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| 1 | Acute pancreatitis at the beginning of the 21st century: The state of the art显示文摘Acute pancreatitis is an acute inflammatory disease of the pancreas which can lead to a systemic inflammatory response syndrome with significant morbidity and mortality in 20% of patients. Gallstones and alcohol consumption are the most frequent causes of pancreatitis in adults. The treatment of mild acute pancreatitis is conservative and supportive; however severe episodes characterized by necrosis of the pancreatic tissue may require surgical intervention. Advanced understanding of the pathology, and increased interest in assessment of disease severity are the cornerstones of future management strategies of this complex and heterogeneous disease in the 21st century. | Alfredo F Tonsi Matilde Bacchion Stefano Crippa Giuseppe Malleo Claudio Bassi | 2009 | World Journal of Gastroenterology2009，15，24： | 54 |
| 2 | Differences between main-duct and branch-duct intraductal papillary mucinous neoplasms of the pancreas显示文摘In the last decade,intraductal papillary mucinous neoplasms(IPMNs) have become commonly diagnosed.From a morphological standpoint,they are classified in main-duct IPMNs(MD-IPMNs) and branch-duct IPMNs(BD-IPMNs),depending on the type of involvement of the pancreatic ductal system by the neoplasm.Despite the fact that our understanding of their natural history is still incomplete,recent data indicate that MD-IPMNs and BD-IPMNs show significant differences in terms of biological behaviour with MD-IPMNs at higher risk of malignant degeneration.In the present paper,clinical and epidemiological characteristics,rates of malignancy and the natural history of MD-IPMNs and BD-IPMNs are analyzed.The profile of IPMNs involving both the main pancreatic duct and its side branches(combined-IPMNs) are also discussed.Finally,general recommendations for management based on these differences are given. | Roberto Salvia Stefano Crippa Stefano Partelli Giulia Armatura Giuseppe Malleo Marina Paini Antonio Pea Claudio Bassi | 2010 | World Journal of Gastrointestinal Surgery2010，2，10： | 14 |
| 3 | 围手术期液体管理与发生术后肠麻痹的潜在关系显示文摘目的:结直肠手术后出现肠麻痹仍是外科医生所面临的难题,它延迟了患者的康复进度并增加了住院时间和住院费用。该研究的目的是在充分、有效地实施加速康复路径的基础上,探讨围手术期液体管理对结直肠手术后发生肠麻痹的影响。方法:这是一项基于公共数据库中前瞻性记录数据的回顾性队列研究。在整个研究期间,该医学中心全面实施标准化的加速康复路径。研究纳入2011-2016年连续收治的、患有良性或恶性肿瘤而接受结直肠切除手术的所有患者。术后肠麻痹(POI)的定义为需重新置入鼻胃管。本研究比较了术后有和无肠麻痹患者的围手术期液体管理和手术学结果。通过多因素Logistic回归分析判断影响患者肠麻痹的潜在危险因素。 | 卓长华 GRASS F LOVELY J K CRIPPA J | 2020 | 结直肠肛门外科2020，26，1： | 7 |
| 4 | Management of ampullary neoplasms: A tailored approach between endoscopy and surgery显示文摘Ampullary neoplasms,although rare,present distinctive clinical and pathological features from other neoplastic lesions of the periampullary region.No specific guidelines about their management are available,and they are often assimilated either to biliary tract or to pancreatic carcinomas.Due to their location,they tend to become symptomatic at an earlier stage compared to pancreatic malignancies.This behaviour results in a higher resectability rate at diagnosis.From a pathological point of view they arise in a zone of transition between two different epithelia,and,according to their origin,may be divided into pancreatobiliary or intestinal type.This classification has a substantial impact on prognosis.In most cases,pancreaticoduodenectomy represents the treatment of choice when there is an overt or highly suspicious malignant behaviour.The rate of potentially curative resection is as high as 90% and in high-volume centres an acceptable rate of complications is reported.In selected situations less invasive approaches,such as ampullectomy,have been advocated,although there are some concerns mainly because of a higher recurrence rate associated with limited resections for invasive carcinomas.Importantly,these methods have the drawback of not including an appropriate lymphadenectomy,while nodal involvement has been shown to be frequently present also in apparently lowrisk carcinomas.Endoscopic ampullectomy is now the procedure of choice in case of low up to high-grade dysplasia providing a proper assessment of the T status by endoscopic ultrasound.In the present paper the evidence currently available is reviewed,with the aim of offering an updated framework for diagnosis and management of this specific type of disease. | Francesca Panzeri Stefano Crippa Paola Castelli Francesca Aleotti Alessandro Pucci Stefano Partelli Giuseppe Zamboni Massimo Falconi | 2015 | World Journal of Gastroenterology2015，21，26： | 6 |
| 5 | Early Versus Late Drain Removal After Standard Pancreatic Resections: Results of a Prospective Randomized Trial显示文摘 | Claudio Bassi Enrico Molinari Giuseppe Malleo Stefano Crippa Giovanni Butturini Roberto Salvia Giorgio Talamini Paolo Pederzoli | 2010 | Annals of Surgery2010，，2： | 5 |
| 6 | Extent of surgical resections for intraductal papillary mucinous neoplasms显示文摘Intraductal papillary mucinous neoplasms(IPMNs) can involve the main pancreatic duct(MD-IPMNs) or its secondary branches(BD-IPMNs) in a segmental of multifocal/diffuse fashion.Growing evidence indicates that BDIPMNs are less likely to harbour cancer and in selected cases these lesions can be managed non operatively.For surgery,clarification is required on:(1) when to resect an IPMN;(2) which type of resection should be performed;and(3) how much pancreas should be resected.In recent years parenchyma-sparing resections as well as laparoscopic procedures have being performed more frequently by pancreatic surgeons in order to decrease the rate of postoperative pancreatic insufficiency and to minimize the surgical impact of these operations.However,oncological radicality is of paramount importance,and extended resections up to total pancreatectomy may be necessary in the setting of IPMNs.In this article the type and extension of surgical resections in patients with MD-IPMNs and BD-IPMNs are analyzed,evaluating perioperative and long-term outcomes.The role of standard and parenchyma-sparing resections is discussed as well as different strategies in the case of multifocal neoplasms. | Stefano Crippa Stefano Partelli Massimo Falconi | 2010 | World Journal of Gastrointestinal Surgery2010，2，10： | 5 |
| 7 | Pancreatic Anastomotic Leakage After Pancreaticoduodenectomy in 1,507 Patients: A Report from the Pancreatic Anastomotic Leak Study Group显示文摘 | Kaye M. Reid-Lombardo Michael B. Farnell Stefano Crippa Matthew Barnett George Maupin Claudio Bassi L. William Traverso | 2007 | Journal of Gastrointestinal Surgery2007，，11： | 4 |
| 8 | A distal-lock electromagnetic targeting device for intramedullary nailing: Suggestions and clinical experience显示文摘 | Guido Antonini Wilfried Stuflesser Cornelio Crippa Georgios Touloupakis | 2016 | Chinese Journal of Traumatology2016，19，6： | 4 |
| 9 | Reduction in sperm aneuploidy levels in severe oligoasthenoteratospermic patients after medical therapy: a preliminary report显示文摘这研究的目的是调查医药治疗是否能减少精子 aneuploidy 层次并且与严重自发的 oligoasthenoteratospermia (燕麦) 在病人改进 intracytoplasmic 精子注射(ICSI ) 的结果。在至少一个失败的 ICSI 周期被考虑以后,因为严重自发的燕麦,要求 ICSI 的 33 对不肥沃的夫妇。精液参数(集中,活动性和形态学), aneuploid 精子的百分比和 ICSI 的结果(卵母细胞的数字使肥沃的、胚胎转的、生物化学的怀孕,临床的怀孕和实时出生)与L肉毒碱在治疗的一堂3月的功课前后被作比较每 day+ 给两次的 1 g ; acetyl-L-carnitine 500 ;每 day+ 给两次的 mg ;一片 30-mg cinnoxicam 药片每 4 天。Aneuploidy 被估计用在在染色体 X,上执行的 situ 杂交(鱼) 荧光灯 Y, 13, 15, 16, 17, 18, 21 和 22。结果证明 33 个病人中的 22 个有 aneuploid 精子的减少的频率并且在治疗(组 1 ) 以后改进了精子形态学,并且 11 没显示出变化(组 2 ) 。生物化学的怀孕,临床的怀孕和实时出生的数字在比在组 2 的组 1 是显著地更高的。没有重要差别关于卵母细胞的数字在这些组之间被发现使肥沃,胚胎转了。副作用是可以忽略的。在严重自发的燕麦病人的 ICSI 怀孕和实时出生的数字与 L 肉毒碱, acetyl-L-carnitine 和 cinnoxicam 的一堂功课改善了。 | Giorgio Cavallini Maria Cristina Magli Andor Crippa Anna Pia Ferraretti Luca Gianaroli | 2012 | Asian Journal of Andrology2012，14，4： | 4 |
| 10 | molecular pathology of intraductal papillary mucinous neoplasms of the pancreas显示文摘Since the first description of intraductal papillary mucinous neoplasms(IPMNs)of the pancreas in the eighties,their identification has dramatically increased in the last decades,hand to hand with the improvements in diagnostic imaging and sampling techniques for the study of pancreatic diseases.However,the heterogeneity of IPMNs and their malignant potential make difficult the management of these lesions.The objective of this review is to identify the molecular characteristics of IPMNs in order to recognize potential markers for the discrimination of more aggressive IPMNs requiring surgical resection from benign IPMNs that could be observed.We briefly summarize recent research findings on the genetics and epigenetics of intraductal papillary mucinous neoplasms,identifying some genes,molecular mechanisms and cellular signaling pathways correlated to the pathogenesis of IPMNs and their progression to malignancy.The knowledge of molecular biology of IPMNs has impressively developed over the last few years.A great amount of genes functioning as oncogenes or tumor suppressor genes have been identified,in pancreatic juice or in blood or in the samples from the pancreatic resections,but further researches are required to use these informations for clinical intent,in order to better define the natural history of these diseases and to improve their management. | Marina Paini Stefano Crippa Stefano Partelli Filippo Scopelliti Domenico Tamburrino Andrea Baldoni Massimo Falconi | 2014 | World Journal of Gastroenterology2014，20，29： | 4 |
| 11 | Gastric metastasis by lung small cell carcinoma显示文摘胃肠道的转移瘤是稀罕的。我们由于主要的肺癌症描述胃的转移的一个案例,由上面的胃肠的内视镜检查法(UGIE ) 揭示了。到胃的造血的转移是一个稀罕事件。到我们的知识,仅仅 55 个案例在国际文学被描述了。在这些病人,预后是很差的。我们此处由肺报导胃的转移的一个案例小房间癌,与关于这个稀罕实体的文学的评论。 | Giovanni Casella Camillo Di Bella Antonino Roberto Cambareri Carmelo Antonio Buda Gianluigi Corti Filippo Magri Stefano Crippa Vittorio Baldini | 2006 | World Journal of Gastroenterology2006，12，25： | 3 |
| 12 | Management of neuroendocrine carcinomas of the pancreas (WHO G3): A tailored approach between proliferation and morphology显示文摘Neuroendocrine carcinomas(NEC) of the pancreas are defined by a mitotic count > 20 mitoses/10 high power fields and/or Ki67 index > 20%, and included all the tumors previously classified as poorly differentiated endocrine carcinomas. These latter are aggressive malignancies with a high propensity for distant metastases and poor prognosis, and they can be further divided into small- and large-cell subtypes. However in the NEC category are included also neuroendocrine tumors with a well differentiated morphology but ki67 index > 20%. This category is associated with better prognosis and does not significantly respond to cisplatin-based chemotherapy, which represents the gold standard therapeutic approach for poorly differentiated NEC. In this review, the differences between well differentiated and poorly differentiated NEC are discussed considering both pathology, imaging features, treatment and prognostic implications. Diagnostic and therapeutic flowcharts are proposed. The need for a revision of current classification system is stressed being well differentiated NEC a more indolent disease compared to poorly differentiated tumors. | Stefano Crippa Stefano Partelli Giulio Belfiori Marco Palucci Francesca Muffatti Olga Adamenko Luca Cardinali Claudio Doglioni Giuseppe Zamboni Massimo Falconi | 2016 | World Journal of Gastroenterology2016，22，45： | 3 |
| 13 | Enhanced recovery pathways in pancreatic surgery: State of the art显示文摘Pancreatic surgery is being offered to an increasing number of patients every year. Although postoperative outcomes have significantly improved in the last decades, even in high-volume centers patients still experience significant postoperative morbidity and full recovery after surgery takes longer than we think. In recent years, enhanced recovery pathways incorporating a large number of evidence-based perioperative interventions have proved to be beneficial i n t e r m s o f i m p rove d p o s t o p e ra t i ve o u t c o m e s, and accelerated patient recovery in the context of gastrointestinal, genitourinary and orthopedic surgery. The role of these pathways for pancreatic surgery is still unclear as high-quality randomized controlled trials are lacking. To date, non-randomized studies have shown that care pathways for pancreaticoduodenectomy and distal pancreatectomy are safe with no difference in postoperative morbidity, leading to early discharge and no increase in hospital readmissions. Hospital costs are reduced due to better organization of care and resource utilization. However, further research is needed to clarify the effect of enhanced recovery pathways on patient recovery and post-discharge outcomes following pancreatic resection. Future studies should be prospective and follow recent recommendations for the design and reporting of enhanced recovery pathways. | Nicolò Pecorelli Sara Nobile Stefano Partelli Luca Cardinali Stefano Crippa Gianpaolo Balzano Luigi Beretta Massimo Falconi | 2016 | World Journal of Gastroenterology2016，22，28： | 2 |
| 14 | Outcomes after resection of locally advanced or borderline resectable pancreatic cancer after neoadjuvant therapy显示文摘 | Giuliano Barugola Stefano Partelli Stefano Crippa Paola Capelli Mirko D’Onofrio Paolo Pederzoli Massimo Falconi | 2012 | The American Journal of Surgery2012，，2： | 2 |
| 15 | ERCC1 predicts outcome in patients with gastric cancer treated with adjuvant cisplatin-based chemotherapy显示文摘 | Sara Dosso Elena Zanellato Martina Nucifora Renzo Boldorini Angelica Sonzogni Roberto Biffi Nicola Fazio Eraldo Bucci Ottavio Beretta Stefano Crippa Piercarlo Saletti Milo Frattini | 2013 | Cancer Chemotherapy and Pharmacology2013，，1： | 2 |
| 16 | Mucin-Producing Neoplasms of the Pancreas: An Analysis of Distinguishing Clinical and Epidemiologic Characteristics显示文摘 | Stefano Crippa Carlos Fernández–del Castillo Roberto Salvia Dianne Finkelstein Claudio Bassi Ismael Domínguez Alona Muzikansky Sarah P. Thayer Massimo Falconi Mari Mino–Kenudson Paola Capelli Gregory Y. Lauwers Stefano Partelli Paolo Pederzoli Andrew L. W | 2010 | Clinical Gastroenterology and Hepatology2010，，2： | 2 |
| 17 | Tumor size correlates with malignancy in nonfunctioning pancreatic endocrine tumor显示文摘 | Rossella Bettini Stefano Partelli Letizia Boninsegna Paola Capelli Stefano Crippa Paolo Pederzoli Aldo Scarpa Massimo Falconi | 2011 | Surgery2011，，： | 2 |
| 18 | Surgical Treatment of Metastatic Tumors to the Pancreas: A Single Center Experience and Review of the Literature显示文摘 | Stefano Crippa MD Carlo Angelini MD Chiara Mussi Claudia Bonardi MD Fabrizio Romano MD Paola Sartori MD Franco Uggeri MD Giorgio Bovo MD | 2006 | World Journal of Surgery2006，，8： | 2 |
| 19 | Antithrombin III (ATILL) replacement therapy in patients with sepsis and/or postsurgical complications: a controlled double-blind, randomized, multicenter study显示文摘 | F. Baudo T. M. Caimi F. deCataldo A. Ravizza S. Arlati G. Casella D. Carugo G. Palareti C. Legnani L. Ridolfi R. Rossi A. D’Angelo L. Crippa D. Giudici G. Gallioli A. Wolfler G. Calori | 1998 | Intensive Care Medicine1998，，4： | 2 |
| 20 | The number of spermatozoa collected with testicular sperm extraction is a novel predictor of intracytoplasmic sperm injection outcome in non-obstructive azoospermic patients显示文摘这研究的目的是决定在精子发生的监视器和 intracytoplasmic 精子注射(ICSI ) 的预言者之间的关系在有经历阴囊的精子抽取(TESE ) 的非妨碍的精子缺乏(NOA ) 的病人的结果。有 NOA 的 79 个病人(吝啬的年龄:43.6 卤 5 .2 年,其中各个让步了(97 000 卤 3 040 ) 有常规 TESE 的精子,在我们的分析被考虑。他们的搭挡(吝啬的年龄:35.8 卤 5 .1 年) 经历了 184 个 ICSI 周期的一个总数;632 个卵母细胞被收集, 221 个卵母细胞被注射, 141 个卵母细胞被使肥沃, 121 个胚胎被获得, 110 个胚胎被转移, 14 临床的怀孕被完成,仅仅一流产发生了。Multivariate 回归分析与下列可变价值显示了在使肥沃的卵母细胞,转移胚胎和临床的怀孕的百分比之间的关系:女搭挡的年龄,精子的数字收集的、阴囊的体积,男搭挡刺激荷尔蒙(FSH ) 的滤泡的层次,收集的卵母细胞的数字,注射的卵母细胞的数字和 ICSI 的数字骑车。一种重要反的关系在女搭挡的年龄或男搭挡的 FSH 层次和生物化学的怀孕之间被发现。一种重要直接关系在 ICSI 周期的数字之间出现了,卵母细胞的百分比使肥沃,转移,并且每阴囊的活体检视在精子的数字之间收集了的胚胎和生物化学的怀孕。精子的数字断然被连接到临床的怀孕的数字, ICSI 周期的数字的独立人士和卵母细胞的数字收集 / 注射。收集的精子的数字, FSH 水平和阴囊的体积是连接到 ICSI 成功的精子发生的监视器。 | Giorgio Cavallini Maria Cristina Magli Andor Crippa Silvia Resta Giovanni Vitali Anna Pia Ferraretti Luca Gianaroli | 2011 | Asian Journal of Andrology2011，13，2： | 2 |
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