curative resection for gastric cancer显示文摘	Bentrem D Gerdes H Tang L	2007	Ann Surg Oncol2007，14，6：	1
18	Control of the estrogen-like actions of the Tamoxifen-estrogen receptor complex by the surface amino acid at position 351显示文摘	Levenson AS MacGregor Schafer JI Bentrem DJ	2001	J Steroid Biochem Mol Biol2001，76，：	1
19	Readmissions following pancreaticoduodenectomy for pancreas cancer: a popula- tion-based appraisal显示文摘	Yermilov I Bentrem D Sekeris E	2009	Ann Surg Oncol2009，16，3：	1
20	Comparison of sentinel lymph node biopsy alone and completion axillary lymph node dissection for node-positive breast cancer显示文摘	Bilimoria KY Bentrem DJ Hansen NM	2009	J Clin Oncol2009，27，18：	1

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