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| 1 | 851 resected cystic tumors of the pancreas: A 33-year experience at the Massachusetts General Hospital显示文摘 | Nakul P. Valsangkar Vicente Morales-Oyarvide Sarah P. Thayer Cristina R. Ferrone Jennifer A. Wargo Andrew L. Warshaw Carlos Fernández-del Castillo | 2012 | Surgery2012，，3： | 3 |
| 2 | Critical size limit of biodegradable nanopartides for enhanced lymph node trafficking and paracortex penetration显示文摘Lymph node (LN) targeti ng through interstitial drain age of nan oparticles (NPs) is an attractive strategy to stimulate a pote nt immune respo nse, as LNs are the primary site for lymphocyte priming by antigen presenting cells (APCs) and triggering of an adaptive immune response. NP size has been shown to influence the efficiency of LN-targeting and retention after subcutaneous injection. For clinical translation, biodegradable NPs are preferred as carrier for vaccine delivery. However, the selective 'size gateM for effective LN-drainage, particularly the kinetics of LN trafficking, is less well defined. This is partly due to the challenge in generating size-controlled NPs from biodegradable polymers in the sub-100-nm range. Here, we report the preparation of three sets of poly(lactic-co-glycolic)-b-poly(ethylene-glycol)(PLGA-b-PEG) NPs with number average diameters of 20-, 40-, and 100-nm and narrow size distributions using flash nanoprecipitation. Using NPs labeled with a near-infrared dye, we showed that 20-nm NPs drain rapidly across proximal and distal LNs following subcutaneous inoculation in mice and are retai ned in LNs more effectively than NPs with a nu mber average diameter of 40-nm. The drain age of 100-nm NPs was n egligible. Furthermore, the 20-nm NPs showed the highest degree of penetration around the paracortex region and had enhanced access to dendritic cells in the LNs. Together, these data confirmed that small, size-controlled PLGA-b-PEG NPs at the lower threshold of about 30-nm are most effective for LN trafficking, retention, and APC uptake after s.c. administration. This report could inform the design of LN-targeted NP carrier for the delivery of therapeutic or prophylactic vaccines. | Gregory P. Howard Garima Verma Xiyu Ke Winter M. Thayer Timothy Hamerly Victoria K. Baxter John E. Lee Rhoel R. Dinglasan Hai-Quan Mao | 2019 | Nano Research2019，12，4： | 3 |
| 3 | The NF-κB pathway mediates lysophosphatidic acid (LPA)-induced VEGF signaling and cell invasion in epithelial ovarian cancer (EOC)显示文摘 | Sonia Dutta Feng-qiang Wang Hai-shan Wu Thayer J. Mukherjee David A. Fishman | 2011 | Gynecologic Oncology2011，，1： | 2 |
| 4 | Mucin-Producing Neoplasms of the Pancreas: An Analysis of Distinguishing Clinical and Epidemiologic Characteristics显示文摘 | Stefano Crippa Carlos Fernández–del Castillo Roberto Salvia Dianne Finkelstein Claudio Bassi Ismael Domínguez Alona Muzikansky Sarah P. Thayer Massimo Falconi Mari Mino–Kenudson Paola Capelli Gregory Y. Lauwers Stefano Partelli Paolo Pederzoli Andrew L. W | 2010 | Clinical Gastroenterology and Hepatology2010，，2： | 2 |
| 5 | Strand spaces:Proving security protocols correct 显示文摘 | Thayer F J Herzog J C Guttman J D | 1999 | Journal of Computer Security1999，7，23： | 2 |
| 6 | Pancreatic ductal adenocarcinoma: Long-term survival does not equal cure显示文摘 | Cristina R. Ferrone Rafael Pieretti-Vanmarcke Jordan P. Bloom Hui Zheng Jackye Szymonifka Jennifer A. Wargo Sarah P. Thayer Gregory Y. Lauwers Vikram Deshpande Mari Mino-Kenudson Carlos Fernández-del Castillo Keith D. Lillemoe Andrew L. Warshaw | 2012 | Surgery2012，，： | 2 |
| 7 | Experimental disease in infantgoats induced by myco- bacterium inolated from a patients with Crohn's disease,a preliminary report显示文摘 | CHIODINI R J THAYER W R | 1986 | Dig Dis Sci1986，31，： | 1 |
| 8 | Genesis makes sebacic acid显示文摘 | THAYER A M | 2003 | Chemical &Engineering News2003，81，2： | 1 |
| 9 | Exposure to bisphenol A advances puberty显示文摘 | Howdeshell KL Hotchkiss AK Thayer KA | 1999 | Nature1999，401，6755： | 1 |
| 10 | Effect of vaccinating breeder chickens with a killed Salmonella vaccine on Salmonella prevalence and loads in breeder and broiler chicken flocks显示文摘 | Berghaus R D Thayer S G Maurer J J | | 0，，05： | 1 |
| 11 | Pulse pressure and pulsewave velocity are related to cognitive decline in the BaltimoreLongitudinal Study of Aging显示文摘 | Waldstein SR Rice SC Thayer JF | | 0，，： | 1 |
| 12 | Effect of angiotensin-converting enzyme insertion/deletion polymorphism DD genotype on high-frequency heart rate variability in African Americans显示文摘 | Thayer JF Merritt MM Sollers JJ | 2003 | Am J Cardiol2003，92，： | 1 |
| 13 | Relative binding affinity-serum modified access (RBA-SMA) assay predicts the relative in vivo bioactivity of the xenoestrogens bisphenol A and octylphenol显示文摘 | Nagel S C Vom S F Thayer K A | 1997 | Environ Health Perspect1997，105，1： | 1 |
| 14 | Related Articles Autonomic balance revisited: panic anxiety and heart rate variability显示文摘 | Friedman BH Thayer JF | 1998 | J Psychosom Res1998，44，1： | 1 |
| 15 | Enzymes at work显示文摘 | Thayer A M | 2006 | Chem Eng News2006，84，33： | 1 |
| 16 | Leaf xanthophyll content and composition in sun and shade determined by HPLC 显示文摘 | THAYER S S BJORKMAN O | 1990 | Photosynthesis Research1990，23，3： | 1 |
| 17 | Intersection of systematic review methodology with the NIH reproducibility initiative 显示文摘 | Thayer KA Wolfe MS Rooney AA | 2014 | Environ Health Perspect2014，122，7： | 1 |
| 18 | Carotenoid distribution and deepoxida-tion in thylakoid pigment-protein complexes from cotton leavesand bundle-sheath cells of maize显示文摘 | Thayer S S Bjorkman 0 | 1992 | Photosynthesis Research1992，33，3： | 1 |
| 19 | Perioperative C19 -9 levels can predict stage and survival in patients with resectable pancreatic adenocarcinoma 显示文摘 | Ferrone C R Finkelstein D M Thayer S P | 2006 | J Clin Oncol2006，24，18： | 1 |
| 20 | Periope- rative CA19-9 levels can predict stage and survival in patients with resectable pancreatic adenocarcinoma显示文摘 | Ferrone CR Finkelstein DM Thayer SP | 2006 | JClin 0ncol2006，24，18： | 1 |
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