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| 1 | 银杏内酯类合成物F抗血小板激活因子和组织胺的实验研究显示文摘目的:研究银杏内酯类合成物F(简称药物F)同时拮抗组织胺(HA)和血小板激活因子(PAF)的作用。方法:测定离休豚鼠肺组织的收缩率以及用药物F后的致敏豚鼠肺功能的变化。结果:(1)加入药物F后离体豚鼠的气管条和肺条对HA的收缩率分别由(50.97±16.00)%和(54.2±12.17)%降至(21.69±3.85)%和(22.97±17.78)%(P<0.05);(2)药物F保护后,离体豚鼠肺条对PAF的相对收缩率由(89.49±16.00)%降至(46.21±14.23)%(P<0.05);(3)药物F保护的豚鼠致敏后,其肺功能较对照组有改善趋势。结论:药物F能同时拮抗离体豚鼠肺组织对HA和PAF的收缩反应,并有改善致敏豚鼠肺功能的趋势,可望用于支气管哮喘的治疗。 | 倪健 董竞成 吴淦桐 Godfroid JJ Heymans F 李明华 | 2000 | 中国中西医结合杂志2000，20，5： | 16 |
| 2 | New developments in immunotherapy for lymphoma显示文摘The development of immunotherapies for lymphoma has undergone a revolutionary evolution over the past decades. Since the advent of rituximab as the first successful immunotherapy for B-cell non-Hodgkin lymphoma over two decades ago, a plethora of new immunotherapeutic approaches to treat lymphoma has ensued. Four of the most exciting classes of immunotherapies include:chimeric antigen receptor T-cells, bispecific antibodies, immune checkpoint inhibitors, and vaccines. However, with addition of these novel therapies the appropriate timing of treatment, optimal patient population, duration of therapy, toxicity, and cost must be considered. In this review, we describe the most-promising immunotherapeutic approaches for the treatment of lymphoma in clinical development, specifically focusing on clinical trials performed to date and strategies for improvement. | Benjamin Heyman Yiping Yang | 2018 | Cancer Biology & Medicine2018，15，3： | 6 |
| 3 | 急性病毒性心肌炎显示文摘 | Dennert R Crijns HJ Heymans S 张瑞生 | 2008 | 中国心血管杂志2008，13，5： | 6 |
| 4 | Extraintestinal Manifestations of Inflammatory Bowel Disease显示文摘 | Folashade A Jose Melvin B Heyman | 2008 | Journal of Pediatric Gastroenterology and Nutrition2008，，2： | 3 |
| 5 | The Anaphase-Promoting Complex/Cyclosome in Control of Plant Development显示文摘关键房间部门蛋白质的时间的控制降级从房间部门节目保证不同房间周期阶段和出口的正确发作。考虑到房间周期,支持后期的 Complex/Cyclosome (APC/C ) 是重要保存多子单元 ubiquitin ligase,标记为由 26S proteasome 的降级的目标。然而,而 APC/C 在酵母和哺乳动物广泛地被学习了,仅仅在最后,十年把植物 APC/C 开始揭开它的秘密。研究结果在 gametogenesis,生长,发信号的荷尔蒙,共生相互作用,和 endoreduplication 发作期间显示出 APC/C 核心建筑群和它的使活跃之物的重要性。最近,另外,第一个植物 APC/C 禁止者被报导了,允许一调整在房间周期期间的 APC/C 活动。和第一个 APC/C 目标的鉴定,一幅图画为许多不同发展过程是必要的 APC/C 活动出现。 | Jefri Heyman Lieven De Veylder | 2012 | Molecular Plant2012，5，6： | 3 |
| 6 | Circulating MicroRNA-208b and MicroRNA-499 Reflect Myocardial Damage in Cardiovascular Disease显示文摘 | Maarten F. Corsten Robert Dennert Sylvia Jochems Tatiana Kuznetsova Yvan Devaux Leon Hofstra Daniel R. Wagner Jan A. Staessen Stephane Heymans Blanche Schroen | 2010 | Circulation: Cardiovascular Genetics2010，，6： | 2 |
| 7 | miR-133 and miR-30 Regulate Connective Tissue Growth Factor: Implications for a Role of MicroRNAs in Myocardial Matrix Remodeling显示文摘 | Rudy F. Duisters Anke J. Tijsen Blanche Schroen Joost J. Leenders Viola Lentink Ingeborg van der Made Veronica Herias Rick E. van Leeuwen Mark W. Schellings Paul Barenbrug Jos G. Maessen Stephane Heymans Yigal M. Pinto Esther E. Creemers | 2009 | Circulation Research2009，，： | 2 |
| 8 | An airflow olfactometer for measuring olfactive responses of hymenopterous parasitoids and other small insects显示文摘 | VET W P van LENTEREN J C HEYMANS M | 1983 | Physidogical Entomology1983，8，： | 2 |
| 9 | Long noncoding RNA MALAT1-derived mascRNA is involved in cardiovascular innate immunity显示文摘Dear Editor,Next-generation sequencing revealed that the majority of the human genome is transcribed but has no coding function.It is estimated that.30000 long noncoding RNAs(lncRNAs)are expressed in humans,but their functions are largely unknown(Suckau et al.,2009;Rinn and Chang,2012;Poller et al.,2013).Consideration of noncoding genomic elements in pathogenetic studies is warranted and enabled by technological advances allowing comprehensive transcriptome mapping of protein-coding genes as well as small and long ncRNAs. | Martina Gast Blanche Schroen Antje Voigt Jan Haas Uwe Kuehl Dirk Lassner Carsten Skurk Felicitas Escher Xiaomin Wang Adelheid Kratzer Katharina Michalik Anna Papageorgiou Tim Peters Madlen Loebel Sabrina Wilk Nadine Althof Kannanganattu VPrasanth Hugo Katus Benjamin Meder Shinichi Nakagawa Carmen Scheibenbogen Heinz-Peter Schultheiss Ulf Landmesser Stefanie Dimmeler Stephane Heymans Wolfgang Poller | 2016 | Journal of Molecular Cell Biology2016，8，2： | 2 |
| 10 | A role of stretch-activated potassium currents in the regulation of uterine smooth muscle contraction显示文摘早熟的出生的率是惊人的并且威胁社会和世界范围的保健系统。早产在超过 50% 盒子导致早熟的出生。Preterm 出生说明婴儿病态和死亡的 three-quarters。在 34 星期怀孕期前熬过出生的孩子经常面对终生的残疾。为劳动正在想要的 preterm 的当前的处理。没有处理被发现了通常有效,任何一个都系统地没在 48 h 以外被评估。preterm 劳动的处理的新途径绝望地被需要。从我们的实验室的最近的研究建议子宫的肌肉是有不同于另外的光滑的肌肉的子宫的松驰的规定的唯一的分隔空间。这里,我们讨论最近的证据机械地激活的 2 毛孔钾隧道, TREK-1,可以贡献在子宫的光滑的肌肉和变体与人的劳动联系了的那 TREK-1 基因发信号的收缩松驰, preterm 劳动可以导致 preterm 劳动和它的可能的预防的更好的理解。 | Iain L O BUXTON Nathanael HEYMAN Yi-ying WU Scott BARNETT Craig ULRICH | 2011 | Acta Pharmacologica Sinica2011，32，6： | 2 |
| 11 | Role of Small Bowel Follow-through in Diagnosing Inflammation of the Terminal Ileum in Pediatric Patients显示文摘 | Matthew Stenerson Eric Vittinghoff Melvin B Heyman Grace E Kim Neera Gupta | 2010 | Journal of Pediatric Gastroenterology and Nutrition2010，，4： | 2 |
| 12 | 推移质运动的随机理论与应用显示文摘陡坡急流条件下的推移质运动常伴有较大幅度的随机变化,这种随机涨落现象在各个时间尺度下普遍存在。由于这种涨落现象的存在,随机理论模型往往更适用于描述这一类问题。为进一步研究推移质运动的随机属性,作者利用包含群体输移机制的Markov随机模型,通过理论和实验方法研究输沙停时的概率密度分布函数(PDF),这些研究揭示出推移质运动中的尺度分离现象。在前人工作的基础上,给出输沙停时PDF理论解的另外一种推导方式推导。与较早的研究相比,该推导更为简洁、直接。该理论解已通过数值和室内实验数据得到了验证。 | 马宏博 METTRA Francois HEYMAN Joris ANCEY Chnstophe 傅旭东 | 2013 | 四川大学学报(工程科学版)2013，，2： | 2 |
| 13 | Inhibition of Urokinase-Type Plasminogen Activator or Matrix Metalloproteinases Prevents Cardiac Injury and Dysfunction During Viral Myocarditis显示文摘 | Pauschinger M De Palma A | 2006 | Circulation2006，114，： | 1 |
| 14 | Acute viral myocarditis显示文摘 | Dennert R Crijns HJ Heymans S | 2008 | Eur Heart J2008，29，17： | 1 |
| 15 | Closure of patent ductus arteriosus with oral ibuprofen suspension in premature newborn:a pilot study显示文摘 | Heyman E Morag I Batash D | 2003 | Pediatrics2003，112，5： | 1 |
| 16 | PPARct and PPARy activators direct tissue-specific transcrip- tional response via a PPRE in the lipoprotein lipase gene显示文摘 | Schoonjans K Peinado-Onsurbe A M Heyman R A | 1996 | EMBO J1996，15，： | 1 |
| 17 | Prophylactic nasogastric tube decompression: is its use justified? 显示文摘 | Schwartz CI Heyman AS Rao AC | 1995 | South Med J1995，88，： | 1 |
| 18 | In- cidence of venousthromboembolism in oral and maxillo- facial surgery: a retrospective analysis 显示文摘 | Forouzanfar T Heymans MW van Schuilenburg A | 2010 | Int J Oral Maxillofac Surg2010，39，3： | 1 |
| 19 | Acute viral myocarditis显示文摘 | Dennert R Crijns HJ Heymans S | 2008 | Eur Heart J2008，29，： | 1 |
| 20 | The research potential of practice nurses显示文摘 | Davies J Heyman B Bryar R | 2002 | Health and Social Care in the Community2002，10，： | 1 |
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