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| 1 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 2 | The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation显示文摘MRE11/RAD50/NBS1 建筑群是很快招募到 DNA 双海滨裂缝(DSB ) 的主要传感器。MRE11 被知道是由在它的 glycine-arginine-rich (长嘴硬鳞鱼) 以内的 PRMT1 的精氨酸 methylated 主题。在这研究,我们报导在 GAR 主题与离氨酸代替精氨酸并且产生 MRE11 缺乏 methylated 精氨酸的 RK 蛋白质。Mre11 RK/RK 老鼠对 γ 过分敏感;照耀(红外) 和从这些老鼠的房间显示了房间周期检查点缺点和染色体不稳定性。而且, Mre11 RK/RK MEF 展出了在 RPA 和 RAD51 的招募表明缺点和缺陷到损坏地点的 ATR/CHK1。M RK 形成的 RN 建筑群并且对 DNA 损坏并且通常的地点局部性响应红外激活 ATM 小径。M RK RN 建筑群在为响应红外在 vivo 观察的损害 DNA 结束切除术和 ATR 激活负责的 vitro 展出了 exonuclease 和 DNA 有约束力的缺点。我们的调查结果在 DSB 修理为 MRE11 长嘴硬鳞鱼主题的关键角色提供基因证据,并且在 MRE11 长嘴硬鳞鱼表明在 translational 以后修正之间的一个机械学的连接主题并且 DSB 处理,以及发信号的 ATR/CHK1 检查点。 | Zhenbao Yu Gillian Vogel Yan Coulombe Danielle Dubeau Elizabeth Spehalski Josee Hebert David O Ferguson Jean Yves Masson Stephane Richard | 2012 | Cell Research2012，22，2： | 5 |
| 3 | A demonstration project of Global Alliance against Chronic Respiratory Diseases:Prediction of interactions between air pollution and allergen exposure—the Mobile Airways Sentinel NetworK-Impact of air POLLution on Asthma and Rhinitis approach显示文摘This review analyzes the state and recent progress in the field of information support for pollen allergy sufferers.For decades,information available for the patients and allergologists consisted of pollen counts,which are vital but insufficient.New technology paves the way to substantial increase in amount and diversity of the data.This paper reviews old and newly suggested methods to predict pollen and air pollutant concentrations in the air and proposes an allergy risk concept,which combines the pollen and pollution information and transforms it into a qualitative risk index.This new index is available in an app(Mobile Airways Sentinel NetworK-air)that was developed in the frame of the European Union grant Impact of Air POLLution on sleep,Asthma and Rhinitis(a project of European Institute of Innovation and Technology-Health).On-going transformation of the pollen allergy information support is based on new technological solutions for pollen and air quality monitoring and predictions.The new information-technology and artificial-intelligence-based solutions help to convert this information into easy-to-use services for both medical practitioners and allergy sufferers. | Mikhail Sofiev Yuliia Palamarchuk Annabelle Bedard Xavier Basagana Josep M.Anto Rostislav Kouznetsov Rodrigo Delgado Urzua Karl Christian Bergmann Joao A.Fonseca Govert De Vries Michiel Van Erd Isabella Annesi-Maesano Daniel Laune Jean Louis Pepin Ingrid Jullian-Desayes Stephane Zeng Wienczyslawa Czarlewski Jean Bousquet | 2020 | Chinese Medical Journal2020，，13： | 3 |
| 4 | 三维骨建模系统在人工全膝关节置换时旋转对位的作用显示文摘目的为了进行人工全膝关节置换时假体旋转对位的量化研究,探讨三维骨建模的计算机辅助手术系统对量化操作的精确性和有效性。方法2002年11月-2003年6月,采用三维骨建模Ceravision系统对21例21膝保守治疗无效的三间隔骨性关节炎患者行人工全膝关节置换术。男5例5膝,女16例16膝;年龄64~79岁,平均72.4岁。左膝10例,右膝11例。主要临床表现为膝关节疼痛和活动受限。病程2~10年。14例膝内翻,7例膝外翻。根据相关的临床体检、影像学和导航系统资料,对术中假体旋转对位量值,并对术后3个月膝关节活动度、膝关节松弛度和髌骨稳定性进行分析。结果全部患者术后切口均Ⅰ期愈合。21例患者均获随访12~16个月,平均13.3个月。术中股骨假体旋转对位内旋1°~外旋5°,胫骨假体旋转对位内旋0°~外旋5°。其中膝内翻患者,股骨假体旋转对位外旋1°~外旋5°,胫骨假体旋转对位外旋2°~外旋5°;膝外翻患者,股骨假体旋转对位内旋1°~外旋4°,胫骨假体旋转对位内旋0°~外旋4°。术后3个月膝关节活动度,最大屈膝度为105~130°,平均115°;膝关节额面松弛度,内侧0.2~0.5cm,平均0.27cm,外侧1.0~2.5cm,平均1.7cm。无膝痛、髌骨失稳和脱位等并发症发生。结论应用三维骨建模的计算机辅助手术系统,可针对患者个体精确地进行假体旋转对位。 | 吴昊 van Driessche Stephane Goutallier Daniel | 2008 | 中国修复重建外科杂志2008，22，1： | 3 |
| 5 | Entry of hepatitis B and C viruses — recent progress and future impact显示文摘 | Thomas F Baumert Luke Meredith Yi Ni Daniel J Felmlee Jane A McKeating Stephan Urban | 2013 | Current Opinion in Virology2013，，： | 3 |
| 6 | Antimicrobial peptides and the gut microbiome in inflammatory bowel disease显示文摘Antimicrobial peptides(AMP)are highly diverse and dynamic molecules that are expressed by specific intestinal epithelial cells,Paneth cells,as well as immune cells in the gastrointestinal(GI)tract.They play critical roles in maintaining tolerance to gut microbiota and protecting against enteric infections.Given that disruptions in tolerance to commensal microbiota and loss of barrier function play major roles in the pathogenesis of inflammatory bowel disease(IBD)and converge on the function of AMP,the significance of AMP as potential biomarkers and novel therapeutic targets in IBD have been increasingly recognized in recent years.In this frontier article,we discuss the function and mechanisms of AMP in the GI tract,examine the interaction of AMP with the gut microbiome,explore the role of AMP in the pathogenesis of IBD,and review translational applications of AMP in patients with IBD. | John Gubatan Derek R Holman Christopher J Puntasecca Danielle Polevoi Samuel JS Rubin Stephan Rogalla | 2021 | World Journal of Gastroenterology2021，27，43： | 3 |
| 7 | Contrast-enhanced coronary artery visualization by dual-source computed tomography—Initial experience显示文摘 | Stephan Achenbach Dieter Ropers Axel Kuettner Thomas Flohr Bernd Ohnesorge Herbert Bruder Heike Theessen Meri Karakaya Werner G. Daniel Werner Bautz Willi A. Kalender Katharina Anders | 2005 | European Journal of Radiology2005，，3： | 3 |
| 8 | Circulating MicroRNA-208b and MicroRNA-499 Reflect Myocardial Damage in Cardiovascular Disease显示文摘 | Maarten F. Corsten Robert Dennert Sylvia Jochems Tatiana Kuznetsova Yvan Devaux Leon Hofstra Daniel R. Wagner Jan A. Staessen Stephane Heymans Blanche Schroen | 2010 | Circulation: Cardiovascular Genetics2010，，6： | 2 |
| 9 | High-pitch spiral acquisition: A new scan mode for coronary CT angiography显示文摘 | Stephan Achenbach Mohamed Marwan Tiziano Schepis Tobias Pflederer Herbert Bruder Thomas Allmendinger Martin Petersilka Katharina Anders Michael Lell Axel Kuettner Dieter Ropers Werner G. Daniel Thomas Flohr | 2009 | Journal of Cardiovascular Computed Tomography2009，，2： | 2 |
| 10 | Decreasing activated sludge thermal hydrolysis temperature reduces product colour, without decreasing degradability显示文摘 | Jason Dwyer Daniel Starrenburg Stephan Tait Keith Barr Damien J. Batstone Paul Lant | 2008 | Water Research2008，，18： | 2 |
| 11 | 10 PW peak power femtosecond laser pulses at ELI-NP显示文摘We report on the generation and delivery of 10.2 PW peak power laser pulses,using the High Power Laser System at the Extreme Laser Infrastructure–Nuclear Physics facility.In this work we demonstrate for the first time,to the best of our knowledge,the compression and propagation of full energy,full aperture,laser pulses that reach a power level of more than 10 PW. | Christophe Radier Olivier Chalus Mathilde Charbonneau Shanjuhan Thambirajah Guillaume Deschamps Stephane David Julien Barbe Eric Etter Guillaume Matras Sandrine Ricaud Vincent Leroux Caroline Richard François Lureau Andrei Baleanu Romeo Banici Andrei Gradinariu Constantin Caldararu Cristian Capiteanu Andrei Naziru Bogdan Diaconescu Vicentiu Iancu Razvan Dabu Daniel Ursescu Ioan Dancus Calin Alexandru Ur Kazuo ATanaka Nicolae Victor Zamfir | 2022 | High Power Laser Science and Engineering2022，10，3： | 2 |
| 12 | Cyclin基因在胃癌患者及其第一代亲属中的表达(英文)显示文摘目的 CyclinD和CyclinE的异常表达常引起细胞周期调节异常而导致肿瘤。为阐明这些Cyclin基因在人体胃癌发生、发展过程中的作用 ,本文对 38例胃癌患者、2 9例胃癌的第一代亲属及 18例健康对照者进行了研究。方法 本研究对上述不同组别及相应的病理组织学表现 ,包括肠化生、萎缩、HP感染及胃炎的状况进行了Cyclin基因表达的研究 ,采取逆转录聚合酶链反应 (RT PCR)的方法。结果 胃癌组织中CyclinD2、D3和E的表达相对于癌旁正常组织明显增高 ,并且CyclinD2和D3的增高表达也发现于胃癌的第一代亲属中 (P <0 0 5 )。不同病理组织学改变 ,肠化生组织CyclinD2、D3和E的表达明显增高 ,胃粘膜萎缩仅CyclinD3表达增高 ,HP感染较未感染组CyclinD2、D3表达增高。但CyclinD1的表达状况与病理组织学改变无关。结论 本研究提示增高的CyclinD2、D3和E是胃癌变过程中的一个常见和早期事件 ,并且基因的异常表达可出现于胃癌患者的第一代亲属中。CyclinD1的表达与胃癌变过程中的临床及病理学变化无明显关系。 | 于君 Stephan Miehlke Matthias P.A.Ebert Daniel Szokodi B.Wehvnignh Peter Malfertheiner G Ehninger Ekkehard Bayerdoerfer | 2002 | Chinese Medical Journal2002，，5： | 2 |
| 13 | Prospectively ECG-triggered high-pitch spiral acquisition for coronary CT angiography using dual source CT: technique and initial experience显示文摘 | Michael Lell Mohamed Marwan Tiziano Schepis Tobias Pflederer Katharina Anders Thomas Flohr Thomas Allmendinger Willi Kalender Dirk Ertel Carsten Thierfelder Axel Kuettner Dieter Ropers Werner G. Daniel Stephan Achenbach | 2009 | European Radiology2009，，11： | 2 |
| 14 | Ionic liquids for extraction of metals and metal containing compounds from communal and industrial waste water显示文摘 | Lisa Fischer Thomas Falta Gunda Koellensperger Anja Stojanovic Daniel Kogelnig Markus Galanski Regina Krachler Bernhard K. Keppler Stephan Hann | 2011 | Water Research2011，，15： | 2 |
| 15 | Diagnosis and Management of the Symptomatic Duodenal Diverticulum: a Case Series and a Short Review of the Literature显示文摘 | Beat Schnueriger Stephan A. Vorburger Vanessa M. Banz Alain M. Schoepfer Daniel Candinas | 2008 | Journal of Gastrointestinal Surgery2008，，9： | 2 |
| 16 | Comparative microarray analysis of microRNA expression profiles in primary cutaneous malignant melanoma, cutaneous malignant melanoma metastases, and benign melanocytic nevi显示文摘 | Michael Sand Marina Skrygan Daniel Sand Dimitrios Georgas Thilo Gambichler Stephan A. Hahn Peter Altmeyer Falk G. Bechara | 2013 | Cell and Tissue Research2013，，1： | 2 |
| 17 | Detection of Coronary Artery Stenoses With Thin-Slice Multi-Detector Row Spiral Computed Tomography and Multiplanar Reconstruction显示文摘 | Dieter Ropers Ulrich Baum Karsten Pohle Katharina Anders Stefan Ulzheimer Bernd Ohnesorge Christian Schlundt Werner Bautz Werner G. Daniel Stephan Achenbach | 2003 | Circulation: Journal of the American Heart Association2003，，5： | 2 |
| 18 | Exploring the limits of complexity: A survey of empirical studies on graph visualisation显示文摘For decades,researchers in information visualisation and graph drawing have focused on developing techniques for the layout and display of very large and complex networks.Experiments involving human participants have also explored the readability of different styles of layout and representations for such networks.In both bodies of literature,networks are frequently referred to as being‘large’or‘complex’,yet these terms are relative.From a human-centred,experiment point-of-view,what constitutes‘large’(for example)depends on several factors,such as data complexity,visual complexity,and the technology used.In this paper,we survey the literature on human-centred experiments to understand how,in practice,different features and characteristics of node–link diagrams affect visual complexity. | Vahan Yoghourdjian Daniel Archambault Stephan Diehl Tim Dwyer Karsten Klein Helen C.Purchase Hsiang-Yun Wu | 2018 | Visual Informatics2018，2，4： | 2 |
| 19 | Multicenter results of stereotactic body radiotherapy (SBRT) for non-resectable primary liver tumors显示文摘 | Rafael A. Ibarra Daniel Rojas Laura Snyder Min Yao Jeffrey Fabien Michael Milano Alan Katz Karyn Goodman Kevin Stephans Galal El-Gazzaz Federico Aucejo Charles Miller John Fung Simon Lo Mitchell Machtay Juan R. Sanabria | 2012 | Acta Oncologica2012，，5： | 2 |
| 20 | Structure and diversity of Cram - negative sulfate-reducing bacteria on rice roots显示文摘 | Daniel S Stephan S | 2001 | FEMS Microbiology Ecology2001，36，23： | 1 |
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