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| 1 | 胃的癌症的多模式的治疗显示文摘 Gastric cancer is the second leading cause of death from malignant disease worldwide.Although complete surgical resection remains the only curative modality for early stage gastric cancer,surgery alone only provides long-term survival in 20%of patients with advancedstage disease.To improve current results,it is necessary to consider multimodality treatment,including chemotherapy,radiotherapy and surgery.Recent clinical trials have shown survival benefit of combining different neoadjuvant or adjuvant protocols compared with surgery with curative intent.Furthermore,the implementation of chemotherapy with novel targeted agents could play an important role in the multimodal management of advanced gastric cancer.In this paper,we focus on a multidisciplinary approach in the treatment of gastric cancer and discuss future strategies to improve the outcome for these patients. | Ilaria Proserpio Stefano Rausei Sabrina Barzaghi Francesco Frattini Federica Galli Domenico Iovino Francesca Rovera Luigi Boni Gianlorenzo Dionigi Graziella Pinotti | 2014 | World Journal of Gastrointestinal Surgery2014，6，4： | 8 |
| 2 | Tumor budding predicts response to anti-EGFR therapies in metastatic colorectal cancer patients显示文摘AIM:To investigate whether the evaluation of tumor budding can complement K-RAS analysis to improve the individualized prediction of response to anti-epidermal growth factor receptor based therapies in metastatic colorectal cancer (mCRC) patients. METHODS:Forty-three patients with mCRC treated with cetuximab or panitumumab were entered into this study. According to the Response Evaluation Criteria in Solid Tumors criteria, 30 patients had stable or progressive disease (non-responsive), while 13 patients had a partial response. Tumor buds were evaluated from whole tissue sections stained for pan-cytokeratin, evaluated in the densest region using a 40 × objective and 'high-grade' tumor budding was defi ned as 15 buds/high-power f ield.RESULTS: Tumor buds and K-RAS mutation both correctly classif ied 68% of patients. All patients with K-RAS mutation (n=7) or high-grade tumor budding (n=11) were non-responsive, of which 4 patients had both features. All 13 partial responders were K-RAS wild-type with low-grade tumor budding. Combined, the predictive value of K-RAS and tumor budding was 80%. Additionally, high-grade tumor budding was significantly related to worse progression-free survival [HR (95% CI): 2.8 (1.3-6.0, P=0.008)].CONCLUSION: If confirmed in larger cohorts, the addition of tumor budding to K-RAS analysis may represent an effective approach for individualized patient management in the metastatic setting. | Inti Zlobec Francesca Molinari Vittoria Martin Luca Mazzucchelli Piercarlo Saletti Rosangela Trezzi Sara De Dosso Tatjana Vlajnic Milo Frattini Alessandro Lugli | 2010 | World Journal of Gastroenterology2010，16，38： | 4 |
| 3 | seventh tumor-node-metastasis staging of gastric cancer: Five-year follow-up显示文摘Seventh tumor-node-metastasis(TNM) classification for gastric cancer,published in 2010,introduced changes in all of its three parameters with the aim to increase its accuracy in prognostication. The aim of this review is to analyze the efficacy of these changes and their implication in clinical practice. We reviewed relevant Literature concerning staging systems in gastric cancer from 2010 up to March 2016. Adenocarcinoma of the esophago-gastric junction still remains a debated entity,due to its peculiar anatomical and histological situation: further improvement in its staging are required. Concerning distant metastases,positive peritoneal cytology has been adopted as a criterion to define metastatic disease: however,its search in clinical practice is still far from being routinely performed,as staging laparoscopy has not yet reached wide diffusion. Regarding definition of T and N: in the era of multimodal treatment these parameters should more influence both staging and surgery. The changes about T-staging suggested some modifications in clinical practice. Differently,many controversies on lymph node staging are still ongoing,with the proposal of alternative classification systems in order to minimize the extent of lymphadenectomy. The next TNM classification should take into account all of these aspects to improve its accuracy and the comparability of prognosis in patients from both Eastern and Western world. | Stefano Rausei Laura Ruspi Federica Galli Vincenzo Pappalardo Giuseppe Di Rocco Francesco Martignoni Francesco Frattini Francesca Rovera Luigi Boni Gianlorenzo Dionigi | 2016 | World Journal of Gastroenterology2016，22，34： | 2 |
| 4 | ERCC1 predicts outcome in patients with gastric cancer treated with adjuvant cisplatin-based chemotherapy显示文摘 | Sara Dosso Elena Zanellato Martina Nucifora Renzo Boldorini Angelica Sonzogni Roberto Biffi Nicola Fazio Eraldo Bucci Ottavio Beretta Stefano Crippa Piercarlo Saletti Milo Frattini | 2013 | Cancer Chemotherapy and Pharmacology2013，，1： | 2 |
| 5 | In advanced gastric cancer:Prognosis and treatment of patients with positive peritoneal cytology显示文摘Positive peritoneal cytology in gastric cancer is classified as M1 disease by the 7thEdition of American Joint Committee on Cancer staging system.With the introduction of laparoscopy and peritoneal washing cytology in the staging of gastric cancer a new category of patients has been identified.These are patients with no macroscopic peritoneal metastases but with peritoneal cytology positive(P0C1).Prognosis and treatment of such patientsrepresent a controversial issue.We evaluate the state of the art of staging system in gastric cancer and discusss tandardisation in staging and treatment procedures.There is still a lack of uniformity in the use of laparoscopy with peritoneal cytology in clinical decision making and in the surgical treatment for gastric cancer.Survival of this patient subset remains poor.Multimodal therapies and new therapeutic strategies are required to improve the survival of these patients. | Francesco Frattini Stefano Rausei Corrado Chiappa Francesca Rovera Luigi Boni Gianlorenzo Dionigi | 2013 | World Journal of Gastrointestinal Surgery2013，5，5： | 2 |
| 6 | The safety of energy-based devices in open thyroidectomy: a prospective, randomised study comparing the LigaSure? (LF1212) and the Harmonic? FOCUS显示文摘 | Gianlorenzo Dionigi Luigi Boni Stefano Rausei Francesco Frattini Cesare Ferrari Alberto Mangano Andrea Leotta Marco Franchin | 2012 | Langenbeck’s Archives of Surgery2012，，5： | 2 |
| 7 | Differential effects of orbital and laminar shear stress on endothelial cells显示文摘 | Dardik A Chen L Frattini J | 2005 | Vasc Surg2005，41，5： | 1 |
| 8 | Intomo alia generazione dei gruppi dioperazioni显示文摘 | Frattini G | | Real Academia dei Lincei Rend0，，： | 1 |
| 9 | Neutron diffraction studies of ceria-zirconia catalysts prepared by high-energy mechanical milling 显示文摘 | Enzo S Frattini R Delogo F | 1999 | Nanostructured Materials1999，12，5： | 1 |
| 10 | One shot: a novel method to dilate the nephrostomy access for percutaneous lithotripsy 显示文摘 | Frattini A Barbieri A Salsi P | 2001 | J Endourol2001，15，9： | 1 |
| 11 | P16^INK4A hypermethylation detected by fluorescent methylation-specific PCR in plasmas from non-small cell lung cancer 显示文摘 | Bearzatto A Conte D Frattini M | 2002 | Clin Cancer Res2002，8，12： | 1 |
| 12 | Quantitative analysis of plasma DNA in colorectal cancer patients: a novel prognostic tool显示文摘 | Frattini M Gallino G Signoroni S | 2007 | Ann N YAcad Sci2007，1075，： | 1 |
| 13 | Higher plasma cate- cholamine and metabolite levels in the early phase of nonsegental vitiligo显示文摘 | Cucchi ML Frattini P Santagostino G | 2000 | Pigment Cell Res2000，13，： | 1 |
| 14 | Quantitative and qualitative characterization of plasma DNA identifies primary and recurrent colorectal cancer显示文摘 | Frattini M Gallino G Singoroni S | 2008 | Cancer Lett2008，263，2： | 1 |
| 15 | Tibial plateau fractures in elderly patients显示文摘 | Frattini ME Vaienti E Soncini G | 2009 | Chir Organi Mov2009，93，3： | 1 |
| 16 | Alternative mutations of BRAF,RET and NTRK1 are associated with similar but distinct gene expression patterns in papillary thyroid cancer 显示文摘 | Frattini M Ferrario C Bressan P | 2004 | Oncogene2004，23，44： | 1 |
| 17 | Osteopetroses and immmlodeficiencies in humans显示文摘 | Villa A Vezzoni P Frattini A | 2006 | Curt Opin Allergy Cfin Immunol2006，6，6： | 1 |
| 18 | Approaches for defining thresholds and return periods for rainfall-triggered shallow landslides显示文摘 | Frattini P Crosta G Sosio R | 2009 | Hydrological Processes2009，23，14： | 1 |
| 19 | Neural modeling helps the BOS process to achieve aimed end-point显示文摘 | Frattini Fileti A M Pacianotto T A Pitasse Cunha A | 2006 | Engineering Applications of Artificial Intelligence2006，19，1： | 1 |
| 20 | Rice calcium-dependent protein kinase isoforms OsCDPK2 and OsCDPKll show different responses to light and different expression pat- terns during seed development 显示文摘 | Frattini M Morello L Breviario | 1999 | Plant Mol Biol1999，41，： | 1 |
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