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| 1 | Patterns of cancer recurrence in localized resected hepatocellular carcinoma显示文摘BACKGROUND:Tumor resection in non-metastatic hepatocellular carcinoma(HCC)patients with adequate liver reserve offers a potential cure,but has a high 5-year recurrence rate.We analyzed the patterns of cancer relapse after partial hepatectomy to guide post-operative management.METHODS:A total of 144 HCC patients(1996-2011)after partial hepatectomy were reviewed.Statistical correlations were determined using univariate and partition analyses.RESULTS:A median follow-up of 20 months showed recurrence in 71(49%)patients,and the median time to recurrence was 11.9 months.Vascular invasion(P<0.01)and number of lesions(P<0.01)predicted for recurrence.Histologic grade was not correlated with recurrence.Twenty-two(31%)patients developed both surgical margin(SM)and concurrent intrahepatic recurrences,and 28(40%)had non-SM intrahepatic recurrences with no other signs of recurrence.On partition analysis,the risk of marginal recurrence in patients with SM<1 mm and SM≥1 mm was 35%and 13.5%respectively.Approximately 57%of patients with intrahepatic recurrence had recurrence≤2.5 cm from SM.CONCLUSIONS:Intrahepatic recurrence after partial hepatectomy is common and is significantly associated with vascular invasion and tumor stage.About 57%of patients with intrahepatic relapse had a recurrence close(≤2.5 cm)to the SM.Additionally,patients with SM<1 mm have a higher recurrence rate and may benefit from adjuvant local therapy. | Aryavarta MS Kumar Elisha T Fredman Christopher Coppa Galal El-Gazzaz Federico N Aucejo May Abdel-Wahab | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，3： | 7 |
| 2 | Liver transplantation in patients with incidental hepatocellular carcinoma/cholangiocarcinoma and intrahepatic cholangiocarcinoma: a single-center experience显示文摘BACKGROUND: Reports of liver transplantation(LT) in patients with mixed hepatocellular carcinoma/cholangiocarcinoma(HCC/CC) and intrahepatic cholangiocarcinoma(ICC) are modest and have been mostly retrospective after pathological categorization in the setting of presumed HCC. Some studies suggest that patients undergoing LT with small and unifocal ICC or mixed HCC/CC can achieve about 40%-60% 5-year post-transplant survival. The study aimed to report our experience in patients undergoing LT with explant pathology revealing HCC/CC and ICC.METHODS: From a prospectively maintained database, we performed cohort analysis. We identified 13 patients who underwent LT with explant pathology revealing HCC/CC or ICC. RESULTS: The observed recurrence rate post-LT was 31%(4/13) and overall survival was 85%, 51%, and 51% at 1, 3 and 5 years, respectively. Disease-free survival was 68%, 51%, and 41% at 1, 3 and 5 years, respectively. In our cohort, four patients would have qualified for exception points based on updated HCC Organ Procurement and Transplantation Network imaging guidelines. CONCLUSIONS: Lesions which lack complete imaging characteristics of HCC may warrant pre-LT biopsy to fully elucidate their pathology. Identified patients with early HCC/CC or ICC may benefit from LT if unresectable. Additionally, incorporating adjunctive perioperative therapies such as in the case of patients undergoing LT with hilar cholangiocarcinoma may improve outcomes but this warrants further investigation. | Mohammed Elshamy Naftali Presser Abdulrahman Y Hammad Daniel J Firl Christopher Coppa John Fung Federico N Aucejo | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，3： | 6 |
| 3 | Neo-adjuvant therapy for hepatocellular carcinoma before liver transplantation:Where do we stand?显示文摘Liver transplantation(LT)for hepatocellular carcinoma(HCC)within Milan criteria is a widely accepted optimal therapy.Neo-adjuvant therapy before transplantation has been used as a bridging therapy to prevent dropout during the waiting period and as a down-staging method for the patient with intermediate HCC to qualify for liver transplantation.Transarterial chemoembolization and radiofrequency ablation are the most commonly used method for locoregional therapy.The data associated with newer modalities including drugeluting beads,radioembolization with Y90,stereotactic radiation therapy and sorafenib will be discussed as a tool for converting advanced HCC to LT candidates.The concept'ablate and wait'has gained the popularity where mandated observation period after neoadjuvant therapy allows for tumor biology to become apparent,thus has been recommended after downstaging.The role of neo-adjuvant therapy with conjunction of'ablate and wait'in living donor liver transplantation for intermediate stage HCC is also discussed in the paper. | Masato Fujiki Federico Aucejo Minsig Choi Richard Kim | 2014 | World Journal of Gastroenterology2014，20，18： | 5 |
| 4 | Split liver transplantation in adults显示文摘Split liver transplantation(SLT),while widely accepted in pediatrics,remains underutilized in adults. Advancements in surgical techniques and donor-recipient matching,however,have allowed expansion of SLT from utilization of the right trisegment graft to now include use of the hemiliver graft as well. Despite less favorable outcomes in the early experience,better outcomes have been reported by experienced centers and have further validated the feasibility of SLT. Importantly,more than two decades of experience have identified key requirements for successful SLT in adults. When these requirements are met,SLT can achieve outcomes equivalent to those achieved with other types of liver transplantation for adults. However,substantial challenges,such as surgical techniques,logistics,and ethics,persist as ongoing barriers to further expansion of this highly complex procedure. This review outlines the current state of SLT in adults,focusing on donor and recipient selection based on physiology,surgical techniques,surgical outcomes,and ethical issues. | koji hashimoto masato fujiki cristiano quintini federico n aucejo teresa diago uso dympna m kelly bijan eghtesad john j fung charles m miller | 2016 | World Journal of Gastroenterology2016，22，33： | 3 |
| 5 | Safety and efficacy of sorafenib for the treatment of recurrent hepatocellular carcinoma after liver transplantation显示文摘 | Abhijeet Waghray Bengi Balci Galal El‐Gazzaz Richard Kim Robert Pelley KV Narayanan Menon Bassam Estfan Carlos Romero‐Marrero Federico Aucejo | 2013 | Clin Transplant2013，，4： | 3 |
| 6 | Comparative Analysis of the Safety and Efficacy of Transcatheter Arterial Chemoembolization and Yttrium-90 Radioembolization in Patients with Unresectable Hepatocellular Carcinoma显示文摘 | Craig Lance Gordon McLennan Nancy Obuchowski Grace Cheah Abraham Levitin Mark Sands James Spain Shyam Srinivas Sankaran Shrikanthan Federico N. Aucejo Richard Kim K.V. Narayanan Menon | 2011 | Journal of Vascular and Interventional Radiology2011，，12： | 3 |
| 7 | Multicenter results of stereotactic body radiotherapy (SBRT) for non-resectable primary liver tumors显示文摘 | Rafael A. Ibarra Daniel Rojas Laura Snyder Min Yao Jeffrey Fabien Michael Milano Alan Katz Karyn Goodman Kevin Stephans Galal El-Gazzaz Federico Aucejo Charles Miller John Fung Simon Lo Mitchell Machtay Juan R. Sanabria | 2012 | Acta Oncologica2012，，5： | 2 |
| 8 | Split Liver Transplantation Using Hemiliver Graft in the MELD Era: A Single Center Experience in the United States显示文摘 | K. Hashimoto C. Quintini F. N. Aucejo M. Fujiki T. Diago M. J. Watson D. M. Kelly C. G. Winans B. Eghtesad J. J. Fung C. M. Miller | 2014 | American Journal of Transplantation2014，，9： | 2 |
| 9 | Diagnosis of boron, fluofine,lead,nickel and zinc toxicity in Citrus plantations in villarreal spain 显示文摘 | AUCEJO A FERRER J GABALDON C | 1997 | Water Air Soil Pollut1997，94，： | 1 |
| 10 | Techniques of radiofrequency-assisted precoagulation in laparoscopic liver resection显示文摘 | Akyildiz HY Morris-Stiff G Aucejo F et a1 | 2011 | Surg Endosc2011，25，4： | 1 |
| 11 | Techniques of radiofrequency-assisted precoagulation in laparoseopic liver resection显示文摘 | Akyildiz HY Morris-Stiff G Aucejo F | 2011 | Surg Endosc2011，25，4： | 1 |
| 12 | Initial experience with a new articulating energy device for laparoscopic liver resection显示文摘 | Eren Berber Muhammet Akyuz Federico Aucejo Shamil Aliyev Erol Aksoy Onur Birsen Eren Taskin | 2014 | Surgical Endoscopy2014，，3： | 1 |
| 13 | Is impaired hepatic arterial buffer response a risk factor for biliary anastomotic stricture in liver transplant recipients?显示文摘 | Koji Hashimoto Charles M. Miller Cristiano Quintini Federico N. Aucejo Kenzo Hirose Teresa Diago Uso Loris Trenti Dympna M. Kelly Charles G. Winans David P. Vogt Bijan Eghtesad John J. Fung | 2010 | Surgery2010，，3： | 1 |
| 14 | Expanding the donor pool:safe transplantation of a cadaveric liver allograft with a 10 cm cavernous hemangioma--a case report显示文摘 | Aucejo FN Ortiz WA Kelly D | | 0，，4： | 1 |
| 15 | Hepatocellular carcinoma beyond Milan criteria: Management and transplant selection criteria显示文摘Liver transplantation(LT) for hepatocellular carcinoma(HCC) has been established as a standard treatment in selected patients for the last two and a half decades. After initially dismal outcomes, the Milan criteria(MC)(single HCC ≤ 5 cm or up to 3 HCCs ≤ 3 cm) have been adopted worldwide to select HCC patients for LT, however cumulative experience has shown that MC can be too strict. This has led to the development of numerous expanded criteria worldwide. Morphometric expansions on MC as well as various criteria which incorporate biomarkers as surrogates of tumor biology have been described. HCC that presents beyond MC initially can be downstaged with locoregional therapy(LRT). Post-LRT monitoring aims to identify candidates with favorable tumor behavior. Similarly, tumor marker levels as response to LRT has been utilized as surrogate of tumor biology. Molecular signatures of HCC have also been correlated to outcomes; these have yet to be incorporated into HCC-LT selection criteria formally. The ongoing discrepancy between organ demand and supply makes patient selection the most challenging element of organ allocation. Further validation of extended HCCLT criteria models and pre-LT treatment strategies are required. | Mohammed Elshamy Federico Aucejo KV Narayanan Menon Bijan Eghtesad | 2016 | World Journal of Hepatology2016，8，21： | 1 |
| 16 | Techniques of radiofrequency-assisted precoagulation in laparoscopic liver resection 显示文摘 | Akyildiz HY Morris-Stiff G Aucejo F | 2011 | SurgEndosc2011，25，4： | 1 |
| 17 | Splenic artery steal syndrome:Reality or myth? A case report suggesting the role of portal hyperperfusion显示文摘 | Aucejo F Hashimoto K Quintini C | 2007 | Liver transplantation2007，13，6： | 1 |
| 18 | Beckmann rearrangement of cyclohexanone oxime on HNaY zeolites:kinetic and spectroscopic studies显示文摘 | Aucejo A Burguet M C Corma A | 1986 | Applied Catalysis1986，22，2： | 1 |
| 19 | Multimodality treatment of neuroendocrine liver metastases显示文摘 | Koray Karabulut Hizir Yakup Akyildiz Craig Lance Federico Aucejo Gordon McLennan Orhan Agcaoglu Allan Siperstein Eren Berber | 2011 | Surgery2011，，2： | 1 |
| 20 | Multicenter results of stereotactic body radiotherapy (SBRT) for non-resectable primary liver tumors显示文摘 | Rafael A. Ibarra Daniel Rojas Laura Snyder Min Yao Jeffrey Fabien Michael Milano Alan Katz Karyn Goodman Kevin Stephans Galal El-Gazzaz Federico Aucejo Charles Miller John Fung Simon Lo Mitchell Machtay Juan R. Sanabria | 2012 | Acta Oncologica2012，，5： | 1 |
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