|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade显示文摘PD-1 blockade represents a major therapeutic avenue in anticancer immunotherapy.Delineating mechanisms of secondary resistance to this strategy is increasingly important.Here,we identified the deleterious role of signaling via the type I interferon(IFN)receptor in tumor and antigen presenting cells,that induced the expression of nitric oxide synthase 2(N0S2),associated with intratumor accumulation of regulatory T cells(Treg)and myeloid cells and acquired resistance to anti-PD-1 monoclonal antibody(mAb).Sustained IFNP transcription was observed in resistant tumors,in turn inducing PD-L1 and N0S2 expression in both tumor and dendritic cells(DC).Whereas PD-L1 was not involved in secondary resistance to anti-PD-1 mAb,pharmacological or genetic inhibition of N0S2 maintained long-term control of tumors by PD-1 blockade,through reduction of Treg and DC activation.Resistance to immunotherapies,including anti-PD-1 mAb in melanoma patients,was also correlated with the induction of a type I IFN signature.Hence,the role of type I IFN in response to PD-1 blockade should be revisited as sustained type I IFN signaling may contribute to resistance to therapy. | Nicolas Jacquelot Takahiro Yamazaki Maria PRoberti Connie PMDuong Miles CAndrews Loic Verlingue Gladys Ferrere Sonia Becharef Marie Vetizou Romain Daillere Meriem Messaoudene David PEnot Gautier Stoll Stefano Ugel Maria Marigo Shin Foong Ngiow Aurelien Marabelle Armelle Prevost-Blondel Pierre-Olivier Gaudreau Vancheswaran Gopalakrishnan Alexander MEggermont Paule Opolon Christophe Klein Gabriele Madonna Paolo AAscierto Antje Sucker Dirk Schadendorf Mark JSm yth Jean-Charles Soria Guido Kroemer Vincenzo Bronte Jennifer Wargo and Laurence Zitvogel | 2019 | Cell Research2019，29，10： | 6 |
| 2 | 851 resected cystic tumors of the pancreas: A 33-year experience at the Massachusetts General Hospital显示文摘 | Nakul P. Valsangkar Vicente Morales-Oyarvide Sarah P. Thayer Cristina R. Ferrone Jennifer A. Wargo Andrew L. Warshaw Carlos Fernández-del Castillo | 2012 | Surgery2012，，3： | 3 |
| 3 | Pancreatic Ductal Adenocarcinoma: Is There a Survival Difference for R1 Resections Versus Locally Advanced Unresectable Tumors? What Is a “True” R0 Resection?显示文摘 | Ioannis T. Konstantinidis Andrew L. Warshaw Jill N. Allen Lawrence S. Blaszkowsky Carlos Fernandez-del Castillo Vikram Deshpande Theodore S. Hong Eunice L. Kwak Gregory Y. Lauwers David P. Ryan Jennifer A. Wargo Keith D. Lillemoe Cristina R. Ferrone | 2013 | Annals of Surgery2013，，4： | 3 |
| 4 | Lymphoepithelial cysts and cystic lymphangiomas: Underrecognized benign cystic lesions of the pancreas显示文摘AIM: To identify their diagnostic and prognostic clinical characteristics in a large series.METHODS: Retrospective review of clinicopathologic and imaging characteristics of patients diagnosed with lymphoepithelial cysts and cystic lymphangiomas of the pancreas at Massachusetts General Hospital.RESULTS: Twelve patients were identified between 1/1/1997 and 8/1/2007. Their median age was 55.5 years(range 19-78 years), and 6 were females. The le-sion was incidentally discovered in half of the patients.Contrast enhanced computed tomography demonstrat-ed that the cysts had thin walls, without calcifications, pancreatic duct dilation or pancreatic parenchyma inva-sion. Endoscopic ultrasound with fine needle aspiration(EUS/FNA) confirmed the diagnosis of a lymphoepithe-lial cyst in 3 patients, one of whom was spared an op-eration and continues to do well after 6 years. Eleven patients had a resection: 3 pancreaticoduodenecto-mies, 7 distal pancreatectomies, and 1 enucleation. The median size of the cysts was 3 cm(range 2-20 cm). At a median follow-up of 57 mo no recurrences or other pancreas-related conditions occurred.CONCLUSION: Lymphoepithelial cysts and cystic lymphangiomas of the pancreas can be diagnosed with a combination of contrast-enhanced computed tomog-raphy scans and EUS/FNA. If the lesion is asymptom-atic, an operation might be avoided. | Ioannis T Konstantinidis Avinash Kambadakone Onofrio A Catalano Dushyant V Sahani Vikram Deshpe David G Forcione Jennifer A Wargo Carlos Fernandez-del Castillo Keith D Lillemoe Andrew L Warshaw Cristina R Ferrone | 2014 | World Journal of Gastrointestinal Surgery2014，6，7： | 2 |
| 5 | Pancreatic ductal adenocarcinoma: Long-term survival does not equal cure显示文摘 | Cristina R. Ferrone Rafael Pieretti-Vanmarcke Jordan P. Bloom Hui Zheng Jackye Szymonifka Jennifer A. Wargo Sarah P. Thayer Gregory Y. Lauwers Vikram Deshpande Mari Mino-Kenudson Carlos Fernández-del Castillo Keith D. Lillemoe Andrew L. Warshaw | 2012 | Surgery2012，，： | 2 |
| 6 | Th2 allergic immune re- sponse to inhaled fungal antigens is modulated by TLR-4-inde- pendent bacterial products 显示文摘 | Allard J B Rinaldi L Wargo M J | 2009 | Eur J Immunol2009，39，3： | 1 |
| 7 | Nutrition management for the promotion of growth in very low birth weight premature infants 显示文摘 | Prince A Groh - Wargo S | 2013 | Nutr Clin Pract2013，28，6： | 1 |
| 8 | Experimental study of thermally generated reverse stratified layers in a fire tunnel 显示文摘 | Hwang C C Wargo J D | 1986 | Combust Flame1986，66，： | 1 |
| 9 | Systematic review of diagnostic utility and therapeutic effectiveness of cervical facet joint interventions显示文摘 | Falco FJ Erhart S Wargo BW | 2009 | Pain Physician2009，12，2： | 1 |
| 10 | A comprehensive review of the loop diuretics:should furosemide be first line显示文摘 | Wargo KA Banta WM | 2009 | Ann Pharmacother2009，43，11： | 1 |
| 11 | Vector and Tensor Based Bond Graphs for Physical System Modelling显示文摘 | Fahrenthold E Wargo J | 1991 | Journal of the Franklin Institute1991，328，： | 1 |
| 12 | Dopant Segregation during Vertical Bridgman-Stockbarger Growth with Melt Stabilization by Strong Axial Magnetic Fields显示文摘 | Matheson D H Wargo M S Motakef D | 1987 | Journal of Crystal Growth1987，，85： | 1 |
| 13 | Experimental study of thermally generatedreverse stratified layers in a fire tunnel显示文摘 | Hwang C C Wargo J D | 1986 | Combustion and Flame1986，66，： | 1 |
| 14 | A TCR targeting the HLA-A* 0201-restricted epitope of MAGE-A3 recognizes multiple epitopes of the MAGE-A antigen superfamily in several types of cancer 显示文摘 | Chinnasamy N Wargo JA Yu Z | 2011 | J Immunol2011，186，2： | 1 |
| 15 | Treatment of posterior tibial ten- don dysfunction without flexor digitorum tendon transfer: a retrospective study of 34 patients 显示文摘 | Didomenico L Stein DY Wargo - Dors- ey M | 2011 | J Foot Ankle Surg2011，50，3： | 1 |
| 16 | Universes collide : combining immunotherapy with targeted therapy for cancer显示文摘 | Wargo JA Cooper ZA Flaherty KT | 2014 | Cancer Discov2014，4，12： | 1 |
| 17 | Cancer immunothera- py highlights from the 2014 ASCO meeting显示文摘 | Harshman LC Drake CG Wargo JA | 2014 | Cancer Immunol Res2014，2，8： | 1 |
| 18 | Effects and consequences of stress on root physiology显示文摘 | WARGO P M | 1983 | Journal of Arboriculture1983，9，： | 1 |
| 19 | Aviation Application Over IPv6:Performance Issues显示文摘 | Chris Wargo and Sachin La1 | 2004 | Computer Networks & Software 7045 Alban Station Court Suite 8 -225 Springfield2004，，： | 1 |
| 20 | Understanding the have-knots: The role of stress in just about everything显示文摘 | Wargo E | 2007 | Observer2007，，20： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员